hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08205.1

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
ARHGAP11A	Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A)	4	UniProt NCBI
PPP1R12A	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)	5	UniProt NCBI
MYL6B	Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B)	5	UniProt NCBI
SPECC1L	Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein)	5	UniProt NCBI
CGN	Cingulin	5	UniProt NCBI
ARHGEF17	Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4)	4	UniProt NCBI
MPRIP	Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)	5	UniProt NCBI
COBL	Protein cordon-bleu	5	UniProt NCBI
LRCH3	DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3)	5	UniProt NCBI
TPM1	Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)	5	UniProt NCBI
CDC42	Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)	5	UniProt NCBI
TPM4	Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)	5	UniProt NCBI
DOCK7	Dedicator of cytokinesis protein 7	5	UniProt NCBI
ABLIM1	Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin)	5	UniProt NCBI
LMO7	LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP)	5	UniProt NCBI
RAI14	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14)	5	UniProt NCBI
PPP1R9A	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:817	5.10764421909e-05	0.125	PPP1R12A MPRIP	MRIP-MBS complex
GO:0007010	6.5532965052e-05	0.6875	ARHGEF17 PPP1R12A PPP1R9A LRCH3 SPECC1L TPM1 CDC42 DOCK7 CGN COBL TPM4	cytoskeleton organization
GO:0015629	9.5787388107e-05	0.5	ABLIM1 PPP1R9A PPP1R12A MPRIP SPECC1L COBL TPM1 TPM4	actin cytoskeleton
CORUM:815	0.000153131458895	0.125	PPP1R12A MPRIP	MRIP-MBS-RHOA complex
GO:0003779	0.000392685496834	0.4375	ABLIM1 PPP1R9A MPRIP COBL TPM1 CGN TPM4	actin binding
HPA:0031323	0.00879035914476	0.1875	CGN COBL TPM1	appendix; enterocytes - Microvilli[High]
REAC:R-HSA-194315	0.0101249656059	0.375	ARHGEF17 DOCK7 CDC42 PPP1R12A ARHGAP11A TPM4	Signaling by Rho GTPases
HPA:0131323	0.0104070397832	0.1875	CGN COBL TPM1	colon; enterocytes - Microvilli[High]
REAC:R-HSA-9716542	0.0114607907459	0.375	ARHGEF17 DOCK7 CDC42 PPP1R12A ARHGAP11A TPM4	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
REAC:R-HSA-9012999	0.0138710600714	0.3125	ARHGAP11A TPM4 ARHGEF17 DOCK7 CDC42	RHO GTPase cycle
HPA:0401323	0.0152717752756	0.1875	CGN COBL TPM1	rectum; enterocytes - Microvilli[High]
HPA:0481323	0.018800257384	0.1875	CGN COBL TPM1	small intestine; enterocytes - Microvilli[High]
REAC:R-HSA-418885	0.021546998337	0.125	ABLIM1 CDC42	DCC mediated attractive signaling
GO:0030036	0.0345486060113	0.4375	ARHGEF17 SPECC1L TPM4 TPM1 CDC42 COBL PPP1R9A	actin cytoskeleton organization
GO:0051015	0.0383892904224	0.3125	TPM1 PPP1R9A MPRIP ABLIM1 TPM4	actin filament binding

Edges

Protein 1	Protein 2	Score	ProteomeHD
DOCK7	LRCH3	1.0
TPM1	TPM4	1.0
SPECC1L	RAI14	0.995	0.18
PPP1R9A	RAI14	0.995	0.09
CGN	LMO7	0.995	0.142
MPRIP	RAI14	0.995
TPM1	RAI14	0.994
MPRIP	SPECC1L	0.994
PPP1R12A	MYL6B	0.992	0.1
PPP1R12A	LRCH3	0.992	0.07
MPRIP	PPP1R9A	0.991
MPRIP	TPM1	0.991
ARHGEF17	CGN	0.991	0.116
SPECC1L	LMO7	0.99	0.106
RAI14	LRCH3	0.99	0.054
SPECC1L	MYL6B	0.989	0.094
DOCK7	COBL	0.988
SPECC1L	CGN	0.988	0.042
CGN	ABLIM1	0.988
ARHGEF17	MPRIP	0.988
RAI14	CGN	0.987	0.1
SPECC1L	TPM4	0.985	0.056
TPM1	SPECC1L	0.985
ARHGAP11A	MYL6B	0.985	0.164188194662
SPECC1L	PPP1R12A	0.982	0.182
DOCK7	MYL6B	0.982
RAI14	ARHGAP11A	0.982	0.166
MPRIP	ARHGAP11A	0.981
MPRIP	ABLIM1	0.981
ABLIM1	LMO7	0.98
TPM1	LMO7	0.978
MPRIP	PPP1R12A	0.978
RAI14	MYL6B	0.977	0.092
SPECC1L	PPP1R9A	0.974	0.064
ARHGEF17	SPECC1L	0.973	0.102
LMO7	ARHGAP11A	0.973	0.154
TPM1	PPP1R9A	0.971
TPM4	ARHGAP11A	0.969	0.12
SPECC1L	LRCH3	0.968	0.04
TPM1	ABLIM1	0.967
PPP1R9A	PPP1R12A	0.965	0.088
TPM1	COBL	0.962
ARHGEF17	RAI14	0.962	0.168
RAI14	TPM4	0.959	0.056
ARHGEF17	LMO7	0.958	0.138
ARHGAP11A	CDC42	0.957	0.236
SPECC1L	ABLIM1	0.957
TPM1	ARHGAP11A	0.956
SPECC1L	CDC42	0.955	0.349222222222
SPECC1L	DOCK7	0.954
MPRIP	TPM4	0.953
CGN	DOCK7	0.95
MYL6B	LRCH3	0.948	0.016
CGN	PPP1R12A	0.945	0.102
SPECC1L	ARHGAP11A	0.944	0.082
LMO7	MYL6B	0.943	0.174
ARHGEF17	PPP1R12A	0.941	0.17
ARHGEF17	ABLIM1	0.936
RAI14	PPP1R12A	0.935	0.192
RAI14	COBL	0.932	0.158
TPM1	PPP1R12A	0.926
MYL6B	CDC42	0.919	0.45
MPRIP	COBL	0.918
ABLIM1	COBL	0.908
LMO7	TPM4	0.905	0.188
CGN	TPM4	0.9	0.054
RAI14	DOCK7	0.891
ABLIM1	MYL6B	0.89
COBL	LRCH3	0.89	0.052
ARHGEF17	TPM1	0.885
ARHGEF17	DOCK7	0.853
PPP1R12A	COBL	0.851	0.072
RAI14	LMO7	0.845	0.108
PPP1R9A	ARHGAP11A	0.841	0.096
RAI14	ABLIM1	0.831
TPM1	CDC42	0.828
DOCK7	ABLIM1	0.808
LMO7	COBL	0.796	0.132
PPP1R9A	ABLIM1	0.781
PPP1R9A	COBL	0.781	0.104
ARHGAP11A	COBL	0.773	0.112
ARHGAP11A	PPP1R12A	0.773	0.122
ARHGEF17	ARHGAP11A	0.773	0.146
SPECC1L	COBL	0.773	0.078
CGN	COBL	0.773	0.084
ARHGEF17	COBL	0.773	0.092
CGN	ARHGAP11A	0.773	0.094
MYL6B	COBL	0.773	0.144
ABLIM1	ARHGAP11A	0.773
DOCK7	TPM4	0.773
DOCK7	PPP1R12A	0.766
DOCK7	ARHGAP11A	0.764
COBL	CDC42	0.764	0.294
ARHGEF17	MYL6B	0.76	0.114
ARHGEF17	TPM4	0.751	0.136
LMO7	LRCH3	0.734	0.032
TPM4	MYL6B	0.731	0.3
CGN	LRCH3	0.729	0.03
TPM1	MYL6B	0.72
TPM1	DOCK7	0.713
MPRIP	CGN	0.691
PPP1R12A	CDC42	0.654	0.268
ABLIM1	TPM4	0.65
PPP1R9A	CGN	0.628	0.08
ABLIM1	PPP1R12A	0.618
TPM1	CGN	0.611
TPM4	LRCH3	0.557	0.026
TPM4	PPP1R12A	0.552	0.118
CGN	MYL6B	0.548	0.158
ABLIM1	LRCH3	0.493
MPRIP	LRCH3	0.453
RAI14	CDC42	0.448	0.277333333333
ARHGAP11A	LRCH3	0.383	0.054
LMO7	CDC42	0.381	0.37
DOCK7	LMO7	0.372
TPM4	COBL	0.357	0.112
ABLIM1	CDC42	0.351
TPM1	LRCH3	0.324
CGN	CDC42	0.311	0.166333333333
LMO7	PPP1R12A	0.307	0.192
PPP1R9A	DOCK7	0.285
MPRIP	LMO7	0.276
PPP1R9A	MYL6B	0.256	0.086
TPM4	CDC42	0.249	0.228
MPRIP	MYL6B	0.221
PPP1R9A	LRCH3	0.186	0.05
MPRIP	DOCK7	0.171
PPP1R9A	TPM4	0.169	0.08
LRCH3	CDC42	0.127	0.0945509259259
PPP1R9A	LMO7	0.125	0.112
PPP1R9A	CDC42	0.045	0.26
ARHGEF17	LRCH3	0.043	0.046
ARHGEF17	PPP1R9A	0.039	0.114
ARHGEF17	CDC42	0.039	0.333739130435
DOCK7	CDC42	0.023
MPRIP	CDC42	0.004

Related Complexes

Genename	Complexes
ARHGAP11A	huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1
PPP1R12A	huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1 huMAP3_12994.1
MYL6B	huMAP3_06763.1 huMAP3_08205.1 huMAP3_09348.1
SPECC1L	huMAP3_03989.1 huMAP3_05613.1 huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1
CGN	huMAP3_05977.1 huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1 huMAP3_13918.1
ARHGEF17	huMAP3_00758.1 huMAP3_03989.1 huMAP3_05613.1 huMAP3_08205.1 huMAP3_09542.1
MPRIP	huMAP3_01198.1 huMAP3_05613.1 huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1
COBL	huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1
LRCH3	huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1 huMAP3_13571.1
TPM1	huMAP3_01231.1 huMAP3_06153.1 huMAP3_08088.1 huMAP3_08205.1 huMAP3_09542.1
CDC42	huMAP3_08205.1 huMAP3_09542.1 huMAP3_11311.1
TPM4	huMAP3_06153.1 huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1
DOCK7	huMAP3_05977.1 huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1 huMAP3_13571.1
ABLIM1	huMAP3_05977.1 huMAP3_08205.1 huMAP3_09542.1 huMAP3_11784.1
LMO7	huMAP3_05977.1 huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1
RAI14	huMAP3_05613.1 huMAP3_08205.1 huMAP3_09542.1
PPP1R9A	huMAP3_03989.1 huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1 huMAP3_14504.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08205.1