hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08081.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CAPN8 | Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain) | 4 | UniProt NCBI |
| CAPNS1 | Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) | 5 | UniProt NCBI |
| TNF | Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form] | 5 | UniProt NCBI |
| CAPN2 | Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05131 | 0.0193802248568 | 0.666666666667 | TNF CAPNS1 | Shigellosis |
| REAC:R-HSA-1474228 | 0.037053837229 | 0.666666666667 | CAPN8 CAPNS1 | Degradation of the extracellular matrix |
| CORUM:6684 | 0.0499402709677 | 0.333333333333 | TNF | TNFR2 signaling complex |
| CORUM:6710 | 0.0499402709677 | 0.333333333333 | CAPNS1 | Calpain 1 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CAPN2 | CAPNS1 | 0.987 | 0.336 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| CAPN8 | CAPNS1 | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TNF | CAPNS1 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CAPN8 | CAPN2 | 0.56 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes