hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08166.1

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
KIAA2013	Uncharacterized protein KIAA2013	3	UniProt NCBI
VMA21	Vacuolar ATPase assembly integral membrane protein VMA21 (Myopathy with excessive autophagy protein)	5	UniProt NCBI
ATP6V0D2	V-type proton ATPase subunit d 2 (V-ATPase subunit d 2) (Vacuolar proton pump subunit d 2)	5	UniProt NCBI
ATP6V0C	V-type proton ATPase 16 kDa proteolipid subunit c (V-ATPase 16 kDa proteolipid subunit c) (Vacuolar proton pump 16 kDa proteolipid subunit c)	5	UniProt NCBI
GPRC5A	Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1)	5	UniProt NCBI
TMEM199	Transmembrane protein 199	5	UniProt NCBI
CYBRD1	Plasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1) (Duodenal cytochrome b) (Ferric-chelate reductase 3)	5	UniProt NCBI
ATP6V0A4	V-type proton ATPase 116 kDa subunit a 4 (V-ATPase 116 kDa isoform a 4) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform)	5	UniProt NCBI
CCDC115	Coiled-coil domain-containing protein 115	5	UniProt NCBI
SLC14A1	Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0016471	5.94654868871e-08	0.5	ATP6V0D2 CCDC115 ATP6V0C ATP6V0A4 TMEM199	vacuolar proton-transporting V-type ATPase complex
GO:0033176	7.59619890697e-08	0.5	ATP6V0D2 CCDC115 ATP6V0C ATP6V0A4 TMEM199	proton-transporting V-type ATPase complex
GO:0007035	2.2154875352e-07	0.5	ATP6V0D2 CCDC115 ATP6V0C ATP6V0A4 TMEM199	vacuolar acidification
GO:0051452	1.683076869e-06	0.5	ATP6V0D2 CCDC115 ATP6V0C ATP6V0A4 TMEM199	intracellular pH reduction
GO:0016469	2.43698089478e-06	0.5	ATP6V0D2 CCDC115 ATP6V0C ATP6V0A4 TMEM199	proton-transporting two-sector ATPase complex
REAC:R-HSA-917937	7.11352916135e-06	0.4	ATP6V0D2 ATP6V0C ATP6V0A4 CYBRD1	Iron uptake and transport
GO:0051453	1.21995924334e-05	0.5	ATP6V0D2 CCDC115 ATP6V0C ATP6V0A4 TMEM199	regulation of intracellular pH
GO:0030641	1.44462629917e-05	0.5	ATP6V0D2 CCDC115 ATP6V0C ATP6V0A4 TMEM199	regulation of cellular pH
GO:0006885	1.84240635874e-05	0.5	ATP6V0D2 CCDC115 ATP6V0C ATP6V0A4 TMEM199	regulation of pH
KEGG:04966	2.04240679823e-05	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	Collecting duct acid secretion
KEGG:05110	0.000162356387571	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	Vibrio cholerae infection
REAC:R-HSA-917977	0.000180911267958	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	Transferrin endocytosis and recycling
REAC:R-HSA-77387	0.000180911267958	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	Insulin receptor recycling
WP:WP4917	0.000204837143209	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	Proximal tubule transport
REAC:R-HSA-1222556	0.000247960694471	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	ROS and RNS production in phagocytes
KEGG:04721	0.000389423767328	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	Synaptic vesicle cycle
KEGG:05120	0.000451423575096	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	Epithelial cell signaling in Helicobacter pylori infection
KEGG:05323	0.000568680046045	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	Rheumatoid arthritis
GO:0030003	0.000832221208375	0.6	CCDC115 ATP6V0C ATP6V0D2 ATP6V0A4 CYBRD1 TMEM199	intracellular monoatomic cation homeostasis
GO:1904949	0.000878022210118	0.5	ATP6V0D2 CCDC115 ATP6V0C ATP6V0A4 TMEM199	ATPase complex
GO:0006873	0.000881677190302	0.6	CCDC115 ATP6V0C ATP6V0D2 ATP6V0A4 CYBRD1 TMEM199	intracellular monoatomic ion homeostasis
GO:0005773	0.00144971593383	0.7	CCDC115 VMA21 ATP6V0C ATP6V0D2 ATP6V0A4 CYBRD1 TMEM199	vacuole
GO:0055080	0.00149863268099	0.6	CCDC115 ATP6V0C ATP6V0D2 ATP6V0A4 CYBRD1 TMEM199	monoatomic cation homeostasis
GO:0050801	0.00166286310361	0.6	CCDC115 ATP6V0C ATP6V0D2 ATP6V0A4 CYBRD1 TMEM199	monoatomic ion homeostasis
GO:0005774	0.00181086328972	0.6	CCDC115 ATP6V0C ATP6V0D2 ATP6V0A4 CYBRD1 TMEM199	vacuolar membrane
REAC:R-HSA-74752	0.00206314708251	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	Signaling by Insulin receptor
KEGG:00190	0.00328560604522	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	Oxidative phosphorylation
REAC:R-HSA-382551	0.00331038810687	0.5	ATP6V0D2 SLC14A1 ATP6V0C ATP6V0A4 CYBRD1	Transport of small molecules
KEGG:04142	0.00336653177296	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	Lysosome
GO:0055082	0.00376099216607	0.6	CCDC115 ATP6V0C ATP6V0D2 ATP6V0A4 CYBRD1 TMEM199	intracellular chemical homeostasis
KEGG:04145	0.00415442612114	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	Phagosome
KEGG:05152	0.00560546698078	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	Tuberculosis
GO:0019725	0.0107350191153	0.6	CCDC115 ATP6V0C ATP6V0D2 ATP6V0A4 CYBRD1 TMEM199	cellular homeostasis
GO:0007042	0.0111127441894	0.3	CCDC115 ATP6V0C TMEM199	lysosomal lumen acidification
HP:0010837	0.0148343034129	0.2	TMEM199 CCDC115	Decreased circulating ceruloplasmin concentration
REAC:R-HSA-983712	0.0165440294353	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	Ion channel transport
HP:0033144	0.0226469783291	0.2	TMEM199 CCDC115	Abnormal circulating ceruloplasmin concentration
GO:0035751	0.0231700664584	0.3	CCDC115 ATP6V0C TMEM199	regulation of lysosomal lumen pH
GO:0048878	0.0305302356832	0.6	CCDC115 ATP6V0C ATP6V0D2 ATP6V0A4 CYBRD1 TMEM199	chemical homeostasis
KEGG:05165	0.0438405134702	0.3	ATP6V0D2 ATP6V0C ATP6V0A4	Human papillomavirus infection

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
VMA21	ATP6V0D2	1.0		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CCDC115	ATP6V0D2	1.0		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TMEM199	ATP6V0C	1.0	0.09	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM
VMA21	TMEM199	1.0	0.04	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM
ATP6V0D2	TMEM199	1.0		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CCDC115	TMEM199	0.999	0.458	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM
VMA21	ATP6V0C	0.999	0.052	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM
ATP6V0D2	ATP6V0C	0.999		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CCDC115	ATP6V0C	0.999	0.044	bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only
KIAA2013	VMA21	0.998	0.096	bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CCDC115	ATP6V0A4	0.997	0.138	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
SLC14A1	CYBRD1	0.997	0.048	bioplex3_WMM bioplex3_HCT116 WMM_only
KIAA2013	CCDC115	0.997	0.078	bioplex () bioplex_WMM bioplex3_WMM
VMA21	CCDC115	0.994	0.092	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
VMA21	ATP6V0A4	0.994	0.056	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
KIAA2013	TMEM199	0.986	0.176	bioplex () bioplex_WMM bioplex3_WMM
CYBRD1	GPRC5A	0.986	0.108	hein_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
SLC14A1	TMEM199	0.985	0.058	bioplex3_WMM bioplex3_HCT116 WMM_only
CYBRD1	CCDC115	0.981	0.102	hein_WMM bioplex3_WMM WMM_only
SLC14A1	CCDC115	0.981	0.092	bioplex3_WMM bioplex3_HCT116 WMM_only
ATP6V0A4	ATP6V0C	0.98	0.086	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
CYBRD1	TMEM199	0.978	0.098	hein_WMM bioplex3_WMM WMM_only
KIAA2013	ATP6V0C	0.972	0.094	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TMEM199	GPRC5A	0.972	0.096	hein_WMM bioplex3_WMM gupta_WMM WMM_only
KIAA2013	ATP6V0D2	0.972		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
SLC14A1	ATP6V0D2	0.972		bioplex3_WMM bioplex3_HCT116 WMM_only
ATP6V0A4	ATP6V0D2	0.972		bioplex3_WMM bioplex3_HCT116 WMM_only
CCDC115	GPRC5A	0.971	0.07	hein_WMM bioplex3_WMM gupta_WMM WMM_only
SLC14A1	ATP6V0C	0.956	0.086	bioplex3_WMM bioplex3_HCT116 WMM_only
ATP6V0A4	TMEM199	0.954	0.116	bioplex3_HEK293 bioplex3_WMM WMM_only
CYBRD1	ATP6V0D2	0.279		bioplex3_WMM WMM_only
CYBRD1	ATP6V0C	0.274	0.118	bioplex3_WMM WMM_only
VMA21	GPRC5A	0.204	0.034	bioplex3_WMM gupta_WMM WMM_only
CYBRD1	VMA21	0.133	0.046	bioplex3_WMM WMM_only
ATP6V0D2	GPRC5A	0.133		bioplex3_WMM WMM_only
KIAA2013	ATP6V0A4	0.116	0.092	bioplex3_HEK293 bioplex3_WMM WMM_only
GPRC5A	ATP6V0C	0.113	0.066	bioplex3_WMM WMM_only
KIAA2013	GPRC5A	0.064	0.022	bioplex3_WMM WMM_only
KIAA2013	CYBRD1	0.056	0.078	bioplex3_WMM WMM_only
SLC14A1	GPRC5A	0.043	0.084	bioplex3_WMM bioplex3_HCT116 WMM_only

Related Complexes

Genename	Complexes
KIAA2013	huMAP3_00308.1 huMAP3_05318.1 huMAP3_07558.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09477.1 huMAP3_09562.1 huMAP3_10511.1 huMAP3_10516.1
VMA21	huMAP3_01342.1 huMAP3_01538.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_11642.1 huMAP3_12042.1 huMAP3_13118.1 huMAP3_13872.1
ATP6V0D2	huMAP3_01501.1 huMAP3_05083.1 huMAP3_05318.1 huMAP3_05805.1 huMAP3_07329.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_08678.1 huMAP3_09477.1 huMAP3_09562.1 huMAP3_09873.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
ATP6V0C	huMAP3_03313.1 huMAP3_05083.1 huMAP3_05318.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_08494.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13872.1
GPRC5A	huMAP3_01609.1 huMAP3_04056.1 huMAP3_04452.1 huMAP3_05687.1 huMAP3_05805.1 huMAP3_08151.1 huMAP3_08166.1 huMAP3_08718.1 huMAP3_09165.1 huMAP3_09440.1 huMAP3_09562.1 huMAP3_10725.1 huMAP3_12042.1
TMEM199	huMAP3_01538.1 huMAP3_04056.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1
CYBRD1	huMAP3_00361.1 huMAP3_01609.1 huMAP3_05805.1 huMAP3_06790.1 huMAP3_08151.1 huMAP3_08166.1 huMAP3_09440.1 huMAP3_09562.1 huMAP3_10516.1 huMAP3_12042.1
ATP6V0A4	huMAP3_01342.1 huMAP3_01538.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1 huMAP3_13118.1 huMAP3_13872.1
CCDC115	huMAP3_01342.1 huMAP3_01538.1 huMAP3_05805.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_12042.1
SLC14A1	huMAP3_00361.1 huMAP3_00622.1 huMAP3_01538.1 huMAP3_04056.1 huMAP3_04243.1 huMAP3_07510.1 huMAP3_08166.1 huMAP3_08182.1 huMAP3_09562.1 huMAP3_09565.1 huMAP3_10511.1 huMAP3_10516.1 huMAP3_11123.1 huMAP3_12042.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08166.1