hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08164.1

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
NDUFAF2	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 (B17.2-like) (B17.2L) (Mimitin) (Myc-induced mitochondrial protein) (MMTN) (NDUFA12-like protein)	5	UniProt NCBI
DNAJC30	DnaJ homolog subfamily C member 30, mitochondrial (Williams-Beuren syndrome chromosomal region 18 protein)	5	UniProt NCBI
FAM185A	Protein FAM185A	2	UniProt NCBI
NDUFV2	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (NDUFV2) (EC 7.1.1.2) (NADH-ubiquinone oxidoreductase 24 kDa subunit)	5	UniProt NCBI
NDUFB2	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (Complex I-AGGG) (CI-AGGG) (NADH-ubiquinone oxidoreductase AGGG subunit)	4	UniProt NCBI
NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (Complex I-MWFE) (CI-MWFE) (NADH-ubiquinone oxidoreductase MWFE subunit)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP4324	1.92051805697e-07	0.666666666667	NDUFAF2 NDUFA1 NDUFB2 NDUFV2	Mitochondrial complex I assembly model OXPHOS system
REAC:R-HSA-6799198	5.69863130112e-07	0.666666666667	NDUFAF2 NDUFA1 NDUFB2 NDUFV2	Complex I biogenesis
REAC:R-HSA-611105	5.40567812429e-06	0.666666666667	NDUFAF2 NDUFA1 NDUFB2 NDUFV2	Respiratory electron transport
REAC:R-HSA-163200	1.21699661842e-05	0.666666666667	NDUFAF2 NDUFA1 NDUFB2 NDUFV2	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
KEGG:04714	2.85554101697e-05	0.666666666667	NDUFAF2 NDUFA1 NDUFB2 NDUFV2	Thermogenesis
REAC:R-HSA-1428517	4.67320107294e-05	0.666666666667	NDUFAF2 NDUFA1 NDUFB2 NDUFV2	The citric acid (TCA) cycle and respiratory electron transport
CORUM:178	5.73686969982e-05	0.5	NDUFV2 NDUFA1 NDUFB2	Respiratory chain complex I (holoenzyme), mitochondrial
HP:0012748	0.000160619133799	0.5	NDUFAF2 NDUFA1 NDUFV2	Focal T2 hyperintense brainstem lesion
HP:0007704	0.000210097176152	0.5	NDUFAF2 NDUFA1 NDUFV2	Paroxysmal involuntary eye movements
HP:0003287	0.000224969386054	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Abnormality of mitochondrial metabolism
GO:0042776	0.000233586241151	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	proton motive force-driven mitochondrial ATP synthesis
HP:0008316	0.000268794104831	0.5	NDUFAF2 NDUFA1 NDUFV2	Abnormal mitochondria in muscle tissue
HP:0012747	0.000268794104831	0.5	NDUFAF2 NDUFA1 NDUFV2	Abnormal brainstem MRI signal intensity
GO:0015986	0.000359278119226	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	proton motive force-driven ATP synthesis
HP:0012103	0.000376746869116	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Abnormality of the mitochondrion
WP:WP111	0.000413392056955	0.5	NDUFV2 NDUFA1 NDUFB2	Electron transport chain OXPHOS system in mitochondria
HP:0000114	0.000476323535437	0.5	NDUFAF2 NDUFA1 NDUFV2	Proximal tubulopathy
KEGG:04723	0.000535244879172	0.5	NDUFV2 NDUFA1 NDUFB2	Retrograde endocannabinoid signaling
KEGG:00190	0.000576849408541	0.5	NDUFV2 NDUFA1 NDUFB2	Oxidative phosphorylation
HP:0003542	0.000648697584007	0.5	NDUFAF2 NDUFA1 NDUFV2	Increased serum pyruvate
HP:0004366	0.000648697584007	0.5	NDUFAF2 NDUFA1 NDUFV2	Abnormality of glycolysis
GO:0006754	0.000684451996602	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	ATP biosynthetic process
HP:0001138	0.000687513326152	0.5	NDUFAF2 NDUFA1 NDUFV2	Optic neuropathy
HP:0003737	0.000727842944018	0.5	NDUFAF2 NDUFA1 NDUFV2	Mitochondrial myopathy
GO:0009206	0.000754897140182	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	purine ribonucleoside triphosphate biosynthetic process
GO:0009145	0.000754897140182	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	purine nucleoside triphosphate biosynthetic process
KEGG:04932	0.000853506949441	0.5	NDUFV2 NDUFA1 NDUFB2	Non-alcoholic fatty liver disease
HP:0025116	0.000904872598217	0.5	NDUFAF2 NDUFA1 NDUFV2	Fetal distress
GO:0009201	0.000954735523984	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	ribonucleoside triphosphate biosynthetic process
HP:0001639	0.000984794049706	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Hypertrophic cardiomyopathy
GO:0009142	0.00109222246905	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	nucleoside triphosphate biosynthetic process
WP:WP4396	0.00113256924048	0.5	NDUFV2 NDUFA1 NDUFB2	Nonalcoholic fatty liver disease
HP:0011013	0.00140289497732	0.5	NDUFAF2 NDUFA1 NDUFV2	Abnormal circulating carbohydrate concentration
KEGG:05415	0.00191301809451	0.5	NDUFV2 NDUFA1 NDUFB2	Diabetic cardiomyopathy
HP:0003800	0.00240122360395	0.5	NDUFAF2 NDUFA1 NDUFV2	Muscle abnormality related to mitochondrial dysfunction
KEGG:05208	0.0026117112518	0.5	NDUFV2 NDUFA1 NDUFB2	Chemical carcinogenesis - reactive oxygen species
GO:0006119	0.0029910931425	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	oxidative phosphorylation
HP:0011923	0.00331442935792	0.5	NDUFAF2 NDUFA1 NDUFV2	Decreased activity of mitochondrial complex I
HP:0000817	0.00390912678804	0.5	NDUFAF2 NDUFA1 NDUFV2	Reduced eye contact
HP:0002415	0.00390912678804	0.5	NDUFAF2 NDUFA1 NDUFV2	Leukodystrophy
HP:0034435	0.00390912678804	0.5	NDUFAF2 NDUFA1 NDUFV2	Abnormal eye contact
GO:0005743	0.00402322779151	0.833333333333	NDUFAF2 NDUFA1 DNAJC30 NDUFB2 NDUFV2	mitochondrial inner membrane
HP:0000124	0.00403597422216	0.5	NDUFAF2 NDUFA1 NDUFV2	Renal tubular dysfunction
KEGG:05012	0.00425749387528	0.5	NDUFV2 NDUFA1 NDUFB2	Parkinson disease
HP:0002490	0.0042978003653	0.5	NDUFAF2 NDUFA1 NDUFV2	Increased CSF lactate
HP:0030085	0.0042978003653	0.5	NDUFAF2 NDUFA1 NDUFV2	Abnormal CSF lactate concentration
KEGG:05020	0.00464093791542	0.5	NDUFV2 NDUFA1 NDUFB2	Prion disease
HP:0000758	0.00471128577267	0.5	NDUFAF2 NDUFA1 NDUFV2	Abnormal nonverbal communicative behavior
HP:0000819	0.00524664184607	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Diabetes mellitus
GO:0019866	0.00534701059771	0.833333333333	NDUFAF2 NDUFA1 DNAJC30 NDUFB2 NDUFV2	organelle inner membrane
HP:0001952	0.00569323351455	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Glucose intolerance
KEGG:05016	0.00626282376918	0.5	NDUFV2 NDUFA1 NDUFB2	Huntington disease
GO:0009060	0.00766019783716	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	aerobic respiration
GO:0009152	0.00945398717911	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	purine ribonucleotide biosynthetic process
HP:0008972	0.00990331418434	0.5	NDUFAF2 NDUFA1 NDUFV2	Decreased activity of mitochondrial respiratory chain
KEGG:05014	0.0106340043214	0.5	NDUFV2 NDUFA1 NDUFB2	Amyotrophic lateral sclerosis
HP:0011922	0.0108621519105	0.5	NDUFAF2 NDUFA1 NDUFV2	Abnormal activity of mitochondrial respiratory chain
HP:0025454	0.0111110959064	0.5	NDUFAF2 NDUFA1 NDUFV2	Abnormal CSF metabolite concentration
GO:0046034	0.0115447654956	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	ATP metabolic process
HP:0002017	0.0116729789752	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Nausea and vomiting
GO:0009260	0.0118285149586	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	ribonucleotide biosynthetic process
KEGG:05010	0.0122631731838	0.5	NDUFV2 NDUFA1 NDUFB2	Alzheimer disease
HP:0034057	0.0122729499249	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Fetal anomaly
GO:0045333	0.0127111069184	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	cellular respiration
HP:0001638	0.0133234346179	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Cardiomyopathy
GO:0046390	0.0136420323234	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	ribose phosphate biosynthetic process
HP:0007663	0.0136512113701	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Reduced visual acuity
GO:0009205	0.0153056641383	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	purine ribonucleoside triphosphate metabolic process
HP:0001637	0.0159919169368	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Abnormal myocardium morphology
GO:0009144	0.0160118650244	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	purine nucleoside triphosphate metabolic process
WP:WP623	0.0170615762461	0.333333333333	NDUFV2 NDUFB2	Oxidative phosphorylation
GO:0009199	0.017497036198	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	ribonucleoside triphosphate metabolic process
GO:0008137	0.0188853212627	0.5	NDUFV2 NDUFA1 NDUFB2	NADH dehydrogenase (ubiquinone) activity
GO:0006164	0.0190828384513	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	purine nucleotide biosynthetic process
HP:0011017	0.0191797189785	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Abnormal cellular physiology
GO:0009141	0.0203408763605	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	nucleoside triphosphate metabolic process
GO:0050136	0.0203731249082	0.5	NDUFV2 NDUFA1 NDUFB2	NADH dehydrogenase (quinone) activity
HP:0000745	0.0210914692517	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Diminished motivation
GO:0072522	0.0212133246817	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	purine-containing compound biosynthetic process
GO:0031966	0.0215578343109	0.833333333333	NDUFAF2 NDUFA1 DNAJC30 NDUFB2 NDUFV2	mitochondrial membrane
KEGG:05022	0.0219191039446	0.5	NDUFV2 NDUFA1 NDUFB2	Pathways of neurodegeneration - multiple diseases
GO:0003954	0.0219369042126	0.5	NDUFV2 NDUFA1 NDUFB2	NADH dehydrogenase activity
HP:5200275	0.0221775876922	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Abnormal motivation
HP:0025354	0.0229784028676	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Abnormal cellular phenotype
GO:0003955	0.0252998897888	0.5	NDUFV2 NDUFA1 NDUFB2	NAD(P)H dehydrogenase (quinone) activity
HP:0003128	0.0261590153267	0.5	NDUFAF2 NDUFA1 NDUFV2	Lactic acidosis
HP:0011014	0.0267593825332	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Abnormal glucose homeostasis
GO:0006120	0.0271028431288	0.5	NDUFV2 NDUFA1 NDUFB2	mitochondrial electron transport, NADH to ubiquinone
HP:0012211	0.0286224707441	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Abnormal renal physiology
GO:0009165	0.0292377969225	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	nucleotide biosynthetic process
GO:0005740	0.0298219178279	0.833333333333	NDUFAF2 NDUFA1 DNAJC30 NDUFB2 NDUFV2	mitochondrial envelope
GO:1901293	0.0315559649506	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	nucleoside phosphate biosynthetic process
GO:0045271	0.0351680546752	0.5	NDUFV2 NDUFA1 NDUFB2	respiratory chain complex I
GO:0030964	0.0351680546752	0.5	NDUFV2 NDUFA1 NDUFB2	NADH dehydrogenase complex
GO:0005747	0.0351680546752	0.5	NDUFV2 NDUFA1 NDUFB2	mitochondrial respiratory chain complex I
GO:0015980	0.0386403705075	0.666666666667	NDUFV2 NDUFA1 DNAJC30 NDUFB2	energy derivation by oxidation of organic compounds
HP:0000543	0.0399718389151	0.5	NDUFAF2 NDUFA1 NDUFV2	Optic disc pallor
HP:0001254	0.0399718389151	0.5	NDUFAF2 NDUFA1 NDUFV2	Lethargy
HP:0012795	0.0416401881978	0.666666666667	NDUFAF2 NDUFA1 DNAJC30 NDUFV2	Abnormal optic disc morphology
HP:0002421	0.0435813356909	0.5	NDUFAF2 NDUFA1 NDUFV2	Poor head control
HP:0002352	0.0442030419385	0.5	NDUFAF2 NDUFA1 NDUFV2	Leukoencephalopathy

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
NDUFV2	NDUFA1	0.999	0.862	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
NDUFB2	NDUFA1	0.994	0.69	bioplex3_WMM bioplex3_HCT116 WMM_only
NDUFAF2	NDUFA1	0.994	0.112	bioplex3_WMM bioplex3_HCT116 WMM_only
NDUFB2	DNAJC30	0.99	0.178	bioplex3_WMM bioplex3_HCT116 WMM_only
DNAJC30	NDUFA1	0.985	0.09	bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
NDUFV2	DNAJC30	0.982	0.388	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
NDUFB2	NDUFV2	0.979	0.828	bioplex3_HEK293 bioplex3_WMM WMM_only
NDUFAF2	NDUFV2	0.968	0.102	bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only
FAM185A	NDUFV2	0.952	0.092	bioplex3_HEK293 bioplex3_WMM WMM_only
NDUFB2	FAM185A	0.87	0.136	bioplex3_WMM WMM_only
NDUFAF2	NDUFB2	0.864	0.178	bioplex3_WMM WMM_only
FAM185A	NDUFA1	0.804	0.32	bioplex3_WMM WMM_only
NDUFAF2	DNAJC30	0.511	0.14	bioplex3_WMM WMM_only
NDUFAF2	FAM185A	0.079	0.07	bioplex3_WMM WMM_only
FAM185A	DNAJC30	0.079	0.134	bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
NDUFAF2	huMAP3_00624.1 huMAP3_02497.1 huMAP3_08164.1 huMAP3_08624.1 huMAP3_09126.1 huMAP3_09567.1 huMAP3_10025.1 huMAP3_10078.1 huMAP3_12617.1 huMAP3_14878.1
DNAJC30	huMAP3_02298.1 huMAP3_02819.1 huMAP3_02928.1 huMAP3_06397.1 huMAP3_08164.1 huMAP3_09567.1 huMAP3_09982.1 huMAP3_14018.1 huMAP3_14878.1
FAM185A	huMAP3_00817.1 huMAP3_01729.1 huMAP3_02819.1 huMAP3_06021.1 huMAP3_06397.1 huMAP3_08164.1 huMAP3_08660.1 huMAP3_09126.1 huMAP3_09567.1 huMAP3_10025.1 huMAP3_12617.1 huMAP3_12654.1 huMAP3_14878.1
NDUFV2	huMAP3_01633.1 huMAP3_01729.1 huMAP3_02819.1 huMAP3_06021.1 huMAP3_06397.1 huMAP3_08164.1 huMAP3_09126.1 huMAP3_09567.1 huMAP3_09982.1 huMAP3_10025.1 huMAP3_14018.1 huMAP3_14878.1
NDUFB2	huMAP3_00817.1 huMAP3_01729.1 huMAP3_02298.1 huMAP3_02819.1 huMAP3_02928.1 huMAP3_06397.1 huMAP3_08164.1 huMAP3_08660.1 huMAP3_09567.1 huMAP3_09982.1 huMAP3_10025.1 huMAP3_12617.1 huMAP3_14878.1
NDUFA1	huMAP3_02819.1 huMAP3_02928.1 huMAP3_06397.1 huMAP3_08164.1 huMAP3_09567.1 huMAP3_09982.1 huMAP3_14018.1 huMAP3_14878.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08164.1