hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07948.1

Complex Portal: CPX-24646

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
ELOA	Elongin-A (EloA) (Elongin 110 kDa subunit) (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Transcription elongation factor B polypeptide 3)	5	UniProt NCBI
CTR9	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1)	5	UniProt NCBI
POLR2G	DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (DNA-directed RNA polymerase II subunit G) (RNA polymerase II 19 kDa subunit) (RPB19)	5	UniProt NCBI
CDC73	Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein)	5	UniProt NCBI
IWS1	Protein IWS1 homolog (IWS1-like protein)	5	UniProt NCBI
GTF2F1	General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74)	5	UniProt NCBI
MYZAP	Myocardial zonula adherens protein (GRINL1A upstream protein) (Gup)	5	UniProt NCBI
SUPT5H	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)	5	UniProt NCBI
GTF2F2	General transcription factor IIF subunit 2 (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-75955	1.58997611034e-14	0.875	CTR9 CDC73 IWS1 POLR2G GTF2F1 SUPT5H ELOA	RNA Polymerase II Transcription Elongation
REAC:R-HSA-112382	1.58997611034e-14	0.875	CTR9 CDC73 IWS1 POLR2G GTF2F1 SUPT5H ELOA	Formation of RNA Pol II elongation complex
REAC:R-HSA-674695	1.74096216418e-13	0.875	CTR9 CDC73 IWS1 POLR2G GTF2F1 SUPT5H ELOA	RNA Polymerase II Pre-transcription Events
REAC:R-HSA-167243	2.13574543247e-07	0.5	ELOA SUPT5H POLR2G GTF2F1	Tat-mediated HIV elongation arrest and recovery
REAC:R-HSA-167238	2.13574543247e-07	0.5	ELOA SUPT5H POLR2G GTF2F1	Pausing and recovery of Tat-mediated HIV elongation
REAC:R-HSA-167290	2.80123063934e-07	0.5	ELOA SUPT5H POLR2G GTF2F1	Pausing and recovery of HIV elongation
REAC:R-HSA-167287	2.80123063934e-07	0.5	ELOA SUPT5H POLR2G GTF2F1	HIV elongation arrest and recovery
REAC:R-HSA-167246	8.70007386216e-07	0.5	ELOA SUPT5H POLR2G GTF2F1	Tat-mediated elongation of the HIV-1 transcript
REAC:R-HSA-167200	8.70007386216e-07	0.5	ELOA SUPT5H POLR2G GTF2F1	Formation of HIV-1 elongation complex containing HIV-1 Tat
REAC:R-HSA-167169	8.70007386216e-07	0.5	ELOA SUPT5H POLR2G GTF2F1	HIV Transcription Elongation
REAC:R-HSA-167152	1.05469981253e-06	0.5	ELOA SUPT5H POLR2G GTF2F1	Formation of HIV elongation complex in the absence of HIV Tat
REAC:R-HSA-6796648	4.03938085227e-06	0.5	ELOA SUPT5H POLR2G GTF2F1	TP53 Regulates Transcription of DNA Repair Genes
GO:0016591	5.19986488571e-06	0.625	GTF2F1 CDC73 CTR9 MYZAP POLR2G	RNA polymerase II, holoenzyme
REAC:R-HSA-167172	6.29400255457e-06	0.5	ELOA SUPT5H POLR2G GTF2F1	Transcription of the HIV genome
GO:0055029	2.44300642267e-05	0.625	GTF2F1 CDC73 CTR9 MYZAP POLR2G	nuclear DNA-directed RNA polymerase complex
GO:0000428	2.58136974103e-05	0.625	GTF2F1 CDC73 CTR9 MYZAP POLR2G	DNA-directed RNA polymerase complex
REAC:R-HSA-73857	2.80793096136e-05	0.875	CTR9 CDC73 IWS1 POLR2G GTF2F1 SUPT5H ELOA	RNA Polymerase II Transcription
GO:0030880	3.03441490958e-05	0.625	GTF2F1 CDC73 CTR9 MYZAP POLR2G	RNA polymerase complex
REAC:R-HSA-167242	3.51023480424e-05	0.375	GTF2F1 POLR2G SUPT5H	Abortive elongation of HIV-1 transcript in the absence of Tat
GO:0006368	3.54883058612e-05	0.625	GTF2F1 CDC73 SUPT5H CTR9 IWS1	transcription elongation by RNA polymerase II
REAC:R-HSA-77075	5.92028436306e-05	0.375	GTF2F1 POLR2G SUPT5H	RNA Pol II CTD phosphorylation and interaction with CE
REAC:R-HSA-167160	5.92028436306e-05	0.375	GTF2F1 POLR2G SUPT5H	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
REAC:R-HSA-74160	6.70866002994e-05	0.875	CTR9 CDC73 IWS1 POLR2G GTF2F1 SUPT5H ELOA	Gene expression (Transcription)
REAC:R-HSA-72086	7.45572658486e-05	0.375	GTF2F1 POLR2G SUPT5H	mRNA Capping
GO:0006354	7.93494916895e-05	0.625	GTF2F1 CDC73 SUPT5H CTR9 IWS1	DNA-templated transcription elongation
REAC:R-HSA-162599	8.65980296911e-05	0.5	ELOA SUPT5H POLR2G GTF2F1	Late Phase of HIV Life Cycle
REAC:R-HSA-113418	0.000112766844535	0.375	GTF2F1 POLR2G SUPT5H	Formation of the Early Elongation Complex
REAC:R-HSA-167158	0.000112766844535	0.375	GTF2F1 POLR2G SUPT5H	Formation of the HIV-1 Early Elongation Complex
REAC:R-HSA-162587	0.000123441958688	0.5	ELOA SUPT5H POLR2G GTF2F1	HIV Life Cycle
CORUM:1167	0.000239030245992	0.25	CDC73 CTR9	Paf complex
GO:0008023	0.000325444840356	0.5	ELOA SUPT5H CTR9 CDC73	transcription elongation factor complex
REAC:R-HSA-162906	0.00072268478922	0.5	ELOA SUPT5H POLR2G GTF2F1	HIV Infection
REAC:R-HSA-6807505	0.00134205528321	0.375	GTF2F1 POLR2G SUPT5H	RNA polymerase II transcribes snRNA genes
CORUM:2685	0.00216982178847	0.25	GTF2F1 POLR2G	RNA polymerase II (RNAPII)
REAC:R-HSA-3700989	0.00388943076684	0.5	ELOA SUPT5H POLR2G GTF2F1	Transcriptional Regulation by TP53
HPA:0090181	0.00395759929536	1.0	CTR9 CDC73 IWS1 POLR2G GTF2F1 SUPT5H ELOA MYZAP	cerebellum; cells in granular layer[>=Low]
CORUM:103	0.00407177869695	0.25	GTF2F1 POLR2G	RNA polymerase II holoenzyme complex
CORUM:2825	0.00499769201238	0.25	GTF2F1 POLR2G	BRCA1-RNA polymerase II complex
GO:0140513	0.00521846176444	0.875	CTR9 CDC73 POLR2G GTF2F1 SUPT5H ELOA MYZAP	nuclear protein-containing complex
GO:0061695	0.00619293428193	0.625	GTF2F1 CDC73 CTR9 MYZAP POLR2G	transferase complex, transferring phosphorus-containing groups
REAC:R-HSA-8851708	0.00849789009901	0.25	GTF2F1 POLR2G	Signaling by FGFR2 IIIa TM
HPA:0510000	0.0118359720879	1.0	CTR9 CDC73 IWS1 POLR2G GTF2F1 SUPT5H ELOA MYZAP	soft tissue 2
HPA:0500000	0.0148623646522	1.0	CTR9 CDC73 IWS1 POLR2G GTF2F1 SUPT5H ELOA MYZAP	soft tissue 1
REAC:R-HSA-1839126	0.0153043597228	0.25	GTF2F1 POLR2G	FGFR2 mutant receptor activation
REAC:R-HSA-6803529	0.0153043597228	0.25	GTF2F1 POLR2G	FGFR2 alternative splicing
HPA:0090161	0.0197252977611	1.0	CTR9 CDC73 IWS1 POLR2G GTF2F1 SUPT5H ELOA MYZAP	cerebellum; Purkinje cells[>=Low]
HPA:0130202	0.0223711503047	0.875	CTR9 CDC73 IWS1 POLR2G GTF2F1 SUPT5H ELOA	colon; endothelial cells[>=Medium]
HPA:0630222	0.0249041935213	0.875	CTR9 CDC73 IWS1 POLR2G GTF2F1 SUPT5H ELOA	cervix; squamous epithelial cells[>=Medium]
REAC:R-HSA-5655253	0.0257351328695	0.25	GTF2F1 POLR2G	Signaling by FGFR2 in disease
HPA:0440000	0.0294872241715	1.0	CTR9 CDC73 IWS1 POLR2G GTF2F1 SUPT5H ELOA MYZAP	skeletal muscle
HPA:0440341	0.0294872241715	1.0	CTR9 CDC73 IWS1 POLR2G GTF2F1 SUPT5H ELOA MYZAP	skeletal muscle; myocytes[>=Low]
HPA:0460641	0.0327882750258	0.875	CTR9 IWS1 POLR2G GTF2F1 SUPT5H ELOA MYZAP	skin 1; Langerhans[>=Low]
HPA:0470682	0.0386765077351	0.875	CTR9 CDC73 IWS1 POLR2G GTF2F1 SUPT5H ELOA	skin 2; epidermal cells[>=Medium]
REAC:R-HSA-168325	0.04306231829	0.25	GTF2F1 POLR2G	Viral Messenger RNA Synthesis
HPA:0620222	0.0434766817865	0.875	CTR9 CDC73 IWS1 POLR2G GTF2F1 SUPT5H ELOA	vagina; squamous epithelial cells[>=Medium]
HPA:0090162	0.0473766132884	0.875	CTR9 CDC73 POLR2G GTF2F1 SUPT5H ELOA MYZAP	cerebellum; Purkinje cells[>=Medium]
CORUM:153	0.0499436884912	0.125	GTF2F1	TFIIF complex (transcription factor IIF)

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
CTR9	CDC73	1.0	0.786	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM
GTF2F2	POLR2G	0.997	0.228		hein_WMM bioplex3_WMM youn_WMM hein ()
GTF2F2	GTF2F1	0.995	0.904	structurally_consistent (dimer)	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction boldt_WMM
POLR2G	GTF2F1	0.995	0.264		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
ELOA	IWS1	0.994	0.198		hein_WMM bioplex3_WMM youn_WMM WMM_only
POLR2G	SUPT5H	0.993	0.484	structurally_consistent (dimer)	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
POLR2G	ELOA	0.992	0.086	structurally_consistent (P30876)	hein_WMM bioplex3_WMM youn_WMM WMM_only
POLR2G	CDC73	0.99	0.17	mutually_exclusive (O15514) structurally_consistent (dimer)	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
CTR9	ELOA	0.985	0.342		hein_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM
SUPT5H	IWS1	0.978	0.452		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
POLR2G	IWS1	0.97	0.302		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
POLR2G	MYZAP	0.966			hein_WMM hein ()
CTR9	IWS1	0.958	0.38	mutually_exclusive (Q9GZS3)	hein_WMM bioplex3_WMM youn_WMM hein () fraction
CDC73	ELOA	0.951	0.336		hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only
CDC73	IWS1	0.926	0.286		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM fraction
POLR2G	CTR9	0.888	0.306		hein_WMM bioplex3_WMM youn_WMM hein () fraction
SUPT5H	CTR9	0.867	0.614		hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM hein () fraction
SUPT5H	ELOA	0.856	0.29		hein_WMM youn () bioplex3_WMM youn_WMM gupta_WMM WMM_only
SUPT5H	CDC73	0.849	0.382		hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction
GTF2F2	SUPT5H	0.804	0.338		hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction
GTF2F2	MYZAP	0.796			hein_WMM WMM_only
GTF2F1	MYZAP	0.641			hein_WMM WMM_only
MYZAP	SUPT5H	0.641			hein_WMM WMM_only
GTF2F1	SUPT5H	0.627	0.262		hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction
GTF2F2	IWS1	0.562	0.156	mutually_exclusive (Q9GZS3)	bioplex3_WMM youn_WMM WMM_only
GTF2F1	IWS1	0.23	0.246		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
GTF2F2	CDC73	0.161	0.416		hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
GTF2F2	ELOA	0.142	0.256	mutually_exclusive (P30876)	bioplex3_WMM youn_WMM gupta_WMM WMM_only
GTF2F1	ELOA	0.114	0.298		bioplex3_WMM youn_WMM gupta_WMM WMM_only
MYZAP	CDC73	0.063			hein_WMM WMM_only
GTF2F1	CDC73	0.044	0.32		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction
GTF2F1	CTR9	0.034	0.374		bioplex3_WMM youn_WMM WMM_only
GTF2F2	CTR9	0.023	0.478		bioplex3_WMM youn_WMM WMM_only

Related Complexes

Genename	Complexes
ELOA	huMAP3_06234.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_07948.1 huMAP3_09843.1 huMAP3_11018.1 huMAP3_11092.1 huMAP3_12111.1
CTR9	huMAP3_06234.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_07948.1 huMAP3_09843.1 huMAP3_11018.1 huMAP3_11092.1 huMAP3_12111.1
POLR2G	huMAP3_02594.1 huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_07948.1 huMAP3_09843.1 huMAP3_11018.1 huMAP3_11092.1 huMAP3_12111.1 huMAP3_14318.1
CDC73	huMAP3_06234.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_07948.1 huMAP3_09843.1 huMAP3_11018.1 huMAP3_11092.1 huMAP3_12111.1
IWS1	huMAP3_07454.1 huMAP3_07749.1 huMAP3_07948.1 huMAP3_09843.1 huMAP3_11018.1 huMAP3_11092.1 huMAP3_12111.1
GTF2F1	huMAP3_02594.1 huMAP3_07948.1 huMAP3_11018.1
MYZAP	huMAP3_02594.1 huMAP3_07948.1 huMAP3_11018.1 huMAP3_12111.1
SUPT5H	huMAP3_02594.1 huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_07948.1 huMAP3_09843.1 huMAP3_11018.1 huMAP3_11092.1 huMAP3_12111.1
GTF2F2	huMAP3_00159.1 huMAP3_02594.1 huMAP3_04078.1 huMAP3_04499.1 huMAP3_07454.1 huMAP3_07749.1 huMAP3_07948.1 huMAP3_09843.1 huMAP3_10292.1 huMAP3_11018.1 huMAP3_11092.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07948.1

Complex Portal: CPX-24646