hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08133.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HCN4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 5 | UniProt NCBI |
| HCN2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) | 5 | UniProt NCBI |
| HCN3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1296061 | 1.86640856459e-09 | 1.0 | HCN4 HCN2 HCN3 | HCN channels |
| GO:0098855 | 3.84480164306e-07 | 1.0 | HCN4 HCN2 HCN3 | HCN channel complex |
| REAC:R-HSA-1296071 | 2.13517139789e-05 | 1.0 | HCN4 HCN2 HCN3 | Potassium Channels |
| WP:WP1992 | 2.37821910987e-05 | 0.666666666667 | HCN4 HCN2 | Genes targeted by miRNAs in adipocytes |
| GO:0005248 | 4.37346186898e-05 | 1.0 | HCN4 HCN2 HCN3 | voltage-gated sodium channel activity |
| GO:0003254 | 0.000249912106799 | 1.0 | HCN4 HCN2 HCN3 | regulation of membrane depolarization |
| GO:0005272 | 0.000281151120149 | 1.0 | HCN4 HCN2 HCN3 | sodium channel activity |
| KEGG:04929 | 0.000754254484718 | 0.666666666667 | HCN3 HCN2 | GnRH secretion |
| GO:0051899 | 0.00102463963787 | 1.0 | HCN4 HCN2 HCN3 | membrane depolarization |
| GO:0005249 | 0.0018839528051 | 1.0 | HCN4 HCN2 HCN3 | voltage-gated potassium channel activity |
| REAC:R-HSA-112316 | 0.00203732306248 | 1.0 | HCN4 HCN2 HCN3 | Neuronal System |
| GO:0008076 | 0.00238416149886 | 1.0 | HCN4 HCN2 HCN3 | voltage-gated potassium channel complex |
| GO:0005267 | 0.00345936027834 | 1.0 | HCN4 HCN2 HCN3 | potassium channel activity |
| GO:0034705 | 0.00345936027834 | 1.0 | HCN4 HCN2 HCN3 | potassium channel complex |
| GO:0022843 | 0.00851239083773 | 1.0 | HCN4 HCN2 HCN3 | voltage-gated monoatomic cation channel activity |
| GO:0035725 | 0.00915870199393 | 1.0 | HCN4 HCN2 HCN3 | sodium ion transmembrane transport |
| KEGG:04024 | 0.00940070336911 | 0.666666666667 | HCN4 HCN2 | cAMP signaling pathway |
| GO:0015079 | 0.00949377645712 | 1.0 | HCN4 HCN2 HCN3 | potassium ion transmembrane transporter activity |
| GO:0015081 | 0.0109157763448 | 1.0 | HCN4 HCN2 HCN3 | sodium ion transmembrane transporter activity |
| GO:0070305 | 0.0140440992017 | 0.666666666667 | HCN4 HCN2 | response to cGMP |
| GO:0071321 | 0.0140440992017 | 0.666666666667 | HCN4 HCN2 | cellular response to cGMP |
| GO:0022832 | 0.0150763323228 | 1.0 | HCN4 HCN2 HCN3 | voltage-gated channel activity |
| GO:0005244 | 0.0150763323228 | 1.0 | HCN4 HCN2 HCN3 | voltage-gated monoatomic ion channel activity |
| GO:0006814 | 0.0213208669114 | 1.0 | HCN4 HCN2 HCN3 | sodium ion transport |
| GO:0071805 | 0.0290879429506 | 1.0 | HCN4 HCN2 HCN3 | potassium ion transmembrane transport |
| GO:0005222 | 0.0294899169624 | 0.666666666667 | HCN4 HCN2 | intracellular cAMP-activated cation channel activity |
| GO:0034703 | 0.0343879058955 | 1.0 | HCN4 HCN2 HCN3 | cation channel complex |
| GO:0006813 | 0.0360123345897 | 1.0 | HCN4 HCN2 HCN3 | potassium ion transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HCN4 | HCN2 | 0.985 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| HCN4 | HCN3 | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| HCN2 | HCN3 | 0.391 | bioplex3_WMM WMM_only |
Related Complexes