hu.MAP 3.0: Complex View

Genename	Protein Name	Uniprot Annotation Score	Links
EIF2S2	Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta)	5	UniProt NCBI
ETHE1	Persulfide dioxygenase ETHE1, mitochondrial (EC 1.13.11.18) (Ethylmalonic encephalopathy protein 1) (Hepatoma subtracted clone one protein) (Sulfur dioxygenase ETHE1)	5	UniProt NCBI
EIF2S3	Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX)	5	UniProt NCBI
EIF2S1	Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha)	5	UniProt NCBI
CDC123	Translation initiation factor eIF2 assembly protein (Cell division cycle protein 123 homolog) (Protein D123) (HT-1080) (PZ32)	5	UniProt NCBI
PRMT7	Protein arginine N-methyltransferase 7 (EC 2.1.1.321) (Histone-arginine N-methyltransferase PRMT7) ([Myelin basic protein]-arginine N-methyltransferase PRMT7)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5183	0.000136445626745	0.4	EIF2S3 EIF2S1	DNA-PK-Ku-eIF2-NF90-NF45 complex
REAC:R-HSA-72731	0.000425287580531	0.4	EIF2S3 EIF2S1	Recycling of eIF2:GDP
WP:WP5027	0.000616503269292	0.4	EIF2S3 EIF2S1	nsp1 from SARS CoV 2 inhibits translation initiation in the host cell
REAC:R-HSA-9648895	0.0013810496636	0.4	EIF2S3 EIF2S1	Response of EIF2AK1 (HRI) to heme deficiency
HPA:0500111	0.00357058254398	1.0	PRMT7 EIF2S3 CDC123 ETHE1 EIF2S1	soft tissue 1; chondrocytes[>=Low]
WP:WP107	0.00687274586933	0.4	EIF2S3 EIF2S1	Translation factors
REAC:R-HSA-381042	0.00704059925156	0.4	EIF2S3 EIF2S1	PERK regulates gene expression
REAC:R-HSA-72695	0.0200193611976	0.4	EIF2S3 EIF2S1	Formation of the ternary complex, and subsequently, the 43S complex
REAC:R-HSA-72702	0.0258071378099	0.4	EIF2S3 EIF2S1	Ribosomal scanning and start codon recognition
REAC:R-HSA-72649	0.0258071378099	0.4	EIF2S3 EIF2S1	Translation initiation complex formation
REAC:R-HSA-72662	0.0266933781073	0.4	EIF2S3 EIF2S1	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
GO:0005850	0.0280843539964	0.4	EIF2S3 EIF2S1	eukaryotic translation initiation factor 2 complex

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
EIF2S2	EIF2S1	1.0	0.946		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 gupta_WMM fraction treiber_WMM
EIF2S3	EIF2S2	1.0	0.97		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction treiber_WMM
EIF2S3	EIF2S1	0.999	0.996	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 gupta_WMM fraction treiber_WMM
EIF2S2	PRMT7	0.998	0.09		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
EIF2S1	PRMT7	0.998	0.27	structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
CDC123	EIF2S2	0.993	0.068		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
EIF2S2	ETHE1	0.951	0.036		bioplex3_WMM bioplex3_HCT116 WMM_only
EIF2S3	PRMT7	0.76	0.208	structurally_consistent (P05198)	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ETHE1	PRMT7	0.596	0.0566		bioplex3_WMM WMM_only
EIF2S3	ETHE1	0.471	0.044		bioplex3_WMM WMM_only
EIF2S3	CDC123	0.418	0.04	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
CDC123	EIF2S1	0.358	0.128	mutually_exclusive (P41091)	bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only
ETHE1	EIF2S1	0.156	0.034		bioplex3_WMM WMM_only
CDC123	PRMT7	0.146	0.068		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
CDC123	ETHE1	0.058	0.02		bioplex3_WMM WMM_only

Genename	Complexes
EIF2S2	huMAP3_00857.1 huMAP3_05497.1 huMAP3_08129.1 huMAP3_11650.1
ETHE1	huMAP3_00857.1 huMAP3_01381.1 huMAP3_06879.1 huMAP3_07034.1 huMAP3_08059.1 huMAP3_08129.1 huMAP3_11650.1 huMAP3_12201.1
EIF2S3	huMAP3_00857.1 huMAP3_05497.1 huMAP3_08129.1 huMAP3_11650.1 huMAP3_15083.1
EIF2S1	huMAP3_05497.1 huMAP3_08129.1 huMAP3_11650.1 huMAP3_11970.1
CDC123	huMAP3_00857.1 huMAP3_01420.1 huMAP3_08129.1 huMAP3_09124.1
PRMT7	huMAP3_08129.1 huMAP3_11178.1 huMAP3_11650.1 huMAP3_13289.1