List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_08216.1

Confidence: High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
PDK1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)	5	UniProt   NCBI
PDHX	Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)	5	UniProt   NCBI
PDK3	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)	5	UniProt   NCBI
PDK2	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)	5	UniProt   NCBI
PDHA1	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)	5	UniProt   NCBI
STAT5B	Signal transducer and activator of transcription 5B	5	UniProt   NCBI
PDHB	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)	5	UniProt   NCBI
DLAT	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-204174	8.67055191222e-13	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	Regulation of pyruvate dehydrogenase (PDH) complex
GO:0006086	1.36107562031e-11	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	acetyl-CoA biosynthetic process from pyruvate
REAC:R-HSA-70268	2.82650725967e-11	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	Pyruvate metabolism
REAC:R-HSA-5362517	8.64225650575e-11	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	Signaling by Retinoic Acid
GO:0006085	3.34086198171e-10	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	acetyl-CoA biosynthetic process
REAC:R-HSA-71406	5.14837835227e-10	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	Pyruvate metabolism and Citric Acid (TCA) cycle
GO:0006084	3.54959615011e-09	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	acetyl-CoA metabolic process
GO:0035384	2.70670481454e-08	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	thioester biosynthetic process
GO:0071616	2.70670481454e-08	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	acyl-CoA biosynthetic process
GO:0033866	9.22826328254e-08	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	nucleoside bisphosphate biosynthetic process
GO:0034030	9.22826328254e-08	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	ribonucleoside bisphosphate biosynthetic process
GO:0034033	9.22826328254e-08	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	purine nucleoside bisphosphate biosynthetic process
REAC:R-HSA-1428517	2.12950310477e-07	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	The citric acid (TCA) cycle and respiratory electron transport
GO:0006790	9.69147168835e-07	1.0	PDK2 PDK3 PDK1 PDHX PDHA1 STAT5B	sulfur compound metabolic process
GO:0035383	1.06305878677e-06	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	thioester metabolic process
GO:0006637	1.06305878677e-06	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	acyl-CoA metabolic process
REAC:R-HSA-9006931	1.44083156877e-06	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	Signaling by Nuclear Receptors
GO:0006090	2.10650266006e-06	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	pyruvate metabolic process
GO:0033875	3.46351231998e-06	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	ribonucleoside bisphosphate metabolic process
GO:0033865	3.46351231998e-06	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	nucleoside bisphosphate metabolic process
GO:0034032	3.46351231998e-06	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	purine nucleoside bisphosphate metabolic process
GO:0010510	7.68841921772e-06	0.5	PDK3 PDK1 PDK2	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0050812	7.68841921772e-06	0.5	PDK3 PDK1 PDK2	regulation of acyl-CoA biosynthetic process
GO:0044272	1.59628307703e-05	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	sulfur compound biosynthetic process
GO:0004740	1.92180881975e-05	0.5	PDK3 PDK1 PDK2	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0009152	3.99218587905e-05	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	purine ribonucleotide biosynthetic process
GO:0009260	5.29122465223e-05	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	ribonucleotide biosynthetic process
GO:0046390	6.33048718711e-05	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	ribose phosphate biosynthetic process
GO:0005967	6.72425931667e-05	0.5	PDHX PDK2 PDHA1	mitochondrial pyruvate dehydrogenase complex
GO:0045254	6.72425931667e-05	0.5	PDHX PDK2 PDHA1	pyruvate dehydrogenase complex
GO:0006164	9.65356116177e-05	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	purine nucleotide biosynthetic process
GO:0072522	0.000110274484426	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	purine-containing compound biosynthetic process
GO:0009165	0.000165063599886	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	nucleotide biosynthetic process
GO:1901293	0.000181682608562	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	nucleoside phosphate biosynthetic process
GO:0042762	0.0002304395259	0.5	PDK3 PDK1 PDK2	regulation of sulfur metabolic process
GO:0006082	0.000301739279423	1.0	PDK2 PDK3 PDK1 PDHX PDHA1 STAT5B	organic acid metabolic process
WP:WP5050	0.00045276091601	0.333333333333	PDHA1 PDK1	TCA cycle in senescence
GO:1900371	0.000873077093697	0.5	PDK3 PDK1 PDK2	regulation of purine nucleotide biosynthetic process
GO:0030808	0.000873077093697	0.5	PDK3 PDK1 PDK2	regulation of nucleotide biosynthetic process
REAC:R-HSA-162582	0.00128853291586	1.0	PDK2 PDK3 PDK1 PDHX PDHA1 STAT5B	Signal Transduction
GO:0009150	0.00130753205757	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	purine ribonucleotide metabolic process
GO:0009259	0.00153005789855	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	ribonucleotide metabolic process
HP:0500231	0.00161951205762	0.333333333333	PDHX PDHA1	Abnormal CSF pyruvate family amino acid concentration
GO:0019693	0.0018359440657	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	ribose phosphate metabolic process
WP:WP4206	0.00190817031826	0.333333333333	PDHA1 PDK1	Hereditary leiomyomatosis and renal cell carcinoma pathway
KEGG:05415	0.00191301809451	0.5	PDK3 PDK2 PDHA1	Diabetic cardiomyopathy
WP:WP581	0.0023190863075	0.333333333333	PDK1 STAT5B	EPO receptor signaling
GO:0006163	0.00344500495836	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	purine nucleotide metabolic process
GO:0072521	0.00423228845334	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	purine-containing compound metabolic process
GO:0005759	0.00456204960132	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	mitochondrial matrix
HP:0002928	0.00485499013014	0.333333333333	PDHX PDHA1	Decreased activity of the pyruvate dehydrogenase complex
GO:0032787	0.00521970580151	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	monocarboxylic acid metabolic process
GO:0009117	0.00547678104343	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	nucleotide metabolic process
GO:0006753	0.00588124258153	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	nucleoside phosphate metabolic process
GO:0090407	0.00638287017442	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	organophosphate biosynthetic process
GO:0097411	0.00702301080125	0.333333333333	PDK3 PDK1	hypoxia-inducible factor-1alpha signaling pathway
WP:WP5220	0.00741608411471	0.333333333333	PDHX PDHA1	Metabolic reprogramming in pancreatic cancer
REAC:R-HSA-389661	0.00771351163082	0.333333333333	PDHX PDHA1	Glyoxylate metabolism and glycine degradation
GO:0055086	0.0107046292506	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	nucleobase-containing small molecule metabolic process
GO:1901137	0.011992285753	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	carbohydrate derivative biosynthetic process
HP:0500184	0.0129324670968	0.333333333333	PDHX PDHA1	Abnormal CSF amino acid concentration
HP:0500183	0.0146541203169	0.333333333333	PDHX PDHA1	Abnormal CSF carboxylic acid concentration
KEGG:05230	0.0158846761267	0.333333333333	PDHA1 PDK1	Central carbon metabolism in cancer
GO:0044281	0.0178283058364	1.0	PDK2 PDK3 PDK1 PDHX PDHA1 STAT5B	small molecule metabolic process
WP:WP4255	0.0220152039288	0.333333333333	PDK1 STAT5B	Non small cell lung cancer
REAC:R-HSA-1430728	0.0258573248266	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	Metabolism
WP:WP3925	0.0337850948883	0.333333333333	PDHX PDHA1	Amino acid metabolism
KEGG:04066	0.034648047564	0.333333333333	PDHA1 PDK1	HIF-1 signaling pathway
GO:0019752	0.035820867033	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	carboxylic acid metabolic process
GO:0043436	0.0404352228548	0.833333333333	PDHA1 PDHX PDK2 PDK1 PDK3	oxoacid metabolic process
CORUM:2013	0.0499436884912	0.166666666667	STAT5B	STAT5B homodimer complex



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Evidence ?
PDHA1	PDHB	1.0	0.958	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     Guru     bioplex3_WMM     Malo     gupta_WMM     fraction     boldt_WMM     treiber_WMM
PDHA1	DLAT	1.0	0.718	hein_WMM     bioplex_WMM     Guru     bioplex3_WMM     youn_WMM     fraction
PDHB	DLAT	1.0	0.694	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     Guru     bioplex3_WMM     youn_WMM     fraction
PDK3	DLAT	0.999	0.118	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     youn_WMM
PDK1	PDK2	0.999	0.058	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     hein ()
PDK3	PDK1	0.999	0.278	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     youn_WMM     hein ()
PDK3	PDHB	0.999	0.124	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     treiber_WMM
PDHX	PDHA1	0.998	0.684	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
PDK3	PDHX	0.998	0.06	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
PDHX	DLAT	0.997	0.652	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
PDK3	PDHA1	0.997	0.18	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     youn_WMM     treiber_WMM
PDHA1	PDK2	0.996	0.204	hein_WMM     bioplex_WMM     bioplex3_WMM     WMM_only
PDK3	PDK2	0.996	0.088	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
PDK1	PDHA1	0.996	0.29	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     youn_WMM
PDK2	DLAT	0.994	0.236	hein_WMM     bioplex_WMM     bioplex3_WMM     WMM_only
PDHX	PDK2	0.994	0.07	hein_WMM     bioplex_WMM     bioplex3_WMM     WMM_only
STAT5B	PDHX	0.993	0.078	hein_WMM     bioplex_WMM     bioplex3_WMM     hein ()
PDHX	PDHB	0.991	0.568	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     boldt_WMM
STAT5B	PDHA1	0.989	0.11	hein_WMM     bioplex_WMM     bioplex3_WMM     hein ()     bioplex3_HCT116
PDK1	PDHX	0.984	0.218	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
STAT5B	PDHB	0.981	0.086	hein_WMM     bioplex_WMM     bioplex3_WMM     hein ()     bioplex3_HCT116
PDK1	PDHB	0.964	0.429538461538	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
PDHB	PDK2	0.957	0.354	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
PDK1	DLAT	0.924	0.3708	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     youn_WMM
STAT5B	DLAT	0.88	0.092	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     hein ()     bioplex3_HCT116
PDK3	STAT5B	0.789	0.024	bioplex_WMM     bioplex3_WMM     WMM_only
STAT5B	PDK2	0.143	0.06	bioplex_WMM     bioplex3_WMM     WMM_only





Related Complexes

Genename	Complexes
PDK1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHX	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDK3	huMAP3_00016.1 huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDK2	huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHA1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
STAT5B	huMAP3_03752.1 huMAP3_04704.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHB	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
DLAT	huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1