hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07948.1
Complex Portal: CPX-24646
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ELOA | Elongin-A (EloA) (Elongin 110 kDa subunit) (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Transcription elongation factor B polypeptide 3) | 5 | UniProt NCBI |
| CTR9 | RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) | 5 | UniProt NCBI |
| POLR2G | DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (DNA-directed RNA polymerase II subunit G) (RNA polymerase II 19 kDa subunit) (RPB19) | 5 | UniProt NCBI |
| CDC73 | Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) | 5 | UniProt NCBI |
| IWS1 | Protein IWS1 homolog (IWS1-like protein) | 5 | UniProt NCBI |
| GTF2F1 | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | 5 | UniProt NCBI |
| MYZAP | Myocardial zonula adherens protein (GRINL1A upstream protein) (Gup) | 5 | UniProt NCBI |
| SUPT5H | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | 5 | UniProt NCBI |
| GTF2F2 | General transcription factor IIF subunit 2 (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-75955 | 1.58997611034e-14 | 0.875 | CDC73 GTF2F1 CTR9 POLR2G ELOA SUPT5H IWS1 | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-112382 | 1.58997611034e-14 | 0.875 | CDC73 GTF2F1 CTR9 POLR2G ELOA SUPT5H IWS1 | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-674695 | 1.74096216418e-13 | 0.875 | CDC73 GTF2F1 CTR9 POLR2G ELOA SUPT5H IWS1 | RNA Polymerase II Pre-transcription Events |
| REAC:R-HSA-167243 | 2.13574543247e-07 | 0.5 | POLR2G SUPT5H ELOA GTF2F1 | Tat-mediated HIV elongation arrest and recovery |
| REAC:R-HSA-167238 | 2.13574543247e-07 | 0.5 | POLR2G SUPT5H ELOA GTF2F1 | Pausing and recovery of Tat-mediated HIV elongation |
| REAC:R-HSA-167290 | 2.80123063934e-07 | 0.5 | POLR2G SUPT5H ELOA GTF2F1 | Pausing and recovery of HIV elongation |
| REAC:R-HSA-167287 | 2.80123063934e-07 | 0.5 | POLR2G SUPT5H ELOA GTF2F1 | HIV elongation arrest and recovery |
| REAC:R-HSA-167246 | 8.70007386216e-07 | 0.5 | POLR2G SUPT5H ELOA GTF2F1 | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167200 | 8.70007386216e-07 | 0.5 | POLR2G SUPT5H ELOA GTF2F1 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167169 | 8.70007386216e-07 | 0.5 | POLR2G SUPT5H ELOA GTF2F1 | HIV Transcription Elongation |
| REAC:R-HSA-167152 | 1.05469981253e-06 | 0.5 | POLR2G SUPT5H ELOA GTF2F1 | Formation of HIV elongation complex in the absence of HIV Tat |
| REAC:R-HSA-6796648 | 4.03938085227e-06 | 0.5 | POLR2G SUPT5H ELOA GTF2F1 | TP53 Regulates Transcription of DNA Repair Genes |
| GO:0016591 | 5.19986488571e-06 | 0.625 | POLR2G GTF2F1 CTR9 MYZAP CDC73 | RNA polymerase II, holoenzyme |
| REAC:R-HSA-167172 | 6.29400255457e-06 | 0.5 | POLR2G SUPT5H ELOA GTF2F1 | Transcription of the HIV genome |
| GO:0055029 | 2.44300642267e-05 | 0.625 | POLR2G GTF2F1 CTR9 MYZAP CDC73 | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 2.58136974103e-05 | 0.625 | POLR2G GTF2F1 CTR9 MYZAP CDC73 | DNA-directed RNA polymerase complex |
| REAC:R-HSA-73857 | 2.80793096136e-05 | 0.875 | CDC73 GTF2F1 CTR9 POLR2G ELOA SUPT5H IWS1 | RNA Polymerase II Transcription |
| GO:0030880 | 3.03441490958e-05 | 0.625 | POLR2G GTF2F1 CTR9 MYZAP CDC73 | RNA polymerase complex |
| REAC:R-HSA-167242 | 3.51023480424e-05 | 0.375 | POLR2G SUPT5H GTF2F1 | Abortive elongation of HIV-1 transcript in the absence of Tat |
| GO:0006368 | 3.54883058612e-05 | 0.625 | CDC73 GTF2F1 CTR9 SUPT5H IWS1 | transcription elongation by RNA polymerase II |
| REAC:R-HSA-77075 | 5.92028436306e-05 | 0.375 | POLR2G SUPT5H GTF2F1 | RNA Pol II CTD phosphorylation and interaction with CE |
| REAC:R-HSA-167160 | 5.92028436306e-05 | 0.375 | POLR2G SUPT5H GTF2F1 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection |
| REAC:R-HSA-74160 | 6.70866002994e-05 | 0.875 | CDC73 GTF2F1 CTR9 POLR2G ELOA SUPT5H IWS1 | Gene expression (Transcription) |
| REAC:R-HSA-72086 | 7.45572658486e-05 | 0.375 | POLR2G SUPT5H GTF2F1 | mRNA Capping |
| GO:0006354 | 7.93494916895e-05 | 0.625 | CDC73 GTF2F1 CTR9 SUPT5H IWS1 | DNA-templated transcription elongation |
| REAC:R-HSA-162599 | 8.65980296911e-05 | 0.5 | POLR2G SUPT5H ELOA GTF2F1 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-113418 | 0.000112766844535 | 0.375 | POLR2G SUPT5H GTF2F1 | Formation of the Early Elongation Complex |
| REAC:R-HSA-167158 | 0.000112766844535 | 0.375 | POLR2G SUPT5H GTF2F1 | Formation of the HIV-1 Early Elongation Complex |
| REAC:R-HSA-162587 | 0.000123441958688 | 0.5 | POLR2G SUPT5H ELOA GTF2F1 | HIV Life Cycle |
| CORUM:1167 | 0.000239030245992 | 0.25 | CDC73 CTR9 | Paf complex |
| GO:0008023 | 0.000325444840356 | 0.5 | CDC73 SUPT5H ELOA CTR9 | transcription elongation factor complex |
| REAC:R-HSA-162906 | 0.00072268478922 | 0.5 | POLR2G SUPT5H ELOA GTF2F1 | HIV Infection |
| REAC:R-HSA-6807505 | 0.00134205528321 | 0.375 | POLR2G SUPT5H GTF2F1 | RNA polymerase II transcribes snRNA genes |
| CORUM:2685 | 0.00216982178847 | 0.25 | POLR2G GTF2F1 | RNA polymerase II (RNAPII) |
| REAC:R-HSA-3700989 | 0.00388943076684 | 0.5 | POLR2G SUPT5H ELOA GTF2F1 | Transcriptional Regulation by TP53 |
| HPA:0090181 | 0.00395759929536 | 1.0 | CDC73 GTF2F1 CTR9 POLR2G ELOA SUPT5H MYZAP IWS1 | cerebellum; cells in granular layer[>=Low] |
| CORUM:103 | 0.00407177869695 | 0.25 | POLR2G GTF2F1 | RNA polymerase II holoenzyme complex |
| CORUM:2825 | 0.00499769201238 | 0.25 | POLR2G GTF2F1 | BRCA1-RNA polymerase II complex |
| GO:0140513 | 0.00521846176444 | 0.875 | CDC73 GTF2F1 POLR2G ELOA SUPT5H MYZAP CTR9 | nuclear protein-containing complex |
| GO:0061695 | 0.00619293428193 | 0.625 | POLR2G GTF2F1 CTR9 MYZAP CDC73 | transferase complex, transferring phosphorus-containing groups |
| REAC:R-HSA-8851708 | 0.00849789009901 | 0.25 | POLR2G GTF2F1 | Signaling by FGFR2 IIIa TM |
| HPA:0510000 | 0.0118359720879 | 1.0 | CDC73 GTF2F1 CTR9 POLR2G ELOA SUPT5H MYZAP IWS1 | soft tissue 2 |
| HPA:0500000 | 0.0148623646522 | 1.0 | CDC73 GTF2F1 CTR9 POLR2G ELOA SUPT5H MYZAP IWS1 | soft tissue 1 |
| REAC:R-HSA-1839126 | 0.0153043597228 | 0.25 | POLR2G GTF2F1 | FGFR2 mutant receptor activation |
| REAC:R-HSA-6803529 | 0.0153043597228 | 0.25 | POLR2G GTF2F1 | FGFR2 alternative splicing |
| HPA:0090161 | 0.0197252977611 | 1.0 | CDC73 GTF2F1 CTR9 POLR2G ELOA SUPT5H MYZAP IWS1 | cerebellum; Purkinje cells[>=Low] |
| HPA:0130202 | 0.0223711503047 | 0.875 | CDC73 GTF2F1 CTR9 POLR2G ELOA SUPT5H IWS1 | colon; endothelial cells[>=Medium] |
| HPA:0630222 | 0.0249041935213 | 0.875 | CDC73 GTF2F1 CTR9 POLR2G ELOA SUPT5H IWS1 | cervix; squamous epithelial cells[>=Medium] |
| REAC:R-HSA-5655253 | 0.0257351328695 | 0.25 | POLR2G GTF2F1 | Signaling by FGFR2 in disease |
| HPA:0440000 | 0.0294872241715 | 1.0 | CDC73 GTF2F1 CTR9 POLR2G ELOA SUPT5H MYZAP IWS1 | skeletal muscle |
| HPA:0440341 | 0.0294872241715 | 1.0 | CDC73 GTF2F1 CTR9 POLR2G ELOA SUPT5H MYZAP IWS1 | skeletal muscle; myocytes[>=Low] |
| HPA:0460641 | 0.0327882750258 | 0.875 | GTF2F1 CTR9 POLR2G ELOA SUPT5H MYZAP IWS1 | skin 1; Langerhans[>=Low] |
| HPA:0470682 | 0.0386765077351 | 0.875 | CDC73 GTF2F1 CTR9 POLR2G ELOA SUPT5H IWS1 | skin 2; epidermal cells[>=Medium] |
| REAC:R-HSA-168325 | 0.04306231829 | 0.25 | POLR2G GTF2F1 | Viral Messenger RNA Synthesis |
| HPA:0620222 | 0.0434766817865 | 0.875 | CDC73 GTF2F1 CTR9 POLR2G ELOA SUPT5H IWS1 | vagina; squamous epithelial cells[>=Medium] |
| HPA:0090162 | 0.0473766132884 | 0.875 | CDC73 GTF2F1 POLR2G ELOA SUPT5H MYZAP CTR9 | cerebellum; Purkinje cells[>=Medium] |
| CORUM:153 | 0.0499436884912 | 0.125 | GTF2F1 | TFIIF complex (transcription factor IIF) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CTR9 | CDC73 | 1.0 | 0.786 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM |
| GTF2F2 | POLR2G | 0.997 | 0.228 | hein_WMM bioplex3_WMM youn_WMM hein () | |
| GTF2F2 | GTF2F1 | 0.995 | 0.904 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction boldt_WMM |
| POLR2G | GTF2F1 | 0.995 | 0.264 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| ELOA | IWS1 | 0.994 | 0.198 | hein_WMM bioplex3_WMM youn_WMM WMM_only | |
| POLR2G | SUPT5H | 0.993 | 0.484 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| POLR2G | ELOA | 0.992 | 0.086 |
structurally_consistent (P30876)
|
hein_WMM bioplex3_WMM youn_WMM WMM_only |
| POLR2G | CDC73 | 0.99 | 0.17 |
mutually_exclusive (O15514)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| CTR9 | ELOA | 0.985 | 0.342 | hein_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM | |
| SUPT5H | IWS1 | 0.978 | 0.452 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| POLR2G | IWS1 | 0.97 | 0.302 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| POLR2G | MYZAP | 0.966 | hein_WMM hein () | ||
| CTR9 | IWS1 | 0.958 | 0.38 |
mutually_exclusive (Q9GZS3)
|
hein_WMM bioplex3_WMM youn_WMM hein () fraction |
| CDC73 | ELOA | 0.951 | 0.336 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| CDC73 | IWS1 | 0.926 | 0.286 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM fraction | |
| POLR2G | CTR9 | 0.888 | 0.306 | hein_WMM bioplex3_WMM youn_WMM hein () fraction | |
| SUPT5H | CTR9 | 0.867 | 0.614 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM hein () fraction | |
| SUPT5H | ELOA | 0.856 | 0.29 | hein_WMM youn () bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SUPT5H | CDC73 | 0.849 | 0.382 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| GTF2F2 | SUPT5H | 0.804 | 0.338 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| GTF2F2 | MYZAP | 0.796 | hein_WMM WMM_only | ||
| MYZAP | SUPT5H | 0.641 | hein_WMM WMM_only | ||
| GTF2F1 | MYZAP | 0.641 | hein_WMM WMM_only | ||
| GTF2F1 | SUPT5H | 0.627 | 0.262 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| GTF2F2 | IWS1 | 0.562 | 0.156 |
mutually_exclusive (Q9GZS3)
|
bioplex3_WMM youn_WMM WMM_only |
| GTF2F1 | IWS1 | 0.23 | 0.246 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| GTF2F2 | CDC73 | 0.161 | 0.416 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| GTF2F2 | ELOA | 0.142 | 0.256 |
mutually_exclusive (P30876)
|
bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| GTF2F1 | ELOA | 0.114 | 0.298 | bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| MYZAP | CDC73 | 0.063 | hein_WMM WMM_only | ||
| GTF2F1 | CDC73 | 0.044 | 0.32 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| GTF2F1 | CTR9 | 0.034 | 0.374 | bioplex3_WMM youn_WMM WMM_only | |
| GTF2F2 | CTR9 | 0.023 | 0.478 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes