hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_08223.1
Confidence: High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UQCRH | Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) | 5 | UniProt NCBI |
| MT-CYB | Cytochrome b (Complex III subunit 3) (Complex III subunit III) (Cytochrome b-c1 complex subunit 3) (Ubiquinol-cytochrome-c reductase complex cytochrome b subunit) | 5 | UniProt NCBI |
| UQCRC2 | Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2) | 5 | UniProt NCBI |
| UQCR10 | Cytochrome b-c1 complex subunit 9 (Complex III subunit 9) (Complex III subunit X) (Cytochrome c1 non-heme 7 kDa protein) (Ubiquinol-cytochrome c reductase complex 7.2 kDa protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4921 | 3.52698537821e-08 | 1.0 | UQCRH MT-CYB UQCR10 | Mitochondrial complex III assembly |
| GO:0008121 | 3.84480164306e-07 | 1.0 | UQCRH MT-CYB UQCR10 | ubiquinol-cytochrome-c reductase activity |
| GO:0016679 | 9.61200410764e-07 | 1.0 | UQCRH MT-CYB UQCR10 | oxidoreductase activity, acting on diphenols and related substances as donors |
| KEGG:04260 | 3.11554307054e-06 | 1.0 | UQCRH MT-CYB UQCR10 | Cardiac muscle contraction |
| WP:WP111 | 1.17898981996e-05 | 1.0 | UQCRH MT-CYB UQCR10 | Electron transport chain OXPHOS system in mitochondria |
| KEGG:00190 | 1.54230874605e-05 | 1.0 | UQCRH MT-CYB UQCR10 | Oxidative phosphorylation |
| GO:0006122 | 1.58598067776e-05 | 1.0 | UQCRH MT-CYB UQCR10 | mitochondrial electron transport, ubiquinol to cytochrome c |
| GO:0005750 | 2.11464090368e-05 | 1.0 | UQCRH MT-CYB UQCR10 | mitochondrial respiratory chain complex III |
| GO:0045275 | 2.11464090368e-05 | 1.0 | UQCRH MT-CYB UQCR10 | respiratory chain complex III |
| KEGG:04932 | 2.28801742777e-05 | 1.0 | UQCRH MT-CYB UQCR10 | Non-alcoholic fatty liver disease |
| WP:WP4396 | 3.24963255001e-05 | 1.0 | UQCRH MT-CYB UQCR10 | Nonalcoholic fatty liver disease |
| KEGG:05415 | 5.16258651055e-05 | 1.0 | UQCRH MT-CYB UQCR10 | Diabetic cardiomyopathy |
| KEGG:05208 | 7.07004693439e-05 | 1.0 | UQCRH MT-CYB UQCR10 | Chemical carcinogenesis - reactive oxygen species |
| REAC:R-HSA-611105 | 7.31860792369e-05 | 1.0 | UQCRH MT-CYB UQCR10 | Respiratory electron transport |
| KEGG:04714 | 7.39136996301e-05 | 1.0 | UQCRH MT-CYB UQCR10 | Thermogenesis |
| KEGG:05012 | 0.00011589966492 | 1.0 | UQCRH MT-CYB UQCR10 | Parkinson disease |
| KEGG:05020 | 0.000126475690353 | 1.0 | UQCRH MT-CYB UQCR10 | Prion disease |
| REAC:R-HSA-163200 | 0.000134372084608 | 1.0 | UQCRH MT-CYB UQCR10 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:05016 | 0.000171368189864 | 1.0 | UQCRH MT-CYB UQCR10 | Huntington disease |
| KEGG:05014 | 0.00029339200738 | 1.0 | UQCRH MT-CYB UQCR10 | Amyotrophic lateral sclerosis |
| KEGG:05010 | 0.000339187774081 | 1.0 | UQCRH MT-CYB UQCR10 | Alzheimer disease |
| GO:0070069 | 0.000351222630093 | 1.0 | UQCRH MT-CYB UQCR10 | cytochrome complex |
| REAC:R-HSA-1428517 | 0.000368729542429 | 1.0 | UQCRH MT-CYB UQCR10 | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:05022 | 0.000613327564103 | 1.0 | UQCRH MT-CYB UQCR10 | Pathways of neurodegeneration - multiple diseases |
| GO:0015453 | 0.00296587998745 | 1.0 | UQCRH MT-CYB UQCR10 | oxidoreduction-driven active transmembrane transporter activity |
| GO:0019646 | 0.00675723888767 | 1.0 | UQCRH MT-CYB UQCR10 | aerobic electron transport chain |
| GO:0098803 | 0.00760107672828 | 1.0 | UQCRH MT-CYB UQCR10 | respiratory chain complex |
| GO:0042775 | 0.00851239083773 | 1.0 | UQCRH MT-CYB UQCR10 | mitochondrial ATP synthesis coupled electron transport |
| GO:0042773 | 0.00851239083773 | 1.0 | UQCRH MT-CYB UQCR10 | ATP synthesis coupled electron transport |
| GO:0070469 | 0.00949377645712 | 1.0 | UQCRH MT-CYB UQCR10 | respirasome |
| GO:0005746 | 0.00949377645712 | 1.0 | UQCRH MT-CYB UQCR10 | mitochondrial respirasome |
| GO:0022904 | 0.0116771431902 | 1.0 | UQCRH MT-CYB UQCR10 | respiratory electron transport chain |
| GO:0015078 | 0.0120707547584 | 1.0 | UQCRH MT-CYB UQCR10 | proton transmembrane transporter activity |
| GO:0009055 | 0.0141719388563 | 1.0 | UQCRH MT-CYB UQCR10 | electron transfer activity |
| GO:0022900 | 0.0150763323228 | 1.0 | UQCRH MT-CYB UQCR10 | electron transport chain |
| KEGG:01100 | 0.0189521995452 | 1.0 | UQCRH MT-CYB UQCR10 | Metabolic pathways |
| GO:1990204 | 0.0219076797621 | 1.0 | UQCRH MT-CYB UQCR10 | oxidoreductase complex |
| GO:0006119 | 0.025655976884 | 1.0 | UQCRH MT-CYB UQCR10 | oxidative phosphorylation |
| GO:0015399 | 0.0328130751425 | 1.0 | UQCRH MT-CYB UQCR10 | primary active transmembrane transporter activity |
| GO:0098800 | 0.0498541011049 | 1.0 | UQCRH MT-CYB UQCR10 | inner mitochondrial membrane protein complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UQCRH | UQCR10 | 0.997 | 0.932 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| UQCRH | MT-CYB | 0.988 | 0.194 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| UQCRC2 | UQCR10 | 0.984 | 0.58 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| UQCRH | UQCRC2 | 0.978 | 0.686 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM |
| MT-CYB | UQCR10 | 0.966 | 0.612 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| UQCRC2 | MT-CYB | 0.958 | 0.78 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM fraction |
Related Complexes