hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08032.1
Complex Portal: CPX-11459
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATP6V0A2 | V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) | 5 | UniProt NCBI |
| ATP6V0E1 | V-type proton ATPase subunit e 1 (V-ATPase subunit e 1) (V-ATPase 9.2 kDa membrane accessory protein) (V-ATPase M9.2 subunit) (Vacuolar proton pump subunit e 1) | 5 | UniProt NCBI |
| TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 (V-ATPase 116 kDa subunit a 3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3) | 5 | UniProt NCBI |
| AQP5 | Aquaporin-5 (AQP-5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04966 | 6.07335157092e-07 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | Collecting duct acid secretion |
| REAC:R-HSA-77387 | 4.59102468944e-06 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | Insulin receptor recycling |
| REAC:R-HSA-917977 | 4.59102468944e-06 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | Transferrin endocytosis and recycling |
| KEGG:05110 | 4.86072516083e-06 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | Vibrio cholerae infection |
| REAC:R-HSA-1222556 | 6.29837429836e-06 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | ROS and RNS production in phagocytes |
| KEGG:04721 | 1.17128735206e-05 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | Synaptic vesicle cycle |
| KEGG:05120 | 1.35902422006e-05 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:05323 | 1.71467161414e-05 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | Rheumatoid arthritis |
| REAC:R-HSA-917937 | 3.0932996971e-05 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | Iron uptake and transport |
| REAC:R-HSA-74752 | 5.2908776296e-05 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | Signaling by Insulin receptor |
| KEGG:00190 | 0.000100732661973 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | Oxidative phosphorylation |
| KEGG:04145 | 0.000127763882829 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | Phagosome |
| REAC:R-HSA-382551 | 0.00031930939946 | 1.0 | ATP6V0E1 AQP5 ATP6V0A2 TCIRG1 | Transport of small molecules |
| REAC:R-HSA-983712 | 0.000432467117837 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | Ion channel transport |
| GO:0007035 | 0.00125794076491 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | vacuolar acidification |
| KEGG:05165 | 0.00141764261548 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | Human papillomavirus infection |
| GO:0051452 | 0.00409056451107 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | intracellular pH reduction |
| GO:0030670 | 0.00440499676786 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | phagocytic vesicle membrane |
| GO:1902600 | 0.0100599149475 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | proton transmembrane transport |
| GO:0051453 | 0.0131184183431 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | regulation of intracellular pH |
| REAC:R-HSA-9639288 | 0.0140623832262 | 0.5 | ATP6V0E1 TCIRG1 | Amino acids regulate mTORC1 |
| GO:0030641 | 0.0144970047051 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | regulation of cellular pH |
| GO:0006885 | 0.0167406494658 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | regulation of pH |
| REAC:R-HSA-9006934 | 0.0183118305735 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | Signaling by Receptor Tyrosine Kinases |
| KEGG:04142 | 0.0186120295723 | 0.5 | TCIRG1 ATP6V0A2 | Lysosome |
| KEGG:05152 | 0.02620193588 | 0.5 | TCIRG1 ATP6V0A2 | Tuberculosis |
| HP:0005425 | 0.0375654511359 | 0.5 | TCIRG1 ATP6V0A2 | Recurrent sinopulmonary infections |
| GO:0045335 | 0.0378152735667 | 0.75 | ATP6V0E1 ATP6V0A2 TCIRG1 | phagocytic vesicle |
| HP:0002812 | 0.0441432413831 | 0.5 | TCIRG1 ATP6V0A2 | Coxa vara |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TCIRG1 | ATP6V0A2 | 0.992 | 0.062 |
mutually_exclusive (P27449)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATP6V0E1 | ATP6V0A2 | 0.966 | bioplex3_HEK293 bioplex () | ||
| ATP6V0A2 | AQP5 | 0.954 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes