hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08193.1

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
PNKP	Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]	5	UniProt NCBI
POLB	DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18)	5	UniProt NCBI
TDP1	Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-)	5	UniProt NCBI
XRCC1	DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)	5	UniProt NCBI
APTX	Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT)	5	UniProt NCBI
LIG3	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:03410	8.41515402485e-12	1.0	TDP1 LIG3 PNKP APTX POLB	Base excision repair
CORUM:362	2.80233355908e-09	0.6	LIG3 PNKP POLB	DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex
CORUM:5243	2.80233355908e-09	0.6	TDP1 PNKP LIG3	XRCC1-LIG3-PNK-TDP1 complex
REAC:R-HSA-5649702	1.09182472013e-07	0.6	LIG3 PNKP POLB	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
WP:WP4752	4.88902625878e-06	0.6	LIG3 PNKP POLB	Base excision repair
REAC:R-HSA-73933	2.03584684634e-05	0.6	LIG3 PNKP POLB	Resolution of Abasic Sites (AP sites)
CORUM:1086	8.18785830799e-05	0.4	POLB LIG3	DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1
CORUM:1085	8.18785830799e-05	0.4	POLB LIG3	DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1
REAC:R-HSA-110381	9.11829675208e-05	0.4	POLB LIG3	Resolution of AP sites via the single-nucleotide replacement pathway
HP:0003380	0.000129597601889	0.6	TDP1 LIG3 APTX	Decreased number of peripheral myelinated nerve fibers
REAC:R-HSA-73894	0.000150476434856	0.8	TDP1 LIG3 PNKP POLB	DNA Repair
REAC:R-HSA-73884	0.000217750033404	0.6	LIG3 PNKP POLB	Base Excision Repair
GO:0006287	0.000274621184043	0.6	LIG3 PNKP POLB	base-excision repair, gap-filling
WP:WP4946	0.00027954510039	0.6	LIG3 PNKP POLB	DNA repair pathways full network
HP:0003431	0.000306872067377	0.6	TDP1 PNKP LIG3	Decreased motor nerve conduction velocity
HP:0040131	0.000343598217885	0.6	TDP1 PNKP LIG3	Abnormal motor nerve conduction velocity
HP:0003124	0.000447946694857	0.6	TDP1 PNKP APTX	Hypercholesterolemia
HP:0003474	0.00112438101994	0.8	TDP1 LIG3 PNKP APTX	Somatic sensory dysfunction
HPA:0570792	0.00116925354694	1.0	TDP1 LIG3 PNKP APTX POLB	testis; round or early spermatids[>=Medium]
HP:0007141	0.00119989499053	0.6	TDP1 PNKP LIG3	Sensorimotor neuropathy
HP:0001272	0.00164044770812	0.8	TDP1 LIG3 PNKP APTX	Cerebellar atrophy
HP:0003130	0.00169289796817	0.6	TDP1 LIG3 APTX	Abnormal peripheral myelination
HP:0000762	0.00174852750004	0.6	TDP1 PNKP LIG3	Decreased nerve conduction velocity
HP:0003073	0.00192267581507	0.6	TDP1 PNKP APTX	Hypoalbuminemia
HP:0012116	0.00192267581507	0.6	TDP1 PNKP APTX	Abnormal circulating albumin concentration
GO:0006281	0.00195208595796	1.0	TDP1 LIG3 PNKP APTX POLB	DNA repair
HP:0040129	0.00198318736699	0.6	TDP1 PNKP LIG3	Abnormal nerve conduction velocity
HP:0009830	0.00208465659319	0.8	TDP1 LIG3 PNKP APTX	Peripheral neuropathy
HP:0002495	0.00237299419328	0.6	TDP1 PNKP APTX	Impaired vibratory sensation
HP:0002936	0.00313025086245	0.6	TDP1 PNKP APTX	Distal sensory impairment
HPA:0570791	0.00318343565729	1.0	TDP1 LIG3 PNKP APTX POLB	testis; round or early spermatids[>=Low]
HP:0003134	0.00338520553001	0.6	TDP1 PNKP LIG3	Abnormality of peripheral nerve conduction
HP:0010831	0.00393572415664	0.6	TDP1 PNKP APTX	Impaired proprioception
HP:0003107	0.00433390348683	0.6	TDP1 PNKP APTX	Abnormal circulating cholesterol concentration
HP:0003621	0.00454732332026	0.8	TDP1 LIG3 PNKP APTX	Juvenile onset
HP:0030177	0.00581076944422	0.6	TDP1 PNKP LIG3	Abnormality of peripheral nervous system electrophysiology
HP:0032120	0.00619327795747	0.6	TDP1 PNKP LIG3	Abnormal peripheral nervous system physiology
HP:0012447	0.00626585706529	0.8	TDP1 LIG3 PNKP APTX	Abnormal myelination
GO:0140097	0.00729542990987	0.8	TDP1 LIG3 POLB APTX	catalytic activity, acting on DNA
GO:0006284	0.0094606249379	0.6	LIG3 PNKP POLB	base-excision repair
HP:0003387	0.00979150178217	0.4	APTX LIG3	Decreased number of large peripheral myelinated nerve fibers
HP:0000764	0.0127746024565	0.6	TDP1 LIG3 APTX	Peripheral axonal degeneration
HP:0003693	0.0138556317341	0.6	TDP1 PNKP APTX	Distal amyotrophy
GO:0006974	0.0141199763351	1.0	TDP1 LIG3 PNKP APTX POLB	DNA damage response
HP:0002460	0.0159509868384	0.6	TDP1 PNKP LIG3	Distal muscle weakness
WP:WP4016	0.017034501082	0.4	TDP1 POLB	DNA IR damage and cellular response via ATR
GO:0006259	0.0192772113985	1.0	TDP1 LIG3 PNKP APTX POLB	DNA metabolic process
HPA:0530712	0.0210155383112	1.0	TDP1 LIG3 PNKP APTX POLB	spleen; cells in red pulp[>=Medium]
GO:0006302	0.0280745884658	0.8	TDP1 LIG3 PNKP POLB	double-strand break repair
GO:0051103	0.0280843539964	0.4	PNKP LIG3	DNA ligation involved in DNA repair
HP:0001761	0.03503731332	0.6	TDP1 PNKP APTX	Pes cavus
HP:0003119	0.0358640546012	0.6	TDP1 PNKP APTX	Abnormal circulating lipid concentration
HP:0001284	0.0367035812988	0.6	TDP1 PNKP APTX	Areflexia
HP:0001317	0.0435465278758	0.8	TDP1 LIG3 PNKP APTX	Abnormal cerebellum morphology
HP:0011282	0.0443303161429	0.8	TDP1 LIG3 PNKP APTX	Abnormal hindbrain morphology
HP:0011283	0.0443303161429	0.8	TDP1 LIG3 PNKP APTX	Abnormal metencephalon morphology
HP:0001324	0.0455255982635	0.8	TDP1 LIG3 PNKP APTX	Muscle weakness
HP:0001251	0.0457271166595	0.8	TDP1 LIG3 PNKP APTX	Ataxia
CORUM:365	0.0498708842806	0.2	LIG3	DNA ligase III-XRCC1 complex
CORUM:363	0.0498708842806	0.2	LIG3	DNA ligase III-XRCC1 complex
CORUM:212	0.0498708842806	0.2	LIG3	DNA ligase III-XRCC1 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
LIG3	XRCC1	1.0	0.55		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
POLB	XRCC1	0.999	0.084	mutually_exclusive (P35244)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
LIG3	POLB	0.999	0.1		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
LIG3	PNKP	0.998	0.18		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
LIG3	APTX	0.997	0.136		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
LIG3	TDP1	0.996	0.0660385964912		bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
PNKP	POLB	0.994	0.108		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PNKP	XRCC1	0.993	0.13		hein_WMM bioplex_WMM bioplex3_WMM hein ()
POLB	APTX	0.99	0.134		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
POLB	TDP1	0.986	0.13		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PNKP	APTX	0.958	0.13		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
XRCC1	APTX	0.951	0.166		hein_WMM bioplex_WMM bioplex3_WMM hein ()
XRCC1	TDP1	0.918	0.172		bioplex_WMM bioplex3_WMM WMM_only
PNKP	TDP1	0.862	0.12		bioplex_WMM bioplex3_WMM WMM_only
TDP1	APTX	0.765	0.14		bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
PNKP	huMAP3_01586.1 huMAP3_02384.1 huMAP3_07457.1 huMAP3_08193.1 huMAP3_09211.1 huMAP3_10578.1 huMAP3_11158.1 huMAP3_13854.1 huMAP3_14846.1
POLB	huMAP3_01586.1 huMAP3_02384.1 huMAP3_07457.1 huMAP3_08193.1 huMAP3_09211.1 huMAP3_10578.1 huMAP3_11158.1 huMAP3_13854.1 huMAP3_14846.1
TDP1	huMAP3_01586.1 huMAP3_02384.1 huMAP3_08193.1 huMAP3_09211.1 huMAP3_10578.1 huMAP3_11158.1 huMAP3_11442.1 huMAP3_12122.1 huMAP3_13854.1 huMAP3_14846.1
XRCC1	huMAP3_01586.1 huMAP3_02384.1 huMAP3_07457.1 huMAP3_08193.1 huMAP3_09211.1 huMAP3_10578.1 huMAP3_11158.1 huMAP3_13854.1 huMAP3_14846.1
APTX	huMAP3_02384.1 huMAP3_07457.1 huMAP3_08193.1 huMAP3_09211.1 huMAP3_10578.1 huMAP3_11158.1 huMAP3_12091.1 huMAP3_13977.1 huMAP3_14505.1
LIG3	huMAP3_00669.1 huMAP3_01586.1 huMAP3_02384.1 huMAP3_07457.1 huMAP3_08193.1 huMAP3_09211.1 huMAP3_10578.1 huMAP3_10730.1 huMAP3_13854.1 huMAP3_14846.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08193.1