hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08218.1
Complex Portal: CPX-14285
Confidence: High  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
F2 | Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] | 5 | UniProt   NCBI |
TTR | Transthyretin (ATTR) (Prealbumin) (TBPA) | 5 | UniProt   NCBI |
HRG | Histidine-rich glycoprotein (Histidine-proline-rich glycoprotein) (HPRG) | 5 | UniProt   NCBI |
KLK9 | Kallikrein-9 (EC 3.4.21.-) (Kallikrein-like protein 3) (KLK-L3) | 3 | UniProt   NCBI |
P2RX6 | P2X purinoceptor 6 (P2X6) (ATP receptor) (P2XM) (Purinergic receptor) (Purinergic receptor P2X-like 1) | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  HP:0001907 | 0.000994005864165 | 0.6 | F2 TTR HRG | Thromboembolism |
  HP:0001977 | 0.00917714185137 | 0.6 | F2 TTR HRG | Abnormal thrombosis |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
---|---|---|---|---|---|
 KLK9 |  P2RX6 | 0.999 |            |
structurally_consistent (dimer)        
|
bioplex3_WMM     bioplex3_HCT116     WMM_only     |
 F2 |  P2RX6 | 0.998 |            |          | bioplex3_WMM     bioplex3_HCT116     WMM_only     |
 P2RX6 |  TTR | 0.991 |            |
structurally_consistent (dimer)        
|
bioplex3_WMM     bioplex3_HCT116     WMM_only     |
 P2RX6 |  HRG | 0.983 |            |          | bioplex3_WMM     bioplex3_HCT116     WMM_only     |
 TTR |  HRG | 0.746 | 0.324           |          | bioplex3_WMM     WMM_only     |
 KLK9 |  TTR | 0.634 |            |
structurally_consistent (O15547)        
|
bioplex3_WMM     WMM_only     |
 KLK9 |  HRG | 0.634 |            |          | bioplex3_WMM     WMM_only     |
 F2 |  KLK9 | 0.633 |            |          | bioplex3_WMM     WMM_only     |
 F2 |  HRG | 0.404 | 0.413090909091           |          | bioplex3_WMM     WMM_only     |
 F2 |  TTR | 0.372 | 0.52           |          | bioplex3_WMM     WMM_only     |
Related Complexes