hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08169.1
Complex Portal: CPX-14459
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TEAD4 | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) | 5 | UniProt NCBI |
| TEAD2 | Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) | 5 | UniProt NCBI |
| TEAD1 | Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8951671 | 2.61297199043e-08 | 1.0 | TEAD2 TEAD4 TEAD1 | RUNX3 regulates YAP1-mediated transcription |
| WP:WP3967 | 4.34090508087e-08 | 1.0 | TEAD2 TEAD4 TEAD1 | miR 509 3p alteration of YAP1 ECM axis |
| WP:WP4533 | 6.32531883213e-08 | 1.0 | TEAD2 TEAD4 TEAD1 | Transcription co factors SKI and SKIL protein partners |
| WP:WP4537 | 7.51131611315e-08 | 1.0 | TEAD2 TEAD4 TEAD1 | Hippo YAP signaling |
| REAC:R-HSA-2032785 | 1.02652471053e-07 | 1.0 | TEAD2 TEAD4 TEAD1 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| KEGG:04392 | 1.35821797173e-07 | 1.0 | TEAD2 TEAD4 TEAD1 | Hippo signaling pathway - multiple species |
| WP:WP4542 | 2.83244056527e-07 | 1.0 | TEAD2 TEAD4 TEAD1 | Leukocyte intrinsic Hippo pathway functions |
| WP:WP4534 | 7.65859682125e-07 | 1.0 | TEAD2 TEAD4 TEAD1 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| WP:WP4540 | 6.86483132075e-06 | 1.0 | TEAD2 TEAD4 TEAD1 | Hippo signaling regulation pathways |
| WP:WP4541 | 1.10755092492e-05 | 1.0 | TEAD2 TEAD4 TEAD1 | Hippo Merlin signaling dysregulation |
| KEGG:04390 | 2.65416687338e-05 | 1.0 | TEAD2 TEAD4 TEAD1 | Hippo signaling pathway |
| REAC:R-HSA-8878159 | 5.1203052561e-05 | 1.0 | TEAD2 TEAD4 TEAD1 | Transcriptional regulation by RUNX3 |
| REAC:R-HSA-9796292 | 0.00024538606603 | 0.666666666667 | TEAD2 TEAD4 | Formation of axial mesoderm |
| WP:WP5087 | 0.000659719901928 | 1.0 | TEAD2 TEAD4 TEAD1 | Pleural mesothelioma |
| GO:0035329 | 0.00110345807156 | 1.0 | TEAD2 TEAD4 TEAD1 | hippo signaling |
| GO:0140552 | 0.00421361424067 | 0.666666666667 | TEAD2 TEAD1 | TEAD-YAP complex |
| REAC:R-HSA-9758941 | 0.00453384142373 | 0.666666666667 | TEAD2 TEAD4 | Gastrulation |
| WP:WP2857 | 0.00901139826353 | 0.666666666667 | TEAD2 TEAD1 | Mesodermal commitment pathway |
| REAC:R-HSA-1266738 | 0.0482660739102 | 1.0 | TEAD2 TEAD4 TEAD1 | Developmental Biology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TEAD2 | TEAD1 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TEAD4 | TEAD1 | 0.999 | 0.38 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TEAD2 | TEAD4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes