hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08012.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VPS13D | Intermembrane lipid transfer protein VPS13D (Vacuolar protein sorting-associated protein 13D) | 5 | UniProt NCBI |
| TMEM31 | Transmembrane protein 31 | 2 | UniProt NCBI |
| UBQLN4 | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) | 5 | UniProt NCBI |
| UBQLN1 | Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1) | 5 | UniProt NCBI |
| UBQLN2 | Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5209 | 0.000136445626745 | 0.4 | UBQLN2 UBQLN1 | Ubiquilin-proteasome complex |
| KEGG:04141 | 0.000570106569601 | 0.6 | UBQLN2 UBQLN4 UBQLN1 | Protein processing in endoplasmic reticulum |
| GO:0016241 | 0.00167734490804 | 0.8 | VPS13D UBQLN2 UBQLN4 UBQLN1 | regulation of macroautophagy |
| KEGG:05014 | 0.00506998141773 | 0.6 | UBQLN2 UBQLN4 UBQLN1 | Amyotrophic lateral sclerosis |
| GO:0031593 | 0.0237169649094 | 0.6 | UBQLN2 UBQLN4 UBQLN1 | polyubiquitin modification-dependent protein binding |
| GO:0016236 | 0.029345634756 | 0.8 | VPS13D UBQLN2 UBQLN4 UBQLN1 | macroautophagy |
| GO:0010506 | 0.0389526852651 | 0.8 | VPS13D UBQLN2 UBQLN4 UBQLN1 | regulation of autophagy |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TMEM31 | UBQLN2 | 0.983 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TMEM31 | UBQLN1 | 0.98 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TMEM31 | UBQLN4 | 0.97 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TMEM31 | VPS13D | 0.96 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UBQLN1 | UBQLN2 | 0.698 | bioplex_WMM bioplex3_WMM fraction | |
| UBQLN2 | UBQLN4 | 0.661 | 0.788 | bioplex_WMM bioplex3_WMM WMM_only |
| UBQLN1 | UBQLN4 | 0.491 | bioplex_WMM bioplex3_WMM fraction | |
| VPS13D | UBQLN2 | 0.034 | 0.03 | bioplex3_WMM WMM_only |
| VPS13D | UBQLN4 | 0.022 | 0.072 | bioplex3_WMM WMM_only |
| VPS13D | UBQLN1 | 0.019 | bioplex3_WMM WMM_only |
Related Complexes