hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08131.1
Confidence: High  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
FAM43A | Protein FAM43A | 2 | UniProt   NCBI |
FTH1 | Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed] | 5 | UniProt   NCBI |
PEX10 | Peroxisome biogenesis factor 10 (EC 2.3.2.27) (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) (RING finger protein 69) | 5 | UniProt   NCBI |
MOK | MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1) | 5 | UniProt   NCBI |
COQ10B | Coenzyme Q-binding protein COQ10 homolog B, mitochondrial | 3 | UniProt   NCBI |
NEK5 | Serine/threonine-protein kinase Nek5 (EC 2.7.11.1) (Never in mitosis A-related kinase 5) (NimA-related protein kinase 5) | 3 | UniProt   NCBI |
NCOA4 | Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ret-activating protein ELE1) | 5 | UniProt   NCBI |
PSKH1 | Serine/threonine-protein kinase H1 (EC 2.7.11.1) (Protein serine kinase H1) (PSK-H1) | 5 | UniProt   NCBI |
KMT5C | Histone-lysine N-methyltransferase KMT5C (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361) | 5 | UniProt   NCBI |
FTL | Ferritin light chain (Ferritin L subunit) | 5 | UniProt   NCBI |
TRNP1 | TMF-regulated nuclear protein 1 | 3 | UniProt   NCBI |
ARHGEF39 | Rho guanine nucleotide exchange factor 39 | 4 | UniProt   NCBI |
ERCC6L2 | DNA excision repair protein ERCC-6-like 2 (EC 3.6.4.-) (DNA repair and recombination protein RAD26-like) | 5 | UniProt   NCBI |
TRIM25 | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | 5 | UniProt   NCBI |
AGTPBP1 | Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (EC 3.4.17.24) (ATP/GTP-binding protein 1) (Nervous system nuclear protein induced by axotomy protein 1 homolog) (Protein deglutamylase CCP1) | 5 | UniProt   NCBI |
DUSP5 | Dual specificity protein phosphatase 5 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH3) | 5 | UniProt   NCBI |
RBBP8 | DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2) | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  CORUM:6135 | 5.10764421909e-05 | 0.125 | FTH1 FTL | Ferritin complex |
  KEGG:04216 | 0.000445969229683 | 0.1875 | FTL FTH1 NCOA4 | Ferroptosis |
  GO:0044754 | 0.00300428100757 | 0.1875 | FTL FTH1 NCOA4 | autolysosome |
  WP:WP4313 | 0.00356572079019 | 0.1875 | FTL FTH1 NCOA4 | Ferroptosis |
  GO:0005767 | 0.00883419058623 | 0.1875 | FTL FTH1 NCOA4 | secondary lysosome |
  WP:WP5172 | 0.00969192001799 | 0.125 | FTH1 FTL | Iron metabolism disorders |
  HP:0040135 | 0.043773961294 | 0.125 | FTH1 FTL | Abnormal transferrin saturation |
  REAC:R-HSA-3000480 | 0.0442583139424 | 0.125 | FTH1 FTL | Scavenging by Class A Receptors |
  CORUM:2717 | 0.0497620750785 | 0.0625 | TRIM25 | Ubiquitin E3 ligase (TRIM25, DDX58) |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD |
---|---|---|---|
 FTH1 |  NCOA4 | 0.999 | 0.184           |
 FTL |  FTH1 | 0.999 | 0.462           |
 FTL |  NCOA4 | 0.998 | 0.136           |
 FTH1 |  FAM43A | 0.998 |            |
 FTL |  AGTPBP1 | 0.997 | 0.243090909091           |
 FTL |  RBBP8 | 0.996 | 0.23           |
 KMT5C |  FTL | 0.994 | 0.126           |
 MOK |  FTL | 0.992 |            |
 PSKH1 |  FTL | 0.991 |            |
 FTL |  TRIM25 | 0.989 | 0.28           |
 COQ10B |  FTL | 0.988 | 0.178           |
 FTL |  DUSP5 | 0.979 |            |
 FTL |  ERCC6L2 | 0.974 |            |
 FTL |  FAM43A | 0.972 |            |
 NEK5 |  FTL | 0.964 |            |
 FTL |  ARHGEF39 | 0.953 |            |
 FTL |  PEX10 | 0.953 | 0.13           |
 FTL |  TRNP1 | 0.953 |            |
 COQ10B |  KMT5C | 0.946 | 0.094           |
 COQ10B |  PSKH1 | 0.946 |            |
 COQ10B |  FAM43A | 0.933 |            |
 MOK |  COQ10B | 0.931 |            |
 COQ10B |  RBBP8 | 0.905 | 0.186           |
 NEK5 |  FAM43A | 0.904 |            |
 TRNP1 |  FAM43A | 0.904 |            |
 MOK |  NEK5 | 0.904 |            |
 NEK5 |  ERCC6L2 | 0.902 |            |
 KMT5C |  ERCC6L2 | 0.902 |            |
 NEK5 |  PSKH1 | 0.902 |            |
 NEK5 |  KMT5C | 0.902 |            |
 PSKH1 |  ERCC6L2 | 0.902 |            |
 COQ10B |  NEK5 | 0.902 |            |
 COQ10B |  ERCC6L2 | 0.902 |            |
 TRNP1 |  DUSP5 | 0.902 |            |
 KMT5C |  TRNP1 | 0.902 |            |
 NEK5 |  DUSP5 | 0.902 |            |
 TRNP1 |  ERCC6L2 | 0.902 |            |
 KMT5C |  DUSP5 | 0.902 |            |
 ERCC6L2 |  DUSP5 | 0.902 |            |
 PSKH1 |  TRNP1 | 0.902 |            |
 NEK5 |  TRNP1 | 0.902 |            |
 COQ10B |  DUSP5 | 0.902 |            |
 PSKH1 |  DUSP5 | 0.902 |            |
 ERCC6L2 |  NCOA4 | 0.902 |            |
 ERCC6L2 |  RBBP8 | 0.902 |            |
 ERCC6L2 |  FAM43A | 0.902 |            |
 COQ10B |  TRNP1 | 0.902 |            |
 MOK |  ERCC6L2 | 0.902 |            |
 MOK |  KMT5C | 0.897 |            |
 DUSP5 |  FAM43A | 0.892 |            |
 NEK5 |  NCOA4 | 0.892 |            |
 COQ10B |  NCOA4 | 0.892 | 0.086           |
 ERCC6L2 |  AGTPBP1 | 0.892 |            |
 NEK5 |  RBBP8 | 0.869 |            |
 COQ10B |  AGTPBP1 | 0.826 | 0.096           |
 AGTPBP1 |  FAM43A | 0.82 |            |
 KMT5C |  RBBP8 | 0.804 | 0.152           |
 PSKH1 |  RBBP8 | 0.804 |            |
 PSKH1 |  FAM43A | 0.804 |            |
 KMT5C |  AGTPBP1 | 0.804 | 0.15           |
 KMT5C |  FAM43A | 0.804 |            |
 PSKH1 |  AGTPBP1 | 0.804 |            |
 MOK |  PSKH1 | 0.804 |            |
 PSKH1 |  NCOA4 | 0.796 |            |
 KMT5C |  NCOA4 | 0.796 | 0.092           |
 PSKH1 |  KMT5C | 0.793 |            |
 MOK |  ARHGEF39 | 0.792 |            |
 NEK5 |  AGTPBP1 | 0.768 |            |
 TRNP1 |  AGTPBP1 | 0.768 |            |
 MOK |  TRNP1 | 0.722 |            |
 AGTPBP1 |  DUSP5 | 0.715 |            |
 TRNP1 |  NCOA4 | 0.696 |            |
 TRNP1 |  RBBP8 | 0.647 |            |
 DUSP5 |  TRIM25 | 0.605 |            |
 RBBP8 |  FAM43A | 0.561 |            |
 MOK |  FAM43A | 0.561 |            |
 MOK |  AGTPBP1 | 0.561 |            |
 AGTPBP1 |  RBBP8 | 0.561 | 0.178           |
 MOK |  RBBP8 | 0.539 |            |
 AGTPBP1 |  NCOA4 | 0.524 | 0.104           |
 NCOA4 |  FAM43A | 0.522 |            |
 AGTPBP1 |  FTH1 | 0.483 | 0.122           |
 MOK |  DUSP5 | 0.478 |            |
 DUSP5 |  NCOA4 | 0.478 |            |
 RBBP8 |  NCOA4 | 0.477 | 0.184           |
 MOK |  NCOA4 | 0.477 |            |
 PSKH1 |  FTH1 | 0.44 |            |
 KMT5C |  FTH1 | 0.44 | 0.068           |
 DUSP5 |  RBBP8 | 0.427 |            |
 KMT5C |  ARHGEF39 | 0.387 |            |
 COQ10B |  FTH1 | 0.383 | 0.062           |
 ERCC6L2 |  FTH1 | 0.332 |            |
 NEK5 |  FTH1 | 0.312 |            |
 RBBP8 |  FTH1 | 0.304 | 0.148           |
 MOK |  FTH1 | 0.284 |            |
 DUSP5 |  FTH1 | 0.256 |            |
 KMT5C |  TRIM25 | 0.242 | 0.23           |
 PSKH1 |  TRIM25 | 0.242 |            |
 TRNP1 |  FTH1 | 0.228 |            |
 ERCC6L2 |  PEX10 | 0.214 |            |
 COQ10B |  PEX10 | 0.21 | 0.142           |
 TRIM25 |  NCOA4 | 0.192 | 0.329894889904           |
 TRIM25 |  FAM43A | 0.165 |            |
 MOK |  TRIM25 | 0.165 |            |
 ERCC6L2 |  TRIM25 | 0.162 |            |
 ERCC6L2 |  ARHGEF39 | 0.146 |            |
 NEK5 |  TRIM25 | 0.13 |            |
 TRIM25 |  RBBP8 | 0.128 | 0.354           |
 COQ10B |  ARHGEF39 | 0.113 |            |
 TRNP1 |  PEX10 | 0.108 |            |
 NEK5 |  PEX10 | 0.108 |            |
 COQ10B |  TRIM25 | 0.107 | 0.262           |
 NCOA4 |  ARHGEF39 | 0.106 |            |
 PEX10 |  NCOA4 | 0.106 | 0.102           |
 AGTPBP1 |  ARHGEF39 | 0.104 |            |
 TRNP1 |  TRIM25 | 0.101 |            |
 AGTPBP1 |  PEX10 | 0.095 | 0.106           |
 TRIM25 |  ARHGEF39 | 0.095 |            |
 FTH1 |  ARHGEF39 | 0.092 |            |
 PEX10 |  RBBP8 | 0.082 | 0.18           |
 PSKH1 |  PEX10 | 0.079 |            |
 PEX10 |  ARHGEF39 | 0.079 |            |
 MOK |  PEX10 | 0.079 |            |
 KMT5C |  PEX10 | 0.079 | 0.098           |
 RBBP8 |  ARHGEF39 | 0.079 |            |
 PSKH1 |  ARHGEF39 | 0.079 |            |
 ARHGEF39 |  FAM43A | 0.079 |            |
 PEX10 |  FAM43A | 0.079 |            |
 PEX10 |  FTH1 | 0.071 | 0.176           |
 TRIM25 |  PEX10 | 0.055 | 0.272713855422           |
 TRNP1 |  ARHGEF39 | 0.055 |            |
 NEK5 |  ARHGEF39 | 0.055 |            |
 DUSP5 |  ARHGEF39 | 0.046 |            |
 DUSP5 |  PEX10 | 0.046 |            |
 TRIM25 |  FTH1 | 0.037 | 0.2334           |
 AGTPBP1 |  TRIM25 | 0.034 | 0.321068870523           |
Related Complexes