hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08023.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EEFSEC | Selenocysteine-specific elongation factor (EC 3.6.5.-) (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific) | 5 | UniProt NCBI |
| RPS27 | Small ribosomal subunit protein eS27 (40S ribosomal protein S27) (Metallopan-stimulin 1) (MPS-1) | 5 | UniProt NCBI |
| RPS27L | Ribosomal protein eS27-like (40S ribosomal protein S27-like) (Small ribosomal subunit protein eS27-like) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2408557 | 5.66851611173e-05 | 1.0 | EEFSEC RPS27 RPS27L | Selenocysteine synthesis |
| REAC:R-HSA-2408522 | 0.000103499353939 | 1.0 | EEFSEC RPS27 RPS27L | Selenoamino acid metabolism |
| REAC:R-HSA-71291 | 0.00257220962738 | 1.0 | EEFSEC RPS27 RPS27L | Metabolism of amino acids and derivatives |
| REAC:R-HSA-9735869 | 0.00453384142373 | 0.666666666667 | RPS27 RPS27L | SARS-CoV-1 modulates host translation machinery |
| KEGG:03010 | 0.00636348549017 | 0.666666666667 | RPS27 RPS27L | Ribosome |
| REAC:R-HSA-9754678 | 0.00867409880878 | 0.666666666667 | RPS27 RPS27L | SARS-CoV-2 modulates host translation machinery |
| REAC:R-HSA-72695 | 0.00902065028483 | 0.666666666667 | RPS27 RPS27L | Formation of the ternary complex, and subsequently, the 43S complex |
| REAC:R-HSA-72702 | 0.0116360425406 | 0.666666666667 | RPS27 RPS27L | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72649 | 0.0116360425406 | 0.666666666667 | RPS27 RPS27L | Translation initiation complex formation |
| REAC:R-HSA-72662 | 0.0120367347963 | 0.666666666667 | RPS27 RPS27L | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| KEGG:05171 | 0.0153557884392 | 0.666666666667 | RPS27 RPS27L | Coronavirus disease - COVID-19 |
| REAC:R-HSA-156902 | 0.02599864763 | 0.666666666667 | RPS27 RPS27L | Peptide chain elongation |
| REAC:R-HSA-192823 | 0.02599864763 | 0.666666666667 | RPS27 RPS27L | Viral mRNA Translation |
| REAC:R-HSA-72764 | 0.0278082114556 | 0.666666666667 | RPS27 RPS27L | Eukaryotic Translation Termination |
| REAC:R-HSA-156842 | 0.0284248695791 | 0.666666666667 | RPS27 RPS27L | Eukaryotic Translation Elongation |
| REAC:R-HSA-9692914 | 0.0290482612381 | 0.666666666667 | RPS27 RPS27L | SARS-CoV-1-host interactions |
| REAC:R-HSA-975956 | 0.0296783854994 | 0.666666666667 | RPS27 RPS27L | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| REAC:R-HSA-9633012 | 0.0336004634561 | 0.666666666667 | RPS27 RPS27L | Response of EIF2AK4 (GCN2) to amino acid deficiency |
| REAC:R-HSA-72689 | 0.0336004634561 | 0.666666666667 | RPS27 RPS27L | Formation of a pool of free 40S subunits |
| REAC:R-HSA-1799339 | 0.0406752460979 | 0.666666666667 | RPS27 RPS27L | SRP-dependent cotranslational protein targeting to membrane |
| REAC:R-HSA-156827 | 0.0406752460979 | 0.666666666667 | RPS27 RPS27L | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-72706 | 0.041419681818 | 0.666666666667 | RPS27 RPS27L | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REAC:R-HSA-927802 | 0.0436932800731 | 0.666666666667 | RPS27 RPS27L | Nonsense-Mediated Decay (NMD) |
| REAC:R-HSA-975957 | 0.0436932800731 | 0.666666666667 | RPS27 RPS27L | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-72613 | 0.0468187221283 | 0.666666666667 | RPS27 RPS27L | Eukaryotic Translation Initiation |
| REAC:R-HSA-72737 | 0.0468187221283 | 0.666666666667 | RPS27 RPS27L | Cap-dependent Translation Initiation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RPS27L | RPS27 | 0.997 | 0.748 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| RPS27 | EEFSEC | 0.981 | 0.284 | hein_WMM bioplex3_HEK293 WMM_only |
| RPS27L | EEFSEC | 0.067 | 0.08 | hein_WMM bioplex3_HEK293 WMM_only |
Related Complexes