hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08046.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain) | 5 | UniProt NCBI |
| TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)] | 5 | UniProt NCBI |
| TNF | Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6347 | 1.02525705128e-05 | 1.0 | TNF TRADD | TNF-R1 signaling complex |
| WP:WP2513 | 2.8092043205e-05 | 1.0 | TNF TRADD | Nanoparticle triggered regulated necrosis |
| WP:WP5182 | 3.87329686614e-05 | 1.0 | TNF TRADD | Pro survival signaling of neuroprotectin D1 |
| WP:WP262 | 9.83221512175e-05 | 1.0 | TNF TRADD | Ebstein Barr virus LMP1 signaling |
| CORUM:6344 | 0.000155497319444 | 1.0 | TNF TRADD | TNF-R1-associated signaling complex |
| KEGG:04920 | 0.000317498613307 | 1.0 | TNF TRADD | Adipocytokine signaling pathway |
| KEGG:04622 | 0.000338144964505 | 1.0 | TNF TRADD | RIG-I-like receptor signaling pathway |
| REAC:R-HSA-5357786 | 0.000471618243588 | 1.0 | TNF TRADD | TNFR1-induced proapoptotic signaling |
| KEGG:04657 | 0.000475678926029 | 1.0 | TNF TRADD | IL-17 signaling pathway |
| KEGG:04064 | 0.000513720234536 | 1.0 | TNF TRADD | NF-kappa B signaling pathway |
| WP:WP5039 | 0.00056439468621 | 1.0 | TNF TRADD | SARS CoV 2 innate immunity evasion and cell specific immune response |
| WP:WP3865 | 0.000609086573127 | 1.0 | TNF TRADD | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04668 | 0.000725873685824 | 1.0 | TNF TRADD | TNF signaling pathway |
| REAC:R-HSA-5357956 | 0.000847545829056 | 1.0 | TNF TRADD | TNFR1-induced NF-kappa-B signaling pathway |
| KEGG:04071 | 0.000853978605069 | 1.0 | TNF TRADD | Sphingolipid signaling pathway |
| WP:WP254 | 0.00111857408398 | 1.0 | TNF TRADD | Apoptosis |
| KEGG:04210 | 0.00116074761854 | 1.0 | TNF TRADD | Apoptosis |
| KEGG:04936 | 0.00123975649005 | 1.0 | TNF TRADD | Alcoholic liver disease |
| KEGG:05160 | 0.00138428094844 | 1.0 | TNF TRADD | Hepatitis C |
| WP:WP231 | 0.00148377064565 | 1.0 | TNF TRADD | TNF alpha signaling pathway |
| KEGG:04217 | 0.00151449927371 | 1.0 | TNF TRADD | Necroptosis |
| REAC:R-HSA-5357905 | 0.00161648861751 | 1.0 | TNF TRADD | Regulation of TNFR1 signaling |
| KEGG:05164 | 0.0016738175743 | 1.0 | TNF TRADD | Influenza A |
| KEGG:05152 | 0.001720800216 | 1.0 | TNF TRADD | Tuberculosis |
| KEGG:05130 | 0.00219956796622 | 1.0 | TNF TRADD | Pathogenic Escherichia coli infection |
| REAC:R-HSA-75893 | 0.00235467369443 | 1.0 | TNF TRADD | TNF signaling |
| KEGG:05169 | 0.00261899777797 | 1.0 | TNF TRADD | Epstein-Barr virus infection |
| KEGG:05163 | 0.00298087791786 | 1.0 | TNF TRADD | Human cytomegalovirus infection |
| KEGG:05170 | 0.0030120912992 | 1.0 | TNF TRADD | Human immunodeficiency virus 1 infection |
| KEGG:05132 | 0.00406034068917 | 1.0 | TNF TRADD | Salmonella infection |
| KEGG:05131 | 0.00417007523294 | 1.0 | TNF TRADD | Shigellosis |
| KEGG:04010 | 0.0047800367266 | 1.0 | TNF TRADD | MAPK signaling pathway |
| KEGG:05165 | 0.00700203931066 | 1.0 | TNF TRADD | Human papillomavirus infection |
| KEGG:05168 | 0.0109183432505 | 1.0 | TNF TRADD | Herpes simplex virus 1 infection |
| REAC:R-HSA-73887 | 0.0136718027788 | 1.0 | TNF TRADD | Death Receptor Signaling |
| KEGG:05310 | 0.0403663802771 | 0.5 | TNF | Asthma |
| WP:WP4480 | 0.049750157242 | 0.5 | TNF | Altered glycosylation of MUC1 in tumor microenvironment |
| WP:WP5414 | 0.049750157242 | 0.5 | TNF | IDO metabolic pathway |
| CORUM:5540 | 0.0499419797295 | 0.5 | TRADD | TRAF2-TRADD complex |
| CORUM:6684 | 0.0499419797295 | 0.5 | TNF | TNFR2 signaling complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TRADD | TNFRSF1A | 0.992 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TNFRSF1A | TNF | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TRADD | TNF | 0.333 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes