hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07916.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RNF31 | E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) | 5 | UniProt NCBI |
| SHARPIN | Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6178 | 5.12628525639e-06 | 1.0 | SHARPIN RNF31 | LUBAC complex |
| REAC:R-HSA-5357786 | 0.000471618243588 | 1.0 | SHARPIN RNF31 | TNFR1-induced proapoptotic signaling |
| REAC:R-HSA-5357956 | 0.000847545829056 | 1.0 | SHARPIN RNF31 | TNFR1-induced NF-kappa-B signaling pathway |
| GO:0071797 | 0.00140460216025 | 1.0 | SHARPIN RNF31 | LUBAC complex |
| KEGG:04217 | 0.00151449927371 | 1.0 | SHARPIN RNF31 | Necroptosis |
| REAC:R-HSA-5357905 | 0.00161648861751 | 1.0 | SHARPIN RNF31 | Regulation of TNFR1 signaling |
| KEGG:04621 | 0.001720800216 | 1.0 | SHARPIN RNF31 | NOD-like receptor signaling pathway |
| REAC:R-HSA-75893 | 0.00235467369443 | 1.0 | SHARPIN RNF31 | TNF signaling |
| KEGG:05131 | 0.00417007523294 | 1.0 | SHARPIN RNF31 | Shigellosis |
| GO:0097039 | 0.00468200720083 | 1.0 | SHARPIN RNF31 | protein linear polyubiquitination |
| REAC:R-HSA-73887 | 0.0136718027788 | 1.0 | SHARPIN RNF31 | Death Receptor Signaling |
| GO:0023035 | 0.0257510396046 | 1.0 | SHARPIN RNF31 | CD40 signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RNF31 | SHARPIN | 1.0 | 0.288 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes