hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08129.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta) | 5 | UniProt NCBI |
| ETHE1 | Persulfide dioxygenase ETHE1, mitochondrial (EC 1.13.11.18) (Ethylmalonic encephalopathy protein 1) (Hepatoma subtracted clone one protein) (Sulfur dioxygenase ETHE1) | 5 | UniProt NCBI |
| EIF2S3 | Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) | 5 | UniProt NCBI |
| EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha) | 5 | UniProt NCBI |
| CDC123 | Translation initiation factor eIF2 assembly protein (Cell division cycle protein 123 homolog) (Protein D123) (HT-1080) (PZ32) | 5 | UniProt NCBI |
| PRMT7 | Protein arginine N-methyltransferase 7 (EC 2.1.1.321) (Histone-arginine N-methyltransferase PRMT7) ([Myelin basic protein]-arginine N-methyltransferase PRMT7) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5183 | 0.000136445626745 | 0.4 | EIF2S3 EIF2S1 | DNA-PK-Ku-eIF2-NF90-NF45 complex |
| REAC:R-HSA-72731 | 0.000425287580531 | 0.4 | EIF2S3 EIF2S1 | Recycling of eIF2:GDP |
| WP:WP5027 | 0.000616503269292 | 0.4 | EIF2S3 EIF2S1 | nsp1 from SARS CoV 2 inhibits translation initiation in the host cell |
| REAC:R-HSA-9648895 | 0.0013810496636 | 0.4 | EIF2S3 EIF2S1 | Response of EIF2AK1 (HRI) to heme deficiency |
| HPA:0500111 | 0.00357058254398 | 1.0 | EIF2S3 CDC123 ETHE1 PRMT7 EIF2S1 | soft tissue 1; chondrocytes[>=Low] |
| WP:WP107 | 0.00687274586933 | 0.4 | EIF2S3 EIF2S1 | Translation factors |
| REAC:R-HSA-381042 | 0.00704059925156 | 0.4 | EIF2S3 EIF2S1 | PERK regulates gene expression |
| REAC:R-HSA-72695 | 0.0200193611976 | 0.4 | EIF2S3 EIF2S1 | Formation of the ternary complex, and subsequently, the 43S complex |
| REAC:R-HSA-72702 | 0.0258071378099 | 0.4 | EIF2S3 EIF2S1 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72649 | 0.0258071378099 | 0.4 | EIF2S3 EIF2S1 | Translation initiation complex formation |
| REAC:R-HSA-72662 | 0.0266933781073 | 0.4 | EIF2S3 EIF2S1 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| GO:0005850 | 0.0280843539964 | 0.4 | EIF2S3 EIF2S1 | eukaryotic translation initiation factor 2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EIF2S2 | EIF2S1 | 1.0 | 0.946 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| EIF2S3 | EIF2S2 | 1.0 | 0.97 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| EIF2S3 | EIF2S1 | 0.999 | 0.996 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| EIF2S2 | PRMT7 | 0.998 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| EIF2S1 | PRMT7 | 0.998 | 0.27 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| CDC123 | EIF2S2 | 0.993 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| EIF2S2 | ETHE1 | 0.951 | 0.036 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| EIF2S3 | PRMT7 | 0.76 | 0.208 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ETHE1 | PRMT7 | 0.596 | 0.0566 | bioplex3_WMM WMM_only |
| EIF2S3 | ETHE1 | 0.471 | 0.044 | bioplex3_WMM WMM_only |
| EIF2S3 | CDC123 | 0.418 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| CDC123 | EIF2S1 | 0.358 | 0.128 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| ETHE1 | EIF2S1 | 0.156 | 0.034 | bioplex3_WMM WMM_only |
| CDC123 | PRMT7 | 0.146 | 0.068 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CDC123 | ETHE1 | 0.058 | 0.02 | bioplex3_WMM WMM_only |
Related Complexes