hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08166.1
Complex Portal: CPX-20016
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KIAA2013 | Uncharacterized protein KIAA2013 | 3 | UniProt NCBI |
| VMA21 | Vacuolar ATPase assembly integral membrane protein VMA21 (Myopathy with excessive autophagy protein) | 5 | UniProt NCBI |
| ATP6V0D2 | V-type proton ATPase subunit d 2 (V-ATPase subunit d 2) (Vacuolar proton pump subunit d 2) | 5 | UniProt NCBI |
| ATP6V0C | V-type proton ATPase 16 kDa proteolipid subunit c (V-ATPase 16 kDa proteolipid subunit c) (Vacuolar proton pump 16 kDa proteolipid subunit c) | 5 | UniProt NCBI |
| GPRC5A | Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1) | 5 | UniProt NCBI |
| TMEM199 | Transmembrane protein 199 | 5 | UniProt NCBI |
| CYBRD1 | Plasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1) (Duodenal cytochrome b) (Ferric-chelate reductase 3) | 5 | UniProt NCBI |
| ATP6V0A4 | V-type proton ATPase 116 kDa subunit a 4 (V-ATPase 116 kDa isoform a 4) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform) | 5 | UniProt NCBI |
| CCDC115 | Coiled-coil domain-containing protein 115 | 5 | UniProt NCBI |
| SLC14A1 | Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016471 | 5.94654868871e-08 | 0.5 | CCDC115 ATP6V0A4 TMEM199 ATP6V0D2 ATP6V0C | vacuolar proton-transporting V-type ATPase complex |
| GO:0033176 | 7.59619890697e-08 | 0.5 | CCDC115 ATP6V0A4 TMEM199 ATP6V0D2 ATP6V0C | proton-transporting V-type ATPase complex |
| GO:0007035 | 2.2154875352e-07 | 0.5 | CCDC115 ATP6V0A4 TMEM199 ATP6V0D2 ATP6V0C | vacuolar acidification |
| GO:0051452 | 1.683076869e-06 | 0.5 | CCDC115 ATP6V0A4 TMEM199 ATP6V0D2 ATP6V0C | intracellular pH reduction |
| GO:0016469 | 2.43698089478e-06 | 0.5 | CCDC115 ATP6V0A4 TMEM199 ATP6V0D2 ATP6V0C | proton-transporting two-sector ATPase complex |
| REAC:R-HSA-917937 | 7.11352916135e-06 | 0.4 | ATP6V0A4 CYBRD1 ATP6V0D2 ATP6V0C | Iron uptake and transport |
| GO:0051453 | 1.21995924334e-05 | 0.5 | CCDC115 ATP6V0A4 TMEM199 ATP6V0D2 ATP6V0C | regulation of intracellular pH |
| GO:0030641 | 1.44462629917e-05 | 0.5 | CCDC115 ATP6V0A4 TMEM199 ATP6V0D2 ATP6V0C | regulation of cellular pH |
| GO:0006885 | 1.84240635874e-05 | 0.5 | CCDC115 ATP6V0A4 TMEM199 ATP6V0D2 ATP6V0C | regulation of pH |
| KEGG:04966 | 2.04240679823e-05 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | Collecting duct acid secretion |
| KEGG:05110 | 0.000162356387571 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | Vibrio cholerae infection |
| REAC:R-HSA-917977 | 0.000180911267958 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | Transferrin endocytosis and recycling |
| REAC:R-HSA-77387 | 0.000180911267958 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | Insulin receptor recycling |
| WP:WP4917 | 0.000204837143209 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | Proximal tubule transport |
| REAC:R-HSA-1222556 | 0.000247960694471 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | ROS and RNS production in phagocytes |
| KEGG:04721 | 0.000389423767328 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | Synaptic vesicle cycle |
| KEGG:05120 | 0.000451423575096 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:05323 | 0.000568680046045 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | Rheumatoid arthritis |
| GO:0030003 | 0.000832221208375 | 0.6 | ATP6V0A4 ATP6V0D2 CCDC115 ATP6V0C TMEM199 CYBRD1 | intracellular monoatomic cation homeostasis |
| GO:1904949 | 0.000878022210118 | 0.5 | CCDC115 ATP6V0A4 TMEM199 ATP6V0D2 ATP6V0C | ATPase complex |
| GO:0006873 | 0.000881677190302 | 0.6 | ATP6V0A4 ATP6V0D2 CCDC115 ATP6V0C TMEM199 CYBRD1 | intracellular monoatomic ion homeostasis |
| GO:0005773 | 0.00144971593383 | 0.7 | ATP6V0A4 ATP6V0D2 CCDC115 ATP6V0C TMEM199 VMA21 CYBRD1 | vacuole |
| GO:0055080 | 0.00149863268099 | 0.6 | ATP6V0A4 ATP6V0D2 CCDC115 ATP6V0C TMEM199 CYBRD1 | monoatomic cation homeostasis |
| GO:0050801 | 0.00166286310361 | 0.6 | ATP6V0A4 ATP6V0D2 CCDC115 ATP6V0C TMEM199 CYBRD1 | monoatomic ion homeostasis |
| GO:0005774 | 0.00181086328972 | 0.6 | ATP6V0A4 ATP6V0D2 CCDC115 ATP6V0C TMEM199 CYBRD1 | vacuolar membrane |
| REAC:R-HSA-74752 | 0.00206314708251 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | Signaling by Insulin receptor |
| KEGG:00190 | 0.00328560604522 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | Oxidative phosphorylation |
| REAC:R-HSA-382551 | 0.00331038810687 | 0.5 | ATP6V0A4 CYBRD1 ATP6V0D2 SLC14A1 ATP6V0C | Transport of small molecules |
| KEGG:04142 | 0.00336653177296 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | Lysosome |
| GO:0055082 | 0.00376099216607 | 0.6 | ATP6V0A4 ATP6V0D2 CCDC115 ATP6V0C TMEM199 CYBRD1 | intracellular chemical homeostasis |
| KEGG:04145 | 0.00415442612114 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | Phagosome |
| KEGG:05152 | 0.00560546698078 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | Tuberculosis |
| GO:0019725 | 0.0107350191153 | 0.6 | ATP6V0A4 ATP6V0D2 CCDC115 ATP6V0C TMEM199 CYBRD1 | cellular homeostasis |
| GO:0007042 | 0.0111127441894 | 0.3 | CCDC115 ATP6V0C TMEM199 | lysosomal lumen acidification |
| HP:0010837 | 0.0148343034129 | 0.2 | CCDC115 TMEM199 | Decreased circulating ceruloplasmin concentration |
| REAC:R-HSA-983712 | 0.0165440294353 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | Ion channel transport |
| HP:0033144 | 0.0226469783291 | 0.2 | CCDC115 TMEM199 | Abnormal circulating ceruloplasmin concentration |
| GO:0035751 | 0.0231700664584 | 0.3 | CCDC115 ATP6V0C TMEM199 | regulation of lysosomal lumen pH |
| GO:0048878 | 0.0305302356832 | 0.6 | ATP6V0A4 ATP6V0D2 CCDC115 ATP6V0C TMEM199 CYBRD1 | chemical homeostasis |
| KEGG:05165 | 0.0438405134702 | 0.3 | ATP6V0A4 ATP6V0D2 ATP6V0C | Human papillomavirus infection |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| VMA21 | ATP6V0D2 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CCDC115 | ATP6V0D2 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TMEM199 | ATP6V0C | 1.0 | 0.09 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| VMA21 | TMEM199 | 1.0 | 0.04 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| ATP6V0D2 | TMEM199 | 1.0 |
structurally_consistent (P27449)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CCDC115 | TMEM199 | 0.999 | 0.458 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| VMA21 | ATP6V0C | 0.999 | 0.052 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| ATP6V0D2 | ATP6V0C | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CCDC115 | ATP6V0C | 0.999 | 0.044 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| KIAA2013 | VMA21 | 0.998 | 0.096 |
mutually_exclusive (P27449)
|
bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CCDC115 | ATP6V0A4 | 0.997 | 0.138 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SLC14A1 | CYBRD1 | 0.997 | 0.048 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| KIAA2013 | CCDC115 | 0.997 | 0.078 | bioplex () bioplex_WMM bioplex3_WMM | |
| VMA21 | CCDC115 | 0.994 | 0.092 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| VMA21 | ATP6V0A4 | 0.994 | 0.056 |
mutually_exclusive (P27449)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| KIAA2013 | TMEM199 | 0.986 | 0.176 | bioplex () bioplex_WMM bioplex3_WMM | |
| CYBRD1 | GPRC5A | 0.986 | 0.108 | hein_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SLC14A1 | TMEM199 | 0.985 | 0.058 |
structurally_consistent (P27449)
|
bioplex3_WMM bioplex3_HCT116 WMM_only |
| CYBRD1 | CCDC115 | 0.981 | 0.102 | hein_WMM bioplex3_WMM WMM_only | |
| SLC14A1 | CCDC115 | 0.981 | 0.092 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ATP6V0A4 | ATP6V0C | 0.98 | 0.086 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CYBRD1 | TMEM199 | 0.978 | 0.098 | hein_WMM bioplex3_WMM WMM_only | |
| KIAA2013 | ATP6V0C | 0.972 | 0.094 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TMEM199 | GPRC5A | 0.972 | 0.096 | hein_WMM bioplex3_WMM gupta_WMM WMM_only | |
| KIAA2013 | ATP6V0D2 | 0.972 |
structurally_consistent (P27449)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SLC14A1 | ATP6V0D2 | 0.972 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ATP6V0A4 | ATP6V0D2 | 0.972 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CCDC115 | GPRC5A | 0.971 | 0.07 | hein_WMM bioplex3_WMM gupta_WMM WMM_only | |
| SLC14A1 | ATP6V0C | 0.956 | 0.086 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATP6V0A4 | TMEM199 | 0.954 | 0.116 |
mutually_exclusive (P27449)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| CYBRD1 | ATP6V0D2 | 0.279 | bioplex3_WMM WMM_only | ||
| CYBRD1 | ATP6V0C | 0.274 | 0.118 | bioplex3_WMM WMM_only | |
| VMA21 | GPRC5A | 0.204 | 0.034 | bioplex3_WMM gupta_WMM WMM_only | |
| CYBRD1 | VMA21 | 0.133 | 0.046 | bioplex3_WMM WMM_only | |
| ATP6V0D2 | GPRC5A | 0.133 | bioplex3_WMM WMM_only | ||
| KIAA2013 | ATP6V0A4 | 0.116 | 0.092 |
mutually_exclusive (P27449)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| GPRC5A | ATP6V0C | 0.113 | 0.066 | bioplex3_WMM WMM_only | |
| KIAA2013 | GPRC5A | 0.064 | 0.022 | bioplex3_WMM WMM_only | |
| KIAA2013 | CYBRD1 | 0.056 | 0.078 | bioplex3_WMM WMM_only | |
| SLC14A1 | GPRC5A | 0.043 | 0.084 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes