hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07957.1
Complex Portal: CPX-22547
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TMEM164 | Transmembrane protein 164 | 3 | UniProt NCBI |
| ADCK2 | Uncharacterized aarF domain-containing protein kinase 2 (EC 2.7.11.-) | 5 | UniProt NCBI |
| NPEPPS | Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S) | 5 | UniProt NCBI |
| LRRC8D | Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D) | 5 | UniProt NCBI |
| LRRC8C | Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C) | 5 | UniProt NCBI |
| LRRC8B | Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6567 | 4.675933868e-08 | 0.5 | LRRC8C LRRC8D LRRC8B | SWELL1-containing complex |
| REAC:R-HSA-5223345 | 8.03604834368e-06 | 0.5 | LRRC8C LRRC8D LRRC8B | Miscellaneous transport and binding events |
| GO:0005225 | 0.000161332517231 | 0.5 | LRRC8C LRRC8D LRRC8B | volume-sensitive anion channel activity |
| WP:WP5083 | 0.000601674904708 | 0.5 | LRRC8C LRRC8D LRRC8B | Neuroinflammation and glutamatergic signaling |
| GO:0098656 | 0.0271028431288 | 0.5 | LRRC8C LRRC8D LRRC8B | monoatomic anion transmembrane transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LRRC8C | LRRC8B | 0.995 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TMEM164 | LRRC8B | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LRRC8D | LRRC8B | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NPEPPS | LRRC8B | 0.983 |
structurally_consistent (Q8TDW0)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ADCK2 | LRRC8B | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NPEPPS | LRRC8D | 0.946 | 0.116 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| NPEPPS | LRRC8C | 0.855 | 0.03 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| LRRC8D | LRRC8C | 0.396 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRRC8D | ADCK2 | 0.165 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ADCK2 | LRRC8C | 0.151 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TMEM164 | LRRC8C | 0.124 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only | |
| TMEM164 | ADCK2 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NPEPPS | ADCK2 | 0.067 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TMEM164 | LRRC8D | 0.051 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| TMEM164 | NPEPPS | 0.033 | 0.092 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes