hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07951.1

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
VPS37B	Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B)	5	UniProt NCBI
MVB12B	Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B)	5	UniProt NCBI
PDCD6IP	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)	5	UniProt NCBI
TSG101	Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)	5	UniProt NCBI
VPS28	Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28)	5	UniProt NCBI
UMAD1	UBAP1-MVB12-associated (UMA)-domain containing protein 1 (RPA3 antisense RNA 1) (RPA3 opposite strand)	2	UniProt NCBI
MVB12A	Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A)	5	UniProt NCBI
UBAP1	Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-162588	5.35010248824e-17	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	Budding and maturation of HIV virion
REAC:R-HSA-174495	1.32188316726e-15	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	Synthesis And Processing Of GAG, GAGPOL Polyproteins
REAC:R-HSA-174490	1.32188316726e-15	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	Membrane binding and targetting of GAG proteins
REAC:R-HSA-175474	3.52419413997e-15	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	Assembly Of The HIV Virion
GO:0000813	2.17334574806e-14	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	ESCRT I complex
GO:0036258	3.72206279962e-14	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	multivesicular body assembly
GO:0036257	4.76395460095e-14	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	multivesicular body organization
REAC:R-HSA-917729	2.60881618845e-13	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	Endosomal Sorting Complex Required For Transport (ESCRT)
REAC:R-HSA-9615710	3.98051919428e-13	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	Late endosomal microautophagy
GO:0043328	8.28185622893e-13	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
REAC:R-HSA-162599	6.32502116214e-12	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	Late Phase of HIV Life Cycle
GO:0032511	7.71102506167e-12	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	late endosome to vacuole transport via multivesicular body sorting pathway
GO:0046755	1.04313379886e-11	0.75	VPS37B MVB12A PDCD6IP VPS28 MVB12B TSG101	viral budding
REAC:R-HSA-162587	1.1892885739e-11	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	HIV Life Cycle
GO:0036452	1.8296293945e-11	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	ESCRT complex
GO:0007032	4.90710516234e-11	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	endosome organization
GO:0045324	7.60119707806e-11	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	late endosome to vacuole transport
GO:0019068	9.35422010656e-11	0.75	VPS37B MVB12A PDCD6IP VPS28 MVB12B TSG101	virion assembly
GO:0043162	1.14315920869e-10	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0032509	1.38795875476e-10	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	endosome transport via multivesicular body sorting pathway
REAC:R-HSA-162906	2.76368860795e-10	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	HIV Infection
GO:0071985	3.95846597189e-10	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	multivesicular body sorting pathway
GO:0090148	4.63651494015e-10	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	membrane fission
REAC:R-HSA-9610379	4.88333392424e-10	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	HCMV Late Events
GO:0072666	2.36395437942e-09	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	establishment of protein localization to vacuole
REAC:R-HSA-9612973	4.24919493794e-09	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	Autophagy
REAC:R-HSA-9609646	4.43613473436e-09	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	HCMV Infection
GO:0039702	7.79777844544e-09	0.625	VPS37B MVB12A VPS28 PDCD6IP TSG101	viral budding via host ESCRT complex
CORUM:1863	9.82248594942e-09	0.375	VPS37B VPS28 TSG101	TSG101-VPS37B-VPS28 complex
KEGG:04144	1.97316055387e-08	0.75	VPS37B MVB12A PDCD6IP VPS28 MVB12B TSG101	Endocytosis
GO:0072665	2.06805536361e-08	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	protein localization to vacuole
GO:0016050	3.54928101551e-07	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	vesicle organization
GO:0007034	6.6792565317e-07	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	vacuolar transport
REAC:R-HSA-9824446	9.44505818541e-07	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	Viral Infection Pathways
REAC:R-HSA-5663205	3.98246607858e-06	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	Infectious disease
GO:0010256	7.94613148449e-06	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	endomembrane system organization
WP:WP4932	1.09422186321e-05	0.5	VPS37B VPS28 MVB12A TSG101	7q11 23 copy number variation syndrome
GO:0019058	1.15297611283e-05	0.75	VPS37B MVB12A PDCD6IP VPS28 MVB12B TSG101	viral life cycle
REAC:R-HSA-199991	1.97177804739e-05	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	Membrane Trafficking
REAC:R-HSA-5653656	2.7250868174e-05	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	Vesicle-mediated transport
GO:0016197	2.77335556993e-05	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	endosomal transport
GO:0061024	4.81352886543e-05	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	membrane organization
CORUM:1192	7.17483486175e-05	0.25	TSG101 VPS28	ESCRT-I complex
GO:0051603	7.68037115105e-05	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	proteolysis involved in protein catabolic process
GO:0016032	0.000117268576796	0.75	VPS37B MVB12A PDCD6IP VPS28 MVB12B TSG101	viral process
REAC:R-HSA-1643685	0.000171277938128	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	Disease
GO:0072594	0.000200688502943	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	establishment of protein localization to organelle
GO:0010008	0.000211590156107	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	endosome membrane
GO:0005768	0.000235535533194	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	endosome
GO:0070925	0.000297188578613	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	organelle assembly
GO:0030163	0.000400485388307	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	protein catabolic process
GO:0006886	0.00171393714913	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	intracellular protein transport
GO:0006511	0.00184452399096	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	ubiquitin-dependent protein catabolic process
GO:0043130	0.00197464201845	0.5	TSG101 MVB12A UBAP1 VPS28	ubiquitin binding
GO:0019941	0.00203139060687	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	modification-dependent protein catabolic process
GO:0043632	0.00231375700448	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	modification-dependent macromolecule catabolic process
GO:0009057	0.00361259705942	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	macromolecule catabolic process
GO:0006508	0.00375873294126	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	proteolysis
GO:1901565	0.00380855360614	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	organonitrogen compound catabolic process
GO:0032182	0.00461836161062	0.5	TSG101 MVB12A UBAP1 VPS28	ubiquitin-like protein binding
GO:0016192	0.00496175592273	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	vesicle-mediated transport
GO:0016236	0.00586429352642	0.625	VPS37B MVB12A VPS28 PDCD6IP TSG101	macroautophagy
GO:0019075	0.0131096201623	0.25	MVB12B MVB12A	virus maturation
GO:0033365	0.0201911294599	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	protein localization to organelle
KEGG:03250	0.0204060704272	0.25	TSG101 PDCD6IP	Viral life cycle - HIV-1
GO:0030659	0.0231270988724	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	cytoplasmic vesicle membrane
GO:0051649	0.0250941260125	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	establishment of localization in cell
GO:0012506	0.0254054411923	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	vesicle membrane
GO:0015031	0.0260031452214	0.75	VPS37B MVB12A VPS28 UBAP1 MVB12B TSG101	protein transport
HPA:0550053	0.0282983872239	0.75	UMAD1 VPS37B MVB12A PDCD6IP VPS28 TSG101	stomach 2; glandular cells[High]
HPA:0540053	0.0291899451541	0.75	UMAD1 VPS37B MVB12A PDCD6IP VPS28 TSG101	stomach 1; glandular cells[High]
GO:1903774	0.0393180950424	0.25	VPS37B TSG101	positive regulation of viral budding via host ESCRT complex
GO:1903772	0.0393180950424	0.25	VPS37B TSG101	regulation of viral budding via host ESCRT complex
GO:1901575	0.0435469655833	0.875	VPS37B MVB12A PDCD6IP VPS28 UBAP1 MVB12B TSG101	organic substance catabolic process

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
MVB12A	VPS28	1.0	0.308	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction
TSG101	MVB12A	1.0	0.366	hein_WMM bioplex_WMM bioplex3_WMM hein () Malo fraction
VPS37B	TSG101	1.0	0.252	hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo fraction
VPS37B	VPS28	1.0	0.534	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 fraction
TSG101	VPS28	1.0	0.912	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction
TSG101	UBAP1	1.0	0.07	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 fraction
VPS28	UBAP1	1.0	0.138	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
MVB12B	VPS28	0.999	0.094	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PDCD6IP	MVB12A	0.997	0.118	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
VPS37B	UBAP1	0.997	0.046	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
VPS37B	MVB12A	0.997	0.268	hein_WMM bioplex_WMM bioplex3_WMM Malo fraction
UMAD1	VPS28	0.996	0.172	hein_WMM bioplex3_HEK293 bioplex3_WMM hein ()
TSG101	UMAD1	0.988	0.154	hein_WMM bioplex3_WMM WMM_only
PDCD6IP	TSG101	0.982	0.246666666667	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
UMAD1	MVB12A	0.981	0.054	hein_WMM bioplex3_WMM WMM_only
MVB12A	UBAP1	0.981	0.08	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
MVB12B	MVB12A	0.972	0.052	bioplex_WMM bioplex3_WMM WMM_only
PDCD6IP	UMAD1	0.963	0.096	hein_WMM bioplex3_WMM WMM_only
MVB12B	VPS37B	0.948	0.126	bioplex_WMM bioplex3_WMM fraction
MVB12B	UBAP1	0.884	0.06	bioplex_WMM bioplex3_WMM WMM_only
UMAD1	UBAP1	0.844	0.124	hein_WMM bioplex3_WMM WMM_only
VPS37B	UMAD1	0.844	0.062	hein_WMM bioplex3_WMM WMM_only
MVB12B	TSG101	0.839	0.072	bioplex_WMM bioplex3_WMM fraction
MVB12B	PDCD6IP	0.696	0.046	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
PDCD6IP	VPS28	0.193	0.124	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
MVB12B	UMAD1	0.089	0.166	bioplex3_WMM WMM_only
PDCD6IP	UBAP1	0.025	0.148	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
VPS37B	PDCD6IP	0.01	0.11	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only

Related Complexes

Genename	Complexes
VPS37B	huMAP3_01514.1 huMAP3_06010.1 huMAP3_07951.1 huMAP3_09572.1 huMAP3_12917.1 huMAP3_13805.1
MVB12B	huMAP3_00501.1 huMAP3_04792.1 huMAP3_06010.1 huMAP3_06241.1 huMAP3_06316.1 huMAP3_07951.1 huMAP3_08364.1 huMAP3_09572.1 huMAP3_10226.1 huMAP3_12917.1 huMAP3_13805.1
PDCD6IP	huMAP3_01514.1 huMAP3_03988.1 huMAP3_06010.1 huMAP3_06089.1 huMAP3_06564.1 huMAP3_07951.1 huMAP3_08679.1 huMAP3_09572.1 huMAP3_10053.1 huMAP3_12409.1 huMAP3_12917.1 huMAP3_13805.1
TSG101	huMAP3_01514.1 huMAP3_06010.1 huMAP3_07951.1 huMAP3_08679.1 huMAP3_09572.1 huMAP3_10053.1 huMAP3_12917.1 huMAP3_13805.1
VPS28	huMAP3_04792.1 huMAP3_06010.1 huMAP3_06533.1 huMAP3_07951.1 huMAP3_09572.1 huMAP3_12917.1 huMAP3_13805.1
UMAD1	huMAP3_01514.1 huMAP3_03988.1 huMAP3_06010.1 huMAP3_06564.1 huMAP3_07951.1 huMAP3_08679.1 huMAP3_09572.1 huMAP3_10053.1 huMAP3_12917.1 huMAP3_13805.1
MVB12A	huMAP3_01514.1 huMAP3_06010.1 huMAP3_07951.1 huMAP3_09572.1 huMAP3_12917.1 huMAP3_13805.1
UBAP1	huMAP3_07951.1 huMAP3_09572.1 huMAP3_12917.1 huMAP3_13805.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07951.1