hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07944.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RCAN1 | Calcipressin-1 (Adapt78) (Down syndrome critical region protein 1) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1) | 5 | UniProt NCBI |
| PPP3R1 | Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) | 5 | UniProt NCBI |
| PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) | 5 | UniProt NCBI |
| GSK3A | Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1) | 5 | UniProt NCBI |
| SIK3 | Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK) | 5 | UniProt NCBI |
| NFATC1 | Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) | 5 | UniProt NCBI |
| TNS4 | Tensin-4 (C-terminal tensin-like protein) | 5 | UniProt NCBI |
| PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform) | 5 | UniProt NCBI |
| NFATC4 | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | 5 | UniProt NCBI |
| PPP3CA | Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) | 5 | UniProt NCBI |
| RCAN3 | Calcipressin-3 (Down syndrome candidate region 1-like protein 2) (Myocyte-enriched calcineurin-interacting protein 3) (MCIP3) (Regulator of calcineurin 3) | 5 | UniProt NCBI |
| RCAN2 | Calcipressin-2 (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin-interacting protein 2) (MCIP2) (Regulator of calcineurin 2) (Thyroid hormone-responsive protein ZAKI-4) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0019722 | 2.38691777724e-10 | 0.727272727273 | RCAN3 RCAN1 PPP3R1 NFATC4 PPP3CC NFATC1 RCAN2 PPP3CA | calcium-mediated signaling |
| WP:WP3414 | 1.0229231024e-09 | 0.454545454545 | NFATC4 NFATC1 PPP3R1 PPP3CA PPP3CC | Initiation of transcription and translation elongation at the HIV 1 LTR |
| GO:0033173 | 1.87726203329e-09 | 0.545454545455 | RCAN1 PPP3R1 NFATC4 PPP3CC NFATC1 PPP3CA | calcineurin-NFAT signaling cascade |
| GO:0097720 | 2.27886277028e-09 | 0.545454545455 | RCAN1 PPP3R1 NFATC4 PPP3CC NFATC1 PPP3CA | calcineurin-mediated signaling |
| KEGG:04921 | 5.55250061832e-09 | 0.545454545455 | RCAN1 PPP3R1 NFATC4 PPP3CC NFATC1 PPP3CA | Oxytocin signaling pathway |
| GO:0008597 | 4.33992010508e-08 | 0.363636363636 | RCAN3 RCAN2 RCAN1 PPP3R1 | calcium-dependent protein serine/threonine phosphatase regulator activity |
| KEGG:05167 | 4.73710038085e-08 | 0.545454545455 | RCAN1 PPP3R1 NFATC4 PPP3CC NFATC1 PPP3CA | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04625 | 1.35333669413e-07 | 0.454545454545 | NFATC4 NFATC1 PPP3R1 PPP3CA PPP3CC | C-type lectin receptor signaling pathway |
| WP:WP428 | 6.65625381718e-07 | 0.454545454545 | NFATC4 NFATC1 PPP3R1 PPP3CA PPP3CC | Wnt signaling |
| KEGG:04022 | 9.54415492081e-07 | 0.454545454545 | NFATC4 NFATC1 PPP3R1 PPP3CA PPP3CC | cGMP-PKG signaling pathway |
| KEGG:04218 | 1.68808045636e-06 | 0.454545454545 | NFATC4 NFATC1 PPP3R1 PPP3CA PPP3CC | Cellular senescence |
| KEGG:04310 | 2.38684624457e-06 | 0.454545454545 | NFATC4 NFATC1 PPP3R1 PPP3CA PPP3CC | Wnt signaling pathway |
| REAC:R-HSA-2025928 | 2.87140947459e-06 | 0.272727272727 | NFATC1 PPP3R1 PPP3CA | Calcineurin activates NFAT |
| KEGG:04020 | 4.73684393722e-06 | 0.454545454545 | NFATC4 NFATC1 PPP3R1 PPP3CA PPP3CC | Calcium signaling pathway |
| REAC:R-HSA-5607763 | 6.88572370608e-06 | 0.272727272727 | NFATC1 PPP3R1 PPP3CA | CLEC7A (Dectin-1) induces NFAT activation |
| KEGG:04662 | 7.03347800046e-06 | 0.363636363636 | NFATC1 PPP3R1 PPP3CA PPP3CC | B cell receptor signaling pathway |
| KEGG:05163 | 8.20405489132e-06 | 0.454545454545 | NFATC4 NFATC1 PPP3R1 PPP3CA PPP3CC | Human cytomegalovirus infection |
| KEGG:05170 | 8.41933896588e-06 | 0.454545454545 | NFATC4 NFATC1 PPP3R1 PPP3CA PPP3CC | Human immunodeficiency virus 1 infection |
| KEGG:05166 | 9.56410402106e-06 | 0.454545454545 | NFATC4 NFATC1 PPP3R1 PPP3CA PPP3CC | Human T-cell leukemia virus 1 infection |
| KEGG:04658 | 9.91454778495e-06 | 0.363636363636 | NFATC1 PPP3R1 PPP3CA PPP3CC | Th1 and Th2 cell differentiation |
| KEGG:05235 | 1.35965274709e-05 | 0.363636363636 | NFATC1 PPP3R1 PPP3CA PPP3CC | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:04659 | 2.18821343446e-05 | 0.363636363636 | NFATC1 PPP3R1 PPP3CA PPP3CC | Th17 cell differentiation |
| CORUM:6023 | 3.41979277617e-05 | 0.181818181818 | PPP3R1 PPP3CA | Calcineurin |
| CORUM:2266 | 3.41979277617e-05 | 0.181818181818 | RCAN1 PPP3CA | PPP3CA-PPP3CA-RCAN1 complex |
| WP:WP4482 | 3.7482998324e-05 | 0.272727272727 | NFATC1 PPP3R1 PPP3CA | Vitamin D in inflammatory diseases |
| KEGG:04660 | 3.7673981402e-05 | 0.363636363636 | NFATC1 PPP3R1 PPP3CA PPP3CC | T cell receptor signaling pathway |
| KEGG:04650 | 4.7295472329e-05 | 0.363636363636 | NFATC1 PPP3R1 PPP3CA PPP3CC | Natural killer cell mediated cytotoxicity |
| KEGG:04380 | 5.86375078119e-05 | 0.363636363636 | NFATC1 PPP3R1 PPP3CA PPP3CC | Osteoclast differentiation |
| REAC:R-HSA-2871809 | 7.91060863268e-05 | 0.272727272727 | NFATC1 PPP3R1 PPP3CA | FCERI mediated Ca+2 mobilization |
| REAC:R-HSA-180024 | 9.30277523171e-05 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | DARPP-32 events |
| CORUM:6374 | 0.000102551658964 | 0.181818181818 | PPP3R1 PPP3CA | Calcineurin-FKBP12 complex |
| GO:0005955 | 0.000158467845213 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | calcineurin complex |
| GO:1905949 | 0.000158467845213 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | negative regulation of calcium ion import across plasma membrane |
| KEGG:04360 | 0.000188270125458 | 0.363636363636 | NFATC4 PPP3R1 PPP3CA PPP3CC | Axon guidance |
| GO:0070884 | 0.000204265929084 | 0.363636363636 | PPP3CC RCAN1 PPP3CA PPP3R1 | regulation of calcineurin-NFAT signaling cascade |
| GO:0106056 | 0.000235601029752 | 0.363636363636 | PPP3CC RCAN1 PPP3CA PPP3R1 | regulation of calcineurin-mediated signaling |
| KEGG:04924 | 0.000274500546174 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | Renin secretion |
| GO:1905665 | 0.000316805542726 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | positive regulation of calcium ion import across plasma membrane |
| KEGG:04370 | 0.000330100949229 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | VEGF signaling pathway |
| KEGG:05417 | 0.000349872648765 | 0.363636363636 | NFATC1 PPP3R1 PPP3CA PPP3CC | Lipid and atherosclerosis |
| KEGG:04720 | 0.000392688035172 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | Long-term potentiation |
| GO:0035556 | 0.000396792670502 | 0.909090909091 | RCAN3 RCAN1 PPP3CA NFATC4 RCAN2 SIK3 PPP3CC NFATC1 GSK3A PPP3R1 | intracellular signal transduction |
| WP:WP1541 | 0.000431185848294 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | Energy metabolism |
| KEGG:05031 | 0.000462662614372 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | Amphetamine addiction |
| GO:0004723 | 0.000554182028596 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | calcium-dependent protein serine/threonine phosphatase activity |
| GO:1905664 | 0.000554182028596 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | regulation of calcium ion import across plasma membrane |
| WP:WP382 | 0.00110903708874 | 0.363636363636 | NFATC1 PPP3R1 PPP3CA PPP3CC | MAPK signaling pathway |
| KEGG:04010 | 0.00114409805002 | 0.363636363636 | NFATC1 PPP3R1 PPP3CA PPP3CC | MAPK signaling pathway |
| KEGG:04724 | 0.00133583396187 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | Glutamatergic synapse |
| WP:WP1544 | 0.00168834524022 | 0.272727272727 | RCAN1 PPP3CA NFATC4 | MicroRNAs in cardiomyocyte hypertrophy |
| REAC:R-HSA-4086398 | 0.00188588147319 | 0.272727272727 | NFATC1 PPP3R1 PPP3CA | Ca2+ pathway |
| GO:0090281 | 0.0018977127037 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | negative regulation of calcium ion import |
| KEGG:04922 | 0.00195729209493 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | Glucagon signaling pathway |
| GO:0090280 | 0.00260828330546 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | positive regulation of calcium ion import |
| KEGG:04114 | 0.00282428645352 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | Oocyte meiosis |
| GO:0050848 | 0.00290404386312 | 0.363636363636 | PPP3CC RCAN1 PPP3CA PPP3R1 | regulation of calcium-mediated signaling |
| KEGG:04728 | 0.00324920943997 | 0.272727272727 | GSK3A PPP3CA PPP3CC | Dopaminergic synapse |
| GO:0019888 | 0.00473722828699 | 0.363636363636 | RCAN3 RCAN2 RCAN1 PPP3R1 | protein phosphatase regulator activity |
| REAC:R-HSA-1168372 | 0.00517368811151 | 0.272727272727 | NFATC1 PPP3R1 PPP3CA | Downstream signaling events of B Cell Receptor (BCR) |
| REAC:R-HSA-111885 | 0.00606173868944 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | Opioid Signalling |
| KEGG:05152 | 0.00774471138932 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | Tuberculosis |
| GO:0019208 | 0.00870298782777 | 0.363636363636 | RCAN3 RCAN2 RCAN1 PPP3R1 | phosphatase regulator activity |
| WP:WP4585 | 0.00912900259179 | 0.181818181818 | NFATC1 NFATC4 | Cancer immunotherapy by PD 1 blockade |
| REAC:R-HSA-5607764 | 0.00931468951254 | 0.272727272727 | NFATC1 PPP3R1 PPP3CA | CLEC7A (Dectin-1) signaling |
| GO:0034763 | 0.0108365738061 | 0.363636363636 | PPP3CC PPP3R1 PPP3CA GSK3A | negative regulation of transmembrane transport |
| WP:WP1528 | 0.0112018513551 | 0.181818181818 | NFATC4 PPP3CA | Physiological and pathological hypertrophy of the heart |
| REAC:R-HSA-983705 | 0.011300641 | 0.272727272727 | NFATC1 PPP3R1 PPP3CA | Signaling by the B Cell Receptor (BCR) |
| WP:WP2583 | 0.0123169771573 | 0.181818181818 | GSK3A PPP3CA | T cell receptor and co stimulatory signaling |
| GO:0070886 | 0.012862104388 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | positive regulation of calcineurin-NFAT signaling cascade |
| GO:0106058 | 0.012862104388 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | positive regulation of calcineurin-mediated signaling |
| GO:0141124 | 0.0133098662165 | 0.727272727273 | RCAN3 RCAN1 PPP3R1 NFATC4 PPP3CC NFATC1 RCAN2 PPP3CA | intracellular signaling cassette |
| WP:WP3888 | 0.0136811677219 | 0.363636363636 | NFATC1 RCAN2 RCAN1 PPP3CA | VEGFA VEGFR2 signaling |
| REAC:R-HSA-111447 | 0.0139350375231 | 0.181818181818 | PPP3R1 PPP3CC | Activation of BAD and translocation to mitochondria |
| REAC:R-HSA-2454202 | 0.0174357153002 | 0.272727272727 | NFATC1 PPP3R1 PPP3CA | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-5621481 | 0.0219936664771 | 0.272727272727 | NFATC1 PPP3R1 PPP3CA | C-type lectin receptors (CLRs) |
| GO:0090279 | 0.0278578876014 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | regulation of calcium ion import |
| WP:WP2447 | 0.0280261977151 | 0.181818181818 | PPP3CC PPP3CA | Amyotrophic lateral sclerosis ALS |
| WP:WP1591 | 0.0297656085673 | 0.181818181818 | NFATC1 NFATC4 | Heart development |
| GO:0098703 | 0.0318245054916 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | calcium ion import across plasma membrane |
| GO:1902656 | 0.0318245054916 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | calcium ion import into cytosol |
| REAC:R-HSA-3858494 | 0.0319007857985 | 0.272727272727 | NFATC1 PPP3R1 PPP3CA | Beta-catenin independent WNT signaling |
| KEGG:05020 | 0.0354269877675 | 0.272727272727 | PPP3R1 PPP3CA PPP3CC | Prion disease |
| CORUM:517 | 0.049976851631 | 0.0909090909091 | PPP3CA | AKAP5-PRKAR2A-PPP3CA complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| RCAN3 | PPP3R1 | 1.0 | |
| PPP3CC | RCAN1 | 1.0 | 0.124 |
| PPP3CA | RCAN1 | 1.0 | 0.106 |
| RCAN1 | PPP3R1 | 1.0 | 0.114 |
| PPP3CB | RCAN1 | 1.0 | 0.146 |
| RCAN3 | PPP3CB | 1.0 | |
| PPP3CC | PPP3R1 | 0.999 | 0.028 |
| RCAN3 | PPP3CC | 0.999 | |
| GSK3A | RCAN1 | 0.999 | 0.184 |
| RCAN3 | PPP3CA | 0.999 | |
| PPP3CC | SIK3 | 0.999 | 0.062 |
| PPP3CC | NFATC1 | 0.998 | 0.118 |
| GSK3A | PPP3CC | 0.997 | 0.11 |
| PPP3CA | PPP3R1 | 0.997 | 0.354 |
| PPP3CB | RCAN2 | 0.997 | |
| PPP3CA | SIK3 | 0.995 | 0.064 |
| PPP3R1 | RCAN2 | 0.993 | |
| PPP3CC | RCAN2 | 0.993 | |
| TNS4 | PPP3R1 | 0.992 | 0.044 |
| PPP3CA | RCAN2 | 0.989 | |
| PPP3CB | TNS4 | 0.987 | 0.082 |
| PPP3CC | PPP3CB | 0.986 | 0.136 |
| GSK3A | PPP3CB | 0.984 | 0.232 |
| PPP3CA | NFATC1 | 0.983 | 0.086 |
| SIK3 | RCAN1 | 0.98 | 0.176 |
| PPP3CC | TNS4 | 0.98 | 0.078 |
| PPP3CC | NFATC4 | 0.974 | 0.084 |
| PPP3CA | TNS4 | 0.971 | 0.05 |
| PPP3CA | PPP3CB | 0.968 | 0.558 |
| GSK3A | PPP3CA | 0.967 | 0.142 |
| PPP3CB | NFATC1 | 0.961 | 0.118 |
| NFATC1 | PPP3R1 | 0.934 | 0.064 |
| PPP3CC | PPP3CA | 0.933 | 0.034 |
| RCAN3 | SIK3 | 0.929 | |
| RCAN3 | RCAN1 | 0.925 | |
| PPP3CB | PPP3R1 | 0.925 | 0.492 |
| SIK3 | NFATC1 | 0.922 | 0.052 |
| SIK3 | PPP3R1 | 0.887 | 0.082 |
| NFATC1 | RCAN1 | 0.877 | 0.098 |
| PPP3CB | SIK3 | 0.876 | 0.148 |
| GSK3A | PPP3R1 | 0.871 | 0.148 |
| RCAN3 | NFATC4 | 0.825 | |
| NFATC4 | NFATC1 | 0.513 | 0.064 |
| NFATC4 | PPP3CA | 0.488 | 0.06 |
| NFATC4 | SIK3 | 0.476 | 0.072 |
| NFATC4 | PPP3R1 | 0.4 | 0.046 |
| RCAN3 | NFATC1 | 0.378 | |
| NFATC4 | RCAN1 | 0.367 | 0.078 |
| NFATC4 | PPP3CB | 0.235 | 0.076 |
| GSK3A | NFATC1 | 0.216 | 0.088 |
| GSK3A | NFATC4 | 0.202 | 0.166 |
| GSK3A | SIK3 | 0.169 | 0.126 |
| GSK3A | RCAN2 | 0.167 | |
| RCAN3 | GSK3A | 0.115 |
Related Complexes