hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_08222.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SIPA1L3 | Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3) | 5 | UniProt NCBI |
| SIPA1L1 | Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1) | 5 | UniProt NCBI |
| ERC1 | ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2) | 5 | UniProt NCBI |
| DENND2B | DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein) | 5 | UniProt NCBI |
| SIPA1 | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) | 5 | UniProt NCBI |
| SRGAP2 | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04015 | 0.00145281635598 | 0.5 | SIPA1 SIPA1L3 SIPA1L1 | Rap1 signaling pathway |
| GO:0030695 | 0.00235090512157 | 0.833333333333 | SRGAP2 DENND2B SIPA1 SIPA1L3 SIPA1L1 | GTPase regulator activity |
| GO:0060589 | 0.00235090512157 | 0.833333333333 | SRGAP2 DENND2B SIPA1 SIPA1L3 SIPA1L1 | nucleoside-triphosphatase regulator activity |
| GO:0005096 | 0.0146230100935 | 0.666666666667 | SRGAP2 SIPA1 SIPA1L3 SIPA1L1 | GTPase activator activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SIPA1L1 | SIPA1L3 | 0.999 | 0.112 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM WMM_only |
| SIPA1 | SIPA1L1 | 0.996 | 0.046 | hein_WMM bioplex3_WMM WMM_only |
| SIPA1 | SIPA1L3 | 0.994 | 0.032 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only |
| DENND2B | SIPA1L3 | 0.989 | 0.132 | hein_WMM bioplex3_WMM WMM_only boldt_WMM |
| DENND2B | SIPA1L1 | 0.986 | 0.096 | hein_WMM bioplex3_WMM WMM_only boldt_WMM |
| DENND2B | SIPA1 | 0.978 | 0.044 | hein_WMM bioplex3_WMM WMM_only |
| ERC1 | SIPA1L1 | 0.976 | 0.054 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| SRGAP2 | SIPA1 | 0.974 | 0.028 | hein_WMM bioplex3_WMM WMM_only |
| SRGAP2 | ERC1 | 0.965 | 0.12 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
| ERC1 | SIPA1 | 0.964 | 0.042 | hein_WMM bioplex3_WMM WMM_only |
| SRGAP2 | DENND2B | 0.963 | 0.092 | hein_WMM bioplex3_WMM WMM_only boldt_WMM |
| ERC1 | SIPA1L3 | 0.955 | 0.08 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| SRGAP2 | SIPA1L1 | 0.955 | 0.044 | hein_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| SRGAP2 | SIPA1L3 | 0.903 | 0.10696 | hein_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM |
| ERC1 | DENND2B | 0.862 | 0.068 | hein_WMM bioplex3_WMM WMM_only |
Related Complexes