hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07936.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MKNK2 | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | 5 | UniProt NCBI |
| RHBDF1 | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | 5 | UniProt NCBI |
| MAPK14 | Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) | 5 | UniProt NCBI |
| DUSP16 | Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7) | 5 | UniProt NCBI |
| MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | 5 | UniProt NCBI |
| MAPKAPK3 | MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK) | 5 | UniProt NCBI |
| MAPK11 | Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP382 | 3.9377760415e-09 | 0.857142857143 | MKNK1 MAPK11 MAPK14 MKNK2 DUSP16 MAPKAPK3 | MAPK signaling pathway |
| KEGG:04010 | 7.15976560307e-09 | 0.857142857143 | MKNK1 MAPK11 MAPK14 MKNK2 DUSP16 MAPKAPK3 | MAPK signaling pathway |
| WP:WP2637 | 2.04577827115e-07 | 0.571428571429 | MAPK14 MKNK2 MAPK11 MKNK1 | Interleukin 1 IL 1 structural pathway |
| REAC:R-HSA-171007 | 1.56249715062e-06 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | p38MAPK events |
| REAC:R-HSA-167044 | 4.73568218926e-06 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Signalling to RAS |
| REAC:R-HSA-450302 | 1.48132609528e-05 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | activated TAK1 mediates p38 MAPK activation |
| REAC:R-HSA-187687 | 3.374300022e-05 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Signalling to ERKs |
| KEGG:04370 | 7.24130742517e-05 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | VEGF signaling pathway |
| GO:0009931 | 0.0001882019462 | 0.428571428571 | MKNK1 MKNK2 MAPKAPK3 | calcium-dependent protein serine/threonine kinase activity |
| GO:0010857 | 0.000282244947588 | 0.428571428571 | MKNK1 MKNK2 MAPKAPK3 | calcium-dependent protein kinase activity |
| REAC:R-HSA-450294 | 0.000357539654198 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | MAP kinase activation |
| REAC:R-HSA-448424 | 0.000487210059522 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Interleukin-17 signaling |
| KEGG:04148 | 0.00106227049151 | 0.428571428571 | MAPK14 DUSP16 MAPK11 | Efferocytosis |
| REAC:R-HSA-376172 | 0.00106560242715 | 0.285714285714 | MAPK14 MAPK11 | DSCAM interactions |
| REAC:R-HSA-168142 | 0.00113617130448 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975871 | 0.00113617130448 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168176 | 0.00113617130448 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975138 | 0.00122193261477 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 0.00126637654584 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 0.00126637654584 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-4420097 | 0.00135845178782 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-2151209 | 0.00136974769985 | 0.285714285714 | MAPK14 MAPK11 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation |
| REAC:R-HSA-168138 | 0.00145485785287 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 0.00155569177621 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166166 | 0.0016610504278 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 0.0016610504278 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-450341 | 0.00171179400053 | 0.285714285714 | MAPK14 MAPK11 | Activation of the AP-1 family of transcription factors |
| REAC:R-HSA-168188 | 0.00177103051244 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.00177103051244 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-194138 | 0.00177103051244 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Signaling by VEGF |
| REAC:R-HSA-168179 | 0.00188572856993 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-187037 | 0.00188572856993 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-181438 | 0.00188572856993 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-2559580 | 0.00253335581071 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Oxidative Stress Induced Senescence |
| WP:WP5272 | 0.00303405736115 | 0.285714285714 | MAPK14 MAPK11 | LDL influence on CD14 and TLR4 |
| WP:WP4767 | 0.00303405736115 | 0.285714285714 | MAPK14 MAPK11 | FGFR3 signaling in chondrocyte proliferation and terminal differentiation |
| REAC:R-HSA-166520 | 0.00306472559835 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Signaling by NTRKs |
| WP:WP4864 | 0.00337040555802 | 0.285714285714 | MAPK14 MAPK11 | Host pathogen interaction of human coronaviruses apoptosis |
| WP:WP1528 | 0.00372433499977 | 0.285714285714 | MAPK14 MAPK11 | Physiological and pathological hypertrophy of the heart |
| WP:WP3879 | 0.00372433499977 | 0.285714285714 | MKNK1 MKNK2 | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| REAC:R-HSA-166016 | 0.00384976500914 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Toll Like Receptor 4 (TLR4) Cascade |
| WP:WP3612 | 0.00409583359214 | 0.285714285714 | MAPK14 MAPK11 | Photodynamic therapy induced NFE2L2 NRF2 survival signaling |
| GO:0051019 | 0.00445787546995 | 0.428571428571 | MAPK14 DUSP16 MAPKAPK3 | mitogen-activated protein kinase binding |
| REAC:R-HSA-9006934 | 0.00475797272612 | 0.571428571429 | MAPK14 MAPKAPK3 MAPK11 MKNK1 | Signaling by Receptor Tyrosine Kinases |
| GO:0004683 | 0.00516068999797 | 0.428571428571 | MKNK1 MKNK2 MAPKAPK3 | calmodulin-dependent protein kinase activity |
| REAC:R-HSA-450604 | 0.00516516478082 | 0.285714285714 | MAPK14 MAPK11 | KSRP (KHSRP) binds and destabilizes mRNA |
| WP:WP3869 | 0.00531562340489 | 0.285714285714 | MAPK14 MAPK11 | Cannabinoid receptor signaling |
| WP:WP722 | 0.00575727775656 | 0.285714285714 | MAPK14 MAPKAPK3 | Serotonin HTR1 group and FOS pathway |
| GO:0004674 | 0.0058499573846 | 0.714285714286 | MAPK14 MAPKAPK3 MKNK2 MAPK11 MKNK1 | protein serine/threonine kinase activity |
| REAC:R-HSA-168898 | 0.00591992337161 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Toll-like Receptor Cascades |
| WP:WP2643 | 0.00621644086214 | 0.285714285714 | MAPK14 MAPK11 | Nanoparticle mediated activation of receptor signaling |
| WP:WP400 | 0.00769886208303 | 0.285714285714 | MAPK14 MKNK1 | p38 MAPK signaling pathway |
| WP:WP4877 | 0.00769886208303 | 0.285714285714 | MAPK14 MAPK11 | Host pathogen interaction of human coronaviruses MAPK signaling |
| REAC:R-HSA-198753 | 0.00796834465067 | 0.285714285714 | MAPK14 MAPK11 | ERK/MAPK targets |
| REAC:R-HSA-5668599 | 0.00796834465067 | 0.285714285714 | MAPK14 MAPK11 | RHO GTPases Activate NADPH Oxidases |
| WP:WP2371 | 0.00991981492579 | 0.285714285714 | MAPK14 MAPK11 | Parkinson 39 s disease pathway |
| REAC:R-HSA-525793 | 0.0104655132242 | 0.285714285714 | MAPK14 MAPK11 | Myogenesis |
| REAC:R-HSA-2559583 | 0.0110497496792 | 0.428571428571 | MAPK14 MAPK11 MAPKAPK3 | Cellular Senescence |
| KEGG:04664 | 0.0139791020136 | 0.285714285714 | MAPK14 MAPK11 | Fc epsilon RI signaling pathway |
| WP:WP3611 | 0.0159344117177 | 0.285714285714 | MAPK14 MAPK11 | Photodynamic therapy induced AP 1 survival signaling |
| REAC:R-HSA-450282 | 0.0164719839916 | 0.285714285714 | MAPK14 MAPK11 | MAPK targets/ Nuclear events mediated by MAP kinases |
| KEGG:05133 | 0.0173334447573 | 0.285714285714 | MAPK14 MAPK11 | Pertussis |
| REAC:R-HSA-168638 | 0.0187732752758 | 0.285714285714 | MAPK14 MAPK11 | NOD1/2 Signaling Pathway |
| WP:WP395 | 0.0190579984179 | 0.285714285714 | MAPK14 MAPK11 | IL 4 signaling pathway |
| KEGG:05140 | 0.0191438277044 | 0.285714285714 | MAPK14 MAPK11 | Leishmaniasis |
| KEGG:04917 | 0.0191438277044 | 0.285714285714 | MAPK14 MAPK11 | Prolactin signaling pathway |
| KEGG:05120 | 0.0197669780141 | 0.285714285714 | MAPK14 MAPK11 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:04622 | 0.0210427715268 | 0.285714285714 | MAPK14 MAPK11 | RIG-I-like receptor signaling pathway |
| KEGG:04912 | 0.0230300913808 | 0.285714285714 | MAPK14 MAPK11 | GnRH signaling pathway |
| KEGG:04750 | 0.0237121385349 | 0.285714285714 | MAPK14 MAPK11 | Inflammatory mediator regulation of TRP channels |
| GO:0004672 | 0.0241566055694 | 0.714285714286 | MAPK14 MAPKAPK3 MKNK2 MAPK11 MKNK1 | protein kinase activity |
| REAC:R-HSA-373752 | 0.0251789059 | 0.285714285714 | MAPK14 MAPK11 | Netrin-1 signaling |
| WP:WP3865 | 0.0251881882105 | 0.285714285714 | MAPK14 MAPK11 | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04658 | 0.0272691209555 | 0.285714285714 | MAPK14 MAPK11 | Th1 and Th2 cell differentiation |
| KEGG:04657 | 0.0295204621358 | 0.285714285714 | MAPK14 MAPK11 | IL-17 signaling pathway |
| WP:WP4538 | 0.0311125325099 | 0.285714285714 | MAPK14 MAPK11 | Regulatory circuits of the STAT3 signaling pathway |
| KEGG:05235 | 0.0318594422662 | 0.285714285714 | MAPK14 MAPK11 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:01522 | 0.0334673599343 | 0.285714285714 | MAPK14 MAPK11 | Endocrine resistance |
| KEGG:04914 | 0.0334673599343 | 0.285714285714 | MAPK14 MAPK11 | Progesterone-mediated oocyte maturation |
| WP:WP4341 | 0.0343057335824 | 0.285714285714 | MAPK14 MAPK11 | Non genomic actions of 1 25 dihydroxyvitamin D3 |
| WP:WP3303 | 0.0343057335824 | 0.285714285714 | MAPK14 MAPK11 | RAC1 PAK1 p38 MMP2 pathway |
| KEGG:04625 | 0.0359519968772 | 0.285714285714 | MAPK14 MAPK11 | C-type lectin receptor signaling pathway |
| KEGG:04670 | 0.0367995848147 | 0.285714285714 | MAPK14 MAPK11 | Leukocyte transendothelial migration |
| KEGG:04620 | 0.0376568492551 | 0.285714285714 | MAPK14 MAPK11 | Toll-like receptor signaling pathway |
| KEGG:04933 | 0.0376568492551 | 0.285714285714 | MAPK14 MAPK11 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:05142 | 0.0385237834173 | 0.285714285714 | MAPK14 MAPK11 | Chagas disease |
| REAC:R-HSA-168643 | 0.0390490515953 | 0.285714285714 | MAPK14 MAPK11 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| WP:WP4746 | 0.039968890476 | 0.285714285714 | MAPK14 MAPKAPK3 | Thyroid hormones production and peripheral downstream signaling effects |
| KEGG:04659 | 0.040286633797 | 0.285714285714 | MAPK14 MAPK11 | Th17 cell differentiation |
| KEGG:05145 | 0.0411825364664 | 0.285714285714 | MAPK14 MAPK11 | Toxoplasmosis |
| KEGG:04668 | 0.0448625057456 | 0.285714285714 | MAPK14 MAPK11 | TNF signaling pathway |
| KEGG:04611 | 0.047723469919 | 0.285714285714 | MAPK14 MAPK11 | Platelet activation |
| WP:WP5087 | 0.0480568023702 | 0.428571428571 | MAPK14 MKNK2 MKNK1 | Pleural mesothelioma |
| KEGG:04066 | 0.0486963242765 | 0.285714285714 | MKNK1 MKNK2 | HIF-1 signaling pathway |
| KEGG:04722 | 0.0496787672026 | 0.285714285714 | MAPK14 MAPK11 | Neurotrophin signaling pathway |
| KEGG:04935 | 0.0496787672026 | 0.285714285714 | MAPK14 MAPK11 | Growth hormone synthesis, secretion and action |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAPKAPK3 | MAPK14 | 1.0 | 0.286 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| MAPK14 | MKNK1 | 0.999 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MAPKAPK3 | MAPK11 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MAPK14 | DUSP16 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MKNK2 | MAPK14 | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RHBDF1 | MAPK14 | 0.968 | 0.04 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MAPK11 | MAPK14 | 0.964 | bioplex_WMM bioplex3_WMM WMM_only | |
| MAPKAPK3 | MKNK1 | 0.884 | 0.224 | bioplex_WMM bioplex3_WMM WMM_only |
| MKNK2 | RHBDF1 | 0.568 | bioplex_WMM bioplex3_WMM WMM_only | |
| MKNK2 | MKNK1 | 0.551 | bioplex_WMM bioplex3_WMM WMM_only | |
| MAPKAPK3 | RHBDF1 | 0.541 | 0.058 | bioplex_WMM bioplex3_WMM WMM_only |
| RHBDF1 | DUSP16 | 0.527 | bioplex_WMM bioplex3_WMM WMM_only | |
| MKNK2 | MAPKAPK3 | 0.513 | bioplex_WMM bioplex3_WMM WMM_only | |
| MKNK2 | DUSP16 | 0.498 | bioplex_WMM bioplex3_WMM WMM_only | |
| MAPKAPK3 | DUSP16 | 0.378 | bioplex_WMM bioplex3_WMM WMM_only | |
| RHBDF1 | MKNK1 | 0.364 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only |
| DUSP16 | MKNK1 | 0.214 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes