hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08111.1
Complex Portal: CPX-20773
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| THOC5 | THO complex subunit 5 homolog (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90) | 5 | UniProt NCBI |
| CCDC9B | Coiled-coil domain-containing protein 9B | 3 | UniProt NCBI |
| ALKBH5 | RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) | 5 | UniProt NCBI |
| SARNP | SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29) | 5 | UniProt NCBI |
| C19orf47 | Uncharacterized protein C19orf47 | 3 | UniProt NCBI |
| KIF1C | Kinesin-like protein KIF1C | 5 | UniProt NCBI |
| THOC1 | THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) (p84N5) (hTREX84) | 5 | UniProt NCBI |
| RBM27 | RNA-binding protein 27 (RNA-binding motif protein 27) | 4 | UniProt NCBI |
| THOC7 | THO complex subunit 7 homolog (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:774 | 1.30992062401e-07 | 0.333333333333 | THOC5 THOC7 THOC1 | THO complex |
| CORUM:6160 | 2.61903437064e-07 | 0.333333333333 | THOC5 THOC7 THOC1 | hTREX84 complex |
| CORUM:770 | 4.58189849981e-07 | 0.333333333333 | THOC5 THOC7 THOC1 | TREX complex |
| GO:0000346 | 1.09198397762e-06 | 0.444444444444 | THOC5 THOC7 SARNP THOC1 | transcription export complex |
| REAC:R-HSA-72187 | 5.28451792598e-06 | 0.444444444444 | THOC5 THOC7 SARNP THOC1 | mRNA 3'-end processing |
| REAC:R-HSA-73856 | 9.20935842442e-06 | 0.444444444444 | THOC5 THOC7 SARNP THOC1 | RNA Polymerase II Transcription Termination |
| GO:0006406 | 9.99904965201e-06 | 0.555555555556 | THOC5 THOC7 ALKBH5 THOC1 SARNP | mRNA export from nucleus |
| REAC:R-HSA-159236 | 1.41485573053e-05 | 0.444444444444 | THOC5 THOC7 SARNP THOC1 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| GO:0051028 | 1.56328999739e-05 | 0.555555555556 | THOC5 THOC7 ALKBH5 THOC1 SARNP | mRNA transport |
| REAC:R-HSA-72202 | 2.31277665371e-05 | 0.444444444444 | THOC5 THOC7 SARNP THOC1 | Transport of Mature Transcript to Cytoplasm |
| GO:0006405 | 3.65405136871e-05 | 0.555555555556 | THOC5 THOC7 ALKBH5 THOC1 SARNP | RNA export from nucleus |
| GO:0050658 | 0.000117830712316 | 0.555555555556 | THOC5 THOC7 ALKBH5 THOC1 SARNP | RNA transport |
| GO:0050657 | 0.000117830712316 | 0.555555555556 | THOC5 THOC7 ALKBH5 THOC1 SARNP | nucleic acid transport |
| GO:0051236 | 0.000135563471558 | 0.555555555556 | THOC5 THOC7 ALKBH5 THOC1 SARNP | establishment of RNA localization |
| GO:0000445 | 0.000161332517231 | 0.333333333333 | THOC5 THOC7 THOC1 | THO complex part of transcription export complex |
| GO:0000347 | 0.000161332517231 | 0.333333333333 | THOC5 THOC7 THOC1 | THO complex |
| GO:0046784 | 0.000282244947588 | 0.333333333333 | THOC5 THOC7 THOC1 | viral mRNA export from host cell nucleus |
| GO:0044417 | 0.000282244947588 | 0.333333333333 | THOC5 THOC7 THOC1 | translocation of molecules into host |
| GO:0006403 | 0.000458669588828 | 0.555555555556 | THOC5 THOC7 ALKBH5 THOC1 SARNP | RNA localization |
| GO:0051168 | 0.000492661158189 | 0.555555555556 | THOC5 THOC7 ALKBH5 THOC1 SARNP | nuclear export |
| GO:0015931 | 0.000627778360589 | 0.555555555556 | THOC5 THOC7 ALKBH5 THOC1 SARNP | nucleobase-containing compound transport |
| KEGG:03013 | 0.00131999171021 | 0.333333333333 | THOC5 THOC7 THOC1 | Nucleocytoplasmic transport |
| REAC:R-HSA-72203 | 0.0033511074443 | 0.444444444444 | THOC5 THOC7 SARNP THOC1 | Processing of Capped Intron-Containing Pre-mRNA |
| CORUM:351 | 0.00527216248346 | 0.333333333333 | THOC5 THOC7 THOC1 | Spliceosome |
| GO:0006913 | 0.00712903067205 | 0.555555555556 | THOC5 THOC7 ALKBH5 THOC1 SARNP | nucleocytoplasmic transport |
| GO:0051169 | 0.00712903067205 | 0.555555555556 | THOC5 THOC7 ALKBH5 THOC1 SARNP | nuclear transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| THOC7 | THOC1 | 1.0 | 0.55 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction | |
| THOC5 | THOC1 | 1.0 | 0.946 |
structurally_consistent (dimer)
|
hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 fraction |
| THOC7 | THOC5 | 1.0 | 0.522 |
structurally_consistent (Q86W42)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () Malo fraction |
| THOC1 | SARNP | 0.999 | 0.282 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| THOC5 | SARNP | 0.999 | 0.326 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| THOC7 | SARNP | 0.997 | 0.412 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| THOC1 | RBM27 | 0.995 | 0.298 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM hein () fraction | |
| KIF1C | THOC1 | 0.992 | 0.068 | hein_WMM bioplex3_WMM hein () | |
| THOC7 | KIF1C | 0.986 | 0.04 | hein_WMM bioplex3_WMM WMM_only | |
| KIF1C | SARNP | 0.986 | 0.174 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KIF1C | C19orf47 | 0.986 | 0.062 | hein_WMM bioplex3_WMM WMM_only | |
| THOC7 | RBM27 | 0.981 | 0.092 | hein_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction | |
| ALKBH5 | THOC1 | 0.977 | 0.052 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ALKBH5 | RBM27 | 0.974 | 0.05 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CCDC9B | THOC1 | 0.966 | 0.056 | hein_WMM hein () | |
| C19orf47 | THOC1 | 0.965 | 0.192 | hein_WMM hein () | |
| C19orf47 | THOC5 | 0.963 | 0.242 | hein_WMM hein () | |
| C19orf47 | SARNP | 0.953 | 0.148 | hein_WMM gupta_WMM WMM_only | |
| THOC7 | ALKBH5 | 0.939 | 0.062 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| THOC7 | CCDC9B | 0.934 | 0.05 | hein_WMM hein () | |
| THOC5 | RBM27 | 0.926 | 0.2 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| THOC7 | C19orf47 | 0.921 | 0.21 | hein_WMM bioplex3_HEK293 bioplex () bioplex3_WMM hein () | |
| THOC5 | ALKBH5 | 0.86 | 0.09 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| KIF1C | THOC5 | 0.803 | 0.072 | hein_WMM bioplex3_WMM hein () | |
| CCDC9B | SARNP | 0.781 | 0.09 | hein_WMM WMM_only | |
| CCDC9B | RBM27 | 0.781 | 0.066 | hein_WMM WMM_only | |
| C19orf47 | CCDC9B | 0.781 | 0.08 | hein_WMM WMM_only | |
| THOC5 | CCDC9B | 0.641 | 0.046 | hein_WMM WMM_only | |
| ALKBH5 | SARNP | 0.59 | 0.06 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| RBM27 | SARNP | 0.468 | 0.214 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| KIF1C | ALKBH5 | 0.397 | 0.076 | bioplex3_WMM WMM_only | |
| CCDC9B | ALKBH5 | 0.248 | 0.072 | hein_WMM WMM_only | |
| KIF1C | CCDC9B | 0.232 | 0.05 | hein_WMM WMM_only | |
| KIF1C | RBM27 | 0.216 | 0.038 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| C19orf47 | ALKBH5 | 0.192 | 0.136 | hein_WMM WMM_only | |
| C19orf47 | RBM27 | 0.192 | 0.22 | hein_WMM gupta_WMM WMM_only |
Related Complexes