hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07920.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MT-ND3 | NADH-ubiquinone oxidoreductase chain 3 (EC 7.1.1.2) (NADH dehydrogenase subunit 3) | 5 | UniProt NCBI |
| NDUFS6 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP623 | 0.000728264938239 | 1.0 | MT-ND3 NDUFS6 | Oxidative phosphorylation |
| KEGG:04723 | 0.0011414018249 | 1.0 | MT-ND3 NDUFS6 | Retrograde endocannabinoid signaling |
| KEGG:00190 | 0.00119992691491 | 1.0 | MT-ND3 NDUFS6 | Oxidative phosphorylation |
| CORUM:178 | 0.00154301186217 | 1.0 | MT-ND3 NDUFS6 | Respiratory chain complex I (holoenzyme), mitochondrial |
| HP:0012748 | 0.00180445241025 | 1.0 | MT-ND3 NDUFS6 | Focal T2 hyperintense brainstem lesion |
| WP:WP111 | 0.00202305274778 | 1.0 | MT-ND3 NDUFS6 | Electron transport chain OXPHOS system in mitochondria |
| HP:0007704 | 0.00215303980768 | 1.0 | MT-ND3 NDUFS6 | Paroxysmal involuntary eye movements |
| HP:0008316 | 0.00253238491666 | 1.0 | MT-ND3 NDUFS6 | Abnormal mitochondria in muscle tissue |
| HP:0012747 | 0.00253238491666 | 1.0 | MT-ND3 NDUFS6 | Abnormal brainstem MRI signal intensity |
| KEGG:05415 | 0.00267768543767 | 1.0 | MT-ND3 NDUFS6 | Diabetic cardiomyopathy |
| REAC:R-HSA-6799198 | 0.0027271837564 | 1.0 | MT-ND3 NDUFS6 | Complex I biogenesis |
| KEGG:05208 | 0.0033003273675 | 1.0 | MT-ND3 NDUFS6 | Chemical carcinogenesis - reactive oxygen species |
| KEGG:04714 | 0.00339933231144 | 1.0 | MT-ND3 NDUFS6 | Thermogenesis |
| HP:0000114 | 0.0036943429081 | 1.0 | MT-ND3 NDUFS6 | Proximal tubulopathy |
| HP:0004366 | 0.00453163616665 | 1.0 | MT-ND3 NDUFS6 | Abnormality of glycolysis |
| HP:0003542 | 0.00453163616665 | 1.0 | MT-ND3 NDUFS6 | Increased serum pyruvate |
| KEGG:05012 | 0.00458495309323 | 1.0 | MT-ND3 NDUFS6 | Parkinson disease |
| HP:0001138 | 0.00470934738887 | 1.0 | MT-ND3 NDUFS6 | Optic neuropathy |
| KEGG:05020 | 0.00485920816781 | 1.0 | MT-ND3 NDUFS6 | Prion disease |
| HP:0003737 | 0.00489047613459 | 1.0 | MT-ND3 NDUFS6 | Mitochondrial myopathy |
| HP:0025116 | 0.00564916635254 | 1.0 | MT-ND3 NDUFS6 | Fetal distress |
| KEGG:05016 | 0.00594761227231 | 1.0 | MT-ND3 NDUFS6 | Huntington disease |
| HP:0011013 | 0.00755614446791 | 1.0 | MT-ND3 NDUFS6 | Abnormal circulating carbohydrate concentration |
| REAC:R-HSA-611105 | 0.00828920325958 | 1.0 | MT-ND3 NDUFS6 | Respiratory electron transport |
| KEGG:05014 | 0.00850662183301 | 1.0 | MT-ND3 NDUFS6 | Amyotrophic lateral sclerosis |
| KEGG:05010 | 0.0093688914925 | 1.0 | MT-ND3 NDUFS6 | Alzheimer disease |
| HP:0003800 | 0.0107993742735 | 1.0 | MT-ND3 NDUFS6 | Muscle abnormality related to mitochondrial dysfunction |
| REAC:R-HSA-163200 | 0.0124056103205 | 1.0 | MT-ND3 NDUFS6 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| HP:0011923 | 0.0133830220427 | 1.0 | MT-ND3 NDUFS6 | Decreased activity of mitochondrial complex I |
| KEGG:05022 | 0.0138982457502 | 1.0 | MT-ND3 NDUFS6 | Pathways of neurodegeneration - multiple diseases |
| HP:0034435 | 0.0149379952371 | 1.0 | MT-ND3 NDUFS6 | Abnormal eye contact |
| HP:0002415 | 0.0149379952371 | 1.0 | MT-ND3 NDUFS6 | Leukodystrophy |
| HP:0000817 | 0.0149379952371 | 1.0 | MT-ND3 NDUFS6 | Reduced eye contact |
| HP:0000124 | 0.0152592424465 | 1.0 | MT-ND3 NDUFS6 | Renal tubular dysfunction |
| HP:0002490 | 0.0159119894358 | 1.0 | MT-ND3 NDUFS6 | Increased CSF lactate |
| HP:0030085 | 0.0159119894358 | 1.0 | MT-ND3 NDUFS6 | Abnormal CSF lactate concentration |
| HP:0000758 | 0.0169167413461 | 1.0 | MT-ND3 NDUFS6 | Abnormal nonverbal communicative behavior |
| HPA:0271123 | 0.0193364490193 | 1.0 | MT-ND3 NDUFS6 | kidney; collecting ducts[High] |
| REAC:R-HSA-1428517 | 0.0242575818332 | 1.0 | MT-ND3 NDUFS6 | The citric acid (TCA) cycle and respiratory electron transport |
| HPA:0271133 | 0.0245263757673 | 1.0 | MT-ND3 NDUFS6 | kidney; distal tubules[High] |
| HP:0008972 | 0.0277776310426 | 1.0 | MT-ND3 NDUFS6 | Decreased activity of mitochondrial respiratory chain |
| HP:0011922 | 0.0295479082178 | 1.0 | MT-ND3 NDUFS6 | Abnormal activity of mitochondrial respiratory chain |
| HP:0025454 | 0.0299990213204 | 1.0 | MT-ND3 NDUFS6 | Abnormal CSF metabolite concentration |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MT-ND3 | NDUFS6 | 0.974 | 0.766 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes