hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07958.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SUMO2 | Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B) | 5 | UniProt NCBI |
| SAE1 | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | 5 | UniProt NCBI |
| UBA2 | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3065676 | 4.66602141148e-09 | 1.0 | SUMO2 SAE1 UBA2 | SUMO is conjugated to E1 (UBA2:SAE1) |
| REAC:R-HSA-3065678 | 9.33204282296e-09 | 1.0 | SUMO2 SAE1 UBA2 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
| REAC:R-HSA-3215018 | 3.91945798564e-08 | 1.0 | SUMO2 SAE1 UBA2 | Processing and activation of SUMO |
| CORUM:5756 | 3.41752350426e-06 | 0.666666666667 | UBA2 SAE1 | SUA1-UBA2 complex |
| CORUM:5755 | 1.02521027753e-05 | 0.666666666667 | UBA2 SAE1 | SUMO1-SUA1-UBA2 complex |
| REAC:R-HSA-2990846 | 0.000330616079734 | 1.0 | SUMO2 SAE1 UBA2 | SUMOylation |
| HPA:0470673 | 0.000890440172922 | 1.0 | SUMO2 SAE1 UBA2 | skin 2; melanocytes[High] |
| GO:0019948 | 0.00140460216025 | 0.666666666667 | UBA2 SAE1 | SUMO activating enzyme activity |
| GO:0031510 | 0.00140460216025 | 0.666666666667 | UBA2 SAE1 | SUMO activating enzyme complex |
| GO:0016925 | 0.00252170927764 | 1.0 | SUMO2 SAE1 UBA2 | protein sumoylation |
| HPA:0460182 | 0.00312059671208 | 1.0 | SUMO2 SAE1 UBA2 | skin 1; cells in granular layer[>=Medium] |
| HPA:0470202 | 0.00474247809279 | 1.0 | SUMO2 SAE1 UBA2 | skin 2; endothelial cells[>=Medium] |
| HPA:0470672 | 0.00503325048482 | 1.0 | SUMO2 SAE1 UBA2 | skin 2; melanocytes[>=Medium] |
| HPA:0460181 | 0.00654790850334 | 1.0 | SUMO2 SAE1 UBA2 | skin 1; cells in granular layer[>=Low] |
| HPA:0470181 | 0.00660698711107 | 1.0 | SUMO2 SAE1 UBA2 | skin 2; cells in granular layer[>=Low] |
| KEGG:04120 | 0.00686279305854 | 0.666666666667 | UBA2 SAE1 | Ubiquitin mediated proteolysis |
| HPA:0470671 | 0.00731212240844 | 1.0 | SUMO2 SAE1 UBA2 | skin 2; melanocytes[>=Low] |
| HPA:0471461 | 0.00905089926356 | 1.0 | SUMO2 SAE1 UBA2 | skin 2; langerhans cells[>=Low] |
| HPA:0471411 | 0.012211103258 | 1.0 | SUMO2 SAE1 UBA2 | skin 2; cells in spinous layer[>=Low] |
| HPA:0470201 | 0.0128004018578 | 1.0 | SUMO2 SAE1 UBA2 | skin 2; endothelial cells[>=Low] |
| GO:0044388 | 0.0140440992017 | 0.666666666667 | UBA2 SAE1 | small protein activating enzyme binding |
| HPA:0471493 | 0.0144360249621 | 0.666666666667 | SUMO2 UBA2 | skin 2; vascular mural cells[High] |
| HPA:0461493 | 0.0163771345036 | 0.666666666667 | SUMO2 UBA2 | skin 1; vascular mural cells[High] |
| GO:0018205 | 0.0250037062852 | 1.0 | SUMO2 SAE1 UBA2 | peptidyl-lysine modification |
| HPA:0461492 | 0.0316049848456 | 0.666666666667 | SUMO2 UBA2 | skin 1; vascular mural cells[>=Medium] |
| HPA:0471492 | 0.0323023843332 | 0.666666666667 | SUMO2 UBA2 | skin 2; vascular mural cells[>=Medium] |
| HPA:0461393 | 0.0323023843332 | 0.666666666667 | SUMO2 UBA2 | skin 1; cells in basal layer[High] |
| HPA:0461413 | 0.037395322848 | 0.666666666667 | SUMO2 UBA2 | skin 1; cells in spinous layer[High] |
| HPA:0461463 | 0.0412590843677 | 0.666666666667 | SUMO2 UBA2 | skin 1; langerhans cells[High] |
| HPA:0570813 | 0.0443510461782 | 1.0 | SUMO2 SAE1 UBA2 | testis; spermatogonia cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SAE1 | UBA2 | 0.998 | 0.936 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () gupta_WMM fraction |
| SUMO2 | UBA2 | 0.994 | 0.486 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| SUMO2 | SAE1 | 0.99 | 0.408 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction |
Related Complexes