hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08039.1
Complex Portal: CPX-21253
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MYH14 | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | 5 | UniProt NCBI |
| FBXO40 | F-box only protein 40 (Muscle disease-related protein) | 4 | UniProt NCBI |
| MYL6 | Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) | 5 | UniProt NCBI |
| MYL12B | Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1) | 5 | UniProt NCBI |
| MYL3 | Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb) | 5 | UniProt NCBI |
| IQGAP2 | Ras GTPase-activating-like protein IQGAP2 | 5 | UniProt NCBI |
| IQGAP1 | Ras GTPase-activating-like protein IQGAP1 (p195) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-416572 | 1.25938591632e-05 | 0.428571428571 | MYH14 MYL12B MYL6 | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-5625900 | 1.25938591632e-05 | 0.428571428571 | MYH14 MYL12B MYL6 | RHO GTPases activate CIT |
| REAC:R-HSA-5627117 | 1.25938591632e-05 | 0.428571428571 | MYH14 MYL12B MYL6 | RHO GTPases Activate ROCKs |
| REAC:R-HSA-195258 | 1.29732652309e-05 | 0.714285714286 | IQGAP2 MYH14 IQGAP1 MYL12B MYL6 | RHO GTPase Effectors |
| REAC:R-HSA-5627123 | 1.48132609528e-05 | 0.428571428571 | MYH14 MYL12B MYL6 | RHO GTPases activate PAKs |
| REAC:R-HSA-400685 | 2.29983491089e-05 | 0.428571428571 | MYH14 MYL12B MYL6 | Sema4D in semaphorin signaling |
| KEGG:04814 | 2.58938574941e-05 | 0.571428571429 | MYH14 MYL3 MYL12B MYL6 | Motor proteins |
| REAC:R-HSA-3928663 | 3.374300022e-05 | 0.428571428571 | MYH14 MYL12B MYL6 | EPHA-mediated growth cone collapse |
| KEGG:04810 | 5.44074779948e-05 | 0.571428571429 | IQGAP1 MYH14 IQGAP2 MYL12B | Regulation of actin cytoskeleton |
| GO:0015629 | 9.54784787211e-05 | 0.857142857143 | MYL6 MYL3 MYH14 MYL12B IQGAP2 IQGAP1 | actin cytoskeleton |
| REAC:R-HSA-373755 | 0.000419050615628 | 0.428571428571 | MYH14 MYL12B MYL6 | Semaphorin interactions |
| REAC:R-HSA-194315 | 0.000554819347598 | 0.714285714286 | IQGAP2 MYH14 IQGAP1 MYL12B MYL6 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.000618457686161 | 0.714285714286 | IQGAP2 MYH14 IQGAP1 MYL12B MYL6 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| REAC:R-HSA-5625740 | 0.00109482956301 | 0.428571428571 | MYH14 MYL12B MYL6 | RHO GTPases activate PKNs |
| REAC:R-HSA-2682334 | 0.00113617130448 | 0.428571428571 | MYH14 MYL12B MYL6 | EPH-Ephrin signaling |
| KEGG:04530 | 0.00149560971039 | 0.428571428571 | MYH14 MYL12B MYL6 | Tight junction |
| GO:0016460 | 0.00593357407009 | 0.428571428571 | MYH14 MYL3 MYL6 | myosin II complex |
| REAC:R-HSA-397014 | 0.00697432613022 | 0.428571428571 | MYL6 MYL3 MYL12B | Muscle contraction |
| WP:WP4352 | 0.0087604039905 | 0.428571428571 | MYL6 IQGAP1 IQGAP2 | Ciliary landscape |
| WP:WP524 | 0.00933842806825 | 0.285714285714 | IQGAP2 IQGAP1 | G13 signaling pathway |
| REAC:R-HSA-5626467 | 0.0153773615715 | 0.285714285714 | IQGAP2 IQGAP1 | RHO GTPases activate IQGAPs |
| GO:0016459 | 0.016587316136 | 0.428571428571 | MYH14 MYL3 MYL6 | myosin complex |
| REAC:R-HSA-445355 | 0.0251789059 | 0.285714285714 | MYL6 MYL12B | Smooth Muscle Contraction |
| GO:1903475 | 0.0294899169624 | 0.285714285714 | IQGAP2 IQGAP1 | mitotic actomyosin contractile ring assembly |
| GO:1903479 | 0.0294899169624 | 0.285714285714 | IQGAP2 IQGAP1 | mitotic actomyosin contractile ring assembly actin filament organization |
| GO:2000689 | 0.0294899169624 | 0.285714285714 | IQGAP2 IQGAP1 | actomyosin contractile ring assembly actin filament organization |
| GO:1902407 | 0.0294899169624 | 0.285714285714 | IQGAP2 IQGAP1 | assembly of actomyosin apparatus involved in mitotic cytokinesis |
| KEGG:04520 | 0.0367995848147 | 0.285714285714 | MYL12B IQGAP1 | Adherens junction |
| KEGG:04270 | 0.0458065539021 | 0.285714285714 | MYH14 MYL6 | Vascular smooth muscle contraction |
| CORUM:1844 | 0.0499958217778 | 0.142857142857 | IQGAP1 | APC-IQGAP1 complex |
| CORUM:6729 | 0.0499958217778 | 0.142857142857 | IQGAP1 | IQGAP1-CXCR2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MYH14 | MYL6 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | ||
| IQGAP2 | MYL6 | 0.995 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| MYL6 | MYL12B | 0.993 | 0.146 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| MYL3 | IQGAP1 | 0.992 | 0.174 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| MYL6 | IQGAP1 | 0.991 | 0.252624 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| MYH14 | MYL12B | 0.99 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | ||
| MYL12B | IQGAP1 | 0.984 | 0.544 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | |
| MYL6 | MYL3 | 0.975 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FBXO40 | MYH14 | 0.963 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MYH14 | MYL3 | 0.947 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MYL12B | MYL3 | 0.869 | 0.676 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IQGAP2 | MYL12B | 0.806 | 0.124 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | |
| IQGAP2 | MYH14 | 0.687 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM treiber_WMM | ||
| IQGAP2 | IQGAP1 | 0.503 | 0.262 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only | |
| MYH14 | IQGAP1 | 0.469 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM | ||
| FBXO40 | MYL6 | 0.012 | bioplex3_HEK293 bioplex () bioplex3_HCT116 | ||
| IQGAP2 | MYL3 | 0.008 | 0.106 | bioplex3_HEK293 bioplex () | |
| FBXO40 | MYL12B | 0.007 | bioplex3_HEK293 bioplex () bioplex3_HCT116 | ||
| FBXO40 | IQGAP1 | 0.006 | bioplex3_HCT116 WMM_only |
Related Complexes