hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08218.1
Complex Portal: CPX-14285
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| F2 | Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] | 5 | UniProt NCBI |
| TTR | Transthyretin (ATTR) (Prealbumin) (TBPA) | 5 | UniProt NCBI |
| HRG | Histidine-rich glycoprotein (Histidine-proline-rich glycoprotein) (HPRG) | 5 | UniProt NCBI |
| KLK9 | Kallikrein-9 (EC 3.4.21.-) (Kallikrein-like protein 3) (KLK-L3) | 3 | UniProt NCBI |
| P2RX6 | P2X purinoceptor 6 (P2X6) (ATP receptor) (P2XM) (Purinergic receptor) (Purinergic receptor P2X-like 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001907 | 0.000994005864165 | 0.6 | HRG F2 TTR | Thromboembolism |
| HP:0001977 | 0.00917714185137 | 0.6 | HRG F2 TTR | Abnormal thrombosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| KLK9 | P2RX6 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| F2 | P2RX6 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| P2RX6 | TTR | 0.991 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| P2RX6 | HRG | 0.983 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TTR | HRG | 0.746 | 0.324 | bioplex3_WMM WMM_only | |
| KLK9 | TTR | 0.634 |
structurally_consistent (O15547)
|
bioplex3_WMM WMM_only | |
| KLK9 | HRG | 0.634 | bioplex3_WMM WMM_only | ||
| F2 | KLK9 | 0.633 | bioplex3_WMM WMM_only | ||
| F2 | HRG | 0.404 | 0.413090909091 | bioplex3_WMM WMM_only | |
| F2 | TTR | 0.372 | 0.52 | bioplex3_WMM WMM_only |
Related Complexes