hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08092.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1) | 5 | UniProt NCBI |
| IRS2 | Insulin receptor substrate 2 (IRS-2) | 5 | UniProt NCBI |
| PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta) | 5 | UniProt NCBI |
| PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) | 5 | UniProt NCBI |
| PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) | 5 | UniProt NCBI |
| PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8853659 | 8.07250602523e-15 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | RET signaling |
| KEGG:04930 | 1.72124236649e-14 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Type II diabetes mellitus |
| KEGG:04923 | 2.33375654195e-14 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Regulation of lipolysis in adipocytes |
| WP:WP4582 | 6.13655396303e-14 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Cancer immunotherapy by CTLA4 blockade |
| KEGG:04213 | 9.88678259178e-14 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Longevity regulating pathway - multiple species |
| REAC:R-HSA-2219530 | 2.16037676721e-13 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Constitutive Signaling by Aberrant PI3K in Cancer |
| GO:0005943 | 1.13442382344e-12 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | phosphatidylinositol 3-kinase complex, class IA |
| GO:0097651 | 1.13442382344e-12 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | phosphatidylinositol 3-kinase complex, class I |
| KEGG:04211 | 1.24235802028e-12 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Longevity regulating pathway |
| WP:WP3879 | 1.57586626189e-12 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| REAC:R-HSA-912631 | 2.30778193041e-12 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Regulation of signaling by CBL |
| REAC:R-HSA-6811558 | 2.51852652295e-12 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-2219528 | 2.97217415752e-12 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | PI3K/AKT Signaling in Cancer |
| KEGG:04931 | 4.0294818242e-12 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Insulin resistance |
| REAC:R-HSA-912526 | 4.03815729609e-12 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Interleukin receptor SHC signaling |
| REAC:R-HSA-199418 | 4.41219796908e-12 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Negative regulation of the PI3K/AKT network |
| KEGG:04935 | 4.56324297181e-12 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Growth hormone synthesis, secretion and action |
| KEGG:04960 | 7.95869538956e-12 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Aldosterone-regulated sodium reabsorption |
| KEGG:04152 | 9.67181841548e-12 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | AMPK signaling pathway |
| KEGG:04068 | 9.67181841548e-12 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | FoxO signaling pathway |
| WP:WP3915 | 1.41492551568e-11 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Angiopoietin like protein 8 regulatory pathway |
| KEGG:04973 | 1.81249162277e-11 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Carbohydrate digestion and absorption |
| KEGG:04910 | 1.88537744134e-11 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Insulin signaling pathway |
| WP:WP3937 | 2.15326945567e-11 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Microglia pathogen phagocytosis pathway |
| KEGG:04932 | 3.43746021006e-11 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Non-alcoholic fatty liver disease |
| WP:WP4396 | 4.36027332076e-11 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Nonalcoholic fatty liver disease |
| REAC:R-HSA-451927 | 4.70658760476e-11 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Interleukin-2 family signaling |
| KEGG:05206 | 5.04248004732e-11 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | MicroRNAs in cancer |
| REAC:R-HSA-198203 | 5.07705636973e-11 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 IRS2 | PI3K/AKT activation |
| WP:WP481 | 5.66572532243e-11 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Insulin signaling |
| KEGG:04929 | 6.81745086665e-11 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | GnRH secretion |
| KEGG:04140 | 6.95239973135e-11 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Autophagy - animal |
| WP:WP4539 | 8.39921445252e-11 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Synaptic signaling pathways associated with autism spectrum disorder |
| REAC:R-HSA-9027276 | 1.01530006227e-10 | 0.666666666667 | PIK3CD PIK3CB PIK3R1 IRS2 | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) |
| REAC:R-HSA-512988 | 1.14138684405e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| KEGG:04370 | 1.31033271711e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | VEGF signaling pathway |
| KEGG:05213 | 1.44964690664e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Endometrial cancer |
| KEGG:04664 | 1.60056024847e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Fc epsilon RI signaling pathway |
| KEGG:05221 | 2.79134211037e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Acute myeloid leukemia |
| REAC:R-HSA-1660499 | 3.03950682117e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Synthesis of PIPs at the plasma membrane |
| WP:WP4155 | 3.23591222875e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Endometrial cancer |
| WP:WP4205 | 3.23591222875e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | MET in type 1 papillary renal cell carcinoma |
| KEGG:04917 | 3.60732872068e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Prolactin signaling pathway |
| KEGG:05218 | 3.60732872068e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Melanoma |
| WP:WP5293 | 3.86863196358e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Acute myeloid leukemia |
| WP:WP4685 | 4.22008431342e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Melanoma |
| WP:WP1403 | 4.59661453128e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | AMP activated protein kinase signaling |
| KEGG:05211 | 4.60377171825e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Renal cell carcinoma |
| KEGG:05230 | 5.38221792566e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Central carbon metabolism in cancer |
| KEGG:04662 | 5.80904554397e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | B cell receptor signaling pathway |
| KEGG:05214 | 5.80904554397e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Glioma |
| KEGG:05223 | 5.80904554397e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Non-small cell lung cancer |
| KEGG:04750 | 6.26251871332e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Inflammatory mediator regulation of TRP channels |
| KEGG:01524 | 6.74386483027e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Platinum drug resistance |
| WP:WP4255 | 7.45942972194e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Non small cell lung cancer |
| KEGG:05212 | 7.79527128226e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Pancreatic cancer |
| WP:WP1544 | 8.67947356824e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:01521 | 8.97383487736e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05220 | 8.97383487736e-10 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Chronic myeloid leukemia |
| KEGG:05100 | 1.0290744588e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Bacterial invasion of epithelial cells |
| KEGG:04012 | 1.0290744588e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | ErbB signaling pathway |
| WP:WP5124 | 1.04865960878e-09 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Alzheimer 39 s disease |
| WP:WP2059 | 1.04865960878e-09 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Alzheimer 39 s disease and miRNA effects |
| KEGG:05210 | 1.1757825847e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Colorectal cancer |
| KEGG:05235 | 1.3387558e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:04914 | 1.51930917465e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Progesterone-mediated oocyte maturation |
| KEGG:01522 | 1.51930917465e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Endocrine resistance |
| KEGG:05231 | 1.61660816733e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Choline metabolism in cancer |
| WP:WP4806 | 1.73956983162e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04070 | 1.82614868447e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Phosphatidylinositol signaling system |
| KEGG:04625 | 1.82614868447e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | C-type lectin receptor signaling pathway |
| KEGG:05222 | 1.93876281439e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Small cell lung cancer |
| KEGG:05146 | 1.93876281439e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Amoebiasis |
| KEGG:04670 | 1.93876281439e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Leukocyte transendothelial migration |
| WP:WP4263 | 1.97738967261e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Pancreatic adenocarcinoma pathway |
| WP:WP673 | 1.97738967261e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | ErbB signaling pathway |
| KEGG:04933 | 2.05686218741e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:04620 | 2.05686218741e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Toll-like receptor signaling pathway |
| KEGG:05142 | 2.18064457563e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Chagas disease |
| WP:WP75 | 2.24052150595e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Toll like receptor signaling pathway |
| KEGG:04725 | 2.31031243669e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Cholinergic synapse |
| KEGG:04666 | 2.44607296805e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Fc gamma R-mediated phagocytosis |
| KEGG:05215 | 2.44607296805e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Prostate cancer |
| REAC:R-HSA-1257604 | 2.61739309821e-09 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | PIP3 activates AKT signaling |
| KEGG:04915 | 2.7367248565e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Estrogen signaling pathway |
| REAC:R-HSA-1483255 | 2.76846766863e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | PI Metabolism |
| GO:0005942 | 2.86714523046e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | phosphatidylinositol 3-kinase complex |
| WP:WP4658 | 3.20195382187e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Small cell lung cancer |
| KEGG:04668 | 3.22385621799e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | TNF signaling pathway |
| KEGG:04611 | 3.7779641684e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Platelet activation |
| KEGG:04066 | 3.97869154712e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | HIF-1 signaling pathway |
| KEGG:04722 | 4.18785619471e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Neurotrophin signaling pathway |
| KEGG:04071 | 4.86862989569e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Sphingolipid signaling pathway |
| KEGG:04660 | 4.86862989569e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | T cell receptor signaling pathway |
| KEGG:04919 | 5.3696302433e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Thyroid hormone signaling pathway |
| REAC:R-HSA-9006335 | 5.61509006183e-09 | 0.666666666667 | PIK3CD PIK3CB PIK3R1 IRS2 | Signaling by Erythropoietin |
| WP:WP710 | 6.10606386e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | DNA damage response only ATM dependent |
| REAC:R-HSA-9006925 | 6.17695829337e-09 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Intracellular signaling by second messengers |
| KEGG:04926 | 6.1976102574e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Relaxin signaling pathway |
| WP:WP4787 | 6.42044116965e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Osteoblast differentiation and related diseases |
| KEGG:04650 | 6.4951996014e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Natural killer cell mediated cytotoxicity |
| KEGG:05010 | 7.85696921525e-09 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Alzheimer disease |
| KEGG:05135 | 8.52974211494e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Yersinia infection |
| KEGG:04380 | 8.52974211494e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Osteoclast differentiation |
| KEGG:04072 | 8.91345308282e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Phospholipase D signaling pathway |
| KEGG:05418 | 9.31084060402e-09 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Fluid shear stress and atherosclerosis |
| KEGG:04550 | 1.05887128876e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04210 | 1.05887128876e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Apoptosis |
| WP:WP4217 | 1.23535088637e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Ebola virus infection in host |
| KEGG:05162 | 1.25066961471e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Measles |
| KEGG:05017 | 1.30270603209e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Spinocerebellar ataxia |
| WP:WP4829 | 1.34126591933e-08 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 PIK3R3 | mBDNF and proBDNF regulation of GABA neurotransmission |
| KEGG:05224 | 1.41197043058e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Breast cancer |
| WP:WP3929 | 1.53069959113e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Chemokine signaling pathway |
| WP:WP3844 | 1.54744482581e-08 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 PIK3R3 | PI3K AKT mTOR signaling pathway and therapeutic opportunities in prostate cancer |
| KEGG:05226 | 1.65246695344e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Gastric cancer |
| KEGG:04630 | 1.65246695344e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | JAK-STAT signaling pathway |
| KEGG:05160 | 1.65246695344e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Hepatitis C |
| WP:WP4630 | 1.66355499762e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Measles virus infection |
| WP:WP51 | 2.0363379852e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Regulation of actin cytoskeleton |
| KEGG:04062 | 2.23152734084e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Chemokine signaling pathway |
| KEGG:04218 | 2.31404348768e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Cellular senescence |
| WP:WP4239 | 2.38024899296e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Epithelial to mesenchymal transition in colorectal cancer |
| REAC:R-HSA-109704 | 2.5402076735e-08 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 IRS2 | PI3K Cascade |
| REAC:R-HSA-114604 | 2.5402076735e-08 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 PIK3R3 | GPVI-mediated activation cascade |
| KEGG:05164 | 2.66885066907e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Influenza A |
| WP:WP4666 | 2.87381650686e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Hepatitis B infection |
| KEGG:05161 | 3.06586313087e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Hepatitis B |
| KEGG:04150 | 3.06586313087e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | mTOR signaling pathway |
| KEGG:04613 | 3.17213427942e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Neutrophil extracellular trap formation |
| KEGG:04360 | 3.74855969386e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Axon guidance |
| REAC:R-HSA-112399 | 3.96532736613e-08 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 IRS2 | IRS-mediated signalling |
| WP:WP4223 | 4.10578692806e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Ras signaling |
| KEGG:04024 | 4.26750751899e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | cAMP signaling pathway |
| KEGG:05225 | 4.40580942992e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Hepatocellular carcinoma |
| REAC:R-HSA-5663202 | 4.72771122339e-08 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Diseases of signal transduction by growth factor receptors and second messengers |
| KEGG:05207 | 4.99529538345e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Chemical carcinogenesis - receptor activation |
| REAC:R-HSA-1266695 | 5.20203979384e-08 | 0.666666666667 | PIK3R2 IRS2 PIK3R1 PIK3R3 | Interleukin-7 signaling |
| KEGG:04015 | 5.47745823212e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Rap1 signaling pathway |
| WP:WP4566 | 5.71139447148e-08 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 PIK3R3 | Translation inhibitors in chronically activated PDGFRA cells |
| KEGG:05167 | 5.81905153423e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-2428928 | 5.91891333952e-08 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 IRS2 | IRS-related events triggered by IGF1R |
| REAC:R-HSA-2404192 | 5.91891333952e-08 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 IRS2 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| REAC:R-HSA-2428924 | 5.91891333952e-08 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 IRS2 | IGF1R signaling cascade |
| KEGG:04510 | 6.74794941991e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Focal adhesion |
| REAC:R-HSA-449147 | 7.00967449411e-08 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Signaling by Interleukins |
| KEGG:05417 | 8.24369453833e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Lipid and atherosclerosis |
| KEGG:05169 | 8.24369453833e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Epstein-Barr virus infection |
| GO:0046854 | 8.26745855359e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | phosphatidylinositol phosphate biosynthetic process |
| REAC:R-HSA-74751 | 8.51756800425e-08 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 IRS2 | Insulin receptor signalling cascade |
| KEGG:05415 | 8.71637435553e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Diabetic cardiomyopathy |
| KEGG:05205 | 8.71637435553e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Proteoglycans in cancer |
| KEGG:04014 | 9.21046809529e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Ras signaling pathway |
| WP:WP306 | 9.35225127637e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Focal adhesion |
| KEGG:05203 | 9.72669366185e-08 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Viral carcinogenesis |
| WP:WP395 | 1.00527533776e-07 | 0.666666666667 | PIK3CD IRS2 PIK3R1 PIK3R2 | IL 4 signaling pathway |
| KEGG:05163 | 1.14155780979e-07 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Human cytomegalovirus infection |
| KEGG:05170 | 1.17185082464e-07 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Human immunodeficiency virus 1 infection |
| KEGG:04810 | 1.23436381825e-07 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Regulation of actin cytoskeleton |
| KEGG:05166 | 1.33310276963e-07 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Human T-cell leukemia virus 1 infection |
| WP:WP585 | 1.40783240751e-07 | 0.666666666667 | PIK3CD IRS2 PIK3R1 PIK3R2 | Interferon type I signaling pathways |
| KEGG:05171 | 1.47446779161e-07 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Coronavirus disease - COVID-19 |
| KEGG:05208 | 1.47446779161e-07 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Chemical carcinogenesis - reactive oxygen species |
| REAC:R-HSA-422475 | 2.29492826104e-07 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Axon guidance |
| REAC:R-HSA-1483257 | 2.61380527035e-07 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Phospholipid metabolism |
| KEGG:05131 | 2.65327655033e-07 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Shigellosis |
| REAC:R-HSA-9675108 | 2.86284035167e-07 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Nervous system development |
| KEGG:05020 | 3.89453467336e-07 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Prion disease |
| WP:WP2037 | 4.31044765976e-07 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 IRS2 | Prolactin signaling pathway |
| WP:WP3932 | 5.73812004279e-07 | 0.833333333333 | PIK3CD PIK3R1 PIK3CB PIK3R2 IRS2 | Focal adhesion PI3K Akt mTOR signaling pathway |
| WP:WP5420 | 7.4177082425e-07 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | ADHD and autism ASD linked metabolic pathways and SNP |
| WP:WP2261 | 7.60204280189e-07 | 0.666666666667 | PIK3CD PIK3CB PIK3R1 PIK3R2 | Glioblastoma signaling pathways |
| REAC:R-HSA-74752 | 8.04336027921e-07 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 IRS2 | Signaling by Insulin receptor |
| REAC:R-HSA-9673770 | 8.4720413934e-07 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Signaling by PDGFRA extracellular domain mutants |
| REAC:R-HSA-9673767 | 8.4720413934e-07 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants |
| REAC:R-HSA-2730905 | 8.4720413934e-07 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Role of LAT2/NTAL/LAB on calcium mobilization |
| KEGG:04151 | 8.47217284084e-07 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | PI3K-Akt signaling pathway |
| WP:WP4172 | 8.95948878869e-07 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | PI3K Akt signaling pathway |
| REAC:R-HSA-1280215 | 9.39784923341e-07 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Cytokine Signaling in Immune system |
| KEGG:05165 | 9.73010153761e-07 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Human papillomavirus infection |
| KEGG:05168 | 2.95688254099e-06 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Herpes simplex virus 1 infection |
| REAC:R-HSA-210993 | 3.20984225624e-06 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Tie2 Signaling |
| GO:0052742 | 3.48770721675e-06 | 0.666666666667 | PIK3CD PIK3CB PIK3R1 PIK3R3 | phosphatidylinositol kinase activity |
| REAC:R-HSA-9671555 | 4.79564882828e-06 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Signaling by PDGFR in disease |
| REAC:R-HSA-9669938 | 4.79564882828e-06 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | Signaling by KIT in disease |
| REAC:R-HSA-9670439 | 4.79564882828e-06 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants |
| REAC:R-HSA-187037 | 4.97663696861e-06 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 IRS2 | Signaling by NTRK1 (TRKA) |
| GO:0006661 | 5.71004820433e-06 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | phosphatidylinositol biosynthetic process |
| WP:WP4262 | 6.95497723728e-06 | 0.666666666667 | PIK3CD PIK3R3 PIK3R1 PIK3R2 | Breast cancer pathway |
| REAC:R-HSA-1266738 | 7.19708522974e-06 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Developmental Biology |
| KEGG:05200 | 7.83947653613e-06 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Pathways in cancer |
| REAC:R-HSA-389357 | 8.03604834368e-06 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | CD28 dependent PI3K/Akt signaling |
| REAC:R-HSA-2029485 | 9.37394499108e-06 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Role of phospholipids in phagocytosis |
| REAC:R-HSA-373753 | 9.37394499108e-06 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Nephrin family interactions |
| REAC:R-HSA-166520 | 9.56649817153e-06 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 IRS2 | Signaling by NTRKs |
| REAC:R-HSA-201556 | 1.08523688914e-05 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Signaling by ALK |
| REAC:R-HSA-2424491 | 1.08523688914e-05 | 0.5 | PIK3R2 PIK3CB PIK3R1 | DAP12 signaling |
| GO:0046488 | 1.258414027e-05 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | phosphatidylinositol metabolic process |
| WP:WP244 | 1.36192169576e-05 | 0.5 | PIK3R2 IRS2 PIK3R1 | Alpha 6 beta 4 signaling pathway |
| WP:WP524 | 1.49788288335e-05 | 0.5 | PIK3CD PIK3CB PIK3R2 | G13 signaling pathway |
| WP:WP4564 | 1.64258598412e-05 | 0.5 | PIK3CD PIK3CB PIK3R3 | Neural crest cell migration during development |
| REAC:R-HSA-186763 | 1.83108883385e-05 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Downstream signal transduction |
| WP:WP4565 | 1.95929934718e-05 | 0.5 | PIK3CD PIK3CB PIK3R3 | Neural crest cell migration in cancer |
| GO:0001727 | 2.31677849716e-05 | 0.666666666667 | PIK3CD PIK3CB PIK3R1 PIK3R3 | lipid kinase activity |
| GO:0019898 | 2.31741536755e-05 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | extrinsic component of membrane |
| REAC:R-HSA-9006934 | 2.37398291815e-05 | 0.833333333333 | PIK3R3 PIK3R2 PIK3CB PIK3R1 IRS2 | Signaling by Receptor Tyrosine Kinases |
| GO:0042113 | 2.48873512689e-05 | 0.833333333333 | PIK3R3 PIK3CD IRS2 PIK3R1 PIK3R2 | B cell activation |
| REAC:R-HSA-389356 | 2.57219421737e-05 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | CD28 co-stimulation |
| REAC:R-HSA-2172127 | 2.57219421737e-05 | 0.5 | PIK3R2 PIK3CB PIK3R1 | DAP12 interactions |
| GO:0007169 | 2.6425732472e-05 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | transmembrane receptor protein tyrosine kinase signaling pathway |
| WP:WP286 | 3.14733202476e-05 | 0.5 | PIK3CD PIK3R1 PIK3R2 | IL 3 signaling pathway |
| REAC:R-HSA-1433557 | 5.02070457715e-05 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | Signaling by SCF-KIT |
| GO:0046474 | 5.45422005277e-05 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | glycerophospholipid biosynthetic process |
| GO:0043491 | 9.14393277353e-05 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO:0008654 | 0.00010460322276 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | phospholipid biosynthetic process |
| GO:0016303 | 0.00010757157937 | 0.5 | PIK3CD PIK3CB PIK3R3 | 1-phosphatidylinositol-3-kinase activity |
| HP:0030381 | 0.000108046320019 | 0.333333333333 | PIK3CD PIK3R1 | Increased proportion of transitional B cells |
| HP:0030379 | 0.000108046320019 | 0.333333333333 | PIK3CD PIK3R1 | Abnormal proportion of transitional B cells |
| REAC:R-HSA-5673001 | 0.000118221861411 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 IRS2 | RAF/MAP kinase cascade |
| REAC:R-HSA-186797 | 0.00012139707053 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Signaling by PDGF |
| GO:0045017 | 0.000125533004234 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | glycerolipid biosynthetic process |
| REAC:R-HSA-76002 | 0.000127366123378 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 PIK3R3 | Platelet activation, signaling and aggregation |
| REAC:R-HSA-5684996 | 0.000127366123378 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 IRS2 | MAPK1/MAPK3 signaling |
| REAC:R-HSA-556833 | 0.000134957179754 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Metabolism of lipids |
| WP:WP4674 | 0.00014942679056 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Head and neck squamous cell carcinoma |
| REAC:R-HSA-1643685 | 0.000200456644481 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Disease |
| REAC:R-HSA-1280218 | 0.00020253555583 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Adaptive Immune System |
| REAC:R-HSA-388841 | 0.000205084871777 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | Costimulation by the CD28 family |
| REAC:R-HSA-5683057 | 0.000220816183191 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 IRS2 | MAPK family signaling cascades |
| REAC:R-HSA-9009391 | 0.000264877822759 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | Extra-nuclear estrogen signaling |
| GO:0006650 | 0.000305090577248 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | glycerophospholipid metabolic process |
| GO:0001775 | 0.000322644200636 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | cell activation |
| HP:0011956 | 0.000324079809263 | 0.333333333333 | PIK3CD PIK3R1 | Intestinal lymphoid nodular hyperplasia |
| GO:0007167 | 0.000341510408951 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | enzyme-linked receptor protein signaling pathway |
| WP:WP5191 | 0.000362274856058 | 0.333333333333 | PIK3CD PIK3CB | Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution |
| REAC:R-HSA-168256 | 0.000431398594432 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Immune System |
| WP:WP4659 | 0.000508958938506 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | Gastrin signaling pathway |
| REAC:R-HSA-2029480 | 0.000531494169007 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| GO:0008286 | 0.000619048899658 | 0.666666666667 | PIK3R2 IRS2 PIK3R1 PIK3R3 | insulin receptor signaling pathway |
| REAC:R-HSA-9013404 | 0.000641417793729 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | RAC2 GTPase cycle |
| GO:0044255 | 0.000671930884891 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | cellular lipid metabolic process |
| GO:0030183 | 0.000684451996602 | 0.666666666667 | PIK3CD PIK3R3 PIK3R1 PIK3R2 | B cell differentiation |
| GO:0061695 | 0.000684514612873 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | transferase complex, transferring phosphorus-containing groups |
| GO:0046935 | 0.000698569295426 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | 1-phosphatidylinositol-3-kinase regulator activity |
| REAC:R-HSA-4420097 | 0.00073948978705 | 0.5 | PIK3R2 PIK3CB PIK3R1 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-202424 | 0.000792051133325 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Downstream TCR signaling |
| WP:WP2380 | 0.000819338628842 | 0.5 | PIK3R2 IRS2 PIK3R1 | Brain derived neurotrophic factor BDNF signaling pathway |
| GO:0006644 | 0.000832874463075 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | phospholipid metabolic process |
| GO:0046486 | 0.000892780050741 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | glycerolipid metabolic process |
| WP:WP22 | 0.000914914863609 | 0.333333333333 | PIK3R2 PIK3R1 | IL 9 signaling pathway |
| REAC:R-HSA-194138 | 0.000964479133971 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Signaling by VEGF |
| REAC:R-HSA-202733 | 0.00119511538043 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Cell surface interactions at the vascular wall |
| WP:WP3935 | 0.00120604069052 | 0.333333333333 | IRS2 PIK3R3 | Leptin insulin signaling overlap |
| REAC:R-HSA-1500931 | 0.00123077845596 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Cell-Cell communication |
| REAC:R-HSA-162582 | 0.00128853291586 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | Signal Transduction |
| REAC:R-HSA-202403 | 0.00134198628361 | 0.5 | PIK3R2 PIK3CB PIK3R1 | TCR signaling |
| WP:WP205 | 0.00136659658622 | 0.333333333333 | PIK3R2 PIK3R1 | IL 7 signaling pathway |
| REAC:R-HSA-2454202 | 0.00154179194332 | 0.5 | PIK3R2 PIK3CB PIK3R1 | Fc epsilon receptor (FCERI) signaling |
| HP:0031693 | 0.00161951205762 | 0.333333333333 | PIK3CD PIK3R1 | Severe Epstein Barr virus infection |
| WP:WP4483 | 0.00190817031826 | 0.333333333333 | PIK3CD PIK3CB | Relationship between inflammation COX 2 and EGFR |
| GO:0071495 | 0.00193018044108 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | cellular response to endogenous stimulus |
| WP:WP5181 | 0.00210864528598 | 0.333333333333 | IRS2 PIK3R1 | Roles of ceramides in development of insulin resistance |
| GO:0006629 | 0.00250973705538 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | lipid metabolic process |
| REAC:R-HSA-416476 | 0.00253713376791 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | G alpha (q) signalling events |
| GO:0009719 | 0.00322757972864 | 1.0 | PIK3R2 PIK3R3 PIK3CB PIK3CD IRS2 PIK3R1 | response to endogenous stimulus |
| WP:WP2533 | 0.00352059040085 | 0.333333333333 | PIK3CD PIK3CB | Glycerophospholipid biosynthetic pathway |
| WP:WP4481 | 0.00379071267612 | 0.333333333333 | PIK3CD PIK3CB | Resistin as a regulator of inflammation |
| REAC:R-HSA-109582 | 0.00428563332784 | 0.666666666667 | PIK3R2 PIK3CB PIK3R1 PIK3R3 | Hemostasis |
| REAC:R-HSA-9013149 | 0.00445044283113 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | RAC1 GTPase cycle |
| WP:WP127 | 0.0046606239013 | 0.333333333333 | PIK3R2 PIK3R1 | IL 5 signaling pathway |
| GO:0032869 | 0.00470234449591 | 0.666666666667 | PIK3R2 IRS2 PIK3R1 PIK3R3 | cellular response to insulin stimulus |
| HP:0011110 | 0.00485499013014 | 0.333333333333 | PIK3CD PIK3R1 | Recurrent tonsillitis |
| HP:0031692 | 0.00485499013014 | 0.333333333333 | PIK3CD PIK3R1 | Severe cytomegalovirus infection |
| HP:0200117 | 0.00485499013014 | 0.333333333333 | PIK3CD PIK3R1 | Recurrent upper and lower respiratory tract infections |
| WP:WP4871 | 0.00497042421358 | 0.333333333333 | PIK3CD PIK3CB | Kisspeptin kisspeptin receptor system in the ovary |
| REAC:R-HSA-983695 | 0.00594265866298 | 0.333333333333 | PIK3CD PIK3R1 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| WP:WP2828 | 0.00595923834675 | 0.333333333333 | PIK3R2 PIK3R1 | Bladder cancer |
| GO:0032868 | 0.0063111355837 | 0.666666666667 | PIK3R2 IRS2 PIK3R1 PIK3R3 | response to insulin |
| GO:0090407 | 0.00638287017442 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | organophosphate biosynthetic process |
| WP:WP2332 | 0.00703705758996 | 0.333333333333 | PIK3R2 PIK3R1 | Interleukin 11 signaling pathway |
| REAC:R-HSA-8939211 | 0.00713416614811 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | ESR-mediated signaling |
| GO:0046649 | 0.00723959301982 | 0.833333333333 | PIK3R3 PIK3CD IRS2 PIK3R1 PIK3R2 | lymphocyte activation |
| WP:WP364 | 0.00741608411471 | 0.333333333333 | PIK3R2 PIK3R1 | IL6 signaling pathway |
| HP:0032170 | 0.00841070885474 | 0.333333333333 | PIK3CD PIK3R1 | Severe varicella zoster infection |
| WP:WP4971 | 0.00861234767009 | 0.333333333333 | PIK3CD PIK3CB | Phosphoinositides metabolism |
| WP:WP5411 | 0.00861234767009 | 0.333333333333 | PIK3CD PIK3CB | Phosphatidyl inositol phosphate pathway |
| WP:WP61 | 0.00945912219359 | 0.333333333333 | PIK3R2 PIK3R1 | Notch signaling pathway |
| GO:0001784 | 0.00949259421943 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | phosphotyrosine residue binding |
| REAC:R-HSA-9680350 | 0.00971370123257 | 0.333333333333 | PIK3CB PIK3R1 | Signaling by CSF1 (M-CSF) in myeloid cells |
| WP:WP2018 | 0.0103452582733 | 0.333333333333 | PIK3R2 PIK3R1 | RANKL RANK signaling pathway |
| GO:0030217 | 0.0107239945371 | 0.666666666667 | PIK3CD PIK3R3 PIK3R1 PIK3R2 | T cell differentiation |
| WP:WP195 | 0.0112707123684 | 0.333333333333 | PIK3R2 PIK3R1 | IL 1 signaling pathway |
| WP:WP304 | 0.0127325196108 | 0.333333333333 | PIK3R2 PIK3R1 | Kit receptor signaling pathway |
| WP:WP5072 | 0.0137560784303 | 0.333333333333 | PIK3R2 PIK3R1 | Modulators of TCR signaling and T cell activation |
| GO:0008610 | 0.0147924859131 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | lipid biosynthetic process |
| WP:WP2032 | 0.0148188030846 | 0.333333333333 | PIK3R2 PIK3R1 | Thyroid stimulating hormone TSH signaling pathway |
| KEGG:00562 | 0.0149489869659 | 0.333333333333 | PIK3CD PIK3CB | Inositol phosphate metabolism |
| GO:0071375 | 0.0153056641383 | 0.666666666667 | PIK3R2 IRS2 PIK3R1 PIK3R3 | cellular response to peptide hormone stimulus |
| REAC:R-HSA-9006931 | 0.0168855312186 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | Signaling by Nuclear Receptors |
| REAC:R-HSA-9013420 | 0.0170865043842 | 0.333333333333 | PIK3R2 PIK3R1 | RHOU GTPase cycle |
| REAC:R-HSA-9696273 | 0.0170865043842 | 0.333333333333 | PIK3R2 PIK3R1 | RND1 GTPase cycle |
| WP:WP69 | 0.0182415379951 | 0.333333333333 | PIK3R2 PIK3R1 | T cell receptor signaling pathway |
| REAC:R-HSA-9696270 | 0.019003715544 | 0.333333333333 | PIK3R2 PIK3R1 | RND2 GTPase cycle |
| GO:0045321 | 0.019672929333 | 0.833333333333 | PIK3R3 PIK3CD IRS2 PIK3R1 PIK3R2 | leukocyte activation |
| REAC:R-HSA-9696264 | 0.0200002568185 | 0.333333333333 | PIK3R2 PIK3R1 | RND3 GTPase cycle |
| HP:0040218 | 0.020461457105 | 0.333333333333 | PIK3CD PIK3R1 | Reduced natural killer cell count |
| WP:WP5094 | 0.0220152039288 | 0.333333333333 | PIK3R2 PIK3R1 | Orexin receptor pathway |
| REAC:R-HSA-9035034 | 0.0220691409046 | 0.333333333333 | PIK3R2 PIK3R1 | RHOF GTPase cycle |
| HP:0025539 | 0.0226111656051 | 0.333333333333 | PIK3CD PIK3R1 | Abnormal B cell subset distribution |
| WP:WP2034 | 0.0226781844519 | 0.333333333333 | PIK3R2 PIK3R1 | Leptin signaling pathway |
| GO:0045309 | 0.0235785344663 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | protein phosphorylated amino acid binding |
| REAC:R-HSA-1430728 | 0.0258573248266 | 0.833333333333 | PIK3R3 PIK3CD PIK3CB PIK3R1 PIK3R2 | Metabolism |
| WP:WP5098 | 0.0268597929621 | 0.333333333333 | PIK3CD PIK3R1 | T cell activation SARS CoV 2 |
| WP:WP23 | 0.0283311425678 | 0.333333333333 | PIK3R2 PIK3R1 | B cell receptor signaling pathway |
| GO:0043434 | 0.0292377969225 | 0.666666666667 | PIK3R2 IRS2 PIK3R1 PIK3R3 | response to peptide hormone |
| GO:1901653 | 0.0309639973592 | 0.666666666667 | PIK3R2 IRS2 PIK3R1 PIK3R3 | cellular response to peptide |
| HP:0040089 | 0.0322780794397 | 0.333333333333 | PIK3CD PIK3R1 | Abnormal natural killer cell count |
| REAC:R-HSA-9013405 | 0.0326270815028 | 0.333333333333 | PIK3R2 PIK3R1 | RHOD GTPase cycle |
| WP:WP138 | 0.0329770277677 | 0.333333333333 | PIK3R2 PIK3R1 | Androgen receptor signaling pathway |
| GO:2000106 | 0.0351680546752 | 0.5 | PIK3CD PIK3CB IRS2 | regulation of leukocyte apoptotic process |
| REAC:R-HSA-9013409 | 0.0352499509777 | 0.333333333333 | PIK3R2 PIK3R1 | RHOJ GTPase cycle |
| HP:0031691 | 0.0406481036194 | 0.333333333333 | PIK3CD PIK3R1 | Severe viral infection |
| GO:0001781 | 0.042122686785 | 0.333333333333 | PIK3CD PIK3CB | neutrophil apoptotic process |
| GO:0033031 | 0.042122686785 | 0.333333333333 | PIK3CD PIK3CB | positive regulation of neutrophil apoptotic process |
| GO:0033029 | 0.042122686785 | 0.333333333333 | PIK3CD PIK3CB | regulation of neutrophil apoptotic process |
| HP:0012176 | 0.0436511011886 | 0.333333333333 | PIK3CD PIK3R1 | Abnormal natural killer cell morphology |
| HP:0100765 | 0.0436511011886 | 0.333333333333 | PIK3CD PIK3R1 | Abnormality of the tonsils |
| REAC:R-HSA-9013026 | 0.0467439411123 | 0.333333333333 | PIK3R2 PIK3R1 | RHOB GTPase cycle |
| HP:0003496 | 0.0467604957305 | 0.333333333333 | PIK3CD PIK3R1 | Increased circulating IgM level |
| GO:0030098 | 0.0476561097968 | 0.666666666667 | PIK3CD PIK3R3 PIK3R1 PIK3R2 | lymphocyte differentiation |
| WP:WP3931 | 0.0489911417376 | 0.333333333333 | PIK3CD PIK3R2 | Embryonic stem cell pluripotency pathways |
| CORUM:7361 | 0.0499436884912 | 0.166666666667 | PIK3R1 | ARAF-PIK3R1 complex |
| CORUM:2574 | 0.0499436884912 | 0.166666666667 | PIK3R1 | CD19-VAV1-PIK3R1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PIK3CB | PIK3R1 | 0.999 | 0.23 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () fraction |
| PIK3CB | PIK3R3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PIK3CD | PIK3R3 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PIK3CD | PIK3R1 | 0.997 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| PIK3R2 | PIK3R1 | 0.995 | 0.31 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PIK3R2 | PIK3R3 | 0.994 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| IRS2 | PIK3R1 | 0.993 | 0.202 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| PIK3CB | PIK3R2 | 0.992 | 0.350883495146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| IRS2 | PIK3CD | 0.979 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PIK3R3 | PIK3R1 | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| IRS2 | PIK3CB | 0.954 | 0.238 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| IRS2 | PIK3R3 | 0.868 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PIK3CB | PIK3CD | 0.838 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PIK3CD | PIK3R2 | 0.141 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only |
| IRS2 | PIK3R2 | 0.041 | 0.342519858782 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes