hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08157.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| INCENP | Inner centromere protein | 5 | UniProt NCBI |
| BIRC5 | Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1120 | 5.12628525639e-06 | 1.0 | INCENP BIRC5 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5) |
| CORUM:2579 | 5.12628525639e-06 | 1.0 | INCENP BIRC5 | Chromosomal passenger complex CPC (INCENP, BIRC5, AURKB) |
| CORUM:1118 | 1.02525705128e-05 | 1.0 | INCENP BIRC5 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| CORUM:1087 | 1.02525705128e-05 | 1.0 | INCENP BIRC5 | BIRC5-AURKB-INCENP-EVI5 complex |
| CORUM:1119 | 1.02525705128e-05 | 1.0 | INCENP BIRC5 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| REAC:R-HSA-4615885 | 0.00147124386858 | 1.0 | INCENP BIRC5 | SUMOylation of DNA replication proteins |
| GO:0032133 | 0.00702301080125 | 1.0 | INCENP BIRC5 | chromosome passenger complex |
| REAC:R-HSA-141444 | 0.00715287669441 | 1.0 | INCENP BIRC5 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 0.00715287669441 | 1.0 | INCENP BIRC5 | Amplification of signal from the kinetochores |
| GO:1903490 | 0.00983221512175 | 1.0 | INCENP BIRC5 | positive regulation of mitotic cytokinesis |
| REAC:R-HSA-69618 | 0.0098732254038 | 1.0 | INCENP BIRC5 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 0.0108130443675 | 1.0 | INCENP BIRC5 | EML4 and NUDC in mitotic spindle formation |
| REAC:R-HSA-2500257 | 0.0124056103205 | 1.0 | INCENP BIRC5 | Resolution of Sister Chromatid Cohesion |
| GO:1902412 | 0.0131096201623 | 1.0 | INCENP BIRC5 | regulation of mitotic cytokinesis |
| GO:1902423 | 0.0131096201623 | 1.0 | INCENP BIRC5 | regulation of attachment of mitotic spindle microtubules to kinetochore |
| GO:1902425 | 0.0131096201623 | 1.0 | INCENP BIRC5 | positive regulation of attachment of mitotic spindle microtubules to kinetochore |
| REAC:R-HSA-5663220 | 0.0147739541089 | 1.0 | INCENP BIRC5 | RHO GTPases Activate Formins |
| REAC:R-HSA-3108232 | 0.0211937720117 | 1.0 | INCENP BIRC5 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.0225607814134 | 1.0 | INCENP BIRC5 | SUMOylation |
| CORUM:2580 | 0.0249718442457 | 0.5 | BIRC5 | Survivin homodimer complex |
| GO:0051987 | 0.0257510396046 | 1.0 | INCENP BIRC5 | positive regulation of attachment of spindle microtubules to kinetochore |
| GO:0051256 | 0.0257510396046 | 1.0 | INCENP BIRC5 | mitotic spindle midzone assembly |
| REAC:R-HSA-2467813 | 0.0287687128588 | 1.0 | INCENP BIRC5 | Separation of Sister Chromatids |
| GO:0051255 | 0.0309012475255 | 1.0 | INCENP BIRC5 | spindle midzone assembly |
| GO:0000022 | 0.0309012475255 | 1.0 | INCENP BIRC5 | mitotic spindle elongation |
| GO:0090235 | 0.0309012475255 | 1.0 | INCENP BIRC5 | regulation of metaphase plate congression |
| GO:0090267 | 0.0309012475255 | 1.0 | INCENP BIRC5 | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| REAC:R-HSA-68877 | 0.0323212285415 | 1.0 | INCENP BIRC5 | Mitotic Prometaphase |
| GO:0051231 | 0.0365196561665 | 1.0 | INCENP BIRC5 | spindle elongation |
| GO:0090232 | 0.0365196561665 | 1.0 | INCENP BIRC5 | positive regulation of spindle checkpoint |
| REAC:R-HSA-68882 | 0.0422969796504 | 1.0 | INCENP BIRC5 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.0426780335212 | 1.0 | INCENP BIRC5 | Mitotic Metaphase and Anaphase |
| CORUM:2581 | 0.0499419797295 | 0.5 | BIRC5 | RasGAP-AURKA-survivin complex |
| CORUM:1117 | 0.0499419797295 | 0.5 | BIRC5 | CRM1-Survivin mitotic complex |
| CORUM:6756 | 0.0499419797295 | 0.5 | BIRC5 | RasGAP-AURKB-survivin complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| BIRC5 | INCENP | 0.994 | 0.758 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes