hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08052.1
Complex Portal: CPX-19063
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EEF1A1 | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | 5 | UniProt NCBI |
| EEF1A2 | Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) | 5 | UniProt NCBI |
| TTLL12 | Tubulin--tyrosine ligase-like protein 12 (Inactive tubulin--tyrosine ligase-like protein 12) | 5 | UniProt NCBI |
| VARS1 | Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) | 5 | UniProt NCBI |
| BRSK2 | Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) | 5 | UniProt NCBI |
| EEF1AKMT1 | EEF1A lysine methyltransferase 1 (EC 2.1.1.-) (N(6)-adenine-specific DNA methyltransferase 2) (Protein-lysine N-methyltransferase N6AMT2) (eEF1A-KMT) | 4 | UniProt NCBI |
| EEF1B2 | Elongation factor 1-beta (EF-1-beta) | 5 | UniProt NCBI |
| ABTB1 | Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein) | 5 | UniProt NCBI |
| EEF1G | Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) | 5 | UniProt NCBI |
| PBDC1 | Protein PBDC1 (Polysaccharide biosynthesis domain-containing protein 1) | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP107 | 0.000178843571676 | 0.375 | EEF1A1 EEF1A2 EEF1B2 | Translation factors |
| GO:0003746 | 0.00118146610329 | 0.375 | EEF1A1 EEF1A2 EEF1B2 | translation elongation factor activity |
| REAC:R-HSA-156842 | 0.00281136504087 | 0.375 | EEF1A1 EEF1A2 EEF1B2 | Eukaryotic Translation Elongation |
| REAC:R-HSA-8876725 | 0.00666866305696 | 0.25 | EEF1A1 EEF1AKMT1 | Protein methylation |
| KEGG:05134 | 0.0144579447004 | 0.25 | EEF1A1 EEF1A2 | Legionellosis |
| KEGG:05140 | 0.0241447644056 | 0.25 | EEF1A1 EEF1A2 | Leishmaniasis |
| GO:0005853 | 0.0393180950424 | 0.25 | EEF1A1 EEF1B2 | eukaryotic translation elongation factor 1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EEF1B2 | EEF1G | 1.0 | 0.842 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| EEF1A1 | EEF1B2 | 1.0 | 0.846 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| EEF1A1 | EEF1G | 1.0 | 0.578 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM | |
| EEF1A1 | PBDC1 | 1.0 | 0.133428571429 |
mutually_exclusive (Q14166)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| EEF1A1 | VARS1 | 0.999 | 0.522 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM | |
| EEF1A2 | EEF1B2 | 0.999 | 0.534 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 fraction treiber_WMM | |
| VARS1 | EEF1B2 | 0.999 | 0.354 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM Malo gupta_WMM fraction boldt_WMM |
| EEF1A1 | EEF1A2 | 0.999 | 0.964 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM | |
| VARS1 | EEF1G | 0.999 | 0.532 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| EEF1A2 | EEF1G | 0.999 | 0.344181818182 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| VARS1 | ABTB1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TTLL12 | PBDC1 | 0.999 | 0.052 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| EEF1A2 | VARS1 | 0.999 | 0.362 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| EEF1A2 | PBDC1 | 0.999 | 0.112 |
mutually_exclusive (Q14166)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EEF1B2 | ABTB1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ABTB1 | EEF1G | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| EEF1A1 | TTLL12 | 0.995 | 0.28 |
mutually_exclusive (Q9BVG4)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction treiber_WMM |
| EEF1A2 | ABTB1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| EEF1A1 | EEF1AKMT1 | 0.994 | 0.24 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| EEF1A2 | TTLL12 | 0.993 | 0.276 |
mutually_exclusive (Q9BVG4)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| EEF1A1 | ABTB1 | 0.978 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| EEF1A2 | EEF1AKMT1 | 0.973 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| EEF1A1 | BRSK2 | 0.962 | 0.206 | hein_WMM bioplex3_WMM WMM_only | |
| TTLL12 | EEF1AKMT1 | 0.944 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BRSK2 | EEF1B2 | 0.445 | 0.052 | hein_WMM youn_WMM WMM_only | |
| BRSK2 | EEF1G | 0.404 | 0.272 | hein_WMM youn_WMM WMM_only | |
| VARS1 | BRSK2 | 0.192 | 0.152 | hein_WMM WMM_only | |
| TTLL12 | VARS1 | 0.099 | 0.33 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM | |
| VARS1 | PBDC1 | 0.044 | 0.114 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| EEF1B2 | PBDC1 | 0.041 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TTLL12 | ABTB1 | 0.04 | bioplex3_WMM WMM_only | ||
| EEF1G | PBDC1 | 0.023 | 0.169666666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ABTB1 | PBDC1 | 0.01 | bioplex3_WMM WMM_only | ||
| TTLL12 | EEF1G | 0.01 | 0.181333333333 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only | |
| TTLL12 | EEF1B2 | 0.009 | 0.11 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| VARS1 | EEF1AKMT1 | 0.004 | 0.12 | bioplex3_HCT116 WMM_only | |
| EEF1AKMT1 | EEF1B2 | 0.001 | 0.12 |
mutually_exclusive (P68104)
|
bioplex3_HEK293 bioplex () bioplex3_HCT116 |
| EEF1AKMT1 | EEF1G | 0.001 | 0.12 | bioplex3_HEK293 bioplex () bioplex3_HCT116 |
Related Complexes