hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08202.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBE2D4 | Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4) | 5 | UniProt NCBI |
| UBE2E2 | Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2) | 5 | UniProt NCBI |
| UBE2D2 | Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1) | 5 | UniProt NCBI |
| RNF25 | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7) | 5 | UniProt NCBI |
| OTUB1 | Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1) | 5 | UniProt NCBI |
| UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-983168 | 2.80350541837e-06 | 0.833333333333 | UBE2D4 RNF25 UBE2D3 UBE2E2 UBE2D2 | Antigen processing: Ubiquitination & Proteasome degradation |
| KEGG:04120 | 5.32941465156e-06 | 0.666666666667 | UBE2D4 UBE2D3 UBE2E2 UBE2D2 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-983169 | 7.81805966072e-06 | 0.833333333333 | UBE2D4 RNF25 UBE2D3 UBE2E2 UBE2D2 | Class I MHC mediated antigen processing & presentation |
| GO:0061631 | 1.07856904359e-05 | 0.666666666667 | UBE2D4 UBE2D3 UBE2E2 UBE2D2 | ubiquitin conjugating enzyme activity |
| GO:0061650 | 2.05958456954e-05 | 0.666666666667 | UBE2D4 UBE2D3 UBE2E2 UBE2D2 | ubiquitin-like protein conjugating enzyme activity |
| KEGG:03083 | 0.000167761438495 | 0.5 | UBE2D4 UBE2D2 UBE2D3 | Polycomb repressive complex |
| REAC:R-HSA-1280218 | 0.00020253555583 | 0.833333333333 | UBE2D4 RNF25 UBE2D3 UBE2E2 UBE2D2 | Adaptive Immune System |
| GO:0000209 | 0.000204308337956 | 0.833333333333 | UBE2D4 RNF25 UBE2D3 UBE2E2 UBE2D2 | protein polyubiquitination |
| GO:0070647 | 0.000374994553892 | 1.0 | UBE2E2 UBE2D3 UBE2D2 RNF25 UBE2D4 OTUB1 | protein modification by small protein conjugation or removal |
| GO:0070936 | 0.000403034704454 | 0.666666666667 | UBE2D4 UBE2D3 UBE2E2 UBE2D2 | protein K48-linked ubiquitination |
| GO:0043687 | 0.000556668958492 | 1.0 | UBE2E2 UBE2D3 UBE2D2 RNF25 UBE2D4 OTUB1 | post-translational protein modification |
| GO:0085020 | 0.000698569295426 | 0.5 | UBE2D4 RNF25 UBE2D3 | protein K6-linked ubiquitination |
| KEGG:04141 | 0.00120621676501 | 0.5 | UBE2D4 UBE2D2 UBE2D3 | Protein processing in endoplasmic reticulum |
| GO:0004842 | 0.00206564891549 | 0.833333333333 | UBE2D4 RNF25 UBE2D3 UBE2E2 UBE2D2 | ubiquitin-protein transferase activity |
| GO:0019787 | 0.00305653552363 | 0.833333333333 | UBE2D4 RNF25 UBE2D3 UBE2E2 UBE2D2 | ubiquitin-like protein transferase activity |
| GO:0016755 | 0.00362983359556 | 0.833333333333 | UBE2D4 RNF25 UBE2D3 UBE2E2 UBE2D2 | aminoacyltransferase activity |
| KEGG:05131 | 0.00369808394071 | 0.5 | UBE2D4 UBE2D2 UBE2D3 | Shigellosis |
| REAC:R-HSA-168927 | 0.00440152140132 | 0.333333333333 | UBE2D3 UBE2D2 | TICAM1, RIP1-mediated IKK complex recruitment |
| REAC:R-HSA-937041 | 0.00488968644054 | 0.333333333333 | UBE2D3 UBE2D2 | IKK complex recruitment mediated by RIP1 |
| GO:0070979 | 0.00627357313526 | 0.5 | UBE2D4 UBE2E2 UBE2D3 | protein K11-linked ubiquitination |
| REAC:R-HSA-9705462 | 0.00650743774508 | 0.333333333333 | UBE2D3 UBE2D2 | Inactivation of CSF3 (G-CSF) signaling |
| REAC:R-HSA-9674555 | 0.00971370123257 | 0.333333333333 | UBE2D3 UBE2D2 | Signaling by CSF3 (G-CSF) |
| REAC:R-HSA-936440 | 0.0135559590666 | 0.333333333333 | UBE2D3 UBE2D2 | Negative regulators of DDX58/IFIH1 signaling |
| GO:0016567 | 0.015833626461 | 0.833333333333 | UBE2D4 RNF25 UBE2D3 UBE2E2 UBE2D2 | protein ubiquitination |
| WP:WP183 | 0.0182415379951 | 0.333333333333 | UBE2D3 UBE2D2 | Proteasome degradation |
| REAC:R-HSA-168256 | 0.0203260039291 | 0.833333333333 | UBE2D4 RNF25 UBE2D3 UBE2E2 UBE2D2 | Immune System |
| GO:0016746 | 0.0235840208806 | 0.833333333333 | UBE2D4 RNF25 UBE2D3 UBE2E2 UBE2D2 | acyltransferase activity |
| REAC:R-HSA-5357905 | 0.0242390006211 | 0.333333333333 | UBE2D3 UBE2D2 | Regulation of TNFR1 signaling |
| REAC:R-HSA-9033241 | 0.0288812004442 | 0.333333333333 | UBE2D3 UBE2D2 | Peroxisomal protein import |
| GO:0032446 | 0.0300759059221 | 0.833333333333 | UBE2D4 RNF25 UBE2D3 UBE2E2 UBE2D2 | protein modification by small protein conjugation |
| REAC:R-HSA-75893 | 0.0352499509777 | 0.333333333333 | UBE2D3 UBE2D2 | TNF signaling |
| REAC:R-HSA-8866654 | 0.03659902859 | 0.333333333333 | UBE2D3 UBE2D2 | E3 ubiquitin ligases ubiquitinate target proteins |
| REAC:R-HSA-1234176 | 0.0498675109087 | 0.333333333333 | UBE2D3 UBE2D2 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RNF25 | UBE2D2 | 0.999 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D3 | 0.998 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D4 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UBE2E2 | OTUB1 | 0.988 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2E2 | 0.984 | 0.046 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UBE2D2 | OTUB1 | 0.982 | 0.246 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| UBE2D3 | UBE2D2 | 0.975 | 0.22 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D4 | OTUB1 | 0.963 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| UBE2D3 | UBE2D4 | 0.909 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| RNF25 | OTUB1 | 0.562 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D4 | UBE2E2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBE2D3 | UBE2E2 | 0.153 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D2 | UBE2D4 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBE2D2 | UBE2E2 | 0.143 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D3 | OTUB1 | 0.034 | 0.396 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM |
Related Complexes