hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08188.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NHLH2 | Helix-loop-helix protein 2 (HEN-2) (Class A basic helix-loop-helix protein 34) (bHLHa34) (Nescient helix loop helix 2) (NSCL-2) | 5 | UniProt NCBI |
| ID1 | DNA-binding protein inhibitor ID-1 (Class B basic helix-loop-helix protein 24) (bHLHb24) (Inhibitor of DNA binding 1) (Inhibitor of differentiation 1) | 5 | UniProt NCBI |
| MYF6 | Myogenic factor 6 (Myf-6) (Class C basic helix-loop-helix protein 4) (bHLHc4) (Muscle-specific regulatory factor 4) | 5 | UniProt NCBI |
| FERD3L | Fer3-like protein (Basic helix-loop-helix protein N-twist) (Class A basic helix-loop-helix protein 31) (bHLHa31) (Nephew of atonal 3) (Neuronal twist) | 5 | UniProt NCBI |
| TCF12 | Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) | 5 | UniProt NCBI |
| ID2 | DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2) | 5 | UniProt NCBI |
| TWIST2 | Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1) | 5 | UniProt NCBI |
| TCF3 | Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) | 5 | UniProt NCBI |
| ASCL4 | Achaete-scute homolog 4 (ASH-4) (hASH4) (Achaete-scute-like protein 4) (Class A basic helix-loop-helix protein 44) (bHLHa44) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9031628 | 0.000112766844535 | 0.375 | ID1 ID2 TCF12 | NGF-stimulated transcription |
| WP:WP3596 | 0.000239030245992 | 0.25 | ID1 ID2 | miR 517 relationship with ARCN1 and USP1 |
| REAC:R-HSA-198725 | 0.000560745073172 | 0.375 | ID1 ID2 TCF12 | Nuclear Events (kinase and transcription factor activation) |
| WP:WP53 | 0.00157457895347 | 0.25 | ID1 ID2 | ID signaling pathway |
| GO:0006357 | 0.00180523733988 | 1.0 | TCF12 FERD3L ID1 NHLH2 MYF6 ASCL4 ID2 TWIST2 | regulation of transcription by RNA polymerase II |
| GO:0006366 | 0.00276616156096 | 1.0 | TCF12 FERD3L ID1 NHLH2 MYF6 ASCL4 ID2 TWIST2 | transcription by RNA polymerase II |
| REAC:R-HSA-187037 | 0.00329649801499 | 0.375 | ID1 ID2 TCF12 | Signaling by NTRK1 (TRKA) |
| WP:WP4239 | 0.00355995355756 | 0.375 | ID1 ID2 TWIST2 | Epithelial to mesenchymal transition in colorectal cancer |
| REAC:R-HSA-166520 | 0.00535285250311 | 0.375 | ID1 ID2 TCF12 | Signaling by NTRKs |
| REAC:R-HSA-525793 | 0.0153043597228 | 0.25 | TCF12 MYF6 | Myogenesis |
| GO:0006355 | 0.019276917338 | 1.0 | TCF12 FERD3L ID1 NHLH2 MYF6 ASCL4 ID2 TWIST2 | regulation of DNA-templated transcription |
| GO:2001141 | 0.0202331041081 | 1.0 | TCF12 FERD3L ID1 NHLH2 MYF6 ASCL4 ID2 TWIST2 | regulation of RNA biosynthetic process |
| GO:0006351 | 0.0281694782025 | 1.0 | TCF12 FERD3L ID1 NHLH2 MYF6 ASCL4 ID2 TWIST2 | DNA-templated transcription |
| GO:0032774 | 0.0306853042962 | 1.0 | TCF12 FERD3L ID1 NHLH2 MYF6 ASCL4 ID2 TWIST2 | RNA biosynthetic process |
| GO:0051252 | 0.0471731106254 | 1.0 | TCF12 FERD3L ID1 NHLH2 MYF6 ASCL4 ID2 TWIST2 | regulation of RNA metabolic process |
| KEGG:04350 | 0.0474398326563 | 0.25 | ID1 ID2 | TGF-beta signaling pathway |
| CORUM:2937 | 0.0499436884912 | 0.125 | TCF12 | PTF1-bHLH complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ID1 | ASCL4 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NHLH2 | ID1 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FERD3L | TCF3 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ASCL4 | ID2 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FERD3L | TCF12 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MYF6 | TCF12 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TCF12 | TCF3 | 0.995 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| NHLH2 | TCF12 | 0.994 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NHLH2 | TCF3 | 0.989 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ID1 | TCF12 | 0.988 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| ASCL4 | TCF3 | 0.986 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ID2 | TCF3 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TCF12 | ASCL4 | 0.984 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TCF12 | TWIST2 | 0.981 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MYF6 | TCF3 | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TWIST2 | TCF3 | 0.964 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TCF12 | ID2 | 0.953 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| ID1 | TCF3 | 0.907 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| ID1 | ID2 | 0.831 | bioplex_WMM bioplex3_WMM WMM_only | |
| TWIST2 | ID2 | 0.53 | bioplex_WMM bioplex3_WMM WMM_only | |
| ID1 | TWIST2 | 0.363 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes