hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08117.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| POLD4 | DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12) | 5 | UniProt NCBI |
| POLD2 | DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) | 5 | UniProt NCBI |
| POLD1 | DNA polymerase delta catalytic subunit (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase subunit delta p125) | 5 | UniProt NCBI |
| REV3L | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:297 | 2.80628050973e-09 | 0.75 | POLD4 POLD2 POLD1 | PCNA-DNA polymerase delta complex |
| REAC:R-HSA-110313 | 7.08856517497e-09 | 1.0 | REV3L POLD4 POLD2 POLD1 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-73893 | 1.71286585035e-08 | 1.0 | REV3L POLD4 POLD2 POLD1 | DNA Damage Bypass |
| CORUM:1107 | 5.8916765743e-08 | 0.75 | POLD4 POLD2 POLD1 | DNA synthesome core complex |
| WP:WP186 | 7.68605108093e-08 | 0.75 | POLD4 POLD2 POLD1 | Homologous recombination |
| CORUM:1098 | 8.41624867868e-08 | 0.75 | POLD4 POLD2 POLD1 | DNA synthesome complex (13 subunits) |
| GO:0042575 | 1.27484697239e-07 | 1.0 | REV3L POLD4 POLD2 POLD1 | DNA polymerase complex |
| WP:WP4946 | 1.54018354349e-07 | 1.0 | REV3L POLD4 POLD2 POLD1 | DNA repair pathways full network |
| CORUM:1108 | 2.0055636204e-07 | 0.75 | POLD4 POLD2 POLD1 | DNA synthesome complex (15 subunits) |
| CORUM:1099 | 2.55240443388e-07 | 0.75 | POLD4 POLD2 POLD1 | DNA synthesome complex (17 subunits) |
| CORUM:1111 | 2.55240443388e-07 | 0.75 | POLD4 POLD2 POLD1 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-5358606 | 5.10480886775e-07 | 0.75 | POLD4 POLD2 POLD1 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| REAC:R-HSA-69109 | 5.10480886775e-07 | 0.75 | POLD4 POLD2 POLD1 | Leading Strand Synthesis |
| REAC:R-HSA-69166 | 5.10480886775e-07 | 0.75 | POLD4 POLD2 POLD1 | Removal of the Flap Intermediate |
| REAC:R-HSA-5358565 | 5.10480886775e-07 | 0.75 | POLD4 POLD2 POLD1 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| REAC:R-HSA-69091 | 5.10480886775e-07 | 0.75 | POLD4 POLD2 POLD1 | Polymerase switching |
| KEGG:03430 | 6.07335157092e-07 | 0.75 | POLD4 POLD2 POLD1 | Mismatch repair |
| WP:WP531 | 6.18377614493e-07 | 0.75 | POLD4 POLD2 POLD1 | DNA mismatch repair |
| REAC:R-HSA-5358508 | 6.38068337719e-07 | 0.75 | POLD4 POLD2 POLD1 | Mismatch Repair |
| REAC:R-HSA-69183 | 6.38068337719e-07 | 0.75 | POLD4 POLD2 POLD1 | Processive synthesis on the lagging strand |
| REAC:R-HSA-174437 | 9.53498684462e-07 | 0.75 | POLD4 POLD2 POLD1 | Removal of the Flap Intermediate from the C-strand |
| REAC:R-HSA-174414 | 1.35859604357e-06 | 0.75 | POLD4 POLD2 POLD1 | Processive synthesis on the C-strand of the telomere |
| GO:0000731 | 1.37772935964e-06 | 1.0 | REV3L POLD4 POLD2 POLD1 | DNA synthesis involved in DNA repair |
| WP:WP4752 | 1.41711470375e-06 | 0.75 | POLD4 POLD2 POLD1 | Base excision repair |
| GO:0043625 | 1.53784171933e-06 | 0.75 | POLD4 POLD2 POLD1 | delta DNA polymerase complex |
| REAC:R-HSA-69186 | 1.59826617962e-06 | 0.75 | POLD4 POLD2 POLD1 | Lagging Strand Synthesis |
| REAC:R-HSA-5651801 | 1.86454808481e-06 | 0.75 | POLD4 POLD2 POLD1 | PCNA-Dependent Long Patch Base Excision Repair |
| KEGG:03030 | 2.44690940764e-06 | 0.75 | POLD4 POLD2 POLD1 | DNA replication |
| REAC:R-HSA-5696397 | 3.2237438451e-06 | 0.75 | POLD4 POLD2 POLD1 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-110373 | 3.2237438451e-06 | 0.75 | POLD4 POLD2 POLD1 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| KEGG:03440 | 3.38522311544e-06 | 0.75 | POLD4 POLD2 POLD1 | Homologous recombination |
| REAC:R-HSA-174411 | 3.64404491129e-06 | 0.75 | POLD4 POLD2 POLD1 | Polymerase switching on the C-strand of the telomere |
| WP:WP466 | 4.00454251624e-06 | 0.75 | POLD4 POLD2 POLD1 | DNA replication |
| KEGG:03410 | 4.22779284136e-06 | 0.75 | POLD4 POLD2 POLD1 | Base excision repair |
| WP:WP4753 | 4.30466180211e-06 | 0.75 | POLD4 POLD2 POLD1 | Nucleotide excision repair |
| REAC:R-HSA-110314 | 5.68914662089e-06 | 0.75 | POLD4 POLD2 POLD1 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-5656169 | 6.29837429836e-06 | 0.75 | POLD4 POLD2 POLD1 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 6.94957302308e-06 | 0.75 | POLD4 POLD2 POLD1 | DNA strand elongation |
| REAC:R-HSA-174417 | 8.38346160394e-06 | 0.75 | POLD4 POLD2 POLD1 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-73933 | 9.16893973468e-06 | 0.75 | POLD4 POLD2 POLD1 | Resolution of Abasic Sites (AP sites) |
| KEGG:03420 | 1.0562525866e-05 | 0.75 | POLD4 POLD2 POLD1 | Nucleotide excision repair |
| REAC:R-HSA-5696400 | 1.49290675587e-05 | 0.75 | POLD4 POLD2 POLD1 | Dual Incision in GG-NER |
| WP:WP5114 | 2.16610999348e-05 | 0.75 | POLD4 POLD2 POLD1 | Nucleotide excision repair in xeroderma pigmentosum |
| REAC:R-HSA-180786 | 2.91499008839e-05 | 0.75 | POLD4 POLD2 POLD1 | Extension of Telomeres |
| REAC:R-HSA-73894 | 3.4398535169e-05 | 1.0 | REV3L POLD4 POLD2 POLD1 | DNA Repair |
| REAC:R-HSA-6782210 | 5.55513549806e-05 | 0.75 | POLD4 POLD2 POLD1 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 5.82803880398e-05 | 0.75 | POLD4 POLD2 POLD1 | Dual incision in TC-NER |
| REAC:R-HSA-5685942 | 6.40033583955e-05 | 0.75 | POLD4 POLD2 POLD1 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-73884 | 9.82762051365e-05 | 0.75 | POLD4 POLD2 POLD1 | Base Excision Repair |
| REAC:R-HSA-6781827 | 0.000102255107087 | 0.75 | POLD4 POLD2 POLD1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-5696399 | 0.000128399139144 | 0.75 | POLD4 POLD2 POLD1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-157579 | 0.000225769742075 | 0.75 | POLD4 POLD2 POLD1 | Telomere Maintenance |
| REAC:R-HSA-5696398 | 0.000284930280132 | 0.75 | POLD4 POLD2 POLD1 | Nucleotide Excision Repair |
| GO:0003887 | 0.000372255315939 | 0.75 | POLD4 POLD1 REV3L | DNA-directed DNA polymerase activity |
| REAC:R-HSA-69239 | 0.000381938496194 | 0.75 | POLD4 POLD2 POLD1 | Synthesis of DNA |
| GO:0006261 | 0.000415139510394 | 1.0 | REV3L POLD4 POLD2 POLD1 | DNA-templated DNA replication |
| REAC:R-HSA-5693567 | 0.000422025999557 | 0.75 | POLD4 POLD2 POLD1 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| GO:0071897 | 0.000439465274636 | 1.0 | REV3L POLD4 POLD2 POLD1 | DNA biosynthetic process |
| REAC:R-HSA-73886 | 0.000464818544718 | 0.75 | POLD4 POLD2 POLD1 | Chromosome Maintenance |
| REAC:R-HSA-5693538 | 0.000487256563506 | 0.75 | POLD4 POLD2 POLD1 | Homology Directed Repair |
| GO:0043601 | 0.000591522022343 | 0.75 | POLD4 POLD2 POLD1 | nuclear replisome |
| GO:0019985 | 0.000680215375943 | 0.75 | REV3L POLD2 POLD1 | translesion synthesis |
| GO:0030894 | 0.000777349058504 | 0.75 | POLD4 POLD2 POLD1 | replisome |
| GO:0034061 | 0.000883305813556 | 0.75 | POLD4 POLD1 REV3L | DNA polymerase activity |
| REAC:R-HSA-5693532 | 0.000897810107574 | 0.75 | POLD4 POLD2 POLD1 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69242 | 0.000915028341188 | 0.75 | POLD4 POLD2 POLD1 | S Phase |
| REAC:R-HSA-69306 | 0.00120023774581 | 0.75 | POLD4 POLD2 POLD1 | DNA Replication |
| GO:0006301 | 0.00190418300832 | 0.75 | REV3L POLD2 POLD1 | postreplication repair |
| GO:0006260 | 0.00227782697336 | 1.0 | REV3L POLD4 POLD2 POLD1 | DNA replication |
| GO:0043596 | 0.00350727150095 | 0.75 | POLD4 POLD2 POLD1 | nuclear replication fork |
| GO:0061695 | 0.00622455085576 | 1.0 | REV3L POLD4 POLD2 POLD1 | transferase complex, transferring phosphorus-containing groups |
| GO:0005657 | 0.0167406494658 | 0.75 | POLD4 POLD2 POLD1 | replication fork |
| GO:0016035 | 0.0168521501606 | 0.5 | POLD2 REV3L | zeta DNA polymerase complex |
| REAC:R-HSA-69278 | 0.0329329593357 | 0.75 | POLD4 POLD2 POLD1 | Cell Cycle, Mitotic |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| POLD2 | POLD1 | 1.0 | 0.766 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 fraction |
| POLD4 | POLD1 | 0.999 | 0.214 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| POLD2 | REV3L | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| POLD2 | POLD4 | 0.996 | 0.122 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| POLD4 | REV3L | 0.912 | bioplex_WMM bioplex3_WMM WMM_only | |
| REV3L | POLD1 | 0.452 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| POLD4 | huMAP3_03515.1 huMAP3_04554.1 huMAP3_08117.1 huMAP3_13172.1 |
| POLD2 | huMAP3_03515.1 huMAP3_04554.1 huMAP3_08117.1 huMAP3_13172.1 |
| POLD1 | huMAP3_04554.1 huMAP3_07550.1 huMAP3_08117.1 |
| REV3L | huMAP3_03515.1 huMAP3_04554.1 huMAP3_08117.1 huMAP3_13172.1 |