hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07978.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KIFAP3 | Kinesin-associated protein 3 (KAP-3) (KAP3) (Smg GDS-associated protein) | 5 | UniProt NCBI |
| KIF3C | Kinesin-like protein KIF3C | 5 | UniProt NCBI |
| KIF3A | Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A) | 5 | UniProt NCBI |
| KIF3B | Kinesin-like protein KIF3B (HH0048) (Microtubule plus end-directed kinesin motor 3B) [Cleaved into: Kinesin-like protein KIF3B, N-terminally processed] | 5 | UniProt NCBI |
| LYG1 | Lysozyme g-like protein 1 (EC 3.2.1.-) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5620924 | 1.06470860481e-07 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | Intraflagellar transport |
| REAC:R-HSA-983189 | 1.34717770914e-07 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | Kinesins |
| GO:0016939 | 9.61200410764e-07 | 0.6 | KIF3B KIFAP3 KIF3A | kinesin II complex |
| REAC:R-HSA-6811434 | 1.24109632959e-06 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-2132295 | 3.14719378971e-06 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | MHC class II antigen presentation |
| KEGG:04814 | 3.50082479815e-06 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | Motor proteins |
| REAC:R-HSA-8856688 | 4.24686934885e-06 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | Golgi-to-ER retrograde transport |
| GO:0005871 | 8.67338862712e-06 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | kinesin complex |
| GO:0072383 | 9.61003071434e-06 | 0.6 | KIF3B KIFAP3 KIF3A | plus-end-directed vesicle transport along microtubule |
| REAC:R-HSA-983231 | 1.03179988059e-05 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | Factors involved in megakaryocyte development and platelet production |
| GO:0072386 | 1.92180881975e-05 | 0.6 | KIF3B KIFAP3 KIF3A | plus-end-directed organelle transport along microtubule |
| GO:0097542 | 1.95582475037e-05 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | ciliary tip |
| REAC:R-HSA-5617833 | 2.17733358367e-05 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | Cilium Assembly |
| REAC:R-HSA-6811442 | 2.36864607463e-05 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-1852241 | 9.81058085249e-05 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | Organelle biogenesis and maintenance |
| CORUM:905 | 0.000136445626745 | 0.4 | KIF3B KIF3A | KIF3A/B-PAR-3-aPKC-PAR-6 complex |
| REAC:R-HSA-1445148 | 0.00016240432487 | 0.6 | KIF3B KIFAP3 KIF3A | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| WP:WP4536 | 0.000181875223355 | 0.6 | KIF3B KIFAP3 KIF3A | Genes related to primary cilium development based on CRISPR |
| GO:0005875 | 0.00118663084114 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | microtubule associated complex |
| REAC:R-HSA-109582 | 0.00129857214677 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | Hemostasis |
| REAC:R-HSA-199991 | 0.00183945180572 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.00228321498701 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | Vesicle-mediated transport |
| REAC:R-HSA-1280218 | 0.00330467394888 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | Adaptive Immune System |
| GO:0047496 | 0.0102064666638 | 0.6 | KIF3B KIFAP3 KIF3A | vesicle transport along microtubule |
| GO:0003777 | 0.0211358171848 | 0.6 | KIF3B KIF3C KIF3A | microtubule motor activity |
| GO:0007018 | 0.0284935982879 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | microtubule-based movement |
| GO:0005874 | 0.0289172689799 | 0.8 | KIF3B KIF3A KIFAP3 KIF3C | microtubule |
| GO:0099518 | 0.0379355065545 | 0.6 | KIF3B KIFAP3 KIF3A | vesicle cytoskeletal trafficking |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| KIFAP3 | KIF3A | 1.0 | 0.47 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| KIF3B | KIF3A | 1.0 | 0.448 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| KIFAP3 | KIF3B | 1.0 | 0.376 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| KIFAP3 | KIF3C | 0.997 | 0.116 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| KIF3C | KIF3A | 0.994 | 0.202 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM |
| LYG1 | KIF3A | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KIF3C | KIF3B | 0.983 | 0.178 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| KIFAP3 | LYG1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIF3B | LYG1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIF3C | LYG1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes