hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07956.1
Complex Portal: CPX-17307
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) | 5 | UniProt NCBI |
| ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) | 5 | UniProt NCBI |
| IRAG1 | Inositol 1,4,5-triphosphate receptor associated 1 (Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate) (JAW1-related protein MRVI1) (Protein MRVI1) | 5 | UniProt NCBI |
| ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) | 5 | UniProt NCBI |
| BBOX1 | Gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-BBH) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase) | 5 | UniProt NCBI |
| BOK | Bcl-2-related ovarian killer protein (hBOK) (Bcl-2-like protein 9) (Bcl2-L-9) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031095 | 4.97036464355e-08 | 0.666666666667 | ITPR3 IRAG1 ITPR2 ITPR1 | platelet dense tubular network membrane |
| GO:0031094 | 1.30147699894e-07 | 0.666666666667 | ITPR3 IRAG1 ITPR2 ITPR1 | platelet dense tubular network |
| REAC:R-HSA-5607763 | 5.93134254527e-07 | 0.5 | ITPR3 ITPR2 ITPR1 | CLEC7A (Dectin-1) induces NFAT activation |
| KEGG:04270 | 1.34365181968e-06 | 0.666666666667 | ITPR3 IRAG1 ITPR2 ITPR1 | Vascular smooth muscle contraction |
| REAC:R-HSA-418346 | 1.48174523696e-06 | 0.666666666667 | ITPR3 IRAG1 ITPR2 ITPR1 | Platelet homeostasis |
| REAC:R-HSA-139853 | 1.55272913081e-06 | 0.5 | ITPR3 ITPR2 ITPR1 | Elevation of cytosolic Ca2+ levels |
| GO:0005220 | 1.92240082153e-06 | 0.5 | ITPR3 ITPR2 ITPR1 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |
| REAC:R-HSA-5218921 | 2.56826946848e-06 | 0.5 | ITPR3 ITPR2 ITPR1 | VEGFR2 mediated cell proliferation |
| KEGG:04022 | 3.90742608633e-06 | 0.666666666667 | ITPR3 IRAG1 ITPR2 ITPR1 | cGMP-PKG signaling pathway |
| REAC:R-HSA-2871809 | 6.83169380613e-06 | 0.5 | ITPR3 ITPR2 ITPR1 | FCERI mediated Ca+2 mobilization |
| WP:WP4698 | 8.03768746193e-06 | 0.5 | ITPR3 ITPR2 ITPR1 | Vitamin D sensitive calcium signaling in depression |
| REAC:R-HSA-2029485 | 9.37394499108e-06 | 0.5 | ITPR3 ITPR2 ITPR1 | Role of phospholipids in phagocytosis |
| REAC:R-HSA-983695 | 1.08523688914e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| REAC:R-HSA-114508 | 1.24783008572e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | Effects of PIP2 hydrolysis |
| REAC:R-HSA-418360 | 1.24783008572e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | Platelet calcium homeostasis |
| WP:WP4756 | 1.64258598412e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | Renin angiotensin aldosterone system RAAS |
| KEGG:04927 | 2.2709010572e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | Cortisol synthesis and secretion |
| KEGG:04929 | 2.80567734252e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | GnRH secretion |
| REAC:R-HSA-9664323 | 2.85755298292e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | FCGR3A-mediated IL10 synthesis |
| KEGG:04730 | 3.41821979132e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | Long-term depression |
| KEGG:04924 | 3.41821979132e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | Renin secretion |
| REAC:R-HSA-381676 | 4.60302232639e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| KEGG:04971 | 4.62612486541e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | Gastric acid secretion |
| KEGG:04720 | 4.89749392973e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | Long-term potentiation |
| REAC:R-HSA-1489509 | 5.02070457715e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | DAG and IP3 signaling |
| KEGG:04918 | 6.75040698371e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | Thyroid hormone synthesis |
| REAC:R-HSA-5578775 | 7.49011945156e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | Ion homeostasis |
| WP:WP5356 | 8.00331206935e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | Affected pathways in Duchenne muscular dystrophy |
| REAC:R-HSA-112043 | 8.06503831344e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | PLC beta mediated events |
| KEGG:04970 | 8.21377308095e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | Salivary secretion |
| KEGG:04912 | 9.87392619558e-05 | 0.5 | ITPR3 ITPR2 ITPR1 | GnRH signaling pathway |
| KEGG:04750 | 0.000103211468895 | 0.5 | ITPR3 ITPR2 ITPR1 | Inflammatory mediator regulation of TRP channels |
| GO:0070679 | 0.00010757157937 | 0.5 | ITPR3 ITPR2 ITPR1 | inositol 1,4,5 trisphosphate binding |
| KEGG:04540 | 0.00011255543672 | 0.5 | ITPR3 ITPR2 ITPR1 | Gap junction |
| REAC:R-HSA-112040 | 0.000113827315454 | 0.5 | ITPR3 ITPR2 ITPR1 | G-protein mediated events |
| KEGG:04972 | 0.000117431011352 | 0.5 | ITPR3 ITPR2 ITPR1 | Pancreatic secretion |
| KEGG:04925 | 0.0001275988674 | 0.5 | ITPR3 ITPR2 ITPR1 | Aldosterone synthesis and secretion |
| REAC:R-HSA-4086398 | 0.00016429546397 | 0.5 | ITPR3 ITPR2 ITPR1 | Ca2+ pathway |
| KEGG:04724 | 0.000167761438495 | 0.5 | ITPR3 ITPR2 ITPR1 | Glutamatergic synapse |
| KEGG:04928 | 0.000180606252479 | 0.5 | ITPR3 ITPR2 ITPR1 | Parathyroid hormone synthesis, secretion and action |
| KEGG:04726 | 0.000187266429718 | 0.5 | ITPR3 ITPR2 ITPR1 | Serotonergic synapse |
| KEGG:04070 | 0.000194087641739 | 0.5 | ITPR3 ITPR2 ITPR1 | Phosphatidylinositol signaling system |
| KEGG:04625 | 0.000194087641739 | 0.5 | ITPR3 ITPR2 ITPR1 | C-type lectin receptor signaling pathway |
| KEGG:04725 | 0.000223020608969 | 0.5 | ITPR3 ITPR2 ITPR1 | Cholinergic synapse |
| KEGG:04915 | 0.000246503663907 | 0.5 | ITPR3 ITPR2 ITPR1 | Estrogen signaling pathway |
| KEGG:04922 | 0.000246503663907 | 0.5 | ITPR3 ITPR2 ITPR1 | Glucagon signaling pathway |
| REAC:R-HSA-9662851 | 0.000264877822759 | 0.5 | ITPR3 ITPR2 ITPR1 | Anti-inflammatory response favouring Leishmania parasite infection |
| REAC:R-HSA-9664433 | 0.000264877822759 | 0.5 | ITPR3 ITPR2 ITPR1 | Leishmania parasite growth and survival |
| KEGG:04611 | 0.000298275635298 | 0.5 | ITPR3 ITPR2 ITPR1 | Platelet activation |
| REAC:R-HSA-422356 | 0.000305777502474 | 0.5 | ITPR3 ITPR2 ITPR1 | Regulation of insulin secretion |
| KEGG:04935 | 0.000317011982633 | 0.5 | ITPR3 ITPR2 ITPR1 | Growth hormone synthesis, secretion and action |
| KEGG:04114 | 0.000356793103324 | 0.5 | ITPR3 ITPR2 ITPR1 | Oocyte meiosis |
| KEGG:04728 | 0.000411001884395 | 0.5 | ITPR3 ITPR2 ITPR1 | Dopaminergic synapse |
| GO:0015278 | 0.00042234232358 | 0.5 | ITPR3 ITPR2 ITPR1 | calcium-release channel activity |
| KEGG:04371 | 0.000434127752155 | 0.5 | ITPR3 ITPR2 ITPR1 | Apelin signaling pathway |
| KEGG:04380 | 0.000482933906752 | 0.5 | ITPR3 ITPR2 ITPR1 | Osteoclast differentiation |
| KEGG:04921 | 0.000521832076753 | 0.5 | ITPR3 ITPR2 ITPR1 | Oxytocin signaling pathway |
| REAC:R-HSA-2029480 | 0.000531494169007 | 0.5 | ITPR3 ITPR2 ITPR1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-111885 | 0.000531494169007 | 0.5 | ITPR3 ITPR2 ITPR1 | Opioid Signalling |
| KEGG:04723 | 0.000535244879172 | 0.5 | ITPR3 ITPR2 ITPR1 | Retrograde endocannabinoid signaling |
| KEGG:04210 | 0.000548884136987 | 0.5 | ITPR3 ITPR2 ITPR1 | Apoptosis |
| WP:WP536 | 0.000618139107763 | 0.5 | ITPR3 ITPR2 ITPR1 | Calcium regulation in cardiac cells |
| KEGG:04934 | 0.000620541886073 | 0.5 | ITPR3 ITPR2 ITPR1 | Cushing syndrome |
| KEGG:05017 | 0.000620541886073 | 0.5 | ITPR3 ITPR2 ITPR1 | Spinocerebellar ataxia |
| REAC:R-HSA-5576891 | 0.000689296551176 | 0.5 | ITPR3 ITPR2 ITPR1 | Cardiac conduction |
| REAC:R-HSA-4420097 | 0.00073948978705 | 0.5 | ITPR3 ITPR2 ITPR1 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-5607764 | 0.000819236589251 | 0.5 | ITPR3 ITPR2 ITPR1 | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-163685 | 0.00084703415394 | 0.5 | ITPR3 ITPR2 ITPR1 | Integration of energy metabolism |
| KEGG:04218 | 0.000872061762815 | 0.5 | ITPR3 ITPR2 ITPR1 | Cellular senescence |
| REAC:R-HSA-194138 | 0.000964479133971 | 0.5 | ITPR3 ITPR2 ITPR1 | Signaling by VEGF |
| KEGG:04621 | 0.000989019592829 | 0.5 | ITPR3 ITPR2 ITPR1 | NOD-like receptor signaling pathway |
| WP:WP289 | 0.000990100982598 | 0.5 | ITPR3 ITPR2 ITPR1 | Myometrial relaxation and contraction pathways |
| REAC:R-HSA-983705 | 0.000995437430554 | 0.5 | ITPR3 ITPR2 ITPR1 | Signaling by the B Cell Receptor (BCR) |
| KEGG:05167 | 0.00150582306317 | 0.5 | ITPR3 ITPR2 ITPR1 | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-2454202 | 0.00154179194332 | 0.5 | ITPR3 ITPR2 ITPR1 | Fc epsilon receptor (FCERI) signaling |
| GO:0099604 | 0.00156505859778 | 0.5 | ITPR3 ITPR2 ITPR1 | ligand-gated calcium channel activity |
| KEGG:04020 | 0.00161563805052 | 0.5 | ITPR3 ITPR2 ITPR1 | Calcium signaling pathway |
| REAC:R-HSA-418457 | 0.00170100530318 | 0.333333333333 | IRAG1 ITPR1 | cGMP effects |
| KEGG:05205 | 0.00191301809451 | 0.5 | ITPR3 ITPR2 ITPR1 | Proteoglycans in cancer |
| REAC:R-HSA-5621481 | 0.00194934586886 | 0.5 | ITPR3 ITPR2 ITPR1 | C-type lectin receptors (CLRs) |
| KEGG:05163 | 0.00224445303032 | 0.5 | ITPR3 ITPR2 ITPR1 | Human cytomegalovirus infection |
| KEGG:05170 | 0.00227953772694 | 0.5 | ITPR3 ITPR2 ITPR1 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-416476 | 0.00253713376791 | 0.5 | ITPR3 ITPR2 ITPR1 | G alpha (q) signalling events |
| GO:0005217 | 0.00254971303757 | 0.5 | ITPR3 ITPR2 ITPR1 | intracellular ligand-gated monoatomic ion channel activity |
| REAC:R-HSA-9824443 | 0.00283909643482 | 0.5 | ITPR3 ITPR2 ITPR1 | Parasitic Infection Pathways |
| REAC:R-HSA-9658195 | 0.00283909643482 | 0.5 | ITPR3 ITPR2 ITPR1 | Leishmania infection |
| REAC:R-HSA-3858494 | 0.00283909643482 | 0.5 | ITPR3 ITPR2 ITPR1 | Beta-catenin independent WNT signaling |
| REAC:R-HSA-392154 | 0.0035019037522 | 0.333333333333 | IRAG1 ITPR1 | Nitric oxide stimulates guanylate cyclase |
| KEGG:05131 | 0.00369808394071 | 0.5 | ITPR3 ITPR2 ITPR1 | Shigellosis |
| REAC:R-HSA-397014 | 0.00380890170895 | 0.5 | ITPR3 ITPR2 ITPR1 | Muscle contraction |
| KEGG:05012 | 0.00425749387528 | 0.5 | ITPR3 ITPR2 ITPR1 | Parkinson disease |
| REAC:R-HSA-109582 | 0.00428563332784 | 0.666666666667 | ITPR3 IRAG1 ITPR2 ITPR1 | Hemostasis |
| KEGG:05020 | 0.00464093791542 | 0.5 | ITPR3 ITPR2 ITPR1 | Prion disease |
| WP:WP2059 | 0.00539895087355 | 0.5 | ITPR3 ITPR2 ITPR1 | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 0.00539895087355 | 0.5 | ITPR3 ITPR2 ITPR1 | Alzheimer 39 s disease |
| REAC:R-HSA-418594 | 0.00724999404577 | 0.5 | ITPR3 ITPR2 ITPR1 | G alpha (i) signalling events |
| REAC:R-HSA-76002 | 0.0114840601602 | 0.5 | ITPR3 ITPR2 ITPR1 | Platelet activation, signaling and aggregation |
| KEGG:05010 | 0.0122631731838 | 0.5 | ITPR3 ITPR2 ITPR1 | Alzheimer disease |
| GO:0016529 | 0.0125202207278 | 0.5 | ITPR3 ITPR2 ITPR1 | sarcoplasmic reticulum |
| GO:0016528 | 0.017471616814 | 0.5 | ITPR3 ITPR2 ITPR1 | sarcoplasm |
| KEGG:04713 | 0.0188598619414 | 0.333333333333 | ITPR3 ITPR1 | Circadian entrainment |
| REAC:R-HSA-9006925 | 0.0208115615403 | 0.5 | ITPR3 ITPR2 ITPR1 | Intracellular signaling by second messengers |
| KEGG:05022 | 0.0219191039446 | 0.5 | ITPR3 ITPR2 ITPR1 | Pathways of neurodegeneration - multiple diseases |
| REAC:R-HSA-195721 | 0.0291878756931 | 0.5 | ITPR3 ITPR2 ITPR1 | Signaling by WNT |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| IRAG1 | BOK | 1.0 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ITPR2 | ITPR3 | 0.999 | 0.174 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ITPR1 | ITPR3 | 0.998 | 0.486 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ITPR1 | IRAG1 | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ITPR2 | ITPR1 | 0.996 | 0.206 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| BBOX1 | BOK | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ITPR1 | BBOX1 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ITPR2 | IRAG1 | 0.996 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| IRAG1 | ITPR3 | 0.993 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ITPR2 | BBOX1 | 0.992 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 bioplex_WMM | ||
| ITPR3 | BBOX1 | 0.962 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 bioplex_WMM | ||
| ITPR1 | BOK | 0.961 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ITPR2 | BOK | 0.95 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ITPR3 | BOK | 0.95 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes