hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08143.1

Complex Portal: CPX-16991

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
H4C1	Histone H4	5	UniProt NCBI
H3-3A	Histone H3.3	5	UniProt NCBI
ASF1A	Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA)	5	UniProt NCBI
PAN3	PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3)	5	UniProt NCBI
ATRX	Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)	5	UniProt NCBI
TLK1	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1)	5	UniProt NCBI
HIRA	Protein HIRA (TUP1-like enhancer of split protein 1)	5	UniProt NCBI
TONSL	Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2)	5	UniProt NCBI
CABIN1	Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN)	5	UniProt NCBI
CDIN1	CDAN1-interacting nuclease 1 (Protein HH114)	5	UniProt NCBI
ASF1B	Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II)	5	UniProt NCBI
MMS22L	Protein MMS22-like (Methyl methanesulfonate-sensitivity protein 22-like)	5	UniProt NCBI
NPAT	Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220)	5	UniProt NCBI
H3-7	Histone H3-7	4	UniProt NCBI
PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2)	5	UniProt NCBI
UBN2	Ubinuclein-2	3	UniProt NCBI
IPO4	Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4)	5	UniProt NCBI
NASP	Nuclear autoantigenic sperm protein (NASP)	5	UniProt NCBI
CDAN1	Codanin-1	5	UniProt NCBI
HAT1	Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1)	5	UniProt NCBI
UBN1	Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1150	5.35713445384e-16	0.315789473684	ASF1A HAT1 ASF1B IPO4 HIRA NASP	Histone H3.3 complex
CORUM:1149	4.46514160395e-12	0.263157894737	ASF1B HAT1 ASF1A NASP IPO4	Histone H3.1 complex
GO:0006334	2.24622950773e-09	0.421052631579	ASF1B ASF1A CABIN1 HAT1 ATRX NASP UBN1 HIRA	nucleosome assembly
GO:0034728	1.08649477658e-08	0.421052631579	ASF1B ASF1A CABIN1 HAT1 ATRX NASP UBN1 HIRA	nucleosome organization
CORUM:6149	7.10994807657e-08	0.157894736842	ASF1A CDAN1 IPO4	Codanin-1-Asf1-histone H3.1-histone H4-importin-4 complex, cytosolic
CORUM:7383	2.84164363312e-07	0.157894736842	CABIN1 HIRA UBN1	OGT-HIRA complex
CORUM:7382	2.84164363312e-07	0.157894736842	CABIN1 HIRA UBN1	Prohibitin-HIRA complex
CORUM:2235	7.0982748846e-07	0.157894736842	ASF1B ASF1A HIRA	ASF1-interacting protein complex
GO:0065004	7.20645907084e-07	0.421052631579	ASF1B ASF1A CABIN1 HAT1 ATRX NASP UBN1 HIRA	protein-DNA complex assembly
REAC:R-HSA-2559584	8.26111415449e-07	0.210526315789	UBN1 CABIN1 ASF1A HIRA	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
CORUM:2236	1.41848909562e-06	0.157894736842	ASF1B ASF1A NASP	ASF1-histone containing complex
GO:0006325	2.78633042066e-06	0.526315789474	ASF1B ASF1A CABIN1 HAT1 TLK1 UBN1 ATRX NASP CDAN1 HIRA	chromatin organization
GO:0071824	1.17746128653e-05	0.526315789474	ASF1B ASF1A CABIN1 HAT1 TLK1 UBN1 ATRX NASP CDAN1 HIRA	protein-DNA complex organization
REAC:R-HSA-2559586	0.000444463627244	0.210526315789	UBN1 CABIN1 ASF1A HIRA	DNA Damage/Telomere Stress Induced Senescence
GO:0006338	0.000803570621614	0.421052631579	ASF1B ASF1A CABIN1 HAT1 ATRX NASP UBN1 HIRA	chromatin remodeling
GO:0006335	0.00185822071527	0.157894736842	ASF1B ASF1A NASP	DNA replication-dependent chromatin assembly
GO:0042393	0.00873520889345	0.315789473684	ASF1A ASF1B TONSL ATRX NASP HIRA	histone binding
GO:0031297	0.0146920699411	0.210526315789	MMS22L ATRX ASF1A TONSL	replication fork processing
REAC:R-HSA-2559583	0.0200285034662	0.210526315789	UBN1 CABIN1 ASF1A HIRA	Cellular Senescence
GO:0045005	0.0265423485334	0.210526315789	MMS22L ATRX ASF1A TONSL	DNA-templated DNA replication maintenance of fidelity

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
ASF1A	HIRA	1.0	0.086	structurally_consistent (dimer)
HIRA	ASF1B	1.0	0.054	structurally_consistent (dimer)
UBN2	ASF1A	1.0	0.09
CABIN1	ASF1A	1.0	0.032
IPO4	ASF1A	0.999	0.05
IPO4	ASF1B	0.999	0.074
TLK1	ASF1B	0.999	0.044	structurally_consistent (dimer)
TLK1	ASF1A	0.999	0.086	structurally_consistent (Q86UE8) structurally_consistent (dimer)
CABIN1	HIRA	0.999	0.252
ASF1B	HAT1	0.999	0.422	structurally_consistent (dimer)
ASF1A	UBN1	0.999	0.07	structurally_consistent (dimer)
ASF1A	PAN3	0.999	0.056
ASF1A	PAN2	0.998	0.068
UBN2	HIRA	0.998	0.266
ASF1B	NASP	0.998		structurally_consistent (dimer)
MMS22L	H4C1	0.998	0.511970984007
H4C1	HAT1	0.998	0.347671230091	structurally_consistent (dimer)
CABIN1	ASF1B	0.997	0.03
ASF1A	CDAN1	0.997	0.114
UBN2	ASF1B	0.997	0.096
CABIN1	UBN2	0.997	0.174
ASF1B	H4C1	0.997	0.322
ASF1A	H4C1	0.997	0.253392125046	structurally_consistent (dimer)
ASF1B	UBN1	0.997	0.036	structurally_consistent (dimer)
H4C1	NASP	0.997		structurally_consistent (dimer)
TONSL	H4C1	0.996	0.298537142857
PAN2	PAN3	0.996	0.19
ASF1A	HAT1	0.995	0.364	mixed_interface
CDIN1	ASF1A	0.994	0.114	structurally_consistent (dimer)
ASF1A	H3-3A	0.994	0.207550390786	structurally_consistent (dimer)
ATRX	H4C1	0.993	0.490862888483
ASF1A	NASP	0.993		structurally_consistent (dimer)
ASF1A	ASF1B	0.991	0.136	mutually_exclusive (P49321)
CDAN1	ASF1B	0.991	0.088	structurally_consistent (dimer)
ASF1B	TONSL	0.989	0.15
H4C1	H3-3A	0.988	0.946	mutually_exclusive (Q5TEC6)
NASP	HAT1	0.984		structurally_consistent (dimer)
ASF1A	TONSL	0.984	0.097
H3-3A	NASP	0.984
ASF1B	PAN3	0.983	0.024
H4C1	NPAT	0.982	0.612
CDIN1	ASF1B	0.982	0.044	structurally_consistent (dimer)
HIRA	UBN1	0.975	0.404	mutually_exclusive (Q9Y294)
UBN2	UBN1	0.972	0.094
HAT1	NPAT	0.969	0.158
ASF1B	H3-3A	0.964	0.282947368421	structurally_consistent (dimer)
ATRX	H3-3A	0.962	0.37697029703
HIRA	H4C1	0.958	0.681310344828
TLK1	HIRA	0.956	0.124	mutually_exclusive (Q9Y294)
IPO4	H4C1	0.956	0.441090909091
ASF1B	NPAT	0.952	0.104
ASF1B	PAN2	0.951	0.032
ASF1B	MMS22L	0.95	0.132
HIRA	HAT1	0.935	0.088
TONSL	MMS22L	0.909	0.452
HIRA	H3-3A	0.897	0.466770053476	mutually_exclusive (Q9Y294)
TLK1	UBN1	0.894	0.158	mutually_exclusive (Q9NVP2)
IPO4	H3-3A	0.892	0.228
CABIN1	UBN1	0.884	0.124
UBN2	H3-3A	0.847	0.180831683168
H3-3A	HAT1	0.841	0.261168408827
NASP	NPAT	0.832
HIRA	NASP	0.823		mutually_exclusive (Q9NVP2)
TLK1	UBN2	0.806	0.154
TLK1	CABIN1	0.806	0.056
CDIN1	CDAN1	0.802	0.098	mutually_exclusive (Q9NVP2)
TONSL	NASP	0.801
IPO4	HIRA	0.794	0.144
TONSL	HAT1	0.781	0.05
TLK1	CDAN1	0.772	0.13
CDAN1	PAN2	0.756	0.09
TLK1	CDIN1	0.72	0.19
ASF1A	NPAT	0.717	0.19
CABIN1	PAN2	0.704	0.088
UBN2	HAT1	0.699	0.144
CABIN1	NASP	0.689
UBN1	PAN2	0.669	0.066
TLK1	NASP	0.666
IPO4	TONSL	0.656	0.052
TLK1	IPO4	0.65	0.016
CABIN1	CDAN1	0.648	0.068
CDAN1	UBN1	0.645	0.04	mutually_exclusive (Q9NVP2)
TLK1	HAT1	0.638	0.06
CDIN1	UBN1	0.634	0.122	mutually_exclusive (Q9NVP2)
UBN2	CDAN1	0.634	0.072
CDIN1	H4C1	0.624	0.316666666667
IPO4	HAT1	0.619	0.108
IPO4	NASP	0.618
UBN2	NASP	0.616
CABIN1	HAT1	0.612	0.074
CDAN1	PAN3	0.608	0.096
CDAN1	H4C1	0.607	0.450155774427
ATRX	NPAT	0.596	0.136
CDIN1	PAN2	0.58	0.104
HIRA	PAN2	0.564	0.148
CDIN1	CABIN1	0.563	0.162
CDIN1	UBN2	0.549	0.092
UBN1	NASP	0.538		mutually_exclusive (Q9NVP2)
CABIN1	H3-3A	0.535	0.586147146563
TLK1	PAN2	0.533	0.076
CABIN1	PAN3	0.526	0.216
TLK1	PAN3	0.525	0.084
CDIN1	PAN3	0.525	0.14
TONSL	H3-3A	0.523	0.292
UBN1	PAN3	0.511	0.184
IPO4	NPAT	0.51	0.072
IPO4	UBN1	0.496	0.06
TLK1	H4C1	0.492	0.480004130376
CABIN1	H4C1	0.474	0.556050941307
UBN2	H4C1	0.466	0.389844035015
HIRA	PAN3	0.461	0.232
TONSL	NPAT	0.46	0.088
CDIN1	HAT1	0.44	0.12
HIRA	CDAN1	0.425	0.082
ASF1A	MMS22L	0.411	0.174
CDAN1	H3-3A	0.401	0.670226741095
MMS22L	ATRX	0.394	0.11
MMS22L	NASP	0.386
CDIN1	H3-3A	0.378	0.414	mutually_exclusive (Q9NVP2)
MMS22L	NPAT	0.375	0.106
CDIN1	HIRA	0.37	0.084	mutually_exclusive (Q9Y294)
MMS22L	HAT1	0.358	0.166
CDAN1	HAT1	0.354	0.104
UBN2	PAN2	0.34	0.134
TLK1	H3-3A	0.334	0.316411214953
ASF1A	ATRX	0.331	0.066
ASF1B	ATRX	0.32	0.012
CDIN1	NASP	0.312
UBN1	H3-3A	0.305	0.447817528736	mutually_exclusive (Q9NVP2)
H3-3A	NPAT	0.293	0.53073458445
TONSL	ATRX	0.283	0.026
TLK1	MMS22L	0.278	0.11
IPO4	MMS22L	0.263	0.146
TONSL	UBN1	0.263	0.062
HIRA	MMS22L	0.239	0.102
HIRA	ATRX	0.239	0.178
IPO4	ATRX	0.237	0.066
CDIN1	TONSL	0.234	0.082
CDAN1	TONSL	0.234	0.134
IPO4	PAN2	0.231	0.044
HIRA	TONSL	0.226	0.074
IPO4	CDAN1	0.194	0.104
UBN2	PAN3	0.192	0.098
CDAN1	MMS22L	0.187	0.194
CDIN1	MMS22L	0.187	0.126
CDAN1	NASP	0.183
MMS22L	PAN3	0.183	0.072
UBN1	H4C1	0.182	0.556615384615
CDIN1	IPO4	0.181	0.07
UBN2	TONSL	0.18	0.112
CABIN1	TONSL	0.18	0.038
PAN2	NASP	0.179
TLK1	TONSL	0.165	0.04
UBN1	MMS22L	0.165	0.07
TONSL	PAN2	0.163	0.06
ATRX	NASP	0.157
CABIN1	IPO4	0.157	0.052
MMS22L	PAN2	0.151	0.108
TONSL	PAN3	0.141	0.088
UBN1	HAT1	0.137	0.098	mutually_exclusive (Q9NVP2)
PAN2	H3-3A	0.133	0.407734328941
UBN2	MMS22L	0.131	0.084
PAN2	HAT1	0.123	0.108
UBN2	ATRX	0.121	0.124
UBN2	IPO4	0.116	0.066
CABIN1	ATRX	0.102	0.128
CABIN1	MMS22L	0.1	0.106
HIRA	NPAT	0.098	0.15
PAN2	H4C1	0.086	0.691217881944
PAN3	H3-3A	0.077	0.266420478279
UBN2	NPAT	0.076	0.158
PAN3	H4C1	0.074	0.531671196604
IPO4	PAN3	0.073	0.072
CABIN1	NPAT	0.062	0.206
ATRX	HAT1	0.051	0.1
MMS22L	H3-3A	0.042	0.499328451883
UBN1	ATRX	0.034	0.116
PAN3	HAT1	0.03	0.082
PAN3	NASP	0.027
PAN2	ATRX	0.006	0.128
PAN3	ATRX	0.005	0.17

Related Complexes

Genename	Complexes
H4C1	huMAP3_01440.1 huMAP3_05517.1 huMAP3_05966.1 huMAP3_06020.1 huMAP3_07824.1 huMAP3_08143.1 huMAP3_09048.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_10862.1 huMAP3_12711.1
H3-3A	huMAP3_01440.1 huMAP3_05966.1 huMAP3_08143.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_12711.1
ASF1A	huMAP3_00115.1 huMAP3_00724.1 huMAP3_05517.1 huMAP3_06020.1 huMAP3_06779.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_11834.1 huMAP3_12711.1 huMAP3_12963.1
PAN3	huMAP3_00724.1 huMAP3_02330.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09764.1 huMAP3_09859.1 huMAP3_11834.1 huMAP3_12015.1 huMAP3_12538.1 huMAP3_12711.1 huMAP3_12963.1 huMAP3_13022.1 huMAP3_15185.1
ATRX	huMAP3_01346.1 huMAP3_01440.1 huMAP3_05966.1 huMAP3_06469.1 huMAP3_08143.1 huMAP3_09859.1 huMAP3_10512.1 huMAP3_10747.1 huMAP3_11539.1
TLK1	huMAP3_00115.1 huMAP3_01778.1 huMAP3_01879.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_10933.1 huMAP3_12566.1 huMAP3_12711.1 huMAP3_12963.1
HIRA	huMAP3_00115.1 huMAP3_00724.1 huMAP3_01912.1 huMAP3_05517.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_11834.1 huMAP3_12711.1 huMAP3_12963.1
TONSL	huMAP3_00115.1 huMAP3_05517.1 huMAP3_06020.1 huMAP3_06779.1 huMAP3_07824.1 huMAP3_08143.1 huMAP3_09466.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_10862.1 huMAP3_12711.1 huMAP3_14306.1
CABIN1	huMAP3_00115.1 huMAP3_00724.1 huMAP3_01912.1 huMAP3_05517.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_11834.1 huMAP3_12711.1 huMAP3_12963.1
CDIN1	huMAP3_00115.1 huMAP3_00724.1 huMAP3_06020.1 huMAP3_06779.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_11832.1 huMAP3_11834.1 huMAP3_12711.1 huMAP3_12963.1
ASF1B	huMAP3_00115.1 huMAP3_00724.1 huMAP3_05517.1 huMAP3_06020.1 huMAP3_06779.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_11834.1 huMAP3_12711.1 huMAP3_12963.1
MMS22L	huMAP3_00545.1 huMAP3_02289.1 huMAP3_03836.1 huMAP3_06020.1 huMAP3_06779.1 huMAP3_07824.1 huMAP3_08143.1 huMAP3_09048.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_10862.1 huMAP3_12711.1 huMAP3_14306.1
NPAT	huMAP3_01440.1 huMAP3_06020.1 huMAP3_06779.1 huMAP3_07299.1 huMAP3_08143.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_12711.1 huMAP3_15128.1
H3-7	huMAP3_01440.1 huMAP3_04941.1 huMAP3_05966.1 huMAP3_07969.1 huMAP3_08143.1 huMAP3_09048.1 huMAP3_09387.1 huMAP3_09859.1 huMAP3_10592.1 huMAP3_10747.1 huMAP3_10862.1
PAN2	huMAP3_00724.1 huMAP3_05456.1 huMAP3_08143.1 huMAP3_08866.1 huMAP3_09289.1 huMAP3_09764.1 huMAP3_09859.1 huMAP3_11834.1 huMAP3_12015.1 huMAP3_12538.1 huMAP3_12711.1 huMAP3_12963.1 huMAP3_13022.1 huMAP3_15185.1
UBN2	huMAP3_00115.1 huMAP3_00724.1 huMAP3_01912.1 huMAP3_05517.1 huMAP3_06020.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_11745.1 huMAP3_11834.1 huMAP3_12711.1 huMAP3_12963.1
IPO4	huMAP3_00115.1 huMAP3_00724.1 huMAP3_03330.1 huMAP3_05068.1 huMAP3_05517.1 huMAP3_06020.1 huMAP3_06779.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09575.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_10785.1 huMAP3_12711.1 huMAP3_14135.1 huMAP3_14456.1
NASP	huMAP3_01440.1 huMAP3_05517.1 huMAP3_05966.1 huMAP3_06020.1 huMAP3_08143.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_12711.1 huMAP3_12925.1
CDAN1	huMAP3_00115.1 huMAP3_00724.1 huMAP3_06020.1 huMAP3_06779.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_11834.1 huMAP3_12711.1 huMAP3_12963.1
HAT1	huMAP3_01440.1 huMAP3_06020.1 huMAP3_06779.1 huMAP3_07299.1 huMAP3_08143.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_12711.1 huMAP3_13482.1 huMAP3_15128.1
UBN1	huMAP3_00115.1 huMAP3_00724.1 huMAP3_01912.1 huMAP3_05517.1 huMAP3_06020.1 huMAP3_08143.1 huMAP3_09289.1 huMAP3_09859.1 huMAP3_10747.1 huMAP3_11834.1 huMAP3_12711.1 huMAP3_12963.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08143.1

Complex Portal: CPX-16991