hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07996.1
Complex Portal: CPX-19525
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| USP27X | Ubiquitin carboxyl-terminal hydrolase 27 (EC 3.4.19.12) (Deubiquitinating enzyme 27) (Ubiquitin carboxyl-terminal hydrolase 22-like) (Ubiquitin thioesterase 27) (Ubiquitin-specific-processing protease 27) (X-linked ubiquitin carboxyl-terminal hydrolase 27) | 5 | UniProt NCBI |
| ATXN7L2 | Ataxin-7-like protein 2 | 2 | UniProt NCBI |
| ATXN7L1 | Ataxin-7-like protein 1 (Ataxin-7-like protein 4) | 4 | UniProt NCBI |
| ENY2 | Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog) | 5 | UniProt NCBI |
| ATXN7L3B | Ataxin-7-like protein 3B | 4 | UniProt NCBI |
| USP22 | Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22) | 5 | UniProt NCBI |
| USP51 | Ubiquitin carboxyl-terminal hydrolase 51 (EC 3.4.19.12) (Deubiquitinating enzyme 51) (Ubiquitin thioesterase 51) (Ubiquitin-specific-processing protease 51) | 5 | UniProt NCBI |
| ATXN7L3 | Ataxin-7-like protein 3 (SAGA-associated factor 11 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6643 | 1.29848862028e-08 | 0.5 | ATXN7L3 USP22 ATXN7L2 ATXN7L1 | SAGA complex, GCN5-linked |
| CORUM:6664 | 9.47897013135e-06 | 0.375 | ENY2 USP22 ATXN7L3 | STAGA complex, SPT3-linked |
| CORUM:6641 | 0.000668735194034 | 0.25 | ATXN7L3 USP22 | USP22-SAGA complex |
| GO:0033276 | 0.0043754188034 | 0.375 | ENY2 USP22 ATXN7L3 | transcription factor TFTC complex |
| GO:0000124 | 0.00712601113833 | 0.375 | ENY2 USP22 ATXN7L3 | SAGA complex |
| REAC:R-HSA-3214847 | 0.00775010993696 | 0.375 | ENY2 USP22 ATXN7L3 | HATs acetylate histones |
| GO:0071819 | 0.0131096201623 | 0.25 | ENY2 ATXN7L3 | DUBm complex |
| GO:0070461 | 0.0381082872278 | 0.375 | ENY2 USP22 ATXN7L3 | SAGA-type complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| USP22 | ATXN7L3 | 1.0 | 0.126 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ENY2 | ATXN7L3 | 1.0 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| USP27X | ATXN7L3 | 0.999 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ATXN7L3 | ATXN7L1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ATXN7L2 | ATXN7L3 | 0.999 |
mutually_exclusive (Q9UPT9)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| USP51 | ATXN7L3 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| USP22 | ATXN7L1 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| USP51 | USP27X | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ENY2 | ATXN7L1 | 0.997 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| USP51 | ENY2 | 0.995 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ATXN7L1 | ATXN7L3B | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| USP27X | ATXN7L1 | 0.976 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| ATXN7L2 | ATXN7L1 | 0.957 |
mutually_exclusive (Q9UPT9)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| ATXN7L2 | USP22 | 0.938 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| USP27X | ATXN7L2 | 0.936 | bioplex_WMM bioplex3_WMM WMM_only | ||
| USP27X | ENY2 | 0.925 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only | |
| ENY2 | USP22 | 0.908 | 0.052 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ATXN7L2 | ENY2 | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| USP27X | USP22 | 0.821 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only | |
| USP27X | ATXN7L3B | 0.415 | 0.089 | bioplex3_WMM WMM_only | |
| ATXN7L3 | ATXN7L3B | 0.415 | 0.142 |
mutually_exclusive (Q9UPT9)
|
bioplex3_WMM WMM_only |
| ENY2 | ATXN7L3B | 0.087 | 0.242 | bioplex3_WMM WMM_only | |
| USP22 | ATXN7L3B | 0.078 | 0.066 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
Related Complexes