hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08199.1
Complex Portal: CPX-20556
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | 5 | UniProt NCBI |
| MEX3B | RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195) | 5 | UniProt NCBI |
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | 5 | UniProt NCBI |
| AFF3 | AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4) | 5 | UniProt NCBI |
| MEX3C | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | 5 | UniProt NCBI |
| PNISR | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | 5 | UniProt NCBI |
| PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | 5 | UniProt NCBI |
| AHCYL1 | S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) | 5 | UniProt NCBI |
| NOS1AP | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) | 5 | UniProt NCBI |
| LENG8 | Leukocyte receptor cluster member 8 | 5 | UniProt NCBI |
| PLCD3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | 5 | UniProt NCBI |
| GRM3 | Metabotropic glutamate receptor 3 (mGluR3) | 5 | UniProt NCBI |
| DIP2C | Disco-interacting protein 2 homolog C (DIP2 homolog C) | 3 | UniProt NCBI |
| UBE2H | Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8847453 | 7.85796421216e-07 | 0.214285714286 | PIP4K2A PIP4K2C PIP4K2B | Synthesis of PIPs in the nucleus |
| WP:WP5411 | 6.73043816113e-06 | 0.285714285714 | PIP4K2A PLCD3 PIP4K2C PIP4K2B | Phosphatidyl inositol phosphate pathway |
| WP:WP4971 | 6.73043816113e-06 | 0.285714285714 | PIP4K2A PLCD3 PIP4K2C PIP4K2B | Phosphoinositides metabolism |
| REAC:R-HSA-6811555 | 1.64551903044e-05 | 0.214285714286 | PIP4K2A PIP4K2C PIP4K2B | PI5P Regulates TP53 Acetylation |
| KEGG:00562 | 1.91835479418e-05 | 0.285714285714 | PIP4K2A PLCD3 PIP4K2C PIP4K2B | Inositol phosphate metabolism |
| GO:0016309 | 3.49876949518e-05 | 0.214285714286 | PIP4K2A PIP4K2C PIP4K2B | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| GO:1902633 | 3.49876949518e-05 | 0.214285714286 | PIP4K2A PIP4K2C PIP4K2B | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process |
| GO:1902635 | 3.49876949518e-05 | 0.214285714286 | PIP4K2A PIP4K2C PIP4K2B | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process |
| KEGG:04070 | 5.67446557337e-05 | 0.285714285714 | PIP4K2A PLCD3 PIP4K2C PIP4K2B | Phosphatidylinositol signaling system |
| REAC:R-HSA-6804758 | 0.000785954680088 | 0.214285714286 | PIP4K2A PIP4K2C PIP4K2B | Regulation of TP53 Activity through Acetylation |
| GO:0016308 | 0.00195378579303 | 0.214285714286 | PIP4K2A PIP4K2C PIP4K2B | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| REAC:R-HSA-1660499 | 0.00310896832534 | 0.214285714286 | PIP4K2A PIP4K2C PIP4K2B | Synthesis of PIPs at the plasma membrane |
| REAC:R-HSA-1483255 | 0.011274553488 | 0.214285714286 | PIP4K2A PIP4K2C PIP4K2B | PI Metabolism |
| REAC:R-HSA-6811558 | 0.0122407047464 | 0.214285714286 | PIP4K2A PIP4K2C PIP4K2B | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-199418 | 0.0160473157166 | 0.214285714286 | PIP4K2A PIP4K2C PIP4K2B | Negative regulation of the PI3K/AKT network |
| GO:2000786 | 0.0236042404358 | 0.214285714286 | PIP4K2A PIP4K2C PIP4K2B | positive regulation of autophagosome assembly |
| REAC:R-HSA-9006925 | 0.0257465778284 | 0.285714285714 | PIP4K2A AHCYL1 PIP4K2C PIP4K2B | Intracellular signaling by second messengers |
| WP:WP51 | 0.0259417942945 | 0.214285714286 | PIP4K2A PIP4K2C PIP4K2B | Regulation of actin cytoskeleton |
| KEGG:04810 | 0.0424845654214 | 0.214285714286 | PIP4K2A PIP4K2C PIP4K2B | Regulation of actin cytoskeleton |
| CORUM:6371 | 0.0499958217778 | 0.0714285714286 | GRM3 | mGluR3-mGluR8 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| PIP4K2B | PIP4K2C | 1.0 | 0.014 | |
| PIP4K2A | PIP4K2C | 1.0 | 0.0883043478261 | |
| PIP4K2A | PIP4K2B | 1.0 | 0.318 | |
| PIP4K2A | PLCD3 | 0.999 | 0.068 |
structurally_consistent (dimer)
|
| PIP4K2A | NOS1AP | 0.997 | 0.074 | |
| PLCD3 | PIP4K2C | 0.994 | 0.15 |
structurally_consistent (O43865)
structurally_consistent (dimer) |
| PIP4K2A | PNISR | 0.99 | 0.024 | |
| PIP4K2A | DIP2C | 0.99 | 0.106 | |
| PIP4K2A | GRM3 | 0.983 | ||
| PIP4K2C | NOS1AP | 0.982 | 0.098 | |
| PIP4K2A | MEX3B | 0.978 | 0.098 | |
| PIP4K2A | AHCYL1 | 0.974 | 0.048 | |
| PIP4K2B | NOS1AP | 0.971 | 0.042 | |
| PIP4K2A | LENG8 | 0.968 | 0.092 | |
| PIP4K2A | UBE2H | 0.964 | 0.048 | |
| PIP4K2A | AFF3 | 0.963 | ||
| PIP4K2A | MEX3C | 0.96 | 0.106 | |
| AHCYL1 | PLCD3 | 0.951 | 0.082 |
structurally_consistent (dimer)
|
| PIP4K2B | PLCD3 | 0.95 | 0.068 |
structurally_consistent (O43865)
structurally_consistent (dimer) |
| PLCD3 | NOS1AP | 0.948 | 0.18 | |
| PLCD3 | PNISR | 0.902 | 0.066 | |
| PIP4K2C | DIP2C | 0.87 | 0.094 | |
| PLCD3 | DIP2C | 0.851 | 0.138 | |
| PLCD3 | LENG8 | 0.729 | 0.194 | |
| DIP2C | LENG8 | 0.687 | 0.098 | |
| UBE2H | DIP2C | 0.674 | 0.066 | |
| GRM3 | MEX3C | 0.572 | ||
| GRM3 | AFF3 | 0.572 | ||
| MEX3B | GRM3 | 0.572 | ||
| MEX3B | NOS1AP | 0.557 | 0.128 | |
| GRM3 | DIP2C | 0.557 | ||
| PIP4K2B | AHCYL1 | 0.552 | 0.042 |
structurally_consistent (dimer)
|
| PIP4K2C | UBE2H | 0.54 | 0.018 | |
| PNISR | GRM3 | 0.502 | ||
| PIP4K2C | MEX3B | 0.473 | 0.17 | |
| PLCD3 | UBE2H | 0.417 | 0.09 | |
| AHCYL1 | PIP4K2C | 0.347 | 0.046 |
structurally_consistent (dimer)
|
| MEX3B | DIP2C | 0.333 | 0.098 | |
| MEX3C | DIP2C | 0.333 | 0.094 | |
| PIP4K2B | GRM3 | 0.333 | ||
| PNISR | DIP2C | 0.333 | 0.104 | |
| AFF3 | DIP2C | 0.333 | ||
| AFF3 | MEX3C | 0.303 | ||
| MEX3B | AFF3 | 0.303 | ||
| UBE2H | GRM3 | 0.302 | ||
| AHCYL1 | MEX3C | 0.276 | 0.132 | |
| AHCYL1 | MEX3B | 0.276 | 0.178 | |
| MEX3B | MEX3C | 0.265 | 0.226 | |
| PIP4K2B | DIP2C | 0.265 | 0.04 | |
| PIP4K2C | MEX3C | 0.244 | 0.08 | |
| UBE2H | NOS1AP | 0.241 | 0.076 | |
| AHCYL1 | DIP2C | 0.241 | 0.1792 | |
| NOS1AP | DIP2C | 0.23 | 0.138 | |
| PIP4K2B | MEX3C | 0.213 | 0.098 | |
| PIP4K2B | AFF3 | 0.213 | ||
| PIP4K2B | MEX3B | 0.213 | 0.068 | |
| PIP4K2B | UBE2H | 0.212 | 0.046 | |
| UBE2H | PNISR | 0.204 | 0.04 | |
| AHCYL1 | AFF3 | 0.2 | ||
| PLCD3 | MEX3B | 0.193 | 0.116 | |
| PLCD3 | MEX3C | 0.193 | 0.072 | |
| PLCD3 | AFF3 | 0.193 | ||
| AHCYL1 | NOS1AP | 0.191 | 0.16 | |
| UBE2H | AFF3 | 0.188 | ||
| UBE2H | MEX3C | 0.188 | 0.142 | |
| MEX3B | UBE2H | 0.188 | 0.068 | |
| AHCYL1 | GRM3 | 0.18 | ||
| PNISR | AFF3 | 0.172 | ||
| MEX3B | PNISR | 0.172 | 0.088 | |
| PNISR | MEX3C | 0.172 | 0.076 | |
| AFF3 | LENG8 | 0.168 | ||
| PNISR | NOS1AP | 0.167 | 0.114 | |
| MEX3B | LENG8 | 0.166 | 0.19 | |
| GRM3 | LENG8 | 0.165 | ||
| UBE2H | LENG8 | 0.157 | 0.062 | |
| AHCYL1 | UBE2H | 0.151 | 0.08 | |
| PIP4K2C | GRM3 | 0.143 | ||
| PLCD3 | GRM3 | 0.142 | ||
| AFF3 | NOS1AP | 0.14 | ||
| MEX3C | NOS1AP | 0.14 | 0.096 | |
| PIP4K2C | AFF3 | 0.134 | ||
| GRM3 | NOS1AP | 0.123 | ||
| AHCYL1 | PNISR | 0.088 | 0.032 | |
| MEX3C | LENG8 | 0.087 | 0.068 | |
| PIP4K2B | PNISR | 0.082 | 0.022 | |
| PIP4K2C | PNISR | 0.075 | 0.054 | |
| PNISR | LENG8 | 0.038 | 0.134 | |
| NOS1AP | LENG8 | 0.035 | 0.114 | |
| PIP4K2B | LENG8 | 0.018 | 0.036 | |
| AHCYL1 | LENG8 | 0.016 | 0.062 | |
| PIP4K2C | LENG8 | 0.009 | 0.048 |
Related Complexes