hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08073.1
Complex Portal: CPX-11108
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GABRB2 | Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2) | 5 | UniProt NCBI |
| GABRB3 | Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05033 | 4.48692356747e-05 | 1.0 | GABRB2 GABRB3 | Nicotine addiction |
| WP:WP4159 | 0.000117475817039 | 1.0 | GABRB2 GABRB3 | GABA receptor signaling |
| WP:WP4829 | 0.000172808629413 | 1.0 | GABRB2 GABRB3 | mBDNF and proBDNF regulation of GABA neurotransmission |
| KEGG:04727 | 0.000359441594481 | 1.0 | GABRB2 GABRB3 | GABAergic synapse |
| KEGG:05032 | 0.00037033376401 | 1.0 | GABRB2 GABRB3 | Morphine addiction |
| KEGG:04726 | 0.000566717954934 | 1.0 | GABRB2 GABRB3 | Serotonergic synapse |
| KEGG:04723 | 0.0011414018249 | 1.0 | GABRB2 GABRB3 | Retrograde endocannabinoid signaling |
| REAC:R-HSA-977443 | 0.00140118463675 | 1.0 | GABRB2 GABRB3 | GABA receptor activation |
| REAC:R-HSA-1236394 | 0.00154301186217 | 1.0 | GABRB2 GABRB3 | Signaling by ERBB4 |
| KEGG:04080 | 0.00282724955659 | 1.0 | GABRB2 GABRB3 | Neuroactive ligand-receptor interaction |
| GO:0071420 | 0.00468200720083 | 1.0 | GABRB2 GABRB3 | cellular response to histamine |
| GO:0034776 | 0.00983221512175 | 1.0 | GABRB2 GABRB3 | response to histamine |
| GO:0022851 | 0.0131096201623 | 1.0 | GABRB2 GABRB3 | GABA-gated chloride ion channel activity |
| HP:0200134 | 0.0143057533888 | 1.0 | GABRB2 GABRB3 | Epileptic encephalopathy |
| WP:WP5420 | 0.0144418640295 | 1.0 | GABRB2 GABRB3 | ADHD and autism ASD linked metabolic pathways and SNP |
| GO:1902711 | 0.0210690324038 | 1.0 | GABRB2 GABRB3 | GABA-A receptor complex |
| GO:0004890 | 0.0210690324038 | 1.0 | GABRB2 GABRB3 | GABA-A receptor activity |
| REAC:R-HSA-112314 | 0.0211937720117 | 1.0 | GABRB2 GABRB3 | Neurotransmitter receptors and postsynaptic signal transmission |
| HP:0100710 | 0.0227948817734 | 1.0 | GABRB2 GABRB3 | Impulsivity |
| GO:1902710 | 0.0309012475255 | 1.0 | GABRB2 GABRB3 | GABA receptor complex |
| GO:0099095 | 0.0309012475255 | 1.0 | GABRB2 GABRB3 | ligand-gated monoatomic anion channel activity |
| GO:1904862 | 0.0309012475255 | 1.0 | GABRB2 GABRB3 | inhibitory synapse assembly |
| REAC:R-HSA-112315 | 0.0350347422039 | 1.0 | GABRB2 GABRB3 | Transmission across Chemical Synapses |
| GO:0016917 | 0.0365196561665 | 1.0 | GABRB2 GABRB3 | GABA receptor activity |
| HP:0002521 | 0.0413178591665 | 1.0 | GABRB2 GABRB3 | Hypsarrhythmia |
| GO:0007214 | 0.0426062655276 | 1.0 | GABRB2 GABRB3 | gamma-aminobutyric acid signaling pathway |
| CORUM:5809 | 0.0499419797295 | 0.5 | GABRB2 | GABA-A receptor (GABRA1, GABRB2, GABRG2) |
| CORUM:7461 | 0.0499419797295 | 0.5 | GABRB2 | GABA-A receptor (GABRA1, GABRB2, GABRG2) |
| CORUM:7462 | 0.0499419797295 | 0.5 | GABRB2 | GABA-A receptor (GABRA1, GABRB2, GABRD) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GABRB2 | GABRB3 | 0.995 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| GABRB2 | huMAP3_03546.1 huMAP3_08073.1 huMAP3_12848.1 huMAP3_13589.1 huMAP3_13976.1 huMAP3_14210.1 |
| GABRB3 | huMAP3_03546.1 huMAP3_08073.1 huMAP3_12848.1 huMAP3_13589.1 huMAP3_13976.1 huMAP3_14210.1 |