hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07933.1

Complex Portal: CPX-15704

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
TSPAN33	Tetraspanin-33 (Tspan-33) (Penumbra) (hPen) (Proerythroblast new membrane)	5	UniProt NCBI
MYOM2	Myomesin-2 (165 kDa connectin-associated protein) (165 kDa titin-associated protein) (M-protein) (Myomesin family member 2)	5	UniProt NCBI
TTN	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14)	5	UniProt NCBI
PYGM	Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase)	5	UniProt NCBI
MYH7	Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)	5	UniProt NCBI
TNNT3	Troponin T, fast skeletal muscle (TnTf) (Beta-TnTF) (Fast skeletal muscle troponin T) (fTnT)	5	UniProt NCBI
MYL11	Myosin regulatory light chain 11 (Fast skeletal myosin light chain 2) (MLC2B) (Myosin light chain 11) (Myosin regulatory light chain 2, skeletal muscle isoform)	5	UniProt NCBI
TLE3	Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)	5	UniProt NCBI
MYOZ1	Myozenin-1 (Calsarcin-2) (Filamin-, actinin- and telethonin-binding protein) (Protein FATZ)	5	UniProt NCBI
LDB3	LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein)	5	UniProt NCBI
NEB	Nebulin	5	UniProt NCBI
MYBPC1	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform)	5	UniProt NCBI
RSPH6A	Radial spoke head protein 6 homolog A (Radial spoke head-like protein 1)	3	UniProt NCBI
LATS2	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)	5	UniProt NCBI
MYH13	Myosin-13 (Myosin heavy chain 13) (Myosin heavy chain, skeletal muscle, extraocular) (MyHC-EO) (Myosin heavy chain, skeletal muscle, laryngeal) (MyHC-IIL) (Superfast myosin)	5	UniProt NCBI
LATS1	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)	5	UniProt NCBI
MYOM1	Myomesin-1 (190 kDa connectin-associated protein) (190 kDa titin-associated protein) (Myomesin family member 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0043292	1.02223323285e-10	0.6	MYBPC1 MYOM1 NEB MYL11 TTN TNNT3 MYH13 MYOZ1 LDB3	contractile fiber
WP:WP383	1.91756607703e-08	0.333333333333	TTN MYBPC1 TNNT3 MYOM1 NEB	Striated muscle contraction pathway
GO:0008307	2.95844789331e-08	0.4	MYBPC1 MYOM1 MYOM2 NEB MYL11 TTN	structural constituent of muscle
GO:0030016	1.07469241068e-06	0.466666666667	MYBPC1 MYOM1 NEB TTN TNNT3 MYOZ1 LDB3	myofibril
REAC:R-HSA-390522	8.64818343999e-06	0.266666666667	TTN MYBPC1 TNNT3 NEB	Striated Muscle Contraction
GO:0030239	2.871912886e-05	0.333333333333	NEB MYOM2 MYOZ1 TNNT3 TTN	myofibril assembly
GO:0055002	3.22905609223e-05	0.333333333333	NEB MYOM2 MYOZ1 TNNT3 TTN	striated muscle cell development
GO:0099512	3.24561078286e-05	0.6	MYBPC1 MYOM1 NEB MYL11 TTN TNNT3 MYH13 MYOZ1 LDB3	supramolecular fiber
GO:0099081	3.62495026124e-05	0.6	MYBPC1 MYOM1 NEB MYL11 TTN TNNT3 MYH13 MYOZ1 LDB3	supramolecular polymer
GO:0030017	4.4185613825e-05	0.4	MYOM1 NEB TTN TNNT3 MYOZ1 LDB3	sarcomere
REAC:R-HSA-397014	8.81622770127e-05	0.333333333333	NEB TTN MYBPC1 TNNT3 MYL11	Muscle contraction
GO:0010927	0.000315337251968	0.333333333333	NEB MYOM2 MYOZ1 TNNT3 TTN	cellular component assembly involved in morphogenesis
GO:0045214	0.000377078861379	0.266666666667	MYOM2 MYOZ1 TNNT3 TTN	sarcomere organization
HP:0003555	0.000438947971843	0.2	TTN LDB3 NEB	Muscle fiber splitting
GO:0061061	0.000652984537477	0.466666666667	MYOM2 MYL11 NEB TTN TNNT3 MYOZ1 LDB3	muscle structure development
HPA:0440342	0.000728906504017	0.8	MYBPC1 TSPAN33 MYOM1 MYOM2 MYL11 NEB TTN TNNT3 LATS2 MYOZ1 LDB3 LATS1	skeletal muscle; myocytes[>=Medium]
HP:0009077	0.000785758218155	0.2	TTN LDB3 NEB	Weakness of long finger extensor muscles
HP:0030059	0.00109246834686	0.133333333333	TTN NEB	Mitochondrial depletion
GO:0055001	0.00113204065575	0.333333333333	NEB MYOM2 MYOZ1 TNNT3 TTN	muscle cell development
HP:0000160	0.00139656047221	0.333333333333	NEB TTN MYBPC1 TNNT3 MYL11	Narrow mouth
GO:0099080	0.00166232386669	0.6	MYBPC1 MYOM1 NEB MYL11 TTN TNNT3 MYH13 MYOZ1 LDB3	supramolecular complex
GO:0030029	0.00172995805611	0.533333333333	LATS1 MYOM2 MYL11 NEB TTN TNNT3 MYOZ1 LDB3	actin filament-based process
GO:0015629	0.00190063226546	0.466666666667	NEB MYL11 TTN TNNT3 MYH13 MYOZ1 LDB3	actin cytoskeleton
GO:0003012	0.0034168082343	0.4	MYOM2 MYL11 TTN TNNT3 MYOZ1 MYH13	muscle system process
HP:0001181	0.003589754236	0.266666666667	NEB MYBPC1 TNNT3 MYL11	Adducted thumb
HP:0003458	0.00372827486879	0.266666666667	TTN MYBPC1 LDB3 NEB	EMG: myopathic abnormalities
GO:0051146	0.0052422970674	0.333333333333	NEB MYOM2 MYOZ1 TNNT3 TTN	striated muscle cell differentiation
HP:0008366	0.00552714476514	0.266666666667	TTN MYBPC1 MYL11 NEB	Foot joint contracture
HP:0003327	0.006799532334	0.2	TTN NEB MYBPC1	Axial muscle weakness
GO:0003779	0.00931913383075	0.4	NEB MYH13 TTN TNNT3 MYOZ1 LDB3	actin binding
HP:0030237	0.0101204427746	0.2	TTN LDB3 NEB	Hand muscle weakness
GO:0031032	0.0124339813078	0.333333333333	NEB MYOM2 MYOZ1 TNNT3 TTN	actomyosin structure organization
GO:0005856	0.0136464432656	0.666666666667	LATS2 LATS1 NEB MYL11 TTN TNNT3 RSPH6A MYH13 MYOZ1 LDB3	cytoskeleton
WP:WP4533	0.0165568854691	0.133333333333	LATS2 LATS1	Transcription co factors SKI and SKIL protein partners
HP:0003306	0.0174054162173	0.2	TTN NEB MYBPC1	Spinal rigidity
KEGG:04392	0.0179606993477	0.133333333333	LATS2 LATS1	Hippo signaling pathway - multiple species
WP:WP4537	0.0184937836061	0.133333333333	LATS2 LATS1	Hippo YAP signaling
GO:0030036	0.0200609012199	0.466666666667	LATS1 MYOM2 NEB TTN TNNT3 MYOZ1 LDB3	actin cytoskeleton organization
HP:0030198	0.0228738874103	0.133333333333	LDB3 NEB	Fatigable weakness of distal limb muscles
HP:0001838	0.0246930674642	0.2	MYBPC1 TNNT3 MYL11	Rocker bottom foot
HP:0011337	0.02739678651	0.333333333333	NEB TTN MYBPC1 TNNT3 MYL11	Abnormality of mouth size
HP:0008365	0.0275063372535	0.2	MYBPC1 TNNT3 MYL11	Abnormal talus morphology
GO:0030018	0.028142612113	0.266666666667	NEB TTN LDB3 MYOZ1	Z disc
KEGG:04814	0.0314446246238	0.2	MYH13 TNNT3 MYL11	Motor proteins
HP:0005750	0.0345199547462	0.266666666667	TTN MYBPC1 MYL11 NEB	Lower-limb joint contracture
HP:0003121	0.036161573566	0.333333333333	NEB TTN MYBPC1 TNNT3 MYL11	Limb joint contracture
HP:0003715	0.0391658859752	0.133333333333	TTN LDB3	Myofibrillar myopathy
GO:0042692	0.0395260758026	0.333333333333	NEB MYOM2 MYOZ1 TNNT3 TTN	muscle cell differentiation
HP:0003323	0.0408600412705	0.2	TTN LDB3 NEB	Progressive muscle weakness
GO:0031674	0.0418250334651	0.266666666667	NEB TTN LDB3 MYOZ1	I band
HP:0002460	0.0423774164592	0.266666666667	TTN MYBPC1 LDB3 NEB	Distal muscle weakness
HP:0001883	0.0427863516732	0.333333333333	NEB TTN MYBPC1 TNNT3 MYL11	Talipes
WP:WP4542	0.0436496232857	0.133333333333	LATS2 LATS1	Leukocyte intrinsic Hippo pathway functions
HP:0005656	0.0448426700545	0.333333333333	NEB TTN MYBPC1 TNNT3 MYL11	Positional foot deformity
GO:0036379	0.0493379236969	0.2	TTN TNNT3 MYOM1	myofilament
CORUM:1987	0.0498224659463	0.0666666666667	MYOM1	MYOM1 homodimer complex
REAC:R-HSA-2028269	0.0498335486393	0.133333333333	LATS2 LATS1	Signaling by Hippo

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
LATS1	MYOZ1	0.997
MYOM2	TSPAN33	0.997		structurally_consistent (dimer)
MYOM1	TSPAN33	0.997
TSPAN33	NEB	0.997
MYBPC1	TSPAN33	0.996
LATS1	LATS2	0.995
TSPAN33	LDB3	0.993
TTN	TSPAN33	0.992
LATS1	MYOM2	0.991
MYH13	RSPH6A	0.99
LATS1	TNNT3	0.99
LATS1	TTN	0.989
LDB3	RSPH6A	0.986
MYL11	TSPAN33	0.986
LATS1	MYBPC1	0.985
MYH13	TSPAN33	0.985
TNNT3	TSPAN33	0.985
LATS1	LDB3	0.984
MYL11	RSPH6A	0.984
LATS1	MYOM1	0.984	0.074
TLE3	MYOM1	0.983
TNNT3	RSPH6A	0.982
MYH7	TSPAN33	0.98
LATS1	MYH13	0.979
TTN	RSPH6A	0.979
LATS1	NEB	0.979	0.182
PYGM	TSPAN33	0.978		structurally_consistent (dimer)
LATS1	MYL11	0.976
LATS1	PYGM	0.972	0.13
MYOM2	RSPH6A	0.971
MYBPC1	RSPH6A	0.971
NEB	RSPH6A	0.961
TLE3	MYH7	0.952	0.036
MYH7	RSPH6A	0.947
LATS1	MYH7	0.945	0.086
PYGM	RSPH6A	0.925
MYL11	TTN	0.918
MYOZ1	TNNT3	0.904
MYOZ1	NEB	0.902
MYOZ1	LDB3	0.902
MYOZ1	MYH13	0.902
MYOZ1	MYBPC1	0.902
MYOZ1	MYL11	0.902
MYOZ1	TTN	0.902
MYOZ1	MYOM1	0.902
MYOZ1	MYOM2	0.902
TTN	NEB	0.892
MYH7	MYL11	0.89
MYOZ1	PYGM	0.881
TNNT3	MYL11	0.87
PYGM	TTN	0.868
PYGM	MYL11	0.865
MYL11	NEB	0.856
TNNT3	NEB	0.856
TNNT3	TTN	0.856
MYL11	MYOM1	0.856
TTN	MYOM1	0.855
MYH7	MYOM1	0.854	0.112
PYGM	NEB	0.843	0.178
MYH7	TTN	0.825
PYGM	TNNT3	0.824
TLE3	TTN	0.799
MYH7	NEB	0.797	0.15
MYH7	MYOM2	0.797
TNNT3	MYBPC1	0.792
PYGM	MYBPC1	0.792
MYOM1	LDB3	0.785
MYL11	MYBPC1	0.785
MYBPC1	LDB3	0.785
MYH13	MYBPC1	0.785
MYH7	LDB3	0.784
MYH7	MYBPC1	0.783
MYH13	TTN	0.783
MYH13	MYOM2	0.777
MYH13	LDB3	0.777
TNNT3	MYOM1	0.777
MYOM2	LDB3	0.777
MYH13	MYL11	0.777
MYH13	NEB	0.777
MYOM1	NEB	0.765	0.09
TTN	MYBPC1	0.765
MYH13	PYGM	0.758
PYGM	MYOM2	0.758
PYGM	LDB3	0.758
MYBPC1	MYOM2	0.757
MYBPC1	NEB	0.757
MYH7	TNNT3	0.757
LDB3	NEB	0.756
MYL11	LDB3	0.756
MYH13	TNNT3	0.756
TTN	LDB3	0.756
MYL11	MYOM2	0.756
TNNT3	MYOM2	0.756
TNNT3	LDB3	0.756
TLE3	MYL11	0.755
MYOM2	NEB	0.744
TTN	MYOM2	0.744
MYH7	PYGM	0.688	0.092
MYH13	MYH7	0.667
MYH13	MYOM1	0.633
MYOM1	MYOM2	0.596
MYBPC1	MYOM1	0.564
PYGM	MYOM1	0.54	0.046
MYOZ1	MYH7	0.388
MYOZ1	LATS2	0.214
LATS2	MYBPC1	0.131
LATS2	MYOM1	0.055
LATS2	MYOM2	0.046
LATS2	NEB	0.046
MYH13	LATS2	0.046
LATS2	LDB3	0.046
LATS2	TTN	0.043
LATS2	MYL11	0.043
LATS2	PYGM	0.043
LATS2	TNNT3	0.042
LATS2	MYH7	0.042
TLE3	PYGM	0.039	0.024
TLE3	LATS2	0.018
TLE3	NEB	0.006	0.076
TLE3	LATS1	0.005	0.100909090909

Related Complexes

Genename	Complexes
TSPAN33	huMAP3_07933.1 huMAP3_09076.1 huMAP3_10799.1 huMAP3_14138.1
MYOM2	huMAP3_03713.1 huMAP3_05027.1 huMAP3_06073.1 huMAP3_07933.1 huMAP3_09076.1 huMAP3_10732.1 huMAP3_10799.1 huMAP3_11143.1 huMAP3_11407.1 huMAP3_11751.1 huMAP3_12644.1 huMAP3_14138.1
TTN	huMAP3_03011.1 huMAP3_07933.1 huMAP3_09076.1 huMAP3_10383.1 huMAP3_10799.1 huMAP3_14138.1
PYGM	huMAP3_02460.1 huMAP3_07933.1 huMAP3_08093.1 huMAP3_09076.1 huMAP3_09760.1 huMAP3_10799.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_14138.1
MYH7	huMAP3_01597.1 huMAP3_07933.1 huMAP3_09076.1 huMAP3_10799.1 huMAP3_14138.1
TNNT3	huMAP3_02931.1 huMAP3_07933.1 huMAP3_09076.1 huMAP3_09693.1 huMAP3_10799.1 huMAP3_14138.1
MYL11	huMAP3_02931.1 huMAP3_07933.1 huMAP3_09076.1 huMAP3_09693.1 huMAP3_10799.1 huMAP3_14138.1
TLE3	huMAP3_00022.1 huMAP3_07933.1 huMAP3_09076.1 huMAP3_10799.1 huMAP3_11616.1 huMAP3_14138.1 huMAP3_14261.1
MYOZ1	huMAP3_00581.1 huMAP3_03011.1 huMAP3_07504.1 huMAP3_07933.1 huMAP3_09076.1 huMAP3_10383.1 huMAP3_10799.1 huMAP3_14138.1
LDB3	huMAP3_07933.1 huMAP3_09076.1 huMAP3_10799.1 huMAP3_14138.1
NEB	huMAP3_07933.1 huMAP3_09076.1 huMAP3_10799.1 huMAP3_14138.1
MYBPC1	huMAP3_03011.1 huMAP3_07933.1 huMAP3_09076.1 huMAP3_10383.1 huMAP3_10799.1 huMAP3_12943.1 huMAP3_14138.1
RSPH6A	huMAP3_07933.1 huMAP3_09076.1 huMAP3_10799.1 huMAP3_12943.1 huMAP3_14138.1
LATS2	huMAP3_00803.1 huMAP3_03011.1 huMAP3_07504.1 huMAP3_07933.1 huMAP3_09076.1 huMAP3_10383.1 huMAP3_11381.1 huMAP3_11502.1
MYH13	huMAP3_00683.1 huMAP3_03725.1 huMAP3_05020.1 huMAP3_07933.1 huMAP3_09076.1 huMAP3_10799.1 huMAP3_14138.1
LATS1	huMAP3_00581.1 huMAP3_03011.1 huMAP3_07504.1 huMAP3_07933.1 huMAP3_09076.1 huMAP3_10383.1 huMAP3_10799.1 huMAP3_14138.1
MYOM1	huMAP3_03011.1 huMAP3_07933.1 huMAP3_09076.1 huMAP3_10383.1 huMAP3_10799.1 huMAP3_14138.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07933.1

Complex Portal: CPX-15704