hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08034.1
Complex Portal: CPX-22083
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BIRC3 | Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1) | 5 | UniProt NCBI |
| HTRA2 | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | 5 | UniProt NCBI |
| DIABLO | Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form] | 5 | UniProt NCBI |
| TANK | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | 5 | UniProt NCBI |
| TRAF2 | TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) | 5 | UniProt NCBI |
| TRAF1 | TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) | 5 | UniProt NCBI |
| IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP231 | 1.04803778153e-08 | 0.714285714286 | TRAF1 TANK TRAF2 BIRC3 DIABLO | TNF alpha signaling pathway |
| KEGG:04210 | 3.71248832939e-08 | 0.714285714286 | TRAF1 HTRA2 TRAF2 BIRC3 DIABLO | Apoptosis |
| REAC:R-HSA-5357905 | 4.81392295814e-07 | 0.571428571429 | TRAF2 IKBKE BIRC3 TRAF1 | Regulation of TNFR1 signaling |
| REAC:R-HSA-75893 | 1.03686148446e-06 | 0.571428571429 | TRAF2 IKBKE BIRC3 TRAF1 | TNF signaling |
| WP:WP254 | 1.79540595718e-06 | 0.571428571429 | TRAF1 TRAF2 BIRC3 DIABLO | Apoptosis |
| REAC:R-HSA-168164 | 9.40454269709e-06 | 0.571428571429 | TANK IKBKE BIRC3 TRAF2 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 1.02705207546e-05 | 0.571428571429 | TANK IKBKE BIRC3 TRAF2 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 1.02705207546e-05 | 0.571428571429 | TANK IKBKE BIRC3 TRAF2 | MyD88-independent TLR4 cascade |
| KEGG:04215 | 1.27633682441e-05 | 0.428571428571 | HTRA2 BIRC3 DIABLO | Apoptosis - multiple species |
| KEGG:04621 | 1.70572201178e-05 | 0.571428571429 | TANK IKBKE BIRC3 TRAF2 | NOD-like receptor signaling pathway |
| REAC:R-HSA-5357786 | 2.62784267685e-05 | 0.428571428571 | TRAF2 BIRC3 IKBKE | TNFR1-induced proapoptotic signaling |
| REAC:R-HSA-166016 | 3.17773652341e-05 | 0.571428571429 | TANK IKBKE BIRC3 TRAF2 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-73887 | 3.61497405074e-05 | 0.571428571429 | TRAF2 IKBKE BIRC3 TRAF1 | Death Receptor Signaling |
| WP:WP2036 | 4.32211615904e-05 | 0.428571428571 | TRAF2 BIRC3 TRAF1 | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| REAC:R-HSA-933541 | 4.73926619295e-05 | 0.428571428571 | TANK IKBKE TRAF2 | TRAF6 mediated IRF7 activation |
| REAC:R-HSA-168898 | 5.66464039369e-05 | 0.571428571429 | TANK IKBKE BIRC3 TRAF2 | Toll-like Receptor Cascades |
| CORUM:5210 | 6.1565588648e-05 | 0.285714285714 | TANK TRAF2 | TANK-TRAF2-TRAF3 complex |
| REAC:R-HSA-5357956 | 6.42919230078e-05 | 0.428571428571 | TRAF2 BIRC3 TRAF1 | TNFR1-induced NF-kappa-B signaling pathway |
| WP:WP3865 | 0.000149593274002 | 0.428571428571 | TANK IKBKE TRAF2 | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04622 | 0.000151447938236 | 0.428571428571 | TANK IKBKE TRAF2 | RIG-I-like receptor signaling pathway |
| GO:0071345 | 0.000220032303889 | 0.857142857143 | HTRA2 IKBKE TANK TRAF2 TRAF1 BIRC3 | cellular response to cytokine stimulus |
| KEGG:04064 | 0.000283987845873 | 0.428571428571 | TRAF2 BIRC3 TRAF1 | NF-kappa B signaling pathway |
| KEGG:05222 | 0.000353303499329 | 0.428571428571 | TRAF2 BIRC3 TRAF1 | Small cell lung cancer |
| GO:0034097 | 0.000446351609603 | 0.857142857143 | HTRA2 IKBKE TANK TRAF2 TRAF1 BIRC3 | response to cytokine |
| WP:WP1772 | 0.000456554183641 | 0.428571428571 | HTRA2 BIRC3 DIABLO | Apoptosis modulation and signaling |
| KEGG:04668 | 0.000476958112953 | 0.428571428571 | TRAF2 BIRC3 TRAF1 | TNF signaling pathway |
| GO:0035631 | 0.000554182028596 | 0.428571428571 | HTRA2 DIABLO TRAF2 | CD40 receptor complex |
| CORUM:5212 | 0.000573957048441 | 0.285714285714 | TANK TRAF2 | Kinase maturation complex 2 |
| GO:0043122 | 0.000643414431898 | 0.714285714286 | TRAF1 TANK IKBKE BIRC3 TRAF2 | regulation of canonical NF-kappaB signal transduction |
| WP:WP4658 | 0.000679987909493 | 0.428571428571 | TRAF2 BIRC3 TRAF1 | Small cell lung cancer |
| REAC:R-HSA-168928 | 0.000867554862533 | 0.428571428571 | TANK IKBKE TRAF2 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| GO:0007249 | 0.00107649837207 | 0.714285714286 | TRAF1 TANK IKBKE BIRC3 TRAF2 | canonical NF-kappaB signal transduction |
| WP:WP5182 | 0.00161645869838 | 0.285714285714 | TRAF2 BIRC3 | Pro survival signaling of neuroprotectin D1 |
| CORUM:6344 | 0.00186280835388 | 0.285714285714 | TRAF2 BIRC3 | TNF-R1-associated signaling complex |
| REAC:R-HSA-5676594 | 0.00209171533568 | 0.285714285714 | TRAF2 BIRC3 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
| REAC:R-HSA-9013973 | 0.00250948572249 | 0.285714285714 | TANK IKBKE | TICAM1-dependent activation of IRF3/IRF7 |
| WP:WP2507 | 0.00303405736115 | 0.285714285714 | HTRA2 DIABLO | Nanomaterial induced apoptosis |
| KEGG:05417 | 0.0032364559788 | 0.428571428571 | TANK IKBKE TRAF2 | Lipid and atherosclerosis |
| REAC:R-HSA-936964 | 0.00345846977329 | 0.285714285714 | TANK IKBKE | Activation of IRF3, IRF7 mediated by TBK1, IKBKE |
| GO:0065009 | 0.00397324378994 | 1.0 | HTRA2 BIRC3 TANK DIABLO TRAF1 TRAF2 IKBKE | regulation of molecular function |
| WP:WP4950 | 0.00575727775656 | 0.285714285714 | TRAF2 TRAF1 | 16p11 2 distal deletion syndrome |
| GO:0019221 | 0.00576225883739 | 0.714285714286 | TRAF1 TANK IKBKE BIRC3 TRAF2 | cytokine-mediated signaling pathway |
| WP:WP5406 | 0.00669310065721 | 0.285714285714 | TRAF2 TRAF1 | 13q12 12 copy number variation |
| GO:0071356 | 0.00993228783009 | 0.571428571429 | TRAF1 TANK BIRC3 TRAF2 | cellular response to tumor necrosis factor |
| WP:WP3941 | 0.0111348137492 | 0.285714285714 | TRAF2 TRAF1 | Oxidative damage response |
| GO:0044093 | 0.0134828550116 | 0.857142857143 | HTRA2 IKBKE TANK DIABLO TRAF2 TRAF1 | positive regulation of molecular function |
| GO:0097190 | 0.0135962440225 | 0.714285714286 | TRAF1 HTRA2 IKBKE DIABLO TRAF2 | apoptotic signaling pathway |
| GO:0009898 | 0.0142054380156 | 0.571428571429 | TRAF1 HTRA2 DIABLO TRAF2 | cytoplasmic side of plasma membrane |
| GO:0097191 | 0.0146147722157 | 0.571428571429 | TRAF1 HTRA2 DIABLO TRAF2 | extrinsic apoptotic signaling pathway |
| REAC:R-HSA-5357801 | 0.0150200835391 | 0.428571428571 | TRAF2 BIRC3 DIABLO | Programmed Cell Death |
| GO:0007166 | 0.0151539774256 | 1.0 | HTRA2 BIRC3 TANK DIABLO TRAF1 TRAF2 IKBKE | cell surface receptor signaling pathway |
| GO:0034612 | 0.0154598067374 | 0.571428571429 | TRAF1 TANK BIRC3 TRAF2 | response to tumor necrosis factor |
| REAC:R-HSA-5675482 | 0.0164719839916 | 0.285714285714 | TRAF2 BIRC3 | Regulation of necroptotic cell death |
| REAC:R-HSA-5213460 | 0.0164719839916 | 0.285714285714 | TRAF2 BIRC3 | RIPK1-mediated regulated necrosis |
| WP:WP2018 | 0.0182511871587 | 0.285714285714 | TRAF2 TRAF1 | RANKL RANK signaling pathway |
| GO:0035556 | 0.021775623789 | 1.0 | HTRA2 BIRC3 TANK DIABLO TRAF1 TRAF2 IKBKE | intracellular signal transduction |
| WP:WP5039 | 0.0233506622299 | 0.285714285714 | TANK TRAF2 | SARS CoV 2 innate immunity evasion and cell specific immune response |
| KEGG:05168 | 0.0266135315089 | 0.428571428571 | TRAF2 BIRC3 IKBKE | Herpes simplex virus 1 infection |
| KEGG:04657 | 0.0295204621358 | 0.285714285714 | TRAF2 IKBKE | IL-17 signaling pathway |
| GO:0098562 | 0.0322799316792 | 0.571428571429 | TRAF1 HTRA2 DIABLO TRAF2 | cytoplasmic side of membrane |
| KEGG:05022 | 0.0378661997772 | 0.428571428571 | HTRA2 TRAF2 TANK | Pathways of neurodegeneration - multiple diseases |
| KEGG:05200 | 0.0470519816091 | 0.428571428571 | TRAF2 BIRC3 TRAF1 | Pathways in cancer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TRAF2 | TRAF1 | 1.0 | 0.088 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | TRAF1 | 0.999 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TANK | TRAF2 | 0.999 | 0.148952380952 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TRAF2 | DIABLO | 0.996 | 0.074 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| HTRA2 | TRAF2 | 0.994 | 0.034 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| TANK | DIABLO | 0.993 | 0.128 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TRAF1 | DIABLO | 0.986 | 0.168 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TANK | IKBKE | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| HTRA2 | TRAF1 | 0.98 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TRAF2 | IKBKE | 0.976 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| HTRA2 | DIABLO | 0.973 | 0.374 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | TRAF2 | 0.969 |
mutually_exclusive (Q9NR28)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | TRAF1 | 0.966 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| BIRC3 | DIABLO | 0.964 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HTRA2 | TANK | 0.952 | 0.096 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| BIRC3 | IKBKE | 0.892 | bioplex3_WMM WMM_only | ||
| TRAF1 | IKBKE | 0.796 | bioplex3_WMM WMM_only | ||
| HTRA2 | IKBKE | 0.451 | bioplex3_WMM WMM_only | ||
| BIRC3 | TANK | 0.384 | bioplex3_WMM WMM_only | ||
| IKBKE | DIABLO | 0.374 | bioplex3_WMM WMM_only | ||
| BIRC3 | HTRA2 | 0.306 | bioplex3_WMM WMM_only |
Related Complexes