hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08187.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SHMT1 | Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | 5 | UniProt NCBI |
| SHMT2 | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP1495 | 1.27691105477e-06 | 1.0 | SHMT1 SHMT2 | Glycine metabolism |
| WP:WP4688 | 8.93837738341e-06 | 1.0 | SHMT1 SHMT2 | Serine metabolism |
| KEGG:00670 | 1.70698179197e-05 | 1.0 | SHMT1 SHMT2 | One carbon pool by folate |
| WP:WP4259 | 3.87329686614e-05 | 1.0 | SHMT1 SHMT2 | Disorders of folate metabolism and transport |
| KEGG:01523 | 5.28351507038e-05 | 1.0 | SHMT1 SHMT2 | Antifolate resistance |
| KEGG:00630 | 5.28351507038e-05 | 1.0 | SHMT1 SHMT2 | Glyoxylate and dicarboxylate metabolism |
| KEGG:00260 | 8.58367986819e-05 | 1.0 | SHMT1 SHMT2 | Glycine, serine and threonine metabolism |
| WP:WP241 | 0.000117475817039 | 1.0 | SHMT1 SHMT2 | One carbon metabolism |
| REAC:R-HSA-196757 | 0.000179419983974 | 1.0 | SHMT1 SHMT2 | Metabolism of folate and pterines |
| KEGG:01230 | 0.000359441594481 | 1.0 | SHMT1 SHMT2 | Biosynthesis of amino acids |
| WP:WP3940 | 0.000384350227487 | 1.0 | SHMT1 SHMT2 | One carbon metabolism and related pathways |
| GO:0004372 | 0.000468200720083 | 1.0 | SHMT1 SHMT2 | glycine hydroxymethyltransferase activity |
| GO:0019264 | 0.000468200720083 | 1.0 | SHMT1 SHMT2 | glycine biosynthetic process from serine |
| WP:WP2525 | 0.000632070972113 | 1.0 | SHMT1 SHMT2 | Trans sulfuration one carbon metabolism and related pathways |
| WP:WP176 | 0.000632070972113 | 1.0 | SHMT1 SHMT2 | Folate metabolism |
| KEGG:01200 | 0.000870723283599 | 1.0 | SHMT1 SHMT2 | Carbon metabolism |
| WP:WP4018 | 0.00118114272566 | 1.0 | SHMT1 SHMT2 | Clear cell renal cell carcinoma pathways |
| GO:0006545 | 0.00140460216025 | 1.0 | SHMT1 SHMT2 | glycine biosynthetic process |
| GO:0070905 | 0.00140460216025 | 1.0 | SHMT1 SHMT2 | serine binding |
| KEGG:01240 | 0.00144865854745 | 1.0 | SHMT1 SHMT2 | Biosynthesis of cofactors |
| WP:WP5355 | 0.00155570330173 | 1.0 | SHMT1 SHMT2 | Metabolic Epileptic Disorders |
| WP:WP5083 | 0.00259851399646 | 1.0 | SHMT1 SHMT2 | Neuroinflammation and glutamatergic signaling |
| GO:0006565 | 0.00468200720083 | 1.0 | SHMT1 SHMT2 | L-serine catabolic process |
| GO:0006544 | 0.00702301080125 | 1.0 | SHMT1 SHMT2 | glycine metabolic process |
| GO:0016742 | 0.00702301080125 | 1.0 | SHMT1 SHMT2 | hydroxymethyl-, formyl- and related transferase activity |
| REAC:R-HSA-196849 | 0.00845837067304 | 1.0 | SHMT1 SHMT2 | Metabolism of water-soluble vitamins and cofactors |
| GO:0009071 | 0.0131096201623 | 1.0 | SHMT1 SHMT2 | serine family amino acid catabolic process |
| GO:0006563 | 0.0131096201623 | 1.0 | SHMT1 SHMT2 | L-serine metabolic process |
| WP:WP5420 | 0.0144418640295 | 1.0 | SHMT1 SHMT2 | ADHD and autism ASD linked metabolic pathways and SNP |
| GO:0035999 | 0.016855225923 | 1.0 | SHMT1 SHMT2 | tetrahydrofolate interconversion |
| GO:0009113 | 0.016855225923 | 1.0 | SHMT1 SHMT2 | purine nucleobase biosynthetic process |
| REAC:R-HSA-196854 | 0.0209254964166 | 1.0 | SHMT1 SHMT2 | Metabolism of vitamins and cofactors |
| GO:0000900 | 0.0210690324038 | 1.0 | SHMT1 SHMT2 | mRNA regulatory element binding translation repressor activity |
| GO:0046655 | 0.0257510396046 | 1.0 | SHMT1 SHMT2 | folic acid metabolic process |
| GO:0009070 | 0.0257510396046 | 1.0 | SHMT1 SHMT2 | serine family amino acid biosynthetic process |
| GO:0046653 | 0.0365196561665 | 1.0 | SHMT1 SHMT2 | tetrahydrofolate metabolic process |
| GO:0006144 | 0.0365196561665 | 1.0 | SHMT1 SHMT2 | purine nucleobase metabolic process |
| GO:0046112 | 0.0426062655276 | 1.0 | SHMT1 SHMT2 | nucleobase biosynthetic process |
| CORUM:7113 | 0.0499419797295 | 0.5 | SHMT1 | ABRAXAS2-SHMT1 complex |
| CORUM:7114 | 0.0499419797295 | 0.5 | SHMT2 | ABRAXAS2-SHMT2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SHMT2 | SHMT1 | 0.997 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
Related Complexes
| Genename | Complexes |
|---|---|
| SHMT1 | huMAP3_08187.1 huMAP3_13864.1 |
| SHMT2 | huMAP3_01447.1 huMAP3_02592.1 huMAP3_08187.1 huMAP3_10482.1 huMAP3_14749.1 |