hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08094.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TUBA1C | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | 5 | UniProt NCBI |
| TUBA1B | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HPA:0471423 | 0.000211231944408 | 1.0 | TUBA1C TUBA1B | skin 2; eccrine glands[High] |
| REAC:R-HSA-190840 | 0.000261440548076 | 1.0 | TUBA1C TUBA1B | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane |
| REAC:R-HSA-190872 | 0.000292198259614 | 1.0 | TUBA1C TUBA1B | Transport of connexons to the plasma membrane |
| KEGG:04540 | 0.000403985690766 | 1.0 | TUBA1C TUBA1B | Gap junction |
| REAC:R-HSA-389977 | 0.000432316723289 | 1.0 | TUBA1C TUBA1B | Post-chaperonin tubulin folding pathway |
| WP:WP2272 | 0.000500549133471 | 1.0 | TUBA1C TUBA1B | Pathogenic Escherichia coli infection |
| REAC:R-HSA-389960 | 0.000512628525639 | 1.0 | TUBA1C TUBA1B | Formation of tubulin folding intermediates by CCT/TriC |
| REAC:R-HSA-9619483 | 0.000512628525639 | 1.0 | TUBA1C TUBA1B | Activation of AMPK downstream of NMDARs |
| REAC:R-HSA-190861 | 0.000645911942305 | 1.0 | TUBA1C TUBA1B | Gap junction assembly |
| REAC:R-HSA-9668328 | 0.000693757271364 | 1.0 | TUBA1C TUBA1B | Sealing of the nuclear envelope (NE) by ESCRT-III |
| REAC:R-HSA-5626467 | 0.000693757271364 | 1.0 | TUBA1C TUBA1B | RHO GTPases activate IQGAPs |
| REAC:R-HSA-389958 | 0.000847545829056 | 1.0 | TUBA1C TUBA1B | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| WP:WP2359 | 0.000969601127591 | 1.0 | TUBA1C TUBA1B | Parkin ubiquitin proteasomal system pathway |
| KEGG:04210 | 0.00116074761854 | 1.0 | TUBA1C TUBA1B | Apoptosis |
| REAC:R-HSA-9609736 | 0.00120125951175 | 1.0 | TUBA1C TUBA1B | Assembly and cell surface presentation of NMDA receptors |
| REAC:R-HSA-8955332 | 0.00120125951175 | 1.0 | TUBA1C TUBA1B | Carboxyterminal post-translational modifications of tubulin |
| REAC:R-HSA-190828 | 0.00126619245833 | 1.0 | TUBA1C TUBA1B | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.00133283416666 | 1.0 | TUBA1C TUBA1B | Gap junction trafficking and regulation |
| HPA:0471422 | 0.00137090133721 | 1.0 | TUBA1C TUBA1B | skin 2; eccrine glands[>=Medium] |
| REAC:R-HSA-9646399 | 0.00140118463675 | 1.0 | TUBA1C TUBA1B | Aggrephagy |
| KEGG:04145 | 0.00140557757842 | 1.0 | TUBA1C TUBA1B | Phagosome |
| KEGG:04530 | 0.00155920593969 | 1.0 | TUBA1C TUBA1B | Tight junction |
| HPA:0471402 | 0.00176086800381 | 1.0 | TUBA1C TUBA1B | skin 2; cells in corneal layer[>=Medium] |
| REAC:R-HSA-437239 | 0.00176856841345 | 1.0 | TUBA1C TUBA1B | Recycling pathway of L1 |
| HPA:0461483 | 0.00185414706758 | 1.0 | TUBA1C TUBA1B | skin 1; sebaceous glands[High] |
| REAC:R-HSA-6811436 | 0.00209323314636 | 1.0 | TUBA1C TUBA1B | COPI-independent Golgi-to-ER retrograde traffic |
| HPA:0471421 | 0.0020978762342 | 1.0 | TUBA1C TUBA1B | skin 2; eccrine glands[>=Low] |
| KEGG:04814 | 0.00212007138563 | 1.0 | TUBA1C TUBA1B | Motor proteins |
| REAC:R-HSA-5620924 | 0.00217867123396 | 1.0 | TUBA1C TUBA1B | Intraflagellar transport |
| KEGG:05130 | 0.00219956796622 | 1.0 | TUBA1C TUBA1B | Pathogenic Escherichia coli infection |
| HPA:0461423 | 0.00219958050373 | 1.0 | TUBA1C TUBA1B | skin 1; eccrine glands[High] |
| REAC:R-HSA-3371497 | 0.00226581808332 | 1.0 | TUBA1C TUBA1B | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| REAC:R-HSA-983189 | 0.0024452380673 | 1.0 | TUBA1C TUBA1B | Kinesins |
| REAC:R-HSA-2995410 | 0.00377807223396 | 1.0 | TUBA1C TUBA1B | Nuclear Envelope (NE) Reassembly |
| REAC:R-HSA-438064 | 0.00389255927135 | 1.0 | TUBA1C TUBA1B | Post NMDA receptor activation events |
| REAC:R-HSA-1445148 | 0.00400875507049 | 1.0 | TUBA1C TUBA1B | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| KEGG:05132 | 0.00406034068917 | 1.0 | TUBA1C TUBA1B | Salmonella infection |
| HPA:0461453 | 0.00408381759188 | 1.0 | TUBA1C TUBA1B | skin 1; hair follicles[High] |
| HPA:0471493 | 0.00451530848687 | 1.0 | TUBA1C TUBA1B | skin 2; vascular mural cells[High] |
| KEGG:05012 | 0.00458495309323 | 1.0 | TUBA1C TUBA1B | Parkinson disease |
| HPA:0471401 | 0.00458932993748 | 1.0 | TUBA1C TUBA1B | skin 2; cells in corneal layer[>=Low] |
| REAC:R-HSA-9663891 | 0.00474181386216 | 1.0 | TUBA1C TUBA1B | Selective autophagy |
| KEGG:05020 | 0.00485920816781 | 1.0 | TUBA1C TUBA1B | Prion disease |
| REAC:R-HSA-8852276 | 0.00486997099357 | 1.0 | TUBA1C TUBA1B | The role of GTSE1 in G2/M progression after G2 checkpoint |
| HPA:0461493 | 0.00512433050323 | 1.0 | TUBA1C TUBA1B | skin 1; vascular mural cells[High] |
| REAC:R-HSA-442755 | 0.00539968713673 | 1.0 | TUBA1C TUBA1B | Activation of NMDA receptors and postsynaptic events |
| KEGG:05016 | 0.00594761227231 | 1.0 | TUBA1C TUBA1B | Huntington disease |
| REAC:R-HSA-390466 | 0.0061002794551 | 1.0 | TUBA1C TUBA1B | Chaperonin-mediated protein folding |
| REAC:R-HSA-380320 | 0.00684359081728 | 1.0 | TUBA1C TUBA1B | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-391251 | 0.00715287669441 | 1.0 | TUBA1C TUBA1B | Protein folding |
| HPA:0461482 | 0.00727576697405 | 1.0 | TUBA1C TUBA1B | skin 1; sebaceous glands[>=Medium] |
| REAC:R-HSA-6811434 | 0.00731008277561 | 1.0 | TUBA1C TUBA1B | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-6807878 | 0.00779195358971 | 1.0 | TUBA1C TUBA1B | COPI-mediated anterograde transport |
| KEGG:05014 | 0.00850662183301 | 1.0 | TUBA1C TUBA1B | Amyotrophic lateral sclerosis |
| REAC:R-HSA-373760 | 0.00880183178522 | 1.0 | TUBA1C TUBA1B | L1CAM interactions |
| REAC:R-HSA-5610787 | 0.00932983916662 | 1.0 | TUBA1C TUBA1B | Hedgehog 'off' state |
| KEGG:05010 | 0.0093688914925 | 1.0 | TUBA1C TUBA1B | Alzheimer disease |
| HPA:0461422 | 0.00948016188107 | 1.0 | TUBA1C TUBA1B | skin 1; eccrine glands[>=Medium] |
| HPA:0461492 | 0.00991225457647 | 1.0 | TUBA1C TUBA1B | skin 1; vascular mural cells[>=Medium] |
| HPA:0471492 | 0.0101319117266 | 1.0 | TUBA1C TUBA1B | skin 2; vascular mural cells[>=Medium] |
| HPA:0461393 | 0.0101319117266 | 1.0 | TUBA1C TUBA1B | skin 1; cells in basal layer[High] |
| REAC:R-HSA-9648025 | 0.0108130443675 | 1.0 | TUBA1C TUBA1B | EML4 and NUDC in mitotic spindle formation |
| HPA:0461481 | 0.0110346123438 | 1.0 | TUBA1C TUBA1B | skin 1; sebaceous glands[>=Low] |
| WP:WP2059 | 0.01130704739 | 1.0 | TUBA1C TUBA1B | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 0.01130704739 | 1.0 | TUBA1C TUBA1B | Alzheimer 39 s disease |
| REAC:R-HSA-2132295 | 0.0115956572499 | 1.0 | TUBA1C TUBA1B | MHC class II antigen presentation |
| REAC:R-HSA-9609690 | 0.0122005589102 | 1.0 | TUBA1C TUBA1B | HCMV Early Events |
| REAC:R-HSA-2500257 | 0.0124056103205 | 1.0 | TUBA1C TUBA1B | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-8856688 | 0.013456498798 | 1.0 | TUBA1C TUBA1B | Golgi-to-ER retrograde transport |
| REAC:R-HSA-1632852 | 0.013456498798 | 1.0 | TUBA1C TUBA1B | Macroautophagy |
| KEGG:05022 | 0.0138982457502 | 1.0 | TUBA1C TUBA1B | Pathways of neurodegeneration - multiple diseases |
| REAC:R-HSA-5358351 | 0.0145501063194 | 1.0 | TUBA1C TUBA1B | Signaling by Hedgehog |
| REAC:R-HSA-5663220 | 0.0147739541089 | 1.0 | TUBA1C TUBA1B | RHO GTPases Activate Formins |
| HPA:0500703 | 0.0148963655838 | 1.0 | TUBA1C TUBA1B | soft tissue 1; peripheral nerve[High] |
| HPA:0471491 | 0.0158484138347 | 1.0 | TUBA1C TUBA1B | skin 2; vascular mural cells[>=Low] |
| HPA:0461421 | 0.0161258438244 | 1.0 | TUBA1C TUBA1B | skin 1; eccrine glands[>=Low] |
| HPA:0461491 | 0.0162654615198 | 1.0 | TUBA1C TUBA1B | skin 1; vascular mural cells[>=Low] |
| REAC:R-HSA-9612973 | 0.0168654784935 | 1.0 | TUBA1C TUBA1B | Autophagy |
| REAC:R-HSA-9609646 | 0.0171064139006 | 1.0 | TUBA1C TUBA1B | HCMV Infection |
| REAC:R-HSA-199977 | 0.0173490580694 | 1.0 | TUBA1C TUBA1B | ER to Golgi Anterograde Transport |
| HPA:0510703 | 0.0205761578668 | 1.0 | TUBA1C TUBA1B | soft tissue 2; peripheral nerve[High] |
| REAC:R-HSA-983231 | 0.0209254964166 | 1.0 | TUBA1C TUBA1B | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-112314 | 0.0211937720117 | 1.0 | TUBA1C TUBA1B | Neurotransmitter receptors and postsynaptic signal transmission |
| HPA:0461452 | 0.0233384217552 | 1.0 | TUBA1C TUBA1B | skin 1; hair follicles[>=Medium] |
| HPA:0471393 | 0.0240136418168 | 1.0 | TUBA1C TUBA1B | skin 2; cells in basal layer[High] |
| REAC:R-HSA-948021 | 0.0251290503268 | 1.0 | TUBA1C TUBA1B | Transport to the Golgi and subsequent modification |
| HPA:0500113 | 0.0252184462405 | 1.0 | TUBA1C TUBA1B | soft tissue 1; chondrocytes[High] |
| HPA:0460203 | 0.0268108101291 | 1.0 | TUBA1C TUBA1B | skin 1; endothelial cells[High] |
| HPA:0470203 | 0.0271712885755 | 1.0 | TUBA1C TUBA1B | skin 2; endothelial cells[High] |
| REAC:R-HSA-2467813 | 0.0287687128588 | 1.0 | TUBA1C TUBA1B | Separation of Sister Chromatids |
| REAC:R-HSA-5617833 | 0.0303578612883 | 1.0 | TUBA1C TUBA1B | Cilium Assembly |
| REAC:R-HSA-69275 | 0.0303578612883 | 1.0 | TUBA1C TUBA1B | G2/M Transition |
| REAC:R-HSA-453274 | 0.0310054819924 | 1.0 | TUBA1C TUBA1B | Mitotic G2-G2/M phases |
| REAC:R-HSA-6811442 | 0.0316599377434 | 1.0 | TUBA1C TUBA1B | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-68877 | 0.0323212285415 | 1.0 | TUBA1C TUBA1B | Mitotic Prometaphase |
| REAC:R-HSA-112315 | 0.0350347422039 | 1.0 | TUBA1C TUBA1B | Transmission across Chemical Synapses |
| HPA:0470673 | 0.035503817072 | 1.0 | TUBA1C TUBA1B | skin 2; melanocytes[High] |
| HPA:0461451 | 0.0357108364136 | 1.0 | TUBA1C TUBA1B | skin 1; hair follicles[>=Low] |
| HPA:0340463 | 0.0376010915058 | 1.0 | TUBA1C TUBA1B | ovary; ovarian stroma cells[High] |
| HPA:0100213 | 0.038242008944 | 1.0 | TUBA1C TUBA1B | cerebral cortex; neuropil[High] |
| HPA:0461473 | 0.0408598407336 | 1.0 | TUBA1C TUBA1B | skin 1; lymphocytes[High] |
| REAC:R-HSA-68882 | 0.0422969796504 | 1.0 | TUBA1C TUBA1B | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.0426780335212 | 1.0 | TUBA1C TUBA1B | Mitotic Metaphase and Anaphase |
| HPA:0461443 | 0.0437936177393 | 1.0 | TUBA1C TUBA1B | skin 1; fibrohistiocytic cells[High] |
| HPA:0301173 | 0.0454154698481 | 1.0 | TUBA1C TUBA1B | lung; alveolar cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TUBA1B | TUBA1C | 0.993 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
Related Complexes