hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08030.1
Complex Portal: CPX-10888
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GRB10 | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR) | 5 | UniProt NCBI |
| WDR24 | GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24) | 5 | UniProt NCBI |
| SESN2 | Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) | 5 | UniProt NCBI |
| WDR59 | GATOR2 complex protein WDR59 (WD repeat-containing protein 59) | 5 | UniProt NCBI |
| MIOS | GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog) | 5 | UniProt NCBI |
| CASTOR2 | Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2) | 5 | UniProt NCBI |
| NRF1 | Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal) | 5 | UniProt NCBI |
| PITHD1 | PITH domain-containing protein 1 | 4 | UniProt NCBI |
| SEH1L | Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein) | 5 | UniProt NCBI |
| PAEP | Glycodelin (GD) (Placental protein 14) (PP14) (Pregnancy-associated endometrial alpha-2 globulin) (PAEG) (PEG) (Progestagen-associated endometrial protein) (Progesterone-associated endometrial protein) (Zona-binding inhibitory factor-1) (ZIF-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6216 | 4.03199797571e-11 | 0.4 | WDR24 SEH1L WDR59 MIOS | GATOR2 complex |
| KEGG:04150 | 5.57790973406e-11 | 0.7 | WDR59 SEH1L MIOS WDR24 GRB10 SESN2 CASTOR2 | mTOR signaling pathway |
| REAC:R-HSA-9639288 | 8.51787906811e-11 | 0.6 | WDR59 SEH1L MIOS WDR24 SESN2 CASTOR2 | Amino acids regulate mTORC1 |
| GO:0061700 | 2.85581378866e-10 | 0.5 | WDR24 SEH1L WDR59 CASTOR2 MIOS | GATOR2 complex |
| CORUM:6753 | 5.63923523184e-10 | 0.4 | WDR24 SEH1L WDR59 MIOS | SOG complex |
| CORUM:6217 | 5.63923523184e-10 | 0.4 | WDR24 SEH1L WDR59 MIOS | GATOR complex |
| GO:0035859 | 2.91368265705e-09 | 0.5 | WDR24 SEH1L WDR59 CASTOR2 MIOS | Seh1-associated complex |
| GO:1904262 | 4.03935480232e-09 | 0.6 | WDR59 SEH1L MIOS WDR24 SESN2 CASTOR2 | negative regulation of TORC1 signaling |
| GO:0032007 | 3.45566118878e-08 | 0.6 | WDR59 SEH1L MIOS WDR24 SESN2 CASTOR2 | negative regulation of TOR signaling |
| REAC:R-HSA-9711097 | 5.84625776562e-08 | 0.6 | WDR59 SEH1L MIOS WDR24 SESN2 CASTOR2 | Cellular response to starvation |
| GO:1903432 | 3.33378095127e-07 | 0.6 | WDR59 SEH1L MIOS WDR24 SESN2 CASTOR2 | regulation of TORC1 signaling |
| GO:0038202 | 4.42538373683e-07 | 0.6 | WDR59 SEH1L MIOS WDR24 SESN2 CASTOR2 | TORC1 signaling |
| GO:0034198 | 2.16066863945e-06 | 0.5 | MIOS WDR24 SEH1L WDR59 SESN2 | cellular response to amino acid starvation |
| GO:1990928 | 2.74082007825e-06 | 0.5 | MIOS WDR24 SEH1L WDR59 SESN2 | response to amino acid starvation |
| GO:0032006 | 3.37267937564e-06 | 0.6 | WDR59 SEH1L MIOS WDR24 SESN2 CASTOR2 | regulation of TOR signaling |
| GO:1904263 | 4.7463094767e-06 | 0.5 | MIOS WDR24 SEH1L WDR59 SESN2 | positive regulation of TORC1 signaling |
| GO:0031929 | 6.46795040383e-06 | 0.6 | WDR59 SEH1L MIOS WDR24 SESN2 CASTOR2 | TOR signaling |
| REAC:R-HSA-2262752 | 1.79248759406e-05 | 0.7 | WDR59 SEH1L MIOS WDR24 GRB10 SESN2 CASTOR2 | Cellular responses to stress |
| GO:0032008 | 1.84240635874e-05 | 0.5 | MIOS WDR24 SEH1L WDR59 SESN2 | positive regulation of TOR signaling |
| REAC:R-HSA-8953897 | 1.91557744164e-05 | 0.7 | WDR59 SEH1L MIOS WDR24 GRB10 SESN2 CASTOR2 | Cellular responses to stimuli |
| GO:0009267 | 0.000401127164141 | 0.5 | MIOS WDR24 SEH1L WDR59 SESN2 | cellular response to starvation |
| GO:0042594 | 0.000786675339155 | 0.5 | MIOS WDR24 SEH1L WDR59 SESN2 | response to starvation |
| GO:0031669 | 0.00183726932671 | 0.5 | MIOS WDR24 SEH1L WDR59 SESN2 | cellular response to nutrient levels |
| GO:0031668 | 0.00241334060906 | 0.5 | MIOS WDR24 SEH1L WDR59 SESN2 | cellular response to extracellular stimulus |
| GO:1902532 | 0.00338452589287 | 0.6 | WDR59 SEH1L MIOS WDR24 SESN2 CASTOR2 | negative regulation of intracellular signal transduction |
| GO:0071496 | 0.00600623217561 | 0.5 | MIOS WDR24 SEH1L WDR59 SESN2 | cellular response to external stimulus |
| GO:0031667 | 0.00855605194101 | 0.5 | MIOS WDR24 SEH1L WDR59 SESN2 | response to nutrient levels |
| GO:0009991 | 0.0109213287997 | 0.5 | MIOS WDR24 SEH1L WDR59 SESN2 | response to extracellular stimulus |
| GO:0009968 | 0.0146686769906 | 0.7 | WDR59 SEH1L MIOS WDR24 GRB10 SESN2 CASTOR2 | negative regulation of signal transduction |
| GO:0010648 | 0.0183051627266 | 0.7 | WDR59 SEH1L MIOS WDR24 GRB10 SESN2 CASTOR2 | negative regulation of cell communication |
| GO:0023057 | 0.01914608214 | 0.7 | WDR59 SEH1L MIOS WDR24 GRB10 SESN2 CASTOR2 | negative regulation of signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| WDR59 | NRF1 | 0.996 | 0.162 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WDR59 | SEH1L | 0.996 | 0.174 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () boldt_WMM |
| WDR24 | PAEP | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MIOS | SEH1L | 0.994 | 0.184 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM |
| WDR24 | MIOS | 0.994 | 0.108 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| GRB10 | WDR59 | 0.993 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MIOS | CASTOR2 | 0.993 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| WDR24 | WDR59 | 0.993 | 0.146 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| PITHD1 | WDR59 | 0.992 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WDR59 | SESN2 | 0.99 | 0.116 |
mutually_exclusive (Q96EE3)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () |
| WDR24 | SESN2 | 0.987 | 0.142 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| WDR59 | MIOS | 0.987 | 0.298 |
structurally_consistent (Q96S15)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| CASTOR2 | SEH1L | 0.982 | 0.028 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| WDR24 | CASTOR2 | 0.98 | 0.084 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| SEH1L | SESN2 | 0.979 | 0.092 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () |
| MIOS | SESN2 | 0.977 | 0.096 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| WDR59 | CASTOR2 | 0.977 | 0.034 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| WDR59 | PAEP | 0.963 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| WDR24 | SEH1L | 0.956 | 0.11 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM |
| GRB10 | NRF1 | 0.89 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| CASTOR2 | SESN2 | 0.664 | 0.114 | hein_WMM hein () | |
| PITHD1 | GRB10 | 0.627 | 0.04 | bioplex_WMM bioplex3_WMM WMM_only | |
| PITHD1 | NRF1 | 0.55 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only | |
| SEH1L | PAEP | 0.058 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MIOS | PAEP | 0.018 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PITHD1 | MIOS | 0.011 | 0.018 | bioplex_WMM WMM_only | |
| PITHD1 | SEH1L | 0.004 | 0.03 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes