hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08013.1
Complex Portal: CPX-15673
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GYG2 | Glycogenin-2 (GN-2) (GN2) (EC 2.4.1.186) | 5 | UniProt NCBI |
| PPP1R3F | Protein phosphatase 1 regulatory subunit 3F (R3F) | 5 | UniProt NCBI |
| STBD1 | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | 5 | UniProt NCBI |
| GYS2 | Glycogen [starch] synthase, liver (EC 2.4.1.11) (Glycogen synthase 2) | 5 | UniProt NCBI |
| PYGB | Glycogen phosphorylase, brain form (EC 2.4.1.1) | 5 | UniProt NCBI |
| PYGL | Glycogen phosphorylase, liver form (EC 2.4.1.1) | 5 | UniProt NCBI |
| AGL | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | 5 | UniProt NCBI |
| PPP1R3C | Protein phosphatase 1 regulatory subunit 3C (Protein phosphatase 1 regulatory subunit 5) (PP1 subunit R5) (Protein targeting to glycogen) (PTG) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0044042 | 8.04069852877e-14 | 1.0 | PYGL PPP1R3C GYG2 PPP1R3F AGL GYS2 STBD1 | glucan metabolic process |
| GO:0005977 | 8.04069852877e-14 | 1.0 | PYGL PPP1R3C GYG2 PPP1R3F AGL GYS2 STBD1 | glycogen metabolic process |
| GO:0006112 | 2.3704943205e-13 | 1.0 | PYGL PPP1R3C GYG2 PPP1R3F AGL GYS2 STBD1 | energy reserve metabolic process |
| GO:0005976 | 7.73017010475e-13 | 1.0 | PYGL PPP1R3C GYG2 PPP1R3F AGL GYS2 STBD1 | polysaccharide metabolic process |
| REAC:R-HSA-8982491 | 3.10843570703e-11 | 0.714285714286 | GYS2 AGL PPP1R3C GYG2 PYGL | Glycogen metabolism |
| GO:0015980 | 8.76668742926e-09 | 1.0 | PYGL PPP1R3C GYG2 PPP1R3F AGL GYS2 STBD1 | energy derivation by oxidation of organic compounds |
| KEGG:00500 | 1.21187654792e-08 | 0.571428571429 | GYS2 AGL GYG2 PYGL | Starch and sucrose metabolism |
| GO:0005975 | 9.24258191086e-08 | 1.0 | PYGL PPP1R3C GYG2 PPP1R3F AGL GYS2 STBD1 | carbohydrate metabolic process |
| WP:WP500 | 1.09591526327e-07 | 0.571428571429 | GYS2 AGL GYG2 PYGL | Glycogen synthesis and degradation |
| GO:0006091 | 1.59608931467e-07 | 1.0 | PYGL PPP1R3C GYG2 PPP1R3F AGL GYS2 STBD1 | generation of precursor metabolites and energy |
| WP:WP5173 | 1.73947038067e-06 | 0.428571428571 | GYS2 GYG2 PYGL | Disorders of galactose metabolism |
| REAC:R-HSA-70221 | 3.72165755864e-06 | 0.428571428571 | AGL GYG2 PYGL | Glycogen breakdown (glycogenolysis) |
| REAC:R-HSA-3322077 | 4.73568218926e-06 | 0.428571428571 | GYS2 GYG2 PPP1R3C | Glycogen synthesis |
| REAC:R-HSA-3229121 | 4.73568218926e-06 | 0.428571428571 | GYS2 GYG2 PPP1R3C | Glycogen storage diseases |
| REAC:R-HSA-71387 | 6.2731355413e-06 | 0.714285714286 | GYS2 AGL PPP1R3C GYG2 PYGL | Metabolism of carbohydrates |
| KEGG:04910 | 9.43045297398e-06 | 0.571428571429 | PPP1R3F PPP1R3C PYGL GYS2 | Insulin signaling pathway |
| GO:0009250 | 3.29649973093e-05 | 0.571428571429 | PPP1R3F PPP1R3C GYG2 GYS2 | glucan biosynthetic process |
| GO:0005978 | 3.29649973093e-05 | 0.571428571429 | PPP1R3F PPP1R3C GYG2 GYS2 | glycogen biosynthetic process |
| REAC:R-HSA-3858516 | 3.8109360937e-05 | 0.285714285714 | GYS2 GYG2 | Glycogen storage disease type 0 (liver GYS2) |
| REAC:R-HSA-5663084 | 5.26476903505e-05 | 0.428571428571 | GYS2 GYG2 PPP1R3C | Diseases of carbohydrate metabolism |
| GO:2001069 | 6.72425931667e-05 | 0.428571428571 | PPP1R3F STBD1 PPP1R3C | glycogen binding |
| REAC:R-HSA-3878781 | 0.00011430200373 | 0.285714285714 | GYS2 GYG2 | Glycogen storage disease type IV (GBE1) |
| GO:0000271 | 0.000163106388622 | 0.571428571429 | PPP1R3F PPP1R3C GYG2 GYS2 | polysaccharide biosynthetic process |
| GO:0005980 | 0.000282244947588 | 0.428571428571 | AGL STBD1 PYGL | glycogen catabolic process |
| GO:0000272 | 0.000282244947588 | 0.428571428571 | AGL STBD1 PYGL | polysaccharide catabolic process |
| GO:0009251 | 0.000282244947588 | 0.428571428571 | AGL STBD1 PYGL | glucan catabolic process |
| KEGG:04931 | 0.00052377688541 | 0.428571428571 | GYS2 PYGL PPP1R3C | Insulin resistance |
| GO:0030247 | 0.000554182028596 | 0.428571428571 | PPP1R3F STBD1 PPP1R3C | polysaccharide binding |
| GO:0030246 | 0.00175371310235 | 0.571428571429 | PPP1R3F PPP1R3C STBD1 PYGL | carbohydrate binding |
| GO:0016051 | 0.00962590095585 | 0.571428571429 | PPP1R3F PPP1R3C GYG2 GYS2 | carbohydrate biosynthetic process |
| REAC:R-HSA-5668914 | 0.0134637920212 | 0.428571428571 | GYS2 GYG2 PPP1R3C | Diseases of metabolism |
| WP:WP4861 | 0.0137733753117 | 0.285714285714 | PPP1R3F PPP1R3C | Endoplasmic reticulum stress response in coronavirus infection |
| WP:WP410 | 0.014476396468 | 0.285714285714 | PPP1R3C STBD1 | Exercise induced circadian regulation |
| HP:0003077 | 0.0189708908941 | 0.428571428571 | GYS2 PYGL AGL | Hyperlipidemia |
| GO:0016758 | 0.0218746163137 | 0.571428571429 | GYS2 AGL GYG2 PYGL | hexosyltransferase activity |
| KEGG:04922 | 0.0420880817615 | 0.285714285714 | GYS2 PYGL | Glucagon signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| STBD1 | AGL | 1.0 | 0.216 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STBD1 | PYGB | 0.999 | 0.185 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| PYGB | PYGL | 0.998 | 0.366 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only | |
| GYG2 | STBD1 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GYG2 | AGL | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| STBD1 | GYS2 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PPP1R3C | STBD1 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PPP1R3F | STBD1 | 0.99 | 0.104 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| STBD1 | PYGL | 0.988 | 0.228 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GYG2 | GYS2 | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| GYG2 | PPP1R3F | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PPP1R3C | AGL | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GYS2 | PYGB | 0.957 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GYG2 | PYGB | 0.948 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| PYGB | AGL | 0.898 | 0.206 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| GYS2 | AGL | 0.893 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PPP1R3F | PYGB | 0.865 | 0.07 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PPP1R3F | AGL | 0.812 | 0.05 | bioplex3_WMM WMM_only | |
| PPP1R3F | GYS2 | 0.745 | bioplex3_WMM WMM_only | ||
| PPP1R3F | PYGL | 0.569 | 0.03 | bioplex3_WMM WMM_only | |
| PPP1R3C | GYS2 | 0.268 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GYS2 | PYGL | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PYGL | AGL | 0.172 | 0.054 | bioplex_WMM bioplex3_WMM fraction | |
| GYG2 | PYGL | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PPP1R3C | PYGL | 0.005 | bioplex3_HEK293 bioplex () |
Related Complexes