hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08093.1

Complex Portal: CPX-21081

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
PPP1R3B	Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG)	4	UniProt NCBI
GYG2	Glycogenin-2 (GN-2) (GN2) (EC 2.4.1.186)	5	UniProt NCBI
PYGM	Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase)	5	UniProt NCBI
PPP1R3F	Protein phosphatase 1 regulatory subunit 3F (R3F)	5	UniProt NCBI
PPP1R3C	Protein phosphatase 1 regulatory subunit 3C (Protein phosphatase 1 regulatory subunit 5) (PP1 subunit R5) (Protein targeting to glycogen) (PTG)	5	UniProt NCBI
NANOS1	Nanos homolog 1 (NOS-1) (EC_Rep1a)	5	UniProt NCBI
STBD1	Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1)	5	UniProt NCBI
GYS2	Glycogen [starch] synthase, liver (EC 2.4.1.11) (Glycogen synthase 2)	5	UniProt NCBI
PYGB	Glycogen phosphorylase, brain form (EC 2.4.1.1)	5	UniProt NCBI
PYGL	Glycogen phosphorylase, liver form (EC 2.4.1.1)	5	UniProt NCBI
AGL	Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]	5	UniProt NCBI
PPP1R3D	Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6)	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0044042	5.28643454881e-18	0.9	AGL PPP1R3D GYG2 STBD1 PPP1R3B GYS2 PYGL PPP1R3F PPP1R3C	glucan metabolic process
GO:0005977	5.28643454881e-18	0.9	AGL PPP1R3D GYG2 STBD1 PPP1R3B GYS2 PYGL PPP1R3F PPP1R3C	glycogen metabolic process
GO:0006112	2.19381543558e-17	0.9	AGL PPP1R3D GYG2 STBD1 PPP1R3B GYS2 PYGL PPP1R3F PPP1R3C	energy reserve metabolic process
GO:0005976	1.03350624796e-16	0.9	AGL PPP1R3D GYG2 STBD1 PPP1R3B GYS2 PYGL PPP1R3F PPP1R3C	polysaccharide metabolic process
GO:2001069	1.36107562031e-11	0.5	STBD1 PPP1R3F PPP1R3D PPP1R3B PPP1R3C	glycogen binding
GO:0015980	1.88282990225e-11	0.9	AGL PPP1R3D GYG2 STBD1 PPP1R3B GYS2 PYGL PPP1R3F PPP1R3C	energy derivation by oxidation of organic compounds
GO:0005975	3.91561419457e-10	0.9	AGL PPP1R3D GYG2 STBD1 PPP1R3B GYS2 PYGL PPP1R3F PPP1R3C	carbohydrate metabolic process
REAC:R-HSA-8982491	4.6340384772e-10	0.5	GYG2 PYGL PPP1R3C AGL GYS2	Glycogen metabolism
GO:0009250	6.99427541614e-10	0.6	PPP1R3D GYG2 PPP1R3B GYS2 PPP1R3F PPP1R3C	glucan biosynthetic process
GO:0005978	6.99427541614e-10	0.6	PPP1R3D GYG2 PPP1R3B GYS2 PPP1R3F PPP1R3C	glycogen biosynthetic process
GO:0006091	7.90924575458e-10	0.9	AGL PPP1R3D GYG2 STBD1 PPP1R3B GYS2 PYGL PPP1R3F PPP1R3C	generation of precursor metabolites and energy
GO:0030247	1.04653440308e-09	0.5	STBD1 PPP1R3F PPP1R3D PPP1R3B PPP1R3C	polysaccharide binding
KEGG:04910	3.74431993364e-09	0.6	PPP1R3D PPP1R3C GYS2 PYGL PPP1R3F PPP1R3B	Insulin signaling pathway
GO:0000271	8.25841709785e-09	0.6	PPP1R3D GYG2 PPP1R3B GYS2 PPP1R3F PPP1R3C	polysaccharide biosynthetic process
KEGG:00500	6.99080030278e-08	0.4	GYG2 GYS2 AGL PYGL	Starch and sucrose metabolism
KEGG:04931	1.51111543582e-07	0.5	PPP1R3D PYGL GYS2 PPP1R3B PPP1R3C	Insulin resistance
GO:0030246	3.09918571455e-07	0.6	PPP1R3D STBD1 PPP1R3C PYGL PPP1R3F PPP1R3B	carbohydrate binding
GO:0000272	6.95089238983e-07	0.4	PYGL PPP1R3B AGL STBD1	polysaccharide catabolic process
GO:0009251	6.95089238983e-07	0.4	PYGL PPP1R3B AGL STBD1	glucan catabolic process
GO:0005980	6.95089238983e-07	0.4	PYGL PPP1R3B AGL STBD1	glycogen catabolic process
WP:WP500	7.10636501755e-07	0.4	GYG2 GYS2 AGL PYGL	Glycogen synthesis and degradation
WP:WP4861	9.82375492679e-07	0.4	PPP1R3D PPP1R3F PPP1R3B PPP1R3C	Endoplasmic reticulum stress response in coronavirus infection
GO:0016051	4.09246954581e-06	0.6	PPP1R3D GYG2 PPP1R3B GYS2 PPP1R3F PPP1R3C	carbohydrate biosynthetic process
WP:WP5173	6.47048187761e-06	0.3	GYG2 GYS2 PYGL	Disorders of galactose metabolism
GO:0008157	7.51529801094e-06	0.4	PPP1R3D PPP1R3F PPP1R3B PPP1R3C	protein phosphatase 1 binding
GO:0000164	1.00171038812e-05	0.4	PPP1R3D PPP1R3F PPP1R3B PPP1R3C	protein phosphatase type 1 complex
REAC:R-HSA-70221	1.58792502117e-05	0.3	GYG2 AGL PYGL	Glycogen breakdown (glycogenolysis)
REAC:R-HSA-3322077	2.02026912702e-05	0.3	GYG2 PPP1R3C GYS2	Glycogen synthesis
REAC:R-HSA-3229121	2.02026912702e-05	0.3	GYG2 PPP1R3C GYS2	Glycogen storage diseases
GO:0005979	4.01817082119e-05	0.4	PPP1R3D PPP1R3F PPP1R3B PPP1R3C	regulation of glycogen biosynthetic process
GO:0010962	4.01817082119e-05	0.4	PPP1R3D PPP1R3F PPP1R3B PPP1R3C	regulation of glucan biosynthetic process
GO:0070873	8.20132428287e-05	0.4	PPP1R3D PPP1R3F PPP1R3B PPP1R3C	regulation of glycogen metabolic process
GO:0032885	8.20132428287e-05	0.4	PPP1R3D PPP1R3F PPP1R3B PPP1R3C	regulation of polysaccharide biosynthetic process
REAC:R-HSA-71387	8.98561536136e-05	0.5	GYG2 PYGL PPP1R3C AGL GYS2	Metabolism of carbohydrates
REAC:R-HSA-3858516	0.000101782765236	0.2	GYG2 GYS2	Glycogen storage disease type 0 (liver GYS2)
GO:0032881	0.000150141664293	0.4	PPP1R3D PPP1R3F PPP1R3B PPP1R3C	regulation of polysaccharide metabolic process
REAC:R-HSA-5663084	0.000224045063065	0.3	GYG2 PPP1R3C GYS2	Diseases of carbohydrate metabolism
REAC:R-HSA-3878781	0.000305236852181	0.2	GYG2 GYS2	Glycogen storage disease type IV (GBE1)
GO:1903293	0.00125344998193	0.4	PPP1R3D PPP1R3F PPP1R3B PPP1R3C	phosphatase complex
GO:0008287	0.00125344998193	0.4	PPP1R3D PPP1R3F PPP1R3B PPP1R3C	protein serine/threonine phosphatase complex
GO:0043255	0.00214496471902	0.4	PPP1R3D PPP1R3F PPP1R3B PPP1R3C	regulation of carbohydrate biosynthetic process
GO:0043467	0.0185681816185	0.4	PPP1R3D PPP1R3F PPP1R3B PPP1R3C	regulation of generation of precursor metabolites and energy
GO:0019903	0.0245846488989	0.4	PPP1R3D PPP1R3F PPP1R3B PPP1R3C	protein phosphatase binding
GO:0016052	0.0245846488989	0.4	PYGL PPP1R3B AGL STBD1	carbohydrate catabolic process
WP:000000	0.029871335992	1.0	AGL PPP1R3D GYG2 STBD1 PPP1R3B GYS2 PPP1R3F NANOS1 PYGL PPP1R3C	WIKIPATHWAYS
GO:0006109	0.0319473224786	0.4	PPP1R3D PPP1R3F PPP1R3B PPP1R3C	regulation of carbohydrate metabolic process
WP:WP410	0.0335282776025	0.2	PPP1R3C STBD1	Exercise induced circadian regulation

Edges

Protein 1	Protein 2	Score	ProteomeHD
STBD1	AGL	1.0	0.216
STBD1	PYGB	0.999	0.185
PPP1R3B	AGL	0.999
PYGB	PYGM	0.998	0.166
PYGB	PYGL	0.998	0.366
PPP1R3B	PPP1R3D	0.998
GYG2	STBD1	0.996
PPP1R3B	PYGB	0.996
GYG2	AGL	0.995
STBD1	GYS2	0.994
PPP1R3C	STBD1	0.994
STBD1	PPP1R3D	0.992	0.112
STBD1	PYGM	0.991	0.178
PPP1R3F	STBD1	0.99	0.104
STBD1	PYGL	0.988	0.228
NANOS1	STBD1	0.988
GYG2	GYS2	0.987
PPP1R3B	STBD1	0.986
GYG2	PPP1R3F	0.981
PPP1R3C	PPP1R3D	0.973
PPP1R3C	AGL	0.97
GYS2	PYGB	0.957
PPP1R3B	GYS2	0.949
GYG2	PYGB	0.948
PPP1R3F	PPP1R3D	0.925	0.14
PYGB	PPP1R3D	0.909	0.082
PYGB	AGL	0.898	0.206
PPP1R3B	PPP1R3F	0.894
GYS2	AGL	0.893
AGL	PPP1R3D	0.871	0.078
GYS2	PPP1R3D	0.866
PPP1R3F	PYGB	0.865	0.07
PYGL	PYGM	0.846	0.368
PPP1R3F	AGL	0.812	0.05
PPP1R3B	PYGM	0.771
PPP1R3F	GYS2	0.745
PPP1R3B	PYGL	0.729
AGL	PYGM	0.723	0.056
PPP1R3D	PYGM	0.633	0.076
PPP1R3F	PYGL	0.569	0.03
PYGL	PPP1R3D	0.515	0.044
PPP1R3F	PYGM	0.499	0.026
GYS2	PYGM	0.373
PPP1R3C	GYS2	0.268
GYG2	PPP1R3D	0.263
NANOS1	GYS2	0.241
GYS2	PYGL	0.215
NANOS1	AGL	0.215
PYGL	AGL	0.172	0.054
NANOS1	GYG2	0.172
NANOS1	PPP1R3D	0.172
GYG2	PYGM	0.158
NANOS1	PPP1R3F	0.146
NANOS1	PPP1R3B	0.146
PPP1R3B	GYG2	0.133
NANOS1	PYGM	0.123
NANOS1	PYGB	0.119
GYG2	PYGL	0.064
NANOS1	PYGL	0.045
PPP1R3C	PYGL	0.005

Related Complexes

Genename	Complexes
PPP1R3B	huMAP3_01396.1 huMAP3_06806.1 huMAP3_08093.1 huMAP3_08342.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
GYG2	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
PYGM	huMAP3_02460.1 huMAP3_07933.1 huMAP3_08093.1 huMAP3_09076.1 huMAP3_09760.1 huMAP3_10799.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_14138.1
PPP1R3F	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
PPP1R3C	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
NANOS1	huMAP3_00933.1 huMAP3_06513.1 huMAP3_06662.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10924.1 huMAP3_11777.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13239.1 huMAP3_13970.1 huMAP3_14335.1 huMAP3_15138.1
STBD1	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
GYS2	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
PYGB	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
PYGL	huMAP3_01396.1 huMAP3_06909.1 huMAP3_07415.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
AGL	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
PPP1R3D	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08093.1 huMAP3_08342.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08093.1

Complex Portal: CPX-21081