hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08067.1

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
SIX2	Homeobox protein SIX2 (Sine oculis homeobox homolog 2)	5	UniProt NCBI
EYA1	Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48)	5	UniProt NCBI
EYA2	Eyes absent homolog 2 (EC 3.1.3.48)	5	UniProt NCBI
SIX1	Homeobox protein SIX1 (Sine oculis homeobox homolog 1)	5	UniProt NCBI
ERCC6L	DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15)	5	UniProt NCBI
EYA3	Eyes absent homolog 3 (EC 3.1.3.48)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0140789	1.92240082153e-06	0.5	EYA1 EYA2 EYA3	histone phosphatase activity
GO:0140793	1.92240082153e-06	0.5	EYA1 EYA2 EYA3	histone H2AXY142 phosphatase activity
CORUM:7364	1.70876175213e-05	0.333333333333	EYA1 SIX2	EYA1-SIX2 complex
CORUM:7363	1.70876175213e-05	0.333333333333	EYA1 SIX1	EYA1-SIX1 complex
WP:WP5053	4.44204157868e-05	0.5	EYA1 SIX2 SIX1	Development of ureteric collection system
WP:WP5236	4.44204157868e-05	0.5	EYA1 SIX2 SIX1	Markers of kidney cell lineage
REAC:R-HSA-5693565	0.000399737323057	0.5	EYA1 EYA2 EYA3	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
REAC:R-HSA-5693606	0.000417052782963	0.5	EYA1 EYA2 EYA3	DNA Double Strand Break Response
HP:0011388	0.000648041335154	0.333333333333	EYA1 SIX1	Enlarged cochlear aqueduct
HP:0009798	0.000648041335154	0.333333333333	EYA1 SIX1	Euthyroid goiter
HP:0004458	0.000648041335154	0.333333333333	EYA1 SIX1	Dilatated internal auditory canal
HP:0100274	0.00107987178333	0.333333333333	EYA1 SIX1	Gustatory lacrimation
HP:0009796	0.00161951205762	0.333333333333	EYA1 SIX1	Branchial cyst
GO:2001240	0.00218580514948	0.5	EYA1 EYA2 EYA3	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:1901099	0.00218580514948	0.5	EYA1 EYA2 EYA3	negative regulation of signal transduction in absence of ligand
HP:0011387	0.0022669030801	0.333333333333	EYA1 SIX1	Enlarged vestibular aqueduct
HP:0008586	0.0022669030801	0.333333333333	EYA1 SIX1	Hypoplasia of the cochlea
HP:0000376	0.0022669030801	0.333333333333	EYA1 SIX1	Incomplete partition of the cochlea type II
HP:0011373	0.00302198579101	0.333333333333	EYA1 SIX1	Incomplete partition of the cochlea
HP:0100799	0.00302198579101	0.333333333333	EYA1 SIX1	Neoplasm of the middle ear
HP:0004712	0.00302198579101	0.333333333333	EYA1 SIX1	Renal malrotation
HP:0011395	0.00302198579101	0.333333333333	EYA1 SIX1	Aplasia/Hypoplasia of the cochlea
HP:0009797	0.00302198579101	0.333333333333	EYA1 SIX1	Cholesteatoma
HP:0008554	0.00388470114881	0.333333333333	EYA1 SIX1	Cochlear malformation
HP:0008774	0.00388470114881	0.333333333333	EYA1 SIX1	Aplasia/Hypoplasia of the inner ear
GO:2001239	0.00440656064028	0.5	EYA1 EYA2 EYA3	regulation of extrinsic apoptotic signaling pathway in absence of ligand
REAC:R-HSA-5693532	0.00445044283113	0.5	EYA1 EYA2 EYA3	DNA Double-Strand Break Repair
HP:0000799	0.00485499013014	0.333333333333	EYA1 SIX1	Renal steatosis
HP:0011094	0.00485499013014	0.333333333333	EYA1 SIX1	Increased overbite
HP:0007925	0.00485499013014	0.333333333333	EYA1 SIX1	Lacrimal duct aplasia
HP:0009795	0.00485499013014	0.333333333333	EYA1 SIX1	Branchial fistula
WP:WP4823	0.00561973689916	0.333333333333	EYA1 SIX1	Genes controlling nephrogenesis
HP:0100267	0.00593279372985	0.333333333333	EYA1 SIX1	Lip pit
HP:0007678	0.00981070246055	0.333333333333	EYA1 SIX1	Lacrimal duct stenosis
GO:0038034	0.0161301339283	0.5	EYA1 EYA2 EYA3	signal transduction in absence of ligand
GO:0097192	0.0161301339283	0.5	EYA1 EYA2 EYA3	extrinsic apoptotic signaling pathway in absence of ligand
HP:0004452	0.0164828756284	0.333333333333	EYA1 SIX1	Abnormality of the middle ear ossicles
HP:0009794	0.0164828756284	0.333333333333	EYA1 SIX1	Branchial anomaly
HP:0012780	0.0184186741717	0.333333333333	EYA1 SIX1	Neoplasm of the ear
HP:0000074	0.0184186741717	0.333333333333	EYA1 SIX1	Ureteropelvic junction obstruction
HP:0011384	0.0184186741717	0.333333333333	EYA1 SIX1	Abnormality of the internal auditory canal
REAC:R-HSA-73894	0.0318872588213	0.5	EYA1 EYA2 EYA3	DNA Repair
HP:0011376	0.0349615340576	0.333333333333	EYA1 SIX1	Abnormal morphology of the vestibule of the inner ear
HP:0008609	0.0349615340576	0.333333333333	EYA1 SIX1	Abnormal middle ear morphology
HP:0000071	0.037751561683	0.333333333333	EYA1 SIX1	Ureteral stenosis
HP:0000375	0.037751561683	0.333333333333	EYA1 SIX1	Abnormal cochlea morphology
HP:0004742	0.0436511011886	0.333333333333	EYA1 SIX1	Abnormal renal collecting system morphology
HP:0000579	0.0436511011886	0.333333333333	EYA1 SIX1	Nasolacrimal duct obstruction
HP:0000402	0.0467604957305	0.333333333333	EYA1 SIX1	Stenosis of the external auditory canal

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
SIX2	ERCC6L	0.999	0.058	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
EYA2	SIX2	0.993		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
EYA1	SIX1	0.989		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
SIX1	ERCC6L	0.988		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
EYA1	SIX2	0.986		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
EYA3	SIX2	0.973	0.054	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
EYA1	EYA2	0.333		bioplex_WMM bioplex3_WMM WMM_only
EYA3	EYA2	0.333		bioplex_WMM bioplex3_WMM WMM_only
EYA3	EYA1	0.265		bioplex_WMM bioplex3_WMM WMM_only
EYA1	ERCC6L	0.216		bioplex_WMM bioplex3_WMM WMM_only
SIX2	SIX1	0.202		bioplex_WMM bioplex3_WMM WMM_only
EYA3	ERCC6L	0.161	0.102	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
EYA2	ERCC6L	0.143		bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
SIX2	huMAP3_01386.1 huMAP3_05663.1 huMAP3_08067.1 huMAP3_08280.1 huMAP3_09419.1 huMAP3_10131.1 huMAP3_10205.1 huMAP3_10248.1
EYA1	huMAP3_00974.1 huMAP3_07869.1 huMAP3_08067.1 huMAP3_08280.1 huMAP3_09419.1 huMAP3_10131.1 huMAP3_10205.1 huMAP3_12169.1 huMAP3_14496.1
EYA2	huMAP3_01386.1 huMAP3_05663.1 huMAP3_08067.1 huMAP3_08280.1 huMAP3_09419.1 huMAP3_10131.1 huMAP3_10248.1
SIX1	huMAP3_01842.1 huMAP3_07869.1 huMAP3_08067.1 huMAP3_10131.1 huMAP3_10205.1 huMAP3_12169.1 huMAP3_14942.1
ERCC6L	huMAP3_08067.1 huMAP3_08280.1 huMAP3_10131.1 huMAP3_10205.1
EYA3	huMAP3_00067.1 huMAP3_01386.1 huMAP3_05663.1 huMAP3_08067.1 huMAP3_08280.1 huMAP3_08335.1 huMAP3_09419.1 huMAP3_10131.1 huMAP3_10248.1 huMAP3_12159.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08067.1