hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08181.1

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
BAK1	Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7)	5	UniProt NCBI
BBC3	Bcl-2-binding component 3, isoforms 3/4 (JFY-1) (p53 up-regulated modulator of apoptosis)	5	UniProt NCBI
BAX	Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)	5	UniProt NCBI
BCL2L1	Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)	5	UniProt NCBI
BCL2L15	Bcl-2-like protein 15 (Bcl2-L-15) (Bcl-2 family kin) (Bfk)	4	UniProt NCBI
BCL2L11	Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)	5	UniProt NCBI
BIK	Bcl-2-interacting killer (Apoptosis inducer NBK) (BIP1) (BP4)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP1772	1.19938353428e-11	0.857142857143	BIK BAX BCL2L1 BBC3 BCL2L11 BAK1	Apoptosis modulation and signaling
KEGG:04215	2.33759984106e-11	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	Apoptosis - multiple species
GO:0090199	5.03304585028e-11	0.857142857143	BIK BAX BCL2L1 BBC3 BCL2L11 BAK1	regulation of release of cytochrome c from mitochondria
GO:0097136	8.73008139488e-11	0.714285714286	BCL2L11 BAX BIK BAK1 BCL2L1	Bcl-2 family protein complex
GO:0001836	1.82318372085e-10	0.857142857143	BIK BAX BCL2L1 BBC3 BCL2L11 BAK1	release of cytochrome c from mitochondria
REAC:R-HSA-109606	1.8946190242e-09	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	Intrinsic Pathway for Apoptosis
GO:0090200	4.96990184286e-09	0.714285714286	BCL2L11 BAX BIK BAK1 BBC3	positive regulation of release of cytochrome c from mitochondria
WP:WP254	5.10550559545e-09	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	Apoptosis
WP:WP3872	6.45069472342e-09	0.571428571429	BAX BAK1 BCL2L15 BCL2L1	Regulation of apoptosis by parathyroid hormone related protein
GO:0008637	6.6205971092e-09	0.857142857143	BIK BAX BCL2L1 BBC3 BCL2L11 BAK1	apoptotic mitochondrial changes
WP:WP4864	8.06204291918e-09	0.571428571429	BCL2L11 BAX BBC3 BCL2L1	Host pathogen interaction of human coronaviruses apoptosis
WP:WP710	2.68372938313e-08	0.714285714286	BCL2L11 BAX BIK BAK1 BBC3	DNA damage response only ATM dependent
KEGG:04210	3.71248832939e-08	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	Apoptosis
GO:1903896	6.44235965654e-08	0.571428571429	BCL2L11 BAX BAK1 BBC3	positive regulation of IRE1-mediated unfolded protein response
GO:0010821	6.85967735126e-08	0.857142857143	BIK BAX BCL2L1 BBC3 BCL2L11 BAK1	regulation of mitochondrion organization
WP:WP3611	2.04577827115e-07	0.571428571429	BCL2L11 BAX BAK1 BCL2L1	Photodynamic therapy induced AP 1 survival signaling
GO:0070059	2.8866785733e-07	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:1900103	4.5526752727e-07	0.571428571429	BCL2L11 BAX BAK1 BBC3	positive regulation of endoplasmic reticulum unfolded protein response
REAC:R-HSA-109581	7.11211430354e-07	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	Apoptosis
KEGG:01524	8.71906835117e-07	0.571428571429	BCL2L1 BAX BAK1 BBC3	Platinum drug resistance
GO:1903894	9.20349554216e-07	0.571428571429	BCL2L11 BAX BAK1 BBC3	regulation of IRE1-mediated unfolded protein response
GO:0010822	1.02626003625e-06	0.714285714286	BCL2L11 BAX BIK BAK1 BBC3	positive regulation of mitochondrion organization
REAC:R-HSA-111453	1.09397266507e-06	0.428571428571	BCL2L1 BBC3 BCL2L11	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
GO:1905897	1.11776248114e-06	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	regulation of response to endoplasmic reticulum stress
WP:WP4216	1.26558831017e-06	0.571428571429	BCL2L11 BAX BAK1 BBC3	Chromosomal and microsatellite instability in colorectal cancer
KEGG:05210	1.35464868137e-06	0.571428571429	BCL2L11 BAX BAK1 BBC3	Colorectal cancer
REAC:R-HSA-5357801	1.55921727729e-06	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	Programmed Cell Death
GO:0036498	2.81160701714e-06	0.571428571429	BCL2L11 BAX BAK1 BBC3	IRE1-mediated unfolded protein response
KEGG:05162	8.84180128664e-06	0.571428571429	BCL2L1 BAX BAK1 BBC3	Measles
GO:1905898	1.1609777329e-05	0.571428571429	BCL2L11 BAX BAK1 BBC3	positive regulation of response to endoplasmic reticulum stress
GO:1900101	1.37183898061e-05	0.571428571429	BCL2L11 BAX BAK1 BBC3	regulation of endoplasmic reticulum unfolded protein response
WP:WP4630	1.48524641855e-05	0.571428571429	BCL2L1 BAX BAK1 BBC3	Measles virus infection
WP:WP4396	2.2922388512e-05	0.571428571429	BCL2L11 BAX BAK1 BBC3	Nonalcoholic fatty liver disease
KEGG:05200	2.69718257825e-05	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	Pathways in cancer
WP:WP3614	3.62383476827e-05	0.428571428571	BAX BAK1 BCL2L1	Photodynamic therapy induced HIF 1 survival signaling
GO:0031334	9.27049887168e-05	0.714285714286	BCL2L11 BAX BIK BAK1 BBC3	positive regulation of protein-containing complex assembly
GO:0007005	0.000113567704922	0.857142857143	BIK BAX BCL2L1 BBC3 BCL2L11 BAK1	mitochondrion organization
GO:0097190	0.000122685114996	0.857142857143	BIK BAX BCL2L1 BBC3 BCL2L11 BAK1	apoptotic signaling pathway
GO:0005741	0.000143025516495	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	mitochondrial outer membrane
KEGG:04115	0.000144487772681	0.428571428571	BAX BBC3 BCL2L1	p53 signaling pathway
GO:0034976	0.00015726409273	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	response to endoplasmic reticulum stress
KEGG:05212	0.000206486888796	0.428571428571	BAX BAK1 BCL2L1	Pancreatic cancer
KEGG:05220	0.000224342633213	0.428571428571	BAX BAK1 BCL2L1	Chronic myeloid leukemia
KEGG:01521	0.000224342633213	0.428571428571	BCL2L11 BAX BCL2L1	EGFR tyrosine kinase inhibitor resistance
GO:0031968	0.000232620911116	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	organelle outer membrane
GO:0019867	0.000239435127266	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	outer membrane
KEGG:05222	0.000353303499329	0.428571428571	BAX BAK1 BCL2L1	Small cell lung cancer
GO:0030968	0.0003606237206	0.571428571429	BCL2L11 BAX BAK1 BBC3	endoplasmic reticulum unfolded protein response
REAC:R-HSA-111457	0.000380832872101	0.285714285714	BAX BAK1	Release of apoptotic factors from the mitochondria
WP:WP4806	0.000474478323214	0.428571428571	BCL2L11 BAX BCL2L1	EGFR tyrosine kinase inhibitor resistance
WP:WP4263	0.000511713817494	0.428571428571	BAX BAK1 BCL2L1	Pancreatic adenocarcinoma pathway
GO:0097193	0.000643414431898	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	intrinsic apoptotic signaling pathway
WP:WP4658	0.000679987909493	0.428571428571	BAX BAK1 BCL2L1	Small cell lung cancer
GO:0034620	0.00078768588516	0.571428571429	BCL2L11 BAX BAK1 BBC3	cellular response to unfolded protein
GO:0008630	0.000835286748042	0.571428571429	BCL2L11 BAX BAK1 BCL2L1	intrinsic apoptotic signaling pathway in response to DNA damage
GO:2001233	0.00112303785524	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	regulation of apoptotic signaling pathway
GO:0035967	0.00143843813729	0.571428571429	BCL2L11 BAX BAK1 BBC3	cellular response to topologically incorrect protein
KEGG:05202	0.00207163121436	0.428571428571	BAX BAK1 BCL2L1	Transcriptional misregulation in cancer
KEGG:05225	0.0022354425134	0.428571428571	BAX BAK1 BCL2L1	Hepatocellular carcinoma
GO:2001056	0.0023201010514	0.571428571429	BCL2L11 BAX BAK1 BBC3	positive regulation of cysteine-type endopeptidase activity
GO:0006986	0.0026497943547	0.571428571429	BCL2L11 BAX BAK1 BBC3	response to unfolded protein
GO:0043254	0.00296956623972	0.714285714286	BCL2L11 BAX BIK BAK1 BBC3	regulation of protein-containing complex assembly
WP:WP1742	0.00303405736115	0.285714285714	BAX BBC3	TP53 network
WP:WP2507	0.00303405736115	0.285714285714	BAX BAK1	Nanomaterial induced apoptosis
WP:WP3982	0.00303405736115	0.285714285714	BAX BBC3	miRNA regulation of p53 pathway in prostate cancer
KEGG:05169	0.0032364559788	0.428571428571	BAX BAK1 BCL2L11	Epstein-Barr virus infection
GO:0032469	0.00382182132582	0.428571428571	BAX BAK1 BBC3	endoplasmic reticulum calcium ion homeostasis
KEGG:05170	0.0039833462196	0.428571428571	BAX BAK1 BCL2L1	Human immunodeficiency virus 1 infection
WP:WP4925	0.00409583359214	0.285714285714	BCL2L11 BBC3	Unfolded protein response
GO:0010950	0.0041654421892	0.571428571429	BCL2L11 BAX BAK1 BBC3	positive regulation of endopeptidase activity
GO:0035966	0.00449874442284	0.571428571429	BCL2L11 BAX BAK1 BBC3	response to topologically incorrect protein
REAC:R-HSA-9614657	0.00455853850403	0.285714285714	BCL2L11 BBC3	FOXO-mediated transcription of cell death genes
REAC:R-HSA-111471	0.00516516478082	0.285714285714	BAX BAK1	Apoptotic factor-mediated response
WP:WP3613	0.00531562340489	0.285714285714	BCL2L11 BBC3	Photodynamic therapy induced unfolded protein response
GO:0010952	0.00561895383414	0.571428571429	BCL2L11 BAX BAK1 BBC3	positive regulation of peptidase activity
KEGG:05216	0.00571580150213	0.285714285714	BAX BAK1	Thyroid cancer
WP:WP4838	0.00575727775656	0.285714285714	BAX BAK1	Regucalcin in proximal tubule epithelial kidney cells
GO:1902235	0.00593357407009	0.428571428571	BCL2L1 BBC3 BCL2L11	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
REAC:R-HSA-6803204	0.0064914715634	0.285714285714	BAX BBC3	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
GO:2001242	0.0084704456326	0.571428571429	BCL2L11 BAX BBC3 BCL2L1	regulation of intrinsic apoptotic signaling pathway
GO:0044089	0.00889461307894	0.714285714286	BCL2L11 BAX BIK BAK1 BBC3	positive regulation of cellular component biogenesis
WP:WP2447	0.00933842806825	0.285714285714	BAX BCL2L1	Amyotrophic lateral sclerosis ALS
REAC:R-HSA-5620971	0.00959557699108	0.285714285714	BAX BAK1	Pyroptosis
GO:0097145	0.00983221512175	0.285714285714	BAX BAK1	BAK complex
GO:2000116	0.0126531584586	0.571428571429	BCL2L11 BAX BAK1 BBC3	regulation of cysteine-type endopeptidase activity
KEGG:05213	0.0134546613266	0.285714285714	BAX BAK1	Endometrial cancer
GO:0010638	0.0135962440225	0.714285714286	BCL2L11 BAX BIK BAK1 BBC3	positive regulation of organelle organization
WP:WP1971	0.0137733753117	0.285714285714	BAX BBC3	Integrated cancer pathway
GO:0080135	0.0143012754774	0.714285714286	BCL2L1 BAX BCL2L11 BAK1 BBC3	regulation of cellular response to stress
GO:0042981	0.0147464161941	0.857142857143	BIK BAX BCL2L1 BBC3 BCL2L11 BAK1	regulation of apoptotic process
KEGG:05217	0.0150576821029	0.285714285714	BAX BAK1	Basal cell carcinoma
REAC:R-HSA-114452	0.0164719839916	0.285714285714	BCL2L11 BBC3	Activation of BH3-only proteins
GO:0033043	0.0175696967364	0.857142857143	BIK BAX BCL2L1 BBC3 BCL2L11 BAK1	regulation of organelle organization
GO:0043067	0.0184020328836	0.857142857143	BIK BAX BCL2L1 BBC3 BCL2L11 BAK1	regulation of programmed cell death
KEGG:05218	0.0191438277044	0.285714285714	BAX BAK1	Melanoma
KEGG:05223	0.0230300913808	0.285714285714	BAX BAK1	Non-small cell lung cancer
KEGG:05214	0.0230300913808	0.285714285714	BAX BAK1	Glioma
WP:WP3959	0.0233506622299	0.285714285714	BAX BAK1	DNA IR double strand breaks and cellular response via ATM
REAC:R-HSA-5633008	0.0265716665994	0.285714285714	BAX BBC3	TP53 Regulates Transcription of Cell Death Genes
KEGG:05168	0.0266135315089	0.428571428571	BAX BAK1 BCL2L1	Herpes simplex virus 1 infection
WP:WP4155	0.028073243565	0.285714285714	BAX BAK1	Endometrial cancer
GO:0097192	0.0281770340738	0.428571428571	BAX BAK1 BCL2L1	extrinsic apoptotic signaling pathway in absence of ligand
GO:0038034	0.0281770340738	0.428571428571	BAX BAK1 BCL2L1	signal transduction in absence of ligand
GO:0051881	0.0305188440994	0.428571428571	BAX BAK1 BCL2L1	regulation of mitochondrial membrane potential
WP:WP4685	0.0311125325099	0.285714285714	BAX BAK1	Melanoma
GO:0052548	0.0322799316792	0.571428571429	BCL2L11 BAX BAK1 BBC3	regulation of endopeptidase activity
KEGG:01522	0.0334673599343	0.285714285714	BAX BIK	Endocrine resistance
GO:2001244	0.0355834449793	0.428571428571	BAX BBC3 BCL2L11	positive regulation of intrinsic apoptotic signaling pathway
WP:WP707	0.0365198824686	0.285714285714	BAX BBC3	DNA damage response
WP:WP1530	0.0365198824686	0.285714285714	BAX BBC3	miRNA regulation of DNA damage response
KEGG:05022	0.0378661997772	0.428571428571	BAX BAK1 BCL2L1	Pathways of neurodegeneration - multiple diseases
WP:WP4255	0.0388021990103	0.285714285714	BAX BAK1	Non small cell lung cancer
WP:WP4298	0.0435709553271	0.285714285714	BAX BCL2L1	Acute viral myocarditis
GO:0097194	0.0441816577212	0.428571428571	BAX BBC3 BCL2L1	execution phase of apoptosis
WP:WP5098	0.0473257570206	0.285714285714	BAX BCL2L1	T cell activation SARS CoV 2
WP:WP5087	0.0480568023702	0.428571428571	BAX BAK1 BBC3	Pleural mesothelioma
CORUM:2000	0.0499958217778	0.142857142857	BAX	BAX homo-oligomer complex
CORUM:3492	0.0499958217778	0.142857142857	BAX	BAX homo-oligomer complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
BCL2L1	BAX	1.0		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
BCL2L1	BCL2L11	0.998	0.208	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
BCL2L11	BAX	0.993		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
BCL2L1	BBC3	0.988		bioplex3_WMM bioplex3_HCT116 WMM_only
BAX	BAK1	0.987		bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
BCL2L1	BIK	0.984		bioplex3_WMM bioplex3_HCT116 WMM_only
BCL2L1	BAK1	0.982	0.0706666666667	bioplex3_WMM bioplex3_HCT116 WMM_only
BCL2L1	BCL2L15	0.975		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
BBC3	BAX	0.966		bioplex_WMM bioplex3_WMM WMM_only
BBC3	BAK1	0.959		bioplex_WMM bioplex3_WMM WMM_only
BCL2L15	BAX	0.959		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
BCL2L11	BBC3	0.956		bioplex_WMM bioplex3_WMM WMM_only
BCL2L11	BAK1	0.947	0.094	bioplex_WMM bioplex3_WMM WMM_only
BIK	BAK1	0.698		bioplex3_WMM WMM_only
BIK	BCL2L11	0.616		bioplex3_WMM WMM_only
BIK	BBC3	0.455		bioplex3_WMM WMM_only
BIK	BAX	0.437		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
BAK1	huMAP3_03350.1 huMAP3_07554.1 huMAP3_08181.1 huMAP3_10695.1 huMAP3_11267.1
BBC3	huMAP3_03350.1 huMAP3_07554.1 huMAP3_08181.1 huMAP3_10695.1 huMAP3_11267.1
BAX	huMAP3_03350.1 huMAP3_07554.1 huMAP3_08181.1 huMAP3_10695.1 huMAP3_11241.1 huMAP3_11267.1
BCL2L1	huMAP3_00428.1 huMAP3_08181.1 huMAP3_10695.1 huMAP3_11267.1
BCL2L15	huMAP3_00428.1 huMAP3_07554.1 huMAP3_08181.1 huMAP3_10695.1 huMAP3_11241.1 huMAP3_11267.1
BCL2L11	huMAP3_03350.1 huMAP3_04180.1 huMAP3_07554.1 huMAP3_08181.1 huMAP3_10156.1 huMAP3_10695.1 huMAP3_11267.1
BIK	huMAP3_01845.1 huMAP3_08181.1 huMAP3_10695.1 huMAP3_11267.1

hu.MAP 3.0: Complex View

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Complex: huMAP3_08181.1