hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08033.1

Complex Portal: CPX-16015

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
ARVCF	Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome)	5	UniProt NCBI
CDH3	Cadherin-3 (Placental cadherin) (P-cadherin)	5	UniProt NCBI
APC	Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)	5	UniProt NCBI
CTNNA2	Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein)	5	UniProt NCBI
ZFP82	Zinc finger protein 82 homolog (Zfp-82) (Zinc finger protein 545)	3	UniProt NCBI
CDH1	Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]	5	UniProt NCBI
CTNNBIP1	Beta-catenin-interacting protein 1 (Inhibitor of beta-catenin and Tcf-4)	5	UniProt NCBI
CDH10	Cadherin-10 (T2-cadherin)	5	UniProt NCBI
CTNNA1	Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13)	5	UniProt NCBI
CDH2	Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)	5	UniProt NCBI
CTNND1	Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))	5	UniProt NCBI
CTNNB1	Catenin beta-1 (Beta-catenin)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0016342	3.12627979937e-11	0.666666666667	CTNNB1 CDH3 CDH10 CTNNA1 CTNNA2 CTNND1	catenin complex
REAC:R-HSA-418990	5.25686745994e-10	0.555555555556	CTNNB1 CDH10 CTNND1 CDH3 CTNNA1	Adherens junctions interactions
REAC:R-HSA-421270	6.50968603152e-09	0.555555555556	CTNNB1 CDH10 CTNND1 CDH3 CTNNA1	Cell-cell junction organization
GO:0005912	7.40524993719e-09	0.777777777778	ARVCF CDH3 CTNNB1 CDH10 CTNNA2 CTNNA1 CTNND1	adherens junction
REAC:R-HSA-446728	7.40895733361e-08	0.555555555556	CTNNB1 CDH10 CTNND1 CDH3 CTNNA1	Cell junction organization
GO:0019897	2.18160127236e-07	0.666666666667	CTNNB1 CDH3 CDH10 CTNNA1 CTNNA2 CTNND1	extrinsic component of plasma membrane
GO:0007043	4.36602769224e-07	0.666666666667	CTNNB1 CDH3 ARVCF CDH10 CTNNA1 CTNND1	cell-cell junction assembly
REAC:R-HSA-1500931	4.60276670205e-07	0.555555555556	CTNNB1 CDH10 CTNND1 CDH3 CTNNA1	Cell-Cell communication
GO:0045216	2.17979781874e-06	0.666666666667	CTNNB1 CDH3 ARVCF CDH10 CTNNA1 CTNND1	cell-cell junction organization
GO:0005911	2.73283753075e-06	0.777777777778	ARVCF CDH3 CTNNB1 CDH10 CTNNA2 CTNNA1 CTNND1	cell-cell junction
GO:0019898	2.97195943126e-06	0.666666666667	CTNNB1 CDH3 CDH10 CTNNA1 CTNNA2 CTNND1	extrinsic component of membrane
GO:0045296	3.35511422711e-06	0.777777777778	ARVCF CDH3 CTNNB1 CDH10 CTNNA2 CTNNA1 CTNND1	cadherin binding
KEGG:04520	6.96038484345e-06	0.444444444444	CTNNA2 CTNNB1 CTNND1 CTNNA1	Adherens junction
KEGG:04670	6.96038484345e-06	0.444444444444	CTNNA2 CTNNB1 CTNND1 CTNNA1	Leukocyte transendothelial migration
WP:WP4541	1.95968401753e-05	0.444444444444	CDH10 CTNNB1 CDH3 CTNNA1	Hippo Merlin signaling dysregulation
GO:0034330	2.55246115587e-05	0.777777777778	ARVCF CDH3 CTNNB1 CDH10 CTNNA2 CTNNA1 CTNND1	cell junction organization
CORUM:6206	2.73623797451e-05	0.222222222222	CTNNB1 CTNNBIP1	ICAT-AR-beta-catenin complex
CORUM:4096	2.73623797451e-05	0.222222222222	CTNNA1 CTNNB1	CTNNA1-CTNNB1 complex
GO:0050839	4.83696324683e-05	0.777777777778	ARVCF CDH3 CTNNB1 CDH10 CTNNA2 CTNNA1 CTNND1	cell adhesion molecule binding
REAC:R-HSA-5218920	7.6950453904e-05	0.333333333333	CTNNA1 CTNND1 CTNNB1	VEGFR2 mediated vascular permeability
REAC:R-HSA-525793	7.6950453904e-05	0.333333333333	CTNNA2 CTNNB1 CTNNA1	Myogenesis
WP:WP5087	0.000109935030996	0.555555555556	CTNNA2 CTNNB1 CTNNA1 CDH3 CDH10	Pleural mesothelioma
GO:0034329	0.00014423052586	0.666666666667	CTNNB1 CDH3 ARVCF CDH10 CTNNA1 CTNND1	cell junction assembly
CORUM:6337	0.000164069436391	0.222222222222	CTNNB1 CTNND1	Amot-cadherin-11-beta-catenin-p120 complex
KEGG:05213	0.00017771708291	0.333333333333	CTNNA2 CTNNB1 CTNNA1	Endometrial cancer
GO:0098609	0.000180280509797	0.777777777778	ARVCF CDH3 CTNNB1 CDH10 CTNNA2 CTNNA1 CTNND1	cell-cell adhesion
GO:0070161	0.000373608616173	0.777777777778	ARVCF CDH3 CTNNB1 CDH10 CTNNA2 CTNNA1 CTNND1	anchoring junction
KEGG:05412	0.000401022621003	0.333333333333	CTNNA2 CTNNB1 CTNNA1	Arrhythmogenic right ventricular cardiomyopathy
WP:WP4155	0.000423991302669	0.333333333333	CTNNA2 CTNNB1 CTNNA1	Endometrial cancer
WP:WP2118	0.000470780212957	0.333333333333	CTNNA2 CTNNB1 CTNNA1	Arrhythmogenic right ventricular cardiomyopathy
KEGG:05100	0.000561145056069	0.333333333333	CTNNA2 CTNNB1 CTNNA1	Bacterial invasion of epithelial cells
WP:WP4540	0.00127341063924	0.333333333333	CDH10 CDH3 CTNNB1	Hippo signaling regulation pathways
GO:0098797	0.00175947848015	0.666666666667	CTNNB1 CDH3 CDH10 CTNNA1 CTNNA2 CTNND1	plasma membrane protein complex
REAC:R-HSA-8876493	0.00286935042585	0.222222222222	CTNNB1 CTNND1	InlA-mediated entry of Listeria monocytogenes into host cells
KEGG:05226	0.00287336310275	0.333333333333	CTNNA2 CTNNB1 CTNNA1	Gastric cancer
REAC:R-HSA-4420097	0.00395224313584	0.333333333333	CTNNA1 CTNND1 CTNNB1	VEGFA-VEGFR2 Pathway
KEGG:04390	0.00396874980186	0.333333333333	CTNNA2 CTNNB1 CTNNA1	Hippo signaling pathway
REAC:R-HSA-194138	0.00514835022343	0.333333333333	CTNNA1 CTNND1 CTNNB1	Signaling by VEGF
GO:0007155	0.00602918038338	0.777777777778	ARVCF CDH3 CTNNB1 CDH10 CTNNA2 CTNNA1 CTNND1	cell adhesion
REAC:R-HSA-8876384	0.0135859457713	0.222222222222	CTNNB1 CTNND1	Listeria monocytogenes entry into host cells
WP:WP4534	0.0237015298022	0.222222222222	CTNNA1 CTNNB1	Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms
GO:0030054	0.0297306990316	0.777777777778	ARVCF CDH3 CTNNB1 CDH10 CTNNA2 CTNNA1 CTNND1	cell junction
REAC:R-HSA-5626467	0.032153801025	0.222222222222	CTNNA1 CTNNB1	RHO GTPases activate IQGAPs
REAC:R-HSA-3769402	0.0497823629923	0.222222222222	CTNNB1 CTNNBIP1	Deactivation of the beta-catenin transactivating complex
CORUM:5281	0.0499842271994	0.111111111111	CTNNB1	Cell-cell junction complex (CDH1-CTNNB1)
CORUM:6336	0.0499842271994	0.111111111111	CTNNB1	CTNNB1-DNMT1 complex
CORUM:5262	0.0499842271994	0.111111111111	CTNNB1	TCF4-CTNNB1 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CTNNB1	CTNNA1	1.0	0.718	structurally_consistent (dimer)
CDH1	CTNNB1	0.999	0.386	structurally_consistent (dimer)
CTNNA2	CTNNB1	0.999		structurally_consistent (dimer)
CTNNBIP1	CTNNB1	0.999	0.094	structurally_consistent (dimer)
CTNNA2	CTNNA1	0.999
APC	CTNNB1	0.999	0.258
CDH10	CTNNB1	0.999	0.096
CTNNBIP1	CTNNA1	0.999	0.118
ARVCF	CTNNA1	0.998	0.122
CTNNB1	ARVCF	0.998	0.154
CDH1	CTNND1	0.995	0.172	structurally_consistent (dimer)
CDH1	CDH10	0.994
CDH10	CTNND1	0.994	0.086
CTNNBIP1	APC	0.993	0.218
ARVCF	CTNND1	0.992	0.084
CTNNA1	CTNND1	0.992	0.686
CDH10	ARVCF	0.991	0.066
CTNNA2	CTNNBIP1	0.99		structurally_consistent (P35222)
APC	CTNNA1	0.989	0.23
CDH3	CTNNB1	0.985	0.152	mixed_interface
ZFP82	CTNNB1	0.983		structurally_consistent (dimer)
CDH1	CTNNA1	0.981	0.52	structurally_consistent (P35222)
CDH1	ARVCF	0.98	0.218
CDH2	CTNNB1	0.98	0.366	structurally_consistent (dimer)
CDH10	CTNNA1	0.947	0.094
CDH2	CTNND1	0.927	0.108
ZFP82	CTNNBIP1	0.905
CTNNB1	CTNND1	0.901	0.606
CDH10	APC	0.821	0.116
CDH3	ARVCF	0.808	0.102
CTNNA2	ARVCF	0.782
CDH3	CDH1	0.759	0.366	mixed_interface
CDH3	CTNNA1	0.75	0.154
APC	ARVCF	0.661	0.072
CDH1	CTNNBIP1	0.652	0.086	mutually_exclusive (P35222)
CDH3	CTNNBIP1	0.646	0.036	mutually_exclusive (P35222)
CDH2	CTNNA1	0.642	0.192
CDH1	CTNNA2	0.64
CTNNA2	APC	0.594
CDH3	CTNNA2	0.572
CDH10	CTNNBIP1	0.502
CDH2	ARVCF	0.357	0.238
CDH1	CDH2	0.331	0.302	mutually_exclusive (P35222)
ZFP82	CTNNA1	0.277
CTNNBIP1	ARVCF	0.237	0.04
CDH10	CDH2	0.215	0.147
CDH1	ZFP82	0.199
CDH3	CDH10	0.188
CDH1	APC	0.186	0.256
CTNNA2	ZFP82	0.179		structurally_consistent (P35222)
CDH3	ZFP82	0.179		mutually_exclusive (P35222)
CDH3	APC	0.177	0.09
CDH3	CTNND1	0.148	0.088	structurally_consistent (P12830)
CTNNA2	CDH2	0.131
ZFP82	APC	0.102
CDH2	APC	0.091	0.226
CTNNA2	CTNND1	0.089
ZFP82	ARVCF	0.078
CDH3	CDH2	0.077	0.154	mutually_exclusive (P35222)
CTNNBIP1	CDH2	0.076	0.126	mutually_exclusive (P35222)
CTNNBIP1	CTNND1	0.068	0.058
ZFP82	CDH2	0.062
APC	CTNND1	0.02	0.084
ZFP82	CTNND1	0.013
CDH10	CTNNA2	0.013

Related Complexes

Genename	Complexes
ARVCF	huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CDH3	huMAP3_00026.1 huMAP3_01242.1 huMAP3_07751.1 huMAP3_08033.1 huMAP3_10927.1
APC	huMAP3_05114.1 huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CTNNA2	huMAP3_05114.1 huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_11960.1 huMAP3_12107.1 huMAP3_13361.1
ZFP82	huMAP3_05114.1 huMAP3_06940.1 huMAP3_07339.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_11965.1 huMAP3_12009.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_13514.1 huMAP3_14353.1 huMAP3_14650.1
CDH1	huMAP3_02788.1 huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1
CTNNBIP1	huMAP3_05114.1 huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_11872.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1 huMAP3_15078.1
CDH10	huMAP3_02788.1 huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CTNNA1	huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CDH2	huMAP3_05114.1 huMAP3_06940.1 huMAP3_07339.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12009.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1 huMAP3_15017.1
CTNND1	huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CTNNB1	huMAP3_05114.1 huMAP3_06940.1 huMAP3_07339.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_11965.1 huMAP3_12009.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_13514.1 huMAP3_14650.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08033.1

Complex Portal: CPX-16015