hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_08216.1

Complex Portal: CPX-24459

Confidence: High

Genename	Protein Name	Uniprot Annotation Score	Links
PDK1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)	5	UniProt NCBI
PDHX	Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)	5	UniProt NCBI
PDK3	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)	5	UniProt NCBI
PDK2	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)	5	UniProt NCBI
PDHA1	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)	5	UniProt NCBI
STAT5B	Signal transducer and activator of transcription 5B	5	UniProt NCBI
PDHB	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)	5	UniProt NCBI
DLAT	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-204174	8.67055191222e-13	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	Regulation of pyruvate dehydrogenase (PDH) complex
GO:0006086	1.36107562031e-11	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	acetyl-CoA biosynthetic process from pyruvate
REAC:R-HSA-70268	2.82650725967e-11	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	Pyruvate metabolism
REAC:R-HSA-5362517	8.64225650575e-11	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	Signaling by Retinoic Acid
GO:0006085	3.34086198171e-10	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	acetyl-CoA biosynthetic process
REAC:R-HSA-71406	5.14837835227e-10	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	Pyruvate metabolism and Citric Acid (TCA) cycle
GO:0006084	3.54959615011e-09	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	acetyl-CoA metabolic process
GO:0035384	2.70670481454e-08	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	thioester biosynthetic process
GO:0071616	2.70670481454e-08	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	acyl-CoA biosynthetic process
GO:0033866	9.22826328254e-08	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	nucleoside bisphosphate biosynthetic process
GO:0034030	9.22826328254e-08	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	ribonucleoside bisphosphate biosynthetic process
GO:0034033	9.22826328254e-08	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	purine nucleoside bisphosphate biosynthetic process
REAC:R-HSA-1428517	2.12950310477e-07	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	The citric acid (TCA) cycle and respiratory electron transport
GO:0006790	9.69147168835e-07	1.0	PDK1 PDK2 STAT5B PDK3 PDHA1 PDHX	sulfur compound metabolic process
GO:0035383	1.06305878677e-06	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	thioester metabolic process
GO:0006637	1.06305878677e-06	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	acyl-CoA metabolic process
REAC:R-HSA-9006931	1.44083156877e-06	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	Signaling by Nuclear Receptors
GO:0006090	2.10650266006e-06	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	pyruvate metabolic process
GO:0033875	3.46351231998e-06	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	ribonucleoside bisphosphate metabolic process
GO:0033865	3.46351231998e-06	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	nucleoside bisphosphate metabolic process
GO:0034032	3.46351231998e-06	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	purine nucleoside bisphosphate metabolic process
GO:0010510	7.68841921772e-06	0.5	PDK1 PDK3 PDK2	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0050812	7.68841921772e-06	0.5	PDK1 PDK3 PDK2	regulation of acyl-CoA biosynthetic process
GO:0044272	1.59628307703e-05	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	sulfur compound biosynthetic process
GO:0004740	1.92180881975e-05	0.5	PDK1 PDK3 PDK2	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0009152	3.99218587905e-05	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	purine ribonucleotide biosynthetic process
GO:0009260	5.29122465223e-05	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	ribonucleotide biosynthetic process
GO:0046390	6.33048718711e-05	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	ribose phosphate biosynthetic process
GO:0005967	6.72425931667e-05	0.5	PDHA1 PDHX PDK2	mitochondrial pyruvate dehydrogenase complex
GO:0045254	6.72425931667e-05	0.5	PDHA1 PDHX PDK2	pyruvate dehydrogenase complex
GO:0006164	9.65356116177e-05	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	purine nucleotide biosynthetic process
GO:0072522	0.000110274484426	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	purine-containing compound biosynthetic process
GO:0009165	0.000165063599886	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	nucleotide biosynthetic process
GO:1901293	0.000181682608562	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	nucleoside phosphate biosynthetic process
GO:0042762	0.0002304395259	0.5	PDK1 PDK3 PDK2	regulation of sulfur metabolic process
GO:0006082	0.000301739279423	1.0	PDK1 PDK2 STAT5B PDK3 PDHA1 PDHX	organic acid metabolic process
WP:WP5050	0.00045276091601	0.333333333333	PDK1 PDHA1	TCA cycle in senescence
GO:1900371	0.000873077093697	0.5	PDK1 PDK3 PDK2	regulation of purine nucleotide biosynthetic process
GO:0030808	0.000873077093697	0.5	PDK1 PDK3 PDK2	regulation of nucleotide biosynthetic process
REAC:R-HSA-162582	0.00128853291586	1.0	PDK1 PDK2 STAT5B PDK3 PDHA1 PDHX	Signal Transduction
GO:0009150	0.00130753205757	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	purine ribonucleotide metabolic process
GO:0009259	0.00153005789855	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	ribonucleotide metabolic process
HP:0500231	0.00161951205762	0.333333333333	PDHA1 PDHX	Abnormal CSF pyruvate family amino acid concentration
GO:0019693	0.0018359440657	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	ribose phosphate metabolic process
WP:WP4206	0.00190817031826	0.333333333333	PDK1 PDHA1	Hereditary leiomyomatosis and renal cell carcinoma pathway
KEGG:05415	0.00191301809451	0.5	PDHA1 PDK3 PDK2	Diabetic cardiomyopathy
WP:WP581	0.0023190863075	0.333333333333	PDK1 STAT5B	EPO receptor signaling
GO:0006163	0.00344500495836	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	purine nucleotide metabolic process
GO:0072521	0.00423228845334	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	purine-containing compound metabolic process
GO:0005759	0.00456204960132	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	mitochondrial matrix
HP:0002928	0.00485499013014	0.333333333333	PDHA1 PDHX	Decreased activity of the pyruvate dehydrogenase complex
GO:0032787	0.00521970580151	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	monocarboxylic acid metabolic process
GO:0009117	0.00547678104343	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	nucleotide metabolic process
GO:0006753	0.00588124258153	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	nucleoside phosphate metabolic process
GO:0090407	0.00638287017442	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	organophosphate biosynthetic process
GO:0097411	0.00702301080125	0.333333333333	PDK1 PDK3	hypoxia-inducible factor-1alpha signaling pathway
WP:WP5220	0.00741608411471	0.333333333333	PDHA1 PDHX	Metabolic reprogramming in pancreatic cancer
REAC:R-HSA-389661	0.00771351163082	0.333333333333	PDHA1 PDHX	Glyoxylate metabolism and glycine degradation
GO:0055086	0.0107046292506	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	nucleobase-containing small molecule metabolic process
GO:1901137	0.011992285753	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	carbohydrate derivative biosynthetic process
HP:0500184	0.0129324670968	0.333333333333	PDHA1 PDHX	Abnormal CSF amino acid concentration
HP:0500183	0.0146541203169	0.333333333333	PDHA1 PDHX	Abnormal CSF carboxylic acid concentration
KEGG:05230	0.0158846761267	0.333333333333	PDK1 PDHA1	Central carbon metabolism in cancer
GO:0044281	0.0178283058364	1.0	PDK1 PDK2 STAT5B PDK3 PDHA1 PDHX	small molecule metabolic process
WP:WP4255	0.0220152039288	0.333333333333	PDK1 STAT5B	Non small cell lung cancer
REAC:R-HSA-1430728	0.0258573248266	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	Metabolism
WP:WP3925	0.0337850948883	0.333333333333	PDHA1 PDHX	Amino acid metabolism
KEGG:04066	0.034648047564	0.333333333333	PDK1 PDHA1	HIF-1 signaling pathway
GO:0019752	0.035820867033	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	carboxylic acid metabolic process
GO:0043436	0.0404352228548	0.833333333333	PDK1 PDHA1 PDK2 PDHX PDK3	oxoacid metabolic process
CORUM:2013	0.0499436884912	0.166666666667	STAT5B	STAT5B homodimer complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
PDHA1	PDHB	1.0	0.958	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM
PDHA1	DLAT	1.0	0.718		hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM fraction
PDHB	DLAT	1.0	0.694		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM fraction
PDK3	DLAT	0.999	0.118	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
PDK1	PDK2	0.999	0.058	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein ()
PDK3	PDK1	0.999	0.278	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein ()
PDK3	PDHB	0.999	0.124	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM treiber_WMM
PDHX	PDHA1	0.998	0.684		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDK3	PDHX	0.998	0.06	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDHX	DLAT	0.997	0.652		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDK3	PDHA1	0.997	0.18	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM
PDHA1	PDK2	0.996	0.204		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
PDK3	PDK2	0.996	0.088	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDK1	PDHA1	0.996	0.29		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
PDK2	DLAT	0.994	0.236	structurally_consistent (dimer)	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
PDHX	PDK2	0.994	0.07		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
STAT5B	PDHX	0.993	0.078		hein_WMM bioplex_WMM bioplex3_WMM hein ()
PDHX	PDHB	0.991	0.568		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM
STAT5B	PDHA1	0.989	0.11		hein_WMM bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
PDK1	PDHX	0.984	0.218		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
STAT5B	PDHB	0.981	0.086		hein_WMM bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
PDK1	PDHB	0.964	0.429538461538		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDHB	PDK2	0.957	0.354	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDK1	DLAT	0.924	0.3708		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
STAT5B	DLAT	0.88	0.092		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
PDK3	STAT5B	0.789	0.024		bioplex_WMM bioplex3_WMM WMM_only
STAT5B	PDK2	0.143	0.06		bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
PDK1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHX	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDK3	huMAP3_00016.1 huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDK2	huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHA1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
STAT5B	huMAP3_03752.1 huMAP3_04704.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHB	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
DLAT	huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_08216.1

Complex Portal: CPX-24459