hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07989.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) | 5 | UniProt NCBI |
| RRM2 | Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) | 5 | UniProt NCBI |
| RRM1 | Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) | 5 | UniProt NCBI |
| FBXO48 | F-box only protein 48 (F-box protein 48) | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4584 | 9.9913533089e-08 | 0.75 | RRM2 RRM2B RRM1 | Biomarkers for pyrimidine metabolism disorders |
| WP:WP4225 | 2.84994785564e-07 | 0.75 | RRM2 RRM2B RRM1 | Pyrimidine metabolism and related diseases |
| GO:0005971 | 3.84480164306e-07 | 0.75 | RRM2 RRM2B RRM1 | ribonucleoside-diphosphate reductase complex |
| GO:0004748 | 3.84480164306e-07 | 0.75 | RRM2 RRM2B RRM1 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| GO:0061731 | 3.84480164306e-07 | 0.75 | RRM2 RRM2B RRM1 | ribonucleoside-diphosphate reductase activity |
| REAC:R-HSA-499943 | 2.4825378684e-06 | 0.75 | RRM2 RRM2B RRM1 | Interconversion of nucleotide di- and triphosphates |
| GO:0016728 | 3.84440695359e-06 | 0.75 | RRM2 RRM2B RRM1 | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor |
| KEGG:00240 | 4.86072516083e-06 | 0.75 | RRM2 RRM2B RRM1 | Pyrimidine metabolism |
| KEGG:00480 | 6.7121712711e-06 | 0.75 | RRM2 RRM2B RRM1 | Glutathione metabolism |
| KEGG:00983 | 1.63910874597e-05 | 0.75 | RRM2 RRM2B RRM1 | Drug metabolism - other enzymes |
| KEGG:01232 | 1.8726845031e-05 | 0.75 | RRM2 RRM2B RRM1 | Nucleotide metabolism |
| GO:0046385 | 2.15253635486e-05 | 0.75 | RRM2 RRM2B RRM1 | deoxyribose phosphate biosynthetic process |
| GO:0009265 | 2.15253635486e-05 | 0.75 | RRM2 RRM2B RRM1 | 2'-deoxyribonucleotide biosynthetic process |
| GO:0009263 | 2.15253635486e-05 | 0.75 | RRM2 RRM2B RRM1 | deoxyribonucleotide biosynthetic process |
| GO:0016725 | 4.61210427592e-05 | 0.75 | RRM2 RRM2B RRM1 | oxidoreductase activity, acting on CH or CH2 groups |
| KEGG:00230 | 5.19578118732e-05 | 0.75 | RRM2 RRM2B RRM1 | Purine metabolism |
| REAC:R-HSA-15869 | 0.000102255107087 | 0.75 | RRM2 RRM2B RRM1 | Metabolism of nucleotides |
| GO:0009394 | 0.000883305813556 | 0.75 | RRM2 RRM2B RRM1 | 2'-deoxyribonucleotide metabolic process |
| GO:0019692 | 0.000883305813556 | 0.75 | RRM2 RRM2B RRM1 | deoxyribose phosphate metabolic process |
| GO:0009262 | 0.000998468305694 | 0.75 | RRM2 RRM2B RRM1 | deoxyribonucleotide metabolic process |
| WP:WP1601 | 0.00103429913449 | 0.5 | RRM2 RRM1 | Fluoropyrimidine activity |
| KEGG:04115 | 0.00502800723414 | 0.5 | RRM2 RRM2B | p53 signaling pathway |
| WP:WP2446 | 0.0092628309276 | 0.5 | RRM2 RRM1 | Retinoblastoma gene in cancer |
| GO:0070318 | 0.0168521501606 | 0.5 | RRM2B RRM1 | positive regulation of G0 to G1 transition |
| GO:1901992 | 0.0175369202004 | 0.75 | RRM2 RRM2B RRM1 | positive regulation of mitotic cell cycle phase transition |
| GO:0009185 | 0.0269276802074 | 0.75 | RRM2 RRM2B RRM1 | ribonucleoside diphosphate metabolic process |
| GO:0009132 | 0.0314640437065 | 0.75 | RRM2 RRM2B RRM1 | nucleoside diphosphate metabolic process |
| GO:1901989 | 0.0351813641256 | 0.75 | RRM2 RRM2B RRM1 | positive regulation of cell cycle phase transition |
| GO:0045931 | 0.0449670283878 | 0.75 | RRM2 RRM2B RRM1 | positive regulation of mitotic cell cycle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RRM2B | RRM2 | 1.0 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RRM2B | RRM1 | 0.979 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RRM1 | FBXO48 | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RRM2 | RRM1 | 0.97 | 0.318 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| RRM2B | FBXO48 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | |
| RRM2 | FBXO48 | 0.32 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes